CNR2 rs2229579 and COMT Val158Met variants, but not CNR2 rs2501432, IL-17 rs763780 and UCP2 rs659366, contribute to susceptibility to substance use disorder in the Turkish population

References

• American PsychiatricAssociation. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Association; 2013.
   Google Scholar
• Loftis JM, Huckans M. Substance use disorders: psychoneuroimmunological mechanisms and new targets for therapy. Pharmacol Ther. 2013;139:289–300. doi: 10.1016/j.pharmthera.2013.04.011
   PubMed Web of Science ®Google Scholar
• Havelka Mestrovic A, Tudor L, Nikolac Perkovic M, et al. Significant association between catechol-O-methyltransferase (COMT) Val158/108Met polymorphism and cognitive function in veterans with PTSD. Neurosci Lett. 2018;666:38–43. doi: 10.1016/j.neulet.2017.12.033
   Web of Science ®Google Scholar
• Okahisa Y, Kodama M, Takaki M, et al. Association study of two cannabinoid ReceptorGenes, CNR1 and CNR2, with methamphetamine dependence. Curr Neuropharmacol. 2011;9:183–189. doi: 10.2174/157015911795017191
   Web of Science ®Google Scholar
• Berdyshev EV. Cannabinoid receptors and the regulation of immune response. Chem Phys Lipids. 2000;108:169–190. doi: 10.1016/S0009-3084(00)00195-X
   PubMed Web of Science ®Google Scholar
• Normoyle KP, Kim M, Farahvar A, et al. The emerging neuroprotective role of mitochondrial uncoupling protein-2 in traumatic brain injury. Transl Neurosci. 2015;6:179–186. doi: 10.1515/tnsci-2015-0019
   Web of Science ®Google Scholar
• Weaver CT, Harrington LE, Mangan PR, et al. Th17: An effector CD4 T cell lineage with regulatory T cell ties. Immunity. 2006;24:677–688. doi: 10.1016/j.immuni.2006.06.002
   PubMed Web of Science ®Google Scholar
• Blandino V, Wetzel J, Kim J, et al. Oral fluid vs. urine analysis to monitor synthetic cannabinoids and classic drugs recent exposure. Curr Pharm Biotechnol. 2017;18:796–805. doi: 10.2174/1389201018666171122113934
   PubMed Web of Science ®Google Scholar
• Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from nucleated cells. Nucleic Acids Res. 1988;16:1215–1215. doi: 10.1093/nar/16.3.1215
   PubMed Web of Science ®Google Scholar
• Białecka M, Droździk M, Kłodowska-Duda G, et al. The effect of monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) polymorphisms on levodopa therapy in patients with sporadic Parkinson’s disease. Acta Neurol Scand. 2004;110:260–266. doi: 10.1111/j.1600-0404.2004.00315.x
   PubMed Web of Science ®Google Scholar
• Tong D, He S, Wang L, et al. Association of single-nucleotide polymorphisms in the cannabinoid receptor 2 gene with schizophrenia in the Han Chinese population. J Mol Neurosci. 2013;51:454–460. doi: 10.1007/s12031-013-0062-0
   Web of Science ®Google Scholar
• Paradowska-Gorycka A, Wojtecka-Lukasik E, Trefler J. Association between IL-17F gene polymorphisms and susceptibility to and severity of rheumatoid arthritis (RA). Scand J Immunol. 2010;72:134–141. doi: 10.1111/j.1365-3083.2010.02411.x
   PubMed Web of Science ®Google Scholar
• Sesti G, Cardellini M, Marini MA, et al. A common polymorphism in the promotor of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes. 2003;52:1280–1283. doi: 10.2337/diabetes.52.5.1280
   Google Scholar
• Altman JE, Glautier S BJ, et al. The biological, social and clinical bases of drug addiction: commentarytary and debate. Psychopharmacology (Berl). 1996;125:285–245. doi: 10.1007/BF02246016
   PubMed Web of Science ®Google Scholar
• Lüscher C, Malenka RC. Drug-evoked synaptic plasticity in addiction:tion: from molecular changes to circuit remodeling. Neuron. 2011;69:650–663. doi: 10.1016/j.neuron.2011.01.017
   PubMed Web of Science ®Google Scholar
• Juárez Olguín H, Calderón Guzmán D, Hernández García E, et al. The role of dopamine and its dysfunction as a consequence of oxidative stress. OxidMed Cell Longev. 2016;2016:9730467.
