Dose–response relationship between functional pain interference and nonmedical analgesic use: Findings from a nationally representative Canadian survey

References

• Gureje O , Simon GE , Von Korff M. A cross-national study of the course of persistent pain in primary care. Pain. 2001;92(1):195–200. doi:10.1016/S0304-3959(00)00483-8. PMID: 11323140.
   Google Scholar
• Elliott AM , Smith BH , Penny KI , Cairns Smith W , Alastair Chambers W . The epidemiology of chronic pain in the community. Lancet. 1999;354(9186):1248–1252. doi:10.1016/S0140-6736(99)03057-3. PMID: 10520633.
   Google Scholar
• Todd KH , Ducharme J , Choiniere M , Crandall CS , Fosnocht DE , Homel P , Tanabe P . Pain in the emergency department: results of the Pain and Emergency Medicine Initiative (PEMI) multicenter study. J Pain. 2007;8(6):460–466. doi:10.1016/j.jpain.2006.12.005. PMID: 17306626.
   Google Scholar
• Boulanger A , Clark AJ , Squire P , Cui E , Horbay G . Chronic pain in Canada: have we improved our management of chronic noncancer pain? Pain Res Manag. 2007;12(1):39–47. doi:10.1155/2007/762180. PMID: 17372633; PMCID: PMC2670724. eng.
   Google Scholar
• Public Health Agency of Canada . Diabetes in Canada: facts and figures from a public health perspective. Ottawa(Canada): Public Health Agency of Canada; 2011.
   Google Scholar
• Public Health Agency of Canada . Tracking heart disease and stroke in Canada, 2009. Ottawa(Canada): Public Health Agency of Canada; 2009.
   Google Scholar
• Advisory Committee on Cancer Statistics . Canadian cancer statistics 2013. Toronto(Canada): Canadian Cancer Society; 2013.
   Google Scholar
• Lippe PM . The decade of pain control and research. Pain Med. 2000;1(4):286–286. doi:10.1046/j.1526-4637.2000.00050.x. PMID: 15101872.
   Google Scholar
• Lanser P , Gesell S . Pain management: the fifth vital sign. Healthc Benchmarks. 2001;8(6):62, 68–70. PMID: 11474948.
   Google Scholar
• Fischer B , Jones W , Rehm J . Trends and changes in prescription opioid analgesic dispensing in Canada 2005–2012: an update with a focus on recent interventions. BMC Health Serv Res. 2014;14(90):1–8. doi:10.1186/1472-6963-14-90. PMID: 24572005; PMCID: PMCPMC3941687.
   Google Scholar
• Fischer B , Jones W , Krahn M , Rehm J . Differences and over-time changes in levels of prescription opioid analgesic dispensing from retail pharmacies in Canada, 2005–2010. Pharmacoepidemiol Drug Saf. 2011;20(12):1269–1277. doi:10.1002/pds.2190. PMID: 21755568.
   Google Scholar
• Fischer B , Argento E . Prescription opioid related misuse, harms, diversion and interventions in Canada: a review. Pain Physician. 2012;15(3 Suppl.):ES191–ES203. PMID: 22786457.
   Google Scholar
• Shield KD , Jones W , Rehm J , Fischer B . Use and nonmedical use of prescription opioid analgesics in the general population of Canada and correlations with dispensing levels in 2009. Pain Res Manag. 2013;18(2):69–74. doi:10.1155/2013/651649. PMID: 23662288; PMCID: PMCPMC3718055.
   Google Scholar
• Fischer B , Jones W , Urbanoski K , Skinner R , Rehm J . Correlations between prescription opioid analgesic dispensing levels and related mortality and morbidity in Ontario, Canada, 2005–2011. Drug Alcohol Rev. 2014;33(1):19–26. doi:10.1111/dar.12089. PMID: 24261474.
