Subclinical Leaflet Thrombosis Post Transcatheter Aortic Valve Replacement – An Update for 2020

References

• Leon MB, Nikolsky E. The next revolution: percutaneous aortic valve replacement. Rambam Maimonides Med J. 2010;1(2):e0016. doi:10.5041/RMMJ.10016.
   Google Scholar
• Leon MB, Smith CR, Mack M, et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010;363(17):1597–1607. doi:10.1056/NEJMoa1008232.
   PubMed Web of Science ®Google Scholar
• Smith CR, Leon MB, Mack MJ, et al. Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med. 2011;364(23):2187–2198. doi:10.1056/NEJMoa1103510.
   PubMed Web of Science ®Google Scholar
• Leon MB, Smith CR, Mack MJ, et al. Transcatheter or surgical aortic-valve replacement in intermediate-risk patients. N Engl J Med. 2016;374(17):1609–1620. doi:10.1056/NEJMoa1514616.
   PubMed Web of Science ®Google Scholar
• Adams DH, Popma JJ, Reardon MJ, et al. Transcatheter aortic-valve replacement with a self-expanding prosthesis. N Engl J Med. 2014;370(19):1790–1798. doi:10.1056/NEJMoa1400590.
   PubMed Web of Science ®Google Scholar
• Popma JJ, Adams DH, Reardon MJ, et al. Transcatheter aortic valve replacement using a self-expanding bioprosthesis in patients with severe aortic stenosis at extreme risk for surgery. J Am Coll Cardiol. 2014;63(19):1972–1981. doi:10.1016/j.jacc.2014.02.556.
   PubMed Web of Science ®Google Scholar
• Popma JJ, Deeb GM, Yakubov SJ, et al. Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients. N Engl J Med. 2019;380(18):1706–1715. doi:10.1056/NEJMoa1816885.
   PubMed Web of Science ®Google Scholar
• Reardon MJ, Van Mieghem NM, Popma JJ, et al. Surgical or transcatheter aortic-valve replacement in intermediate-risk patients. N Engl J Med. 2017;376(14):1321–1331. doi:10.1056/NEJMoa1700456.
   PubMed Web of Science ®Google Scholar
• Anantha-Narayanan M, Kandasamy VV, Reddy YN, et al. Low-risk transcatheter versus surgical aortic valve replacement – an updated meta-analysis of randomized controlled trials. Cardiovasc Revasc Med. 2019;21(4):441-452.
   Google Scholar
• Waksman R, Rogers T, Torguson R, et al. Transcatheter aortic valve replacement in low-risk patients with symptomatic severe aortic stenosis. J Am Coll Cardiol. 2018;72(18):2095–2105. doi:10.1016/j.jacc.2018.08.1033.
   PubMed Web of Science ®Google Scholar
• Hamm CW, Mollmann H, Holzhey D, et al. The German Aortic Valve Registry (GARY): in-hospital outcome. Eur Heart J. 2014;35(24):1588–1598. doi:10.1093/eurheartj/eht381.
   Web of Science ®Google Scholar
• Di Mario C, Eltchaninoff H, Moat N, et al. The 2011-12 pilot European sentinel registry of transcatheter aortic valve implantation: in-hospital results in 4,571 patients. EuroIntervention. 2013;8(12):1362–1371. doi:10.4244/EIJV8I12A209.
   PubMed Web of Science ®Google Scholar
• Gilard M, Eltchaninoff H, Iung B, et al. Registry of transcatheter aortic-valve implantation in high-risk patients. N Engl J Med. 2012;366(18):1705–1715. doi:10.1056/NEJMoa1114705.
   PubMed Web of Science ®Google Scholar
• Sondergaard L, Steinbruchel DA, Ihlemann N, et al. Two-year outcomes in patients with severe aortic valve stenosis randomized to transcatheter versus surgical aortic valve replacement: the all-comers nordic aortic valve intervention randomized clinical trial. Circ Cardiovasc Interv. 2016;9(6):e003665.
   Web of Science ®Google Scholar
• Thyregod HG, Søndergaard L, Ihlemann N, et al. The Nordic Aortic Valve Intervention (NOTION) trial comparing transcatheter versus surgical valve implantation: study protocol for a randomised controlled trial. Trials. 2013;14(1):11. doi:10.1186/1745-6215-14-11.