   PubMed Web of Science ®Google Scholar
• González-Castro TB, Hernández-Díaz Y, Juárez-Rojop IE, et al. The role of COMT gene Val108/158Met polymorphism in suicidal behavior: systematic review and updated meta-analysis. Neuropsychiatr Dis Treat. 2018;14:2485–2496. doi: 10.2147/NDT.S172243
   PubMed Web of Science ®Google Scholar
• Chen J, Lipska BK, Halim N, et al. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, enzyme activity in postmortem human brain. Am J Hum Genet. 2004;75:807–821. doi: 10.1086/425589
   PubMed Web of Science ®Google Scholar
• González-Castro TB, Hernández-Díaz Y, Juárez-Rojop IE, et al. The role of a catechol-o-methyltransferase (COMT) Val158Met genetic polymorphism in schizophrenia: a systematic review and updated meta-analysis on 32,816 subjects. Neuromolecular Med. 2016;18:216–231. doi: 10.1007/s12017-016-8392-z
   Web of Science ®Google Scholar
• Burdick KE, Funke B, Goldberg JF, et al. COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Bipolar Disord. 2007;9:370–376. doi: 10.1111/j.1399-5618.2007.00384.x
   PubMed Web of Science ®Google Scholar
• Vandenbergh DJ, Rodriguez LA, Miller IT, et al. High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers. Am J Med Genet. 1997;74:439–442. doi: 10.1002/(SICI)1096-8628(19970725)74:4<439::AID-AJMG16>3.0.CO;2-J
   Web of Science ®Google Scholar
• Serý O, Didden W, Mikes V, et al. The association between high-activity COMT allele and alcoholism. Neuro Endocrinol Lett. 2006;27:231–235.
   PubMed Web of Science ®Google Scholar
• Horowitz R, Kotler M, Shufman E, et al. Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study. Am J Med Genet. 2000;96:599–603. doi: 10.1002/1096-8628(20001009)96:5<599::AID-AJMG4>3.0.CO;2-O
   PubMed Web of Science ®Google Scholar
• Lohoff FW, Weller AE, Bloch PJ, et al. Association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and cocaine dependence. Neuropsychopharmacology. 2008;33:3078–3084. doi: 10.1038/npp.2008.126
   Web of Science ®Google Scholar
• Hosák L, Libiger J, Cizek J, et al. The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: preliminary results. Neuro Endocrinol Lett. 2006;27:799–802.
   PubMed Web of Science ®Google Scholar
• Intharachutia W, Ittiwut R, Listman J, et al. Polymorphism of COMT Val158Met is associated with inhalant use and dependence: a Thai substance dependence treatment cohort. Asian Biomed. 2012;6(4):549–556.
   Web of Science ®Google Scholar
• Hartman CA, Hopfer CJ, Haberstick B, et al. The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults. Drug Alcohol Depend. 2009;104:11–16. doi: 10.1016/j.drugalcdep.2009.01.022
   PubMed Web of Science ®Google Scholar
• Proudnikov D, Kroslak T, Sipe JC, et al. Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. Pharmacogenomics J. 2010;10:232–242. doi: 10.1038/tpj.2009.59
   PubMed Web of Science ®Google Scholar
• Zuo L, Kranzler HR, Luo X, et al. CNR1 variation modulates risk for drug and alcohol dependence. Biol Psychiatry. 2007;62:616–626. doi: 10.1016/j.biopsych.2006.12.004
   PubMed Web of Science ®Google Scholar
• Kolla NJ, Mishra A. The endocannabinoid system, aggression, and the violence of synthetic cannabinoid use, borderline personality disorder, antisocial personality disorder, and other psychiatric disorders. Front Behav Neurosci. 2018;12:41.
