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Toxicology Communications Volume 6, 2022 - Issue 1
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Case Report

Severe colchicine poisoning treated successfully with kidney replacement therapy and plasmapheresis: a case report

D. H. Schaffera Department of Emergency Medicine, Brigham and Women’s Hospital, Boston, MA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1597-0726View further author information
ORCID Icon,
D. L. Overbeekb Department of Emergency Medicine, University of Rochester Medical Center, Rochester, NY, USAView further author information
,
T. B. Ericksona Department of Emergency Medicine, Brigham and Women’s Hospital, Boston, MA, USA;c Harvard Humanitarian Initiative, Cambridge, MA, USAORCID Iconhttps://orcid.org/0000-0002-1809-4805View further author information
ORCID Icon,
E. W. Boyerd Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USAView further author information
,
C. Goldfinea Department of Emergency Medicine, Brigham and Women’s Hospital, Boston, MA, USAView further author information
,
S. A. Muhsine Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAView further author information
&
P. R. Chaia Department of Emergency Medicine, Brigham and Women’s Hospital, Boston, MA, USA;f Department of Psychosocial Oncology and Palliative Care, Dana Farber Cancer Institute, Boston, MA, USA;g The Koch Institute for Integrated Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA;h The Fenway Institute, Boston, MA, USAORCID Iconhttps://orcid.org/0000-0003-0955-4117View further author information
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Pages 46-50 | Published online: 24 Mar 2022

References

  • Leung YY, Yao Hui LL, Kraus VB. Colchicine-update on mechanisms of action and therapeutic uses. Semin Arthritis Rheum. 2015;45(3):341–350.
  • Santos CD, Schier JG. Colchicine, podophyllin, and the vinca alkaloids. In: Hoffman RS, Goldfrank LR, Smith SW, Lewin NA, Howland MA, Nelson LS, editors. Goldfrank’s toxicologic emergencies, Eleventh Edition, Eleventh. New York: The McGraw-Hill Companies; 2019, pp. 501–510.
  • Milne ST, Meek PD. Fatal colchicine overdose: report of a case and review of the literature. Am J Emerg Med. 1998;16(6):603–608.
  • Bismuth C, Baud F, Dally S. Standardized prognosis evaluation in acute toxicology its benefit in colchicine, paraquat and digitalis poisonings. J Toxicol Clin Exp. 1986;6(1):33–38.
  • Bismuth C, Gaultier M, Conso F. Medullary aplasia after acute colchicine poisoning. 20 cases. Nouv Presse Med. 1977;6(19):1625–1629.
  • Iosfina I, Lan J, Chin C, et al. Massive colchicine overdose with recovery. Case Rep Nephrol Urol. 2012;2(1):20–24.
  • Mullins ME, Carrico EA, Horowitz BZ. Fatal cardiovascular collapse following acute colchicine ingestion. J Toxicol Clin Toxicol. 2000;38(1):51–54.
  • Ozdemir R, Bayrakci B, Teksam O. Fatal poisoning in children: Acute colchicine intoxication and new treatment approaches. Clin Toxicol. 2011;49(8):739–743.
  • Finkelstein Y, Aks SE, Hutson JR, et al. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol. 2010;48(5):407–414.
  • Rahman O, Jacobi J, Peter H, Mowry J, Sohail M. Demonstration of Colchicine Clearance by Continuous Venovenous Hemofilration (CVVH) in Severe Toxicity. Am J Respir Crit Care Med. 2018;197:A6917.
  • Demirkol D, Karacabey BN, Aygun F. Plasma exchange treatment in a case of colchicine intoxication. Ther Apher Dial. 2015;19(1):95–97.
  • Harris R, Marx G, Gillett M, Kark A, Arunanthy S. Colchicine-induced bone marrow suppression: Treatment with granulocyte colony-stimulating factor. The Journal of Emergency Medicine 2000;18:435–440.
  • Lee S-H, Park S-W, Han S-K, et al. Acute colchicine poisoning treated with granulocyte colony stimulating factor and transfusion. Korean J Crit Care Med. 2015;30(3):207–211.
  • Baud F, Deye N, Malissin I, et al. Inefficacy of extracorporeal life support in four cases of acute colchicine poisoning: a preliminary report. Clin Toxicol. 2014;52:409–410.
  • Baud FJ, Sabouraud A, Vicaut E, et al . Brief report: treatment of severe colchicine overdose with colchicine-specific Fab fragments. N Engl J Med. 1995;332(10):642–645.
  • Fabresse N, Allard J, Sardaby M, et al. LC–MS/MS quantification of free and fab-bound colchicine in plasma, urine and organs following colchicine administration and colchicine-specific fab fragments treatment in göttingen minipigs. J Chromatogr B Anal Technol Biomed Life Sci. 2017;1060:400–406.
  • Eddleston M, Fabresse N, Thompson A, et al. Anti-colchicine fab fragments prevent lethal colchicine toxicity in a porcine model: a pharmacokinetic and clinical study. Clin Toxicol (Phila). 2018;56(8):773–781.

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