   Google Scholar
• Siontis GCM, Overtchouk P, Cahill TJ, et al. Transcatheter aortic valve implantation vs. surgical aortic valve replacement for treatment of symptomatic severe aortic stenosis: an updated meta-analysis. Eur Heart J. 2019;40(38):3143–3153. doi:10.1093/eurheartj/ehz275.
   PubMed Web of Science ®Google Scholar
• Pache G, Blanke P, Zeh W, Jander N. Cusp thrombosis after transcatheter aortic valve replacement detected by computed tomography and echocardiography. Eur Heart J. 2013;34(46):3546. doi:10.1093/eurheartj/eht316.
   Web of Science ®Google Scholar
• Sondergaard L, De Backer O, Kofoed KF, et al. Natural history of subclinical leaflet thrombosis affecting motion in bioprosthetic aortic valves. Eur Heart J. 2017;38(28):2201–2207. doi:10.1093/eurheartj/ehx369.
   PubMed Web of Science ®Google Scholar
• Jimenez C, Ohana M, Marchandot B, et al. Impact of antithrombotic regimen and platelet inhibition extent on leaflet thrombosis detected by cardiac MDCT after transcatheter aortic valve replacement. J Clin Med. 2019;8(4):506. doi:10.3390/jcm8040506.
   Web of Science ®Google Scholar
• Makkar RR, Fontana G, Jilaihawi H, et al. Possible subclinical leaflet thrombosis in bioprosthetic aortic valves. N Engl J Med. 2015;373(21):2015–2024. doi:10.1056/NEJMoa1509233.
   PubMed Web of Science ®Google Scholar
• Leetmaa T, Hansson NC, Leipsic J, et al. Early aortic transcatheter heart valve thrombosis. Circ Cardiovasc Interv. 2015;8(4):e001596. doi:10.1161/CIRCINTERVENTIONS.114.001596.
   Web of Science ®Google Scholar
• Pache G, Pache G, Schoechlin S, Blanke P, Dorfs S. Early hypo-attenuated leaflet thickening in balloon-expandable transcatheter aortic heart valves. Eur Heart J. 2016;37(28):2263–2271. doi:10.1093/eurheartj/ehv526.
   PubMed Web of Science ®Google Scholar
• Hansson NC, Grove EL, Andersen HR, et al. Transcatheter aortic valve thrombosis: incidence, predisposing factors, and clinical implications. J Am Coll Cardiol. 2016;68(19):2059–2069. doi:10.1016/j.jacc.2016.08.010.
   PubMed Web of Science ®Google Scholar
• Yanagisawa R, Hayashida K, Yamada Y, et al. Incidence, predictors, and mid-term outcomes of possible leaflet thrombosis after TAVR. JACC Cardiovasc Imaging. 2017;10(1):1–11. doi:10.1016/j.jcmg.2016.11.005.
   Web of Science ®Google Scholar
• Chakravarty T, Søndergaard L, Friedman J, et al. Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study. Lancet. 2017;389(10087):2383–2392. doi:10.1016/S0140-6736(17)30757-2.
   PubMed Web of Science ®Google Scholar
• Vollema EM, Kong WKF, Katsanos S, et al. Transcatheter aortic valve thrombosis: the relation between hypo-attenuated leaflet thickening, abnormal valve haemodynamics, and stroke. Eur Heart J. 2017;38(16):1207–1217. doi:10.1093/eurheartj/ehx031.
   PubMed Web of Science ®Google Scholar
• Ruile P, Jander N, Blanke P, et al. Course of early subclinical leaflet thrombosis after transcatheter aortic valve implantation with or without oral anticoagulation. Clin Res Cardiol. 2017;106(2):85–95. doi:10.1007/s00392-016-1052-3.
   PubMed Web of Science ®Google Scholar
• Rashid HN, Gooley RP, Nerlekar N, et al. Bioprosthetic aortic valve leaflet thrombosis detected by multidetector computed tomography is associated with adverse cerebrovascular events: a meta-analysis of observational studies. EuroIntervention. 2018;13(15):e1748–e1755. doi:10.4244/EIJ-D-17-01062.
   Web of Science ®Google Scholar
• Marwan M, Mekkhala N, Göller M, et al. Leaflet thrombosis following transcatheter aortic valve implantation. J Cardiovasc Comput Tomogr 2018;12(1):8–13. doi:10.1016/j.jcct.2017.11.002.