   Google Scholar
• Fischer B , Jones W , Rehm J . High correlations between levels of consumption and mortality related to strong prescription opioid analgesics in British Columbia and Ontario, 2005–2009. Pharmacoepidemiol Drug Saf. 2013;22(4):438–442. doi:10.1002/pds.3404. PMID: 23319301.
   Google Scholar
• McCarthy M . Drug overdose has become leading cause of death from injury in U.S. BMJ. 2015;350:h3328–h3328. doi:10.1136/bmj.h3328. PMID: 26101223.
   Google Scholar
• Coroners Service of British Columbia . Opiate deaths. Burnaby (Canada): BC Ministry of Justice; 2013.
   Google Scholar
• Voon P , Kerr T . “Nonmedical” prescription opioid use in North America: a call for priority action [Editorial]. Subst Abuse Treat Prev Policy. 2013;8(39):1–4. doi:10.1186/1747-597X-8-39. PMID: 24289260; PMCID: PMC24289260.
   Google Scholar
• Barry DT , Goulet JL , Kerns RK , Becker WC , Gordon AJ , Justice AC , Fiellin DA . Nonmedical use of prescription opioids and pain in veterans with and without HIV. Pain. 2011;152(5):1133–1138. doi:10.1016/j.pain.2011.01.038. PMID: 21354703; PMCID: PMC3086805.
   Google Scholar
• Becker WC , Fiellin DA , Gallagher RM , Barth KS , Ross JT , Oslin DW . The association between chronic pain and prescription drug abuse in Veterans. Pain Med. 2009;10(3):531–536. doi:10.1111/j.1526-4637.2009.00584.x. PMID: 19425211.
   Google Scholar
• Lusted A , Roerecke M , Goldner E , Rehm J, Fischer B. Prevalence of pain among nonmedical prescription opioid users in substance use treatment populations: systematic review and meta-analyses. Pain Physician. 2013;16(6):E671–E684. PMID: 24284850.
   Google Scholar
• Vowles KE , McEntee ML , Julnes PS , Frohe T , Ney JP , Van Der Goes DN . Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis. Pain. 2015;156(4):569–576. doi:10.1097/01.j.pain.0000460357.01998.f1. PMID: 25785523.
   Google Scholar
• Baldacchino A , Gilchrist G , Fleming R , Bannister J . Guilty until proven innocent: a qualitative study of the management of chronic non-cancer pain among patients with a history of substance abuse. Addict Behav. 2010;35(3):270–272. doi:10.1016/j.addbeh.2009.10.008. PMID: 19897313.
   Google Scholar
• Berg KM , Arnsten JH , Sacajiu G , Karasz A . Providers’ experiences treating chronic pain among opioid-dependent drug users. J Gen Intern Med. 2009;24(4):482–488. doi:10.1007/s11606-009-0908-x. PMID: 19189194; PMCID: PMC2659151.
   Google Scholar
• Voon P , Callon C , Nguyen P , Dobrer S , Montaner J , Wood E , Kerr T . Self-management of pain among people who inject drugs in Vancouver. Pain Manag. 2014;4(1):27–35. doi:10.2217/pmt.13.62. PMID: 24641341; PMCID: PMC3962749. eng.
   Google Scholar
• Voon P , Callon C , Nguyen P , Dobrer S , Montaner JSG , Wood E , Kerr T . Denial of prescription analgesia among people who inject drugs in a Canadian setting. Drug Alcohol Rev. 2015;34(2):221–228. doi:10.1111/dar.12226. PMID: 25521168.
   Google Scholar
• Mars SG , Bourgois P , Karandinos G , Montero F , Ciccarone D . “Every ‘never’ I ever said came true”: transitions from opioid pills to heroin injecting. Int J Drug Policy. 2014;25(2):257–266. doi:10.1016/j.drugpo.2013.10.004. PMID: 24238956; PMCID: PMCPMC3961517.
   Google Scholar
• Firestone M , Fischer B . A qualitative exploration of prescription opioid injection among street-based drug users in Toronto: behaviours, preferences and drug availability. Harm Reduct J. 2008;5(30):1–10. doi:10.1186/1477-7517-5-30. PMID: 18928556; PMCID: PMCPMC2577634.
