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Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Revue canadienne des soins respiratoires et critiques et de la médecine du sommeil
Volume 3, 2019 - Issue 3
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Original Research

Optimizing sputum cell counts prior to bronchial thermoplasty: A preliminary report

Sarah SvenningsenFirestone Institute for Respiratory Health, St Joseph’s Healthcare, Hamilton, Canada; ;Department of Medicine, McMaster University, Hamilton, Canada; View further author information
,
Hui Fang LimFirestone Institute for Respiratory Health, St Joseph’s Healthcare, Hamilton, Canada; View further author information
,
Sarah GoodwinFirestone Institute for Respiratory Health, St Joseph’s Healthcare, Hamilton, Canada; View further author information
,
Melanie KjarsgaardFirestone Institute for Respiratory Health, St Joseph’s Healthcare, Hamilton, Canada; View further author information
,
Grace ParragaRobarts Research Institute, London, Canada; ;Department of Medical Biophysics, Western University, London, CanadaView further author information
,
John MillerFirestone Institute for Respiratory Health, St Joseph’s Healthcare, Hamilton, Canada; ;Department of Medicine, McMaster University, Hamilton, Canada; View further author information
,
Gerard CoxFirestone Institute for Respiratory Health, St Joseph’s Healthcare, Hamilton, Canada; ;Department of Medicine, McMaster University, Hamilton, Canada; View further author information
&
Parameswaran NairFirestone Institute for Respiratory Health, St Joseph’s Healthcare, Hamilton, Canada; ;Department of Medicine, McMaster University, Hamilton, Canada; Correspondence[email protected]
View further author information
 show all
Pages 143-147 | Published online: 26 Feb 2019

References

  • Cox G, Thomson NC, Rubin AS, et al. Asthma control during the year after bronchial thermoplasty. N Engl J Med. 2007;356(13):1327–1337.
  • Pavord ID, Cox G, Thomson NC, et al. Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. Am J Respir Crit Care Med. 2007;176(12):1185–1191.
  • Castro M, Rubin AS, Laviolette M, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010;181(2):116–124.
  • Chakir J, Haj-Salem I, Gras D, et al. Effects of bronchial thermoplasty on airway smooth muscle and collagen deposition in asthma. Ann Am Thorac Soc. 2015;12(11):1612–1618.
  • Pretolani M, Dombret MC, Thabut G, et al. Reduction of airway smooth muscle mass by bronchial thermoplasty in patients with severe asthma. Am J Respir Crit Care Med. 2014;190(12):1452–1454.
  • Langton D, Sha J, Ing A, Fielding D, Wood E. Bronchial thermoplasty in severe asthma in Australia. Intern Med J. 2017;47(5):536–541.
  • Bicknell S, Chaudhuri R, Lee N, et al. Effectiveness of bronchial thermoplasty in severe asthma in “real life” patients compared with those recruited to clinical trials in the same centre. Ther Adv Respir Dis. 2015;9(6):267–271.
  • Pretolani M, Bergqvist A, Thabut G, et al. Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: Clinical and histopathologic correlations. J Allergy Clin Immunol. 2017;139(4):1176–1185.
  • Jayaram L, Pizzichini MM, Cook RJ, et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J. 2006;27(3):483–494.
  • Aziz-Ur-Rehman A, Dasgupta A, Kjarsgaard M, Hargreave FE, Nair P. Sputum cell counts to manage prednisone-dependent asthma: effects on FEV1 and eosinophilic exacerbations. Allergy Asthma Clin Immunol. 2017;13:17.
  • Juniper EF, Svensson K, Mork AC, Stahl E. Measurement properties and interpretation of three shortened versions of the asthma control questionnaire. Respir Med. 2005;99(5):553–558.
  • Juniper EF, Guyatt GH, Willan A, Griffith LE. Determining a minimal important change in a disease-specific quality of life questionnaire. J Clin Epidemiol. 1994;47(1):81–87.
  • Cox C, Kjarsgaard M, Surette MG, Cox PG, Nair P. A multidimensional approach to the management of severe asthma: inflammometry, molecular microbiology and bronchial thermoplasty. Can Respir J. 2015;22(4):221–224.
  • Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID. Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med. 2002;346(22):1699–1705.
  • Berthon BS, Gibson PG, Wood LG, MacDonald-Wicks LK, Baines KJ. A sputum gene expression signature predicts oral corticosteroid response in asthma. Eur Respir J. 2017;49(6):17000180

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