   PubMed Web of Science ®Google Scholar
• Ruile P, Minners J, Breitbart P, et al. Medium-term follow-up of early leaflet thrombosis after transcatheter aortic valve replacement. JACC Cardiovasc Interv. 2018;11(12):1164–1171. doi:10.1016/j.jcin.2018.04.006.
   Web of Science ®Google Scholar
• Tang L, Lesser JR, Schneider LM, et al. Prospective evaluation for hypoattenuated leaflet thickening following transcatheter aortic valve implantation. Am J Cardiol. 2019;123(4):658–666. doi:10.1016/j.amjcard.2018.11.012.
   PubMed Web of Science ®Google Scholar
• Yanagisawa R, Tanaka M, Yashima F, et al. Early and late leaflet thrombosis after transcatheter aortic valve replacement. Circ Cardiovasc Interv. 2019;12(2):e007349. doi:10.1161/CIRCINTERVENTIONS.118.007349.
   Web of Science ®Google Scholar
• Hein M, Minners J, Jander N, et al. Haemodynamic prosthetic valve performance in patients with early leaflet thrombosis after transcatheter aortic valve implantation. Clin Res Cardiol. 2019;108(9):1017–1024. doi:10.1007/s00392-019-01429-7.
   Web of Science ®Google Scholar
• Nührenberg TG, Hromek J, Kille A, et al. Impact of on-clopidogrel platelet reactivity on incidence of hypoattenuated leaflet thickening after transcatheter aortic valve replacement. JACC Cardiovasc Interv. 2019;12(1):12–18. doi:10.1016/j.jcin.2018.08.008.
   Web of Science ®Google Scholar
• De Backer O, Dangas GD, Jilaihawi H, et al. Reduced leaflet motion after transcatheter aortic-valve replacement. N Engl J Med. 2020;382:130–139.
   Web of Science ®Google Scholar
• Jilaihawi H, Asch FM, Manasse E, et al. Systematic CT methodology for the evaluation of subclinical leaflet thrombosis. JACC Cardiovasc Imaging. 2017;10(4):461–470. doi:10.1016/j.jcmg.2017.02.005.
   PubMed Web of Science ®Google Scholar
• Makkar RR, Blanke P, Leipsic J, et al. Subclinical leaflet thrombosis in transcatheter and surgical bioprosthetic valves: PARTNER 3 cardiac computed tomography substudy. J Am Coll Cardiol. 2020;75(24):3003–3015. doi:10.1016/j.jacc.2020.04.043.
   Google Scholar
• Kanjanauthai S, Pirelli L, Nalluri N, Kliger CA. Subclinical leaflet thrombosis following transcatheter aortic valve replacement. J Interv Cardiol. 2018;31(5):640–647. doi:10.1111/joic.12521.
   Web of Science ®Google Scholar
• Brown RA, Khanji MY, Mullen M, Patel RS, Bhattacharyya S. Hypoattenuated leaflet thickening associated with symptomatic thrombotic prosthetic valve obstruction: early complication following transcatheter aortic valve implantation. Eur Heart J Cardiovasc Imaging. 2019. Epub ahead of print. doi:10.1093/ehjci/jez181.
   Web of Science ®Google Scholar
• Dangas GD, Tijssen JGP, Wöhrle J, et al. A controlled trial of rivaroxaban after transcatheter aortic-valve replacement. N Engl J Med. 2020;382:120–129.
   Web of Science ®Google Scholar
• Van Mieghem NM, Unverdorben M, Valgimigli M, et al. Edoxaban versus standard of care and their effects on clinical outcomes in patients having undergone transcatheter aortic valve implantation in atrial fibrillation-rationale and design of the ENVISAGE-TAVI AF trial. Am Heart J. 2018;205:63–69. doi:10.1016/j.ahj.2018.07.006.
   PubMed Web of Science ®Google Scholar
• Collet JP, Berti S, Cequier A, et al. Oral anti-Xa anticoagulation after trans-aortic valve implantation for aortic stenosis: the randomized ATLANTIS trial. Am Heart J. 2018;200:44–50. doi:10.1016/j.ahj.2018.03.008.