   Google Scholar
• Guarino H , Marsch LA , Deren S , Straussner SLA , Teper A . Opioid use trajectories, injection drug use, and hepatitis C virus risk among young adult immigrants from the former soviet union living in New York City. J Addict Dis. 2015;34(2–3):162–177. doi:10.1080/10550887.2015.1059711. PMID: 26132715; PMCID: PMCPMC4583065.
   Google Scholar
• Young AM , Havens JR . Transition from first illicit drug use to first injection drug use among rural Appalachian drug users: a cross-sectional comparison and retrospective survival analysis. Addiction. 2012;107(3):587–596. doi:10.1111/j.1360-0443.2011.03635.x. PMID: 21883604; PMCID: PMCPMC3262084.
   Google Scholar
• Statistics Canada . Canadian Community Health Survey (CCHS)–Mental Health user guide: microdata files. Ottawa (Canada): Statistics Canada; 2013.
   Google Scholar
• Howard MM , Weiler RM , Haddox JD . Development and reliability of items measuring the nonmedical use of prescription drugs for the Youth Risk Behavior Survey: results from an initial pilot test. J Sch Health. 2009;79(11):554–560. doi:10.1111/j.1746-1561.2009.00448.x. PMID: 19840233.
   Google Scholar
• Sehgal N , Manchikanti L , Smith HS . Prescription opioid abuse in chronic pain: a review of opioid abuse predictors and strategies to curb opioid abuse. Pain Physician. 2012;15(3 Suppl.):ES67–ES92. PMID: 22786463.
   Google Scholar
• Government of Canada . Statistics Act. Ottawa(Canada): Government of Canada; 2005 Consolidated Act No. R.S.C., 1985, c. S-19.
   Google Scholar
• University of British Columbia Board of Governors . Research involving human participants. Vancouver(Canada): University of British Columbia; 2012. Policy No. 89.
   Google Scholar
• Jones CM . Frequency of prescription pain reliever nonmedical use: 2002–2003 and 2009–2010. Arch Intern Med. 2012;172(16):1265–1267. doi:10.1001/archinternmed.2012.2533. PMID: 22733257.
   Google Scholar
• Shield KD , Ialomiteanu A , Fischer B , Rehm J . Assessing the prevalence of non-medical prescription opioid use in the Canadian general adult population: evidence of large variation depending on survey questions used. BMC Psychiatry. 2013;13(6)1–8. doi:10.1186/1471-244X-13-6. PMID: 23286378; PMCID: PMCPMC3546044.
   Google Scholar
• Health Canada . Canadian Alcohol and Drug Use Monitoring Survey. Table 3: prevalence of drug use and harms, total population, CAS 2004, CADUMS 2008–2012. Ottawa (Canada): Health Canada; 2014 [ cited 2015 Nov 04]. http://www.hc-sc.gc.ca/hc-ps/drugs-drogues/stat/_2012/tables-tableaux-eng.php-t3.
   Google Scholar
• Schopflocher D , Taenzer P , Jovey R . The prevalence of chronic pain in Canada. Pain Res Manag. 2011;16(6):445–450. doi:10.1155/2011/876306. PMID: 22184555; PMCID: PMCPMC3298051.
   Google Scholar
• Fischer B , Lusted A , Roerecke M , Taylor B , Rehm J . The prevalence of mental health and pain symptoms in general population samples reporting nonmedical use of prescription opioids: a systematic review and meta-analysis. J Pain. 2012;13(11):1029–1044. doi:10.1016/j.jpain.2012.07.013. PMID: 23040158.
   Google Scholar
• Novak SP , Herman-Stahl M , Flannery B , Zimmerman M . Physical pain, common psychiatric and substance use disorders, and the non-medical use of prescription analgesics in the United States. Drug Alcohol Depend. 2009;100(1–2):63–70. doi:10.1016/j.drugalcdep.2008.09.013. PMID: 19010611; PMCID: PMCPMC2647685.
