Advanced search
Publication Cover
Toxicology Communications Volume 5, 2021 - Issue 1
Submit an article Journal homepage
936
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Unmet clinical laboratory need in patients hospitalized for acute poisoning from long-acting anticoagulant rodenticides

Richard B. van Breemena Linus Pauling Institute, Oregon State University, Corvallis, OR, USAView further author information
,
John W. Hafnerb Department of Emergency Medicine, University of Illinois, Peoria, IL, USAView further author information
,
Daniel G. Nosala Linus Pauling Institute, Oregon State University, Corvallis, OR, USAView further author information
,
Douglas L. Feinsteinc Department of Anesthesiology, University of Illinois, Chicago, IL, USA;d Jesse Brown VA Medical Center, Chicago, IL, USAView further author information
&
Israel Rubinsteind Jesse Brown VA Medical Center, Chicago, IL, USA;e Department of Medicine, University of Illinois, Chicago, IL, USACorrespondence[email protected]
View further author information
Pages 93-96 | Published online: 04 Jun 2021

References

  • Kelkar AH, Smith NA, Martial A, et al. An outbreak of synthetic cannabinoid-associated coagulopathy in Illinois. N Engl J Med. 2018;379:1216–1223.
  • Devgun JM, Rasin A, Kim T, et al. An outbreak of severe coagulopathy from synthetic cannabinoids tainted with long-acting anticoagulant rodenticides. Clin Toxicol. [Phila] 2019;4:1–8.
  • Navon L, Moritz E, Austin C, et al. The public health response to a large poisoning outbreak involving an illicit substance: Synthetic cannabinoids contaminated with a long-acting anticoagulant rodenticide, Illinois, March-July, 2018. J Public Health Manag Pract. 2020;26:E1–E7.
  • Bruno GR, Howland MA, McMeeking A, et al. Long-acting anticoagulant overdose: brodifacoum kinetics and optimal vitamin K dosing. Ann Emerg Med. 2000;36:262–267.
  • Olmos V, López CM. Brodifacoum poisoning with toxicokinetic data. Clin Toxicol [Phila]. 2007;45:487–489.
  • Yip L, Stanton NV, Middleberg RA. Vitamin K[1] treatment duration in patients with brodifacoum poisoning. N Engl J Med. 2020;382:1764–1765.
  • Schaff JE, Montgomery MA. An HPLC-HR-MS-MS method for identification of anticoagulant rodenticides in blood. J Anal Toxicol. 2013;37:321–325.
  • Feinstein DL, Nosal DG, Ramanathan S, et al. Effects of vitamin K1 treatment on plasma concentrations of long-acting anticoagulant rodenticide enantiomers following inhalation of contaminated synthetic cannabinoids. Clin Toxicol [Phila]. 2020;58:716–724.
  • Tole M, LaBedz S, Feinstein DL, et al. Adherence to long-term follow-up of patients with life-threatening, inhaled synthetic cannabinoids-associated coagulopathy in Chicago. Lung. 2019;197:349–352.
  • Rasin A, Devgun JM, Nodal DG, et al. Coagulopathy after synthetic cannabinoid use: a case report. Ann Intern Med. 2019;171:595–596.
  • U. S. Food and Drug Administration Guidance for Bioanalytical Method Validation 2018. https://www.fda.gov/files/drugs/published/Bioanalytical-Method-Validation-Guidance-for-Industry.pdf. [accessed March 5, 2021].
  • Wisconsin State Laboratory of Hygiene. https://slhstream2.ad.slh.wisc.edu/Mediasite/Play/35e5ce9959ce494b9fb05d30442be8aa1d. [accessed March 5, 2021].
  • Middleberg RA, Homan J. Qualitative identification of rodenticide anticoagulants by LC-MS/MS. Methods Mol Biol. 2012;902:139–148.
  • Hauck ZZ, Feinstein DL, van Breemen RB. LC-MS-MS analysis of brodifacoum isomers in rat tissue. J Anal Toxicol. 2016;40(4):304–309.
  • Nosal DG, Feinstein DL, Chen L, et al. Separation and quantification of superwarfarin rodenticide diastereomers-bromadiolone, difenacoum, flocoumafen, brodifacoum, and difethialone-in human plasma. J AOAC Int. 2020;103(3):770–778.
  • Nosal DG, Feinstein DL, van Breemen RB. Chiral liquid chromatography-tandem mass spectrometry analysis of superwarfarin rodenticide stereoisomers - bromadiolone, difenacoum and brodifacoum - in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2021;1165:122529.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.