   PubMed Web of Science ®Google Scholar
• Nijenhuis VJ, Bennaghmouch N, Hassell M, et al. Rationale and design of popular-TAVI: antiplatelet therapy for patients undergoing transcatheter aortic valve implantation. Am Heart J. 2016;173:77–85. doi:10.1016/j.ahj.2015.11.008.
   PubMed Web of Science ®Google Scholar
• Vahidkhah K, Barakat M, Abbasi M, et al. Valve thrombosis following transcatheter aortic valve replacement: significance of blood stasis on the leaflets. Eur J Cardiothorac Surg. 2017;51:927–935.
   PubMed Web of Science ®Google Scholar
• Kappetein AP, Head SJ, Généreux P, et al. Updated standardized endpoint definitions for transcatheter aortic valve implantation. Valve Acad Res Consortium-2 Consens Doc. 2012;60:1438–1454.
   Google Scholar
• Baumgartner H, Falk V, Bax JJ, et al. ESC/EACTS guidelines for the management of valvular heart disease. Eur Heart J. 2017;2017(38):2739–2791. doi:10.1093/eurheartj/ehx391.
   Google Scholar
• Egbe AC, Pislaru SV, Pellikka PA, et al. Bioprosthetic valve thrombosis versus structural failure. Clin. Echocardiographic Predictors. 2015;66:2285–2294.
   Google Scholar
• Nishimura RA, Otto CM, Bonow RO, et al. 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease. Rep Am College Cardiol/Am Heart Assoc Task Force Clin Pract Guide. 2017;70:252–289.
   Google Scholar
• Puri R, Auffret V, Rodés-Cabau J. Bioprosthetic valve thrombosis. J Am Coll Cardiol. 2017;69(17):2193–2211. doi:10.1016/j.jacc.2017.02.051.
   PubMed Web of Science ®Google Scholar
• Blanke P, Weir-McCall JR, Achenbach S, et al. Computed tomography imaging in the context of Transcatheter Aortic Valve Implantation (TAVI)/Transcatheter Aortic Valve Replacement (TAVR): an expert consensus document of the society of cardiovascular computed tomography. JACC Cardiovasc Imaging. 2019;12(1):1–24. doi:10.1016/j.jcmg.2018.12.003.
   PubMed Web of Science ®Google Scholar
• Ruile P, Neumann F-J. Valve thrombosis after TAVI. Eur Heart J. 2017;38(36):2700–2701. doi:10.1093/eurheartj/ehx472.
   Web of Science ®Google Scholar
• Johnston DR, Soltesz EG, Vakil N, et al. Long-term durability of bioprosthetic aortic valves: implications from 12,569 implants. Ann Thorac Surg. 2015;99(4):1239–1247. doi:10.1016/j.athoracsur.2014.10.070.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Gabella T, Voisine P, Puri R, Pibarot P, Rodes-Cabau J. Aortic bioprosthetic valve durability: incidence, mechanisms, predictors, and management of surgical and transcatheter valve degeneration. J Am Coll Cardiol. 2017;70(8):1013–1028. doi:10.1016/j.jacc.2017.07.715.
   PubMed Web of Science ®Google Scholar
• Zoghbi WA, Chambers JB, Dumesnil JG, et al. Recommendations for evaluation of prosthetic valves with echocardiography and doppler ultrasound: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Task Force on Prosthetic Valves, developed in conjunction with the American College of Cardiology Cardiovascular Imaging Committee, Cardiac Imaging Committee of the American Heart Association, the European Association of Echocardiography, a registered branch of the European Society of Cardiology, the Japanese Society of Echocardiography and the Canadian Society of Echocardiography, endorsed by the American College of Cardiology Foundation, American Heart Association, European Association of Echocardiography, a registered branch of the European Society of Cardiology, the Japanese Society of Echocardiography, and Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2009;22:975–1014. quiz 1082-4.
   PubMed Web of Science ®Google Scholar
• Vahanian A, Alfieri O, Andreotti F, et al. Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur J Cardiothorac Surg. 2012;42(4):S1–44. doi:10.1093/ejcts/ezs455.
   PubMed Web of Science ®Google Scholar
• Lancellotti P, Pibarot P, Chambers J, et al. Recommendations for the imaging assessment of prosthetic heart valves: a report from the European Association of Cardiovascular Imaging endorsed by the Chinese Society of Echocardiography, the Inter-American Society of Echocardiography, and the Brazilian Department of Cardiovascular Imaging†. Eur Heart J Cardiovasc Imaging. 2016;17:589–590.