   Google Scholar
• Liebschutz JM , Saitz R , Weiss RD , Averbuch T , Schwartz S , Meltzer EC , Claggett-Borne E , Cabral H , Samet JH . Clinical factors associated with prescription drug use disorder in urban primary care patients with chronic pain. J Pain. 2010;11(11):1047–1055. doi:10.1016/j.jpain.2009.10.012. PMID: 20338815; PMCID: PMCPMC2892730.
   Google Scholar
• Jamison RN , Link CL , Marceau LD . Do pain patients at high risk for substance misuse experience more pain? A longitudinal outcomes study. Pain Med. 2009;10(6):1084–1094. doi:10.1111/j.1526-4637.2009.00679.x. PMID: 19671087.
   Google Scholar
• Sullivan MD , Von Korff M , Banta-Green C , Merrill JO , Saunders K . Problems and concerns of patients receiving chronic opioid therapy for chronic non-cancer pain. Pain. 2010;149(2):345–353. doi:10.1016/j.pain.2010.02.037. PMID: 20334974; PMCID: PMCPMC3318978.
   Google Scholar
• Amari E , Rehm J , Goldner E , Fischer B . Nonmedical prescription opioid use and mental health and pain comorbidities: a narrative review. Can J Psychiatry. 2011;56(8):495–502. doi:10.1177/070674371105600808. PMID: 21878161.
   Google Scholar
• Edlund MJ , Steffick D , Hudson T , Harris KM , Sullivan M . Risk factors for clinically recognized opioid abuse and dependence among veterans using opioids for chronic non-cancer pain. Pain. 2007;129(3):355–362. doi:10.1016/j.pain.2007.02.014. PMID: 17449178.
   Google Scholar
• Ives TJ , Chelminski PR , Hammett-Stabler CA , Malone RM , Perhac JS , Potisek NM , Shilliday BB , DeWalt DA , Pignone MP . Predictors of opioid misuse in patients with chronic pain: a prospective cohort study. BMC Health Serv Res. 2006;6(46)1–10. doi:10.1186/1472-6963-6-46. PMID: 16595013; PMCID: PMCPMC1513222.
   Google Scholar
• McCabe SE , West BT , Teter CJ , Boyd CJ . Trends in medical use, diversion, and nonmedical use of prescription medications among college students from 2003 to 2013: connecting the dots. Addict Behav. 2014;39(7):1176–1182. doi:10.1016/j.addbeh.2014.03.008. PMID: 24727278; PMCID: PMCPMC4349373.
   Google Scholar
• McCabe SE , West BT , Boyd CJ . Motives for medical misuse of prescription opioids among adolescents. J Pain. 2013;14(10):1208–1216. doi:10.1016/j.jpain.2013.05.004. PMID: 23954519; PMCID: PMCPMC3792708.
   Google Scholar
• Zhao J , Stockwell T , Macdonald S . Non-response bias in alcohol and drug population surveys. Drug Alcohol Rev. 2009;28(6):648–657. doi:10.1111/j.1465-3362.2009.00077.x. PMID: 19930019.
   Google Scholar
• Voon P . Further defining and conceptualizing opioid misuse in chronic pain. Pain. 2015;156(10):2107–2107. doi:10.1097/j.pain.0000000000000246. PMID: 26390311.
   Google Scholar
• Zacny JP , Lichtor SA . Nonmedical use of prescription opioids: motive and ubiquity issues. J Pain. 2008;9(6):473–486. doi:10.1016/j.jpain.2007.12.008. PMID: 18342577; PMCID: PMCPMC2409193.
   Google Scholar
• Volkow ND , McLellan TA . Curtailing diversion and abuse of opioid analgesics without jeopardizing pain treatment. JAMA. 2011 6;305(13):1346–1347. doi:10.1001/jama.2011.369. PMID: 21467287.
   Google Scholar