   Web of Science ®Google Scholar
• Rodríguez-Arias M, Navarrete F, Blanco-Gandia MC, et al. Role of CB2 receptors in social and aggressive behavior in male mice. Psychopharmacology (Berl.). 2015;232:3019–3031. doi: 10.1007/s00213-015-3939-5
   Web of Science ®Google Scholar
• Ishiguro H, Carpio O, Horiuchi Y, et al. A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands. Synapse. 2010;64:92–96. doi: 10.1002/syn.20714
   Web of Science ®Google Scholar
• Minocci D, Massei J, Martino A, et al. Genetic association between bipolar disorder and 524A > C (Leu133Ile) polymorphism of CNR2 gene, encoding for CB2 cannabinoid receptor. J Affect Disord. 2011;134:427–430. doi: 10.1016/j.jad.2011.05.023
   Web of Science ®Google Scholar
• Ishiguro H, Iwasaki S, Teasenfitz L, et al. Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans. Pharmacogenomics J. 2007;7:380–385. doi: 10.1038/sj.tpj.6500431
   PubMed Web of Science ®Google Scholar
• Laskowski KR, Russell RR. Uncoupling proteins in heart failure. Curr Heart Fail Rep. 2008;5:75–79. doi: 10.1007/s11897-008-0013-1
   Google Scholar
• Sullivan PG, Dubé C, Dorenbos K, et al. Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol. 2003;53:711–717. doi: 10.1002/ana.10543
   Web of Science ®Google Scholar
• Yanovski JA, Diament AL, Sovik KN, et al. Associations between uncoupling protein. Associations between uncoupling protein 2, body composition, and resting energy expenditure in lean and obese African American, white, and Asian children. Am J Clin Nutr. 2000;71:1405–1420. doi: 10.1093/ajcn/71.6.1405
   Web of Science ®Google Scholar
• Kovacs P, Ma L, Hanson RL, et al. Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians. Diabetologia. 2005;48:2292–2295. doi: 10.1007/s00125-005-1934-9
   Web of Science ®Google Scholar
• Ochoa MC, Santos JL, Azcona C, et al. GENOI members. Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents. Mol Genet Metab. 2007;92:351–358. doi: 10.1016/j.ymgme.2007.07.011
   Web of Science ®Google Scholar
• Vogler S, Goedde R, Miterski B, et al. Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis. J Mol Med (Berl). 2005;83:806–811. doi: 10.1007/s00109-005-0661-5
   PubMed Web of Science ®Google Scholar
• Yamasaki H, Sasaki H, Ogawa K, et al. Uncoupling protein 2 promoter polymorphism -866G/A affects peripheral nerve dysfunction in Japanese type 2 diabetic patients. Diabetes Care. 2006;29:888–894. doi: 10.2337/diacare.29.04.06.dc05-1984
   PubMed Web of Science ®Google Scholar
• Yasuno K A, Misumi S S, et al. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:250–253. doi: 10.1002/ajmg.b.30443
   Web of Science ®Google Scholar
• Cui C, Shurtleff D, Harris RA. Neuroimmune mechanisms of alcohol and drug addiction. Int RevNeurobiol. 2014;118:1–12.
   PubMed Web of Science ®Google Scholar
• Moreira FP, Medeiros JR, Lhullier AC, et al. Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10. Drug Alcohol Depend. 2016;158:181–185. doi: 10.1016/j.drugalcdep.2015.11.024
   PubMed Web of Science ®Google Scholar
• Marcos M, Pastor I, González-Sarmiento R, et al. Interleukin-10 gene polymorphism is associated with alcoholism but not with alcoholic liver disease. Alcohol Alcohol. 2008;43:523–528. doi: 10.1093/alcalc/agn026
   PubMed Web of Science ®Google Scholar
• Saiz PA, Garcia-Portilla MP, Florez G, et al. Polymorphisms of the IL-1 gene complex are associated with alcohol dependence in Spanish Caucasians: Data from an association study. Alcohol Clin Exp Res. 2009;33:2147–2153. doi: 10.1111/j.1530-0277.2009.01058.x
   Web of Science ®Google Scholar
• Du J, Han JG, Zhang YJ, et al. Single-Nucleotide Polymorphisms of IL-17 Gene Are associated with Asthma Susceptibility in an Asian Population. Med Sci Monit. 2016;22:780–787. doi: 10.12659/MSM.895494
   Web of Science ®Google Scholar
• Akbulut UE, Cebi AH, Sag E, et al. Interleukin-6 and interleukin-17 gene polymorphism association with celiac disease in children. Turk J Gastroenterol. 2017;28:471–475. doi: 10.5152/tjg.2017.17092
   Web of Science ®Google Scholar
• Zhang X, Yu P, Wang Y, et al. Genetic polymorphisms of interleukin 17A and interleukin 17F and their association with inflammatory bowel disease in a Chinese Han population. Inflamm Res. 2013;62:743–750. doi: 10.1007/s00011-013-0629-9
   PubMed Web of Science ®Google Scholar
• Heinz R, Waltenbaugh C. Ethanol consumption modifies dendritic cell antigen presentation in mice. Alcohol Clin Exp Res. 2007;31:1759–1771. doi: 10.1111/j.1530-0277.2007.00479.x
   Web of Science ®Google Scholar