Advanced search
Publication Cover
Toxicology Communications Volume 7, 2023 - Issue 1
Submit an article Journal homepage
472
Views
0
CrossRef citations to date
0
Altmetric
Case Reports

Posterior reversible encephalopathy syndrome following iatrogenic acetylcysteine overdose: a case report

James Jaea Department of Medicine, Western University, London, CanadaView further author information
,
Yilong Lib Department of Microbiology and Immunology, Western University, London, CanadaView further author information
&
Constance A. Mackenziea Department of Medicine, Western University, London, CanadaCorrespondence[email protected]
View further author information
Article: 2292879 | Received 21 May 2023, Accepted 03 Dec 2023, Published online: 14 Dec 2023

References

  • When the antidote causes harm: preventing errors with intravenous acetylcysteine. ISMP Can Saf Bull. 2023;23(7):1–13. https://ismpcanada.ca/bulletin/when-the-antidote-causes-harm-preventing-errors-with-intravenous-acetylcysteine/#
  • Bailey B, McGuigan MA. Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med. 1998;31(6):1–5. doi:10.1016/S0196-0644(98)70229-X.
  • Kao LW, Kirk MA, Furbee RB, et al. What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning? Ann Emerg Med. 2003;42(6):741–750. doi:10.1016/S0196-0644(03)00508-0.
  • Bailey B, Blais R, Letarte A. Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death. Ann Emerg Med. 2004;44(4):401–406. doi:10.1016/j.annemergmed.2004.05.014.
  • Heard K, Schaeffer TH. Massive acetylcysteine overdose associated with cerebral edema and seizures. Clin Toxicol (Phila). 2011;49(5):423–425. doi:10.3109/15563650.2011.583664.
  • Fugate JE, Rabinstein AA. Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions. Lancet Neurol. 2015;14(9):914–925. doi:10.1016/S1474-4422(15)00111-8.
  • Brady E, Parikh NS, Navi BB, et al. The imaging spectrum of posterior reversible encephalopathy syndrome: a pictorial review. Clin Imaging. 2018;47:80–89. doi:10.1016/j.clinimag.2017.08.008.
  • Bartynski WS, Boardman JF. Distinct imaging patterns and lesion distribution in posterior reversible encephalopathy syndrome. AJNR Am J Neuroradiol. 2007;28(7):1320–1327. doi:10.3174/ajnr.A0549.
  • Hinchey J, Chaves C, Appignani B, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med. 1996;334(8):494–500. doi:10.1056/NEJM199602223340803.
  • Riley DS, Barber MS, Kienle GS, et al. CARE guidelines for case reports: explanation and elaboration document. J Clin Epidemiol. 2017;89:218–235. doi:10.1016/j.jclinepi.2017.04.026.
  • Mullins ME, Yarema MC, Sivilotti MLA, et al. Comment on “transition to two-bag intravenous acetylcysteine for acetaminophen overdose”. Clin Toxicol (Phila). 2020;58(5):433–435. doi:10.1080/15563650.2019.1649418.
  • Fischer M, Schmutzhard E. Posterior reversible encephalopathy syndrome. J Neurol. 2017;264(8):1608–1616. doi:10.1007/s00415-016-8377-8.
  • Mant TG, Tempowski JH, Volans GN, et al. Adverse reactions to acetylcysteine and effects of overdose. Br Med J (Clin Res Ed). 1984;289(6439):217–219. doi:10.1136/bmj.289.6439.217.
  • Spence EEM, Shwetz S, Ryan L, et al. Non-intentional N-acetylcysteine overdose associated with cerebral edema and brain death. Case Rep Gastroenterol. 2023;17(1):96–103. Published online February 8 doi:10.1159/000529169.
  • Hendrickson RG. What is the most appropriate dose of N -acetylcysteine after massive acetaminophen overdose? Clin Toxicol (Phila). 2019;57(8):686–691. doi:10.1080/15563650.2019.1579914.
  • Hieda S, Ishimaru N, Ohnishi J, et al. Posterior reversible encephalopathy syndrome complicating hyperosmolar hyperglycemic syndrome. Am J Emerg Med. 2021;49:438.e5-438–e6. doi:10.1016/j.ajem.2021.04.051.
  • John ES, Sedhom R, Dalal I, et al. Posterior reversible encephalopathy syndrome in alcoholic hepatitis: hepatic encephalopathy a common theme. World J Gastroenterol. 2017;23(2):373–376. doi:10.3748/wjg.v23.i2.373.
  • Mann G, Gunja N. Paracetamol overdose complicated by posterior reversible encephalopathy syndrome (PRES). Clin Toxicol (Phila). 2020;58(1):68–70. doi:10.1080/15563650.2019.1609023.
  • Mettananda S, Fernando AD, Ginige N. Posterior reversible encephalopathy syndrome in a survivor of valproate-induced acute liver failure: a case report. J Med Case Rep. 2013;7(1):144. doi:10.1186/1752-1947-7-144.
  • Hershkovitz E, Shorer Z, Levitas A, et al. Status epilepticus following intravenous N-acetylcysteine therapy. Isr J Med Sci. 1996;32(11):1102–1104.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.