   PubMed Web of Science ®Google Scholar
• Bourguignon T, Bouquiaux-Stablo AL, Candolfi P, et al. Very long-term outcomes of the Carpentier-Edwards Perimount valve in aortic position. Ann Thorac Surg. 2015;99(3):831–837. doi:10.1016/j.athoracsur.2014.09.030.
   PubMed Web of Science ®Google Scholar
• Capodanno D, Petronio AS, Prendergast B, et al. Standardized definitions of structural deterioration and valve failure in assessing long-term durability of transcatheter and surgical aortic bioprosthetic valves: a consensus statement from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) endorsed by the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2017;38:3382–3390.
   PubMed Web of Science ®Google Scholar
• Dvir D, Bourguignon T, Otto CM, et al. Standardized definition of structural valve degeneration for surgical and transcatheter bioprosthetic aortic valves. Circulation. 2018;137(4):388–399. doi:10.1161/CIRCULATIONAHA.117.030729.
   PubMed Web of Science ®Google Scholar
• Sellers SL, Turner CT, Sathananthan J, et al. Transcatheter aortic heart valves: histological analysis providing insight to leaflet thickening and structural valve degeneration. JACC Cardiovasc Imaging. 2019;12(1):135–145. doi:10.1016/j.jcmg.2018.06.028.
   PubMed Web of Science ®Google Scholar
• Yahagi K, Ladich E, Kutys R, et al. Pathology of balloon-expandable transcatheter aortic valves. Catheter Cardiovasc Interv. 2017;90(6):1048–1057. doi:10.1002/ccd.27160.
   Web of Science ®Google Scholar
• Yahagi K, Torii S, Ladich E, et al. Pathology of self-expanding transcatheter aortic valves: findings from the CoreValve US pivotal trials. Catheter Cardiovasc Interv. 2018;91(5):947–955. doi:10.1002/ccd.27314.
   Web of Science ®Google Scholar
• Foroutan F, Guyatt GH, Otto CM, et al. Structural valve deterioration after transcatheter aortic valve implantation. Heart. 2017;103(23):1899–1905. doi:10.1136/heartjnl-2017-311329.
   PubMed Web of Science ®Google Scholar
• Mack MJ, Leon MB, Smith CR, et al. 5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial. Lancet. 2015;385(9986):2477–2484. doi:10.1016/S0140-6736(15)60308-7.
   PubMed Web of Science ®Google Scholar
• Blackman DJ, Saraf S, MacCarthy PA, et al. Long-term durability of transcatheter aortic valve prostheses. J Am Coll Cardiol. 2019;73(5):537–545. doi:10.1016/j.jacc.2018.10.078.
   PubMed Web of Science ®Google Scholar
• Del Trigo M, Muñoz-Garcia AJ, Wijeysundera HC, et al. Incidence, timing, and predictors of valve hemodynamic deterioration after transcatheter aortic valve replacement. Multicenter Reg. 2016;67:644–655.
   Google Scholar
• Hatoum H, Moore BL, Maureira P, Dollery J, Crestanello JA, Dasi LP. Aortic sinus flow stasis likely in valve-in-valve transcatheter aortic valve implantation. J Thorac Cardiovasc Surg. 2017;154(32–43.e1):32–43.e1. doi:10.1016/j.jtcvs.2017.03.053.
   Google Scholar
• Vahidkhah K, Azadani AN. Supra-annular valve-in-valve implantation reduces blood stasis on the transcatheter aortic valve leaflets. J Biomech. 2017;58:114–122. doi:10.1016/j.jbiomech.2017.04.020.
   Web of Science ®Google Scholar
• Cartlidge TRG, Doris MK, Sellers SL, et al. Detection and prediction of bioprosthetic aortic valve degeneration. J Am Coll Cardiol. 2019;73(10):1107–1119. doi:10.1016/j.jacc.2018.12.056.
   Web of Science ®Google Scholar
• Simionescu A, Schulte JB, Fercana G, Simionescu DT. Inflammation in cardiovascular tissue engineering: the challenge to a promise: a minireview. Int J Inflammation. 2011;2011:958247. doi:10.4061/2011/958247.
   Google Scholar