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Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Revue canadienne des soins respiratoires et critiques et de la médecine du sommeil
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Barriers to multisite research in Canada: Experiences from a minimal risk COVID-19 study

Celeste Lumiaa Sunnybrook Health Sciences Centre, Toronto, Ontario, CanadaCorrespondence[email protected]
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Samir Guptab Li Ka Shing Knowledge Institute of St Michael’s Hospital, Toronto, Ontario, Canada;c University of Toronto, Toronto Ontario, CanadaView further author information
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Don Sind Centre for Heart Lung Innovation, St. Paul’s Hospital and Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada;ORCID Iconhttps://orcid.org/0000-0002-0756-6643View further author information
ORCID Icon,
Teresa Toc University of Toronto, Toronto Ontario, Canada;e Hospital for Sick Children, Toronto, Ontario, CanadaView further author information
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Michael Sticklandf University of Alberta, Edmonton Alberta, CanadaORCID Iconhttps://orcid.org/0000-0001-8234-4760View further author information
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Janice Leungd Centre for Heart Lung Innovation, St. Paul’s Hospital and Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada;View further author information
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Manali Mukherjeeg Department of Medicine McMaster University, Hamilton, Ontario, Canada;h Research Institute of St. Joe’s Hamilton, St Joseph’s Hospital, Hamilton, Ontario, Canada;ORCID Iconhttps://orcid.org/0000-0002-7924-7211View further author information
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Shawn D. Aaroni Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaView further author information
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Kim Lavoiej Université du Québec à Montréal, Montreal Quebec, CanadaView further author information
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Pat G. Campd Centre for Heart Lung Innovation, St. Paul’s Hospital and Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada;ORCID Iconhttps://orcid.org/0000-0002-9152-8251View further author information
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Geoffrey Maksymk Dalhousie University, Halifax, Nova Scotia, CanadaORCID Iconhttps://orcid.org/0000-0003-4686-7059View further author information
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Paul Hernandezk Dalhousie University, Halifax, Nova Scotia, CanadaView further author information
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Andréanne Côtél Université Laval, Quebec, Quebec, Canada;ORCID Iconhttps://orcid.org/0000-0001-5653-4931View further author information
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M. Diane Lougheedm Department of Medicine Queen’s University, Kingston, Ontario, CanadaORCID Iconhttps://orcid.org/0000-0001-6387-8759View further author information
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Erika Penzn University of Saskatchewan, Saskatoon, Saskatchewan, Canada;ORCID Iconhttps://orcid.org/0000-0003-2610-8450View further author information
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Rachel Limo University of Calgary, Calgary, Alberta, Canada;ORCID Iconhttps://orcid.org/0000-0003-4449-4447View further author information
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Christopher Licskaip University of Western Ontario, London, Ontario, CanadaORCID Iconhttps://orcid.org/0000-0002-1675-657XView further author information
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Andrea S. Gershona Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada;c University of Toronto, Toronto Ontario, CanadaORCID Iconhttps://orcid.org/0000-0002-0246-594XView further author information
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Received 11 Jul 2023, Accepted 01 May 2024, Published online: 06 Aug 2024

References

  • Murthy S, Fowler RA, Laupacis A. How Canada can better embed randomized trials into clinical care. CMAJ. 2020;192(32):E928–E929. doi:10.1503/cmaj.201764.
  • Lamontagne F, Rowan KM, Guyatt G. Integrating research into clinical practice: challenges and solutions for Canada. CMAJ. 2021;193(4):E127–E131. doi:10.1503/cmaj.202397.
  • Hanney SR, Straus SE, Holmes BJ. Saving millions of lives but some resources squandered: emerging lessons from health research system pandemic achievements and challenges. Health Res Policy Syst. 2022;20(1):99. doi:10.1186/s12961-022-00883-6.
  • Tri-Council. Policy Statement: Ethical Conduct for Research Involving Humans – TCPS 2 [Internet]. Available from: ethics.gc.ca/eng/policy-politique_tcps2-eptc2_2022.html.
  • Clinical Trials Ontario. CTO stream: How it works. [Internet]. 2022. https://www.ctontario.ca/cto-programs/streamlined-research-ethics-review/cto-stream-how-it-works/.
  • Racine E, Bell E, Deslauriers C. Canadian research ethics boards and multisite research: Experiences from two minimal-risk studies. Ethics Hum Res. 2010;32(3):12–18.
  • Ezzat H, Ross S, von Dadelszen P, et al. Ethics review as a component of institutional approval for a multicentre continuous quality improvement project: the investigator’s perspective. BMC Health Serv Res. 2010;10(1):223. doi:10.1186/1472-6963-10-223.
  • Greene SM, Geiger AM. A review finds that multicenter studies face substantial challenges but strategies exist to achieve institutional review board approval. J Clin Epidemiol. 2006;59(8):784–790. doi:10.1016/j.jclinepi.2005.11.018.

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