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Toxicology Communications Volume 7, 2023 - Issue 1
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Case Reports

Severe and refractory hypotension after intentional minoxidil overdose: a case report

Mir MazharDepartment of Trauma and Acute Care Surgery, Mohawk Valley Health System, Utica, NY, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0009-0005-9792-7287View further author information
ORCID Icon,
Adrian EstradaDepartment of Trauma and Acute Care Surgery, Mohawk Valley Health System, Utica, NY, USAView further author information
,
Alexander ZornDepartment of Trauma and Acute Care Surgery, Mohawk Valley Health System, Utica, NY, USAView further author information
,
Robert V. MadlingerDepartment of Trauma and Acute Care Surgery, Mohawk Valley Health System, Utica, NY, USAView further author information
&
Maurizio MigliettaDepartment of Trauma and Acute Care Surgery, Mohawk Valley Health System, Utica, NY, USAView further author information
Article: 2293403 | Received 22 Sep 2023, Accepted 04 Dec 2023, Published online: 21 Dec 2023

References

  • Sica DA. Minoxidil: an underused vasodilator for resistant or severe hypertension. J Clin Hypertens (Greenwich). 2004;6(5):1–3. doi:10.1111/j.1524-6175.2004.03585.x.
  • Lowenthal DT, Affrime MB. Pharmacology and pharmacokinetics of minoxidil. J Cardiovasc Pharmacol. 1980;2 Suppl 2(2):S93–S106. doi:10.1097/00005344-198000022-00002.
  • Patel P, Nessel TA, Kumar DD. Minoxidil. [Updated 2023 Nov 15]. In: statPearls [internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482378/
  • Forrester MB. Pediatric minoxidil exposures reported to Texas poison centers. Pediatr Emerg Care. 2018;34(6):413–416. doi:10.1097/PEC.0000000000001226.
  • Sinha A, Raheja H, Kupfer Y. Myocardial infarction after accidental minoxidil poisoning. Am J Ther. 2018;25(2):e279–e281. doi:10.1097/mjt.00000000000005.
  • McCormick MA, Forman MH, Manoguerra AS. Severe toxicity from ingestion of a topical minoxidil preparation. Am J Emerg Med. 1989;7(4):419–421. doi:10.1016/0735-6757(89)90053-3.
  • Kikuchi S, Fujita Y, Onodera M, et al. Prolonged hypotension induced by ingesting a topical minoxidil solution: analysis of minoxidil and its metabolites. Acute Med Surg. 2016;3(4):384–387. doi:10.1002/ams2.196.
  • Chakar B, Salter M, Roberts DM. Minoxidil overdose with hypotension effectively managed with norepinephrine, rather than dopamine. Clin Toxicol (Phila). 2023;61(2):133–134. doi:10.1080/15563650.2022.2159831.
  • Scharman EJ. Minoxidil. Encyclopedia of toxicology. 2nd ed. Philip Wexler ed.; Academic Press 2005. pages 114–115. doi:10.1016/b0-12-369400-0/00631-1, Massachusetts: Cambridge.

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