Clinical manifestations in anti-Ro52/SS-A antibody-seropositive patients with Sjögren's syndrome

References

• Mariette X, Criswell LA. Primary Sjögren's syndrome. N Engl J Med. 2018;378(10):931–939.
   PubMed Web of Science ®Google Scholar
• Nakamura H, Kawakami A, Eguchi K. Mechanisms of autoantibody production and the relationship between autoantibodies and the clinical manifestations in Sjögren's syndrome. Transl Res. 2006;148(6):281–288.
   PubMed Web of Science ®Google Scholar
• Psianou K, Panagoulias I, Papanastasiou AD, et al. Clinical and immunological parameters of Sjögren's syndrome. Autoimmun Rev. 2018;17(10):1053–1064.
   Web of Science ®Google Scholar
• Vitali C, Bombardieri S, Jonsson R, et al. Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61(6):554–558.
   PubMed Web of Science ®Google Scholar
• Shiboski CH, Shiboski SC, Seror R, the International Sjögren's Syndrome Criteria Working Group, et al. 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome: a consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis. 2017;76(1):9–16.
   PubMed Web of Science ®Google Scholar
• Tsuboi H, Hagiwara S, Asashima H, et al. Validation of different sets of criteria for the diagnosis of Sjögren's syndrome in Japanese patients. Mod Rheumatol. 2013;23(2):219–225.
   PubMed Web of Science ®Google Scholar
• Brauner S, Ivanchenko M, Thorlacius GE, et al. The Sjögren's syndrome-associated autoantigen Ro52/TRIM21 modulates follicular B cell homeostasis and immunoglobulin production. Clin Exp Immunol. 2018;194(3):315–326.
   Web of Science ®Google Scholar
• Robbins A, Hentzien M, Toquet S, et al. Diagnostic utility of separate anti-Ro60 and anti-Ro52/TRIM21 antibody detection in autoimmune diseases. Front Immunol. 2019;10:444.
   Web of Science ®Google Scholar
• Ben-Chetrit E, Fox RI, Tan EM. Dissociation of immune responses to the SS. A (Ro) 52-kd and 60-kd Polypeptides in Systemic Lupus Erythematosus and Sjögren's Syndrome. 1990;33(3):349–355.
   Google Scholar
• Retamozo S, Akasbi M, Brito-Zerón P, et al. Anti-Ro52 antibody testing influences the classification and clinical characterisation of primary Sjögren's syndrome. Clin Exp Rheumatol. 2012;30:686–692.
   PubMed Web of Science ®Google Scholar
• Quartuccio L, Isola M, Baldini C, et al. Biomarkers of lymphoma in Sjogren's syndrome and evaluation of the lymphoma risk in prelymphomatous conditions: results of a multicenter study. J Autoimm. 2014;51:75–80.
   PubMed Web of Science ®Google Scholar
• Acar-Denizli N, Horváth IF, Mandl T, et al. Systemic phenotype related to primary Sjögren's syndrome in 279 patients carrying isolated anti-La/SSB antibodies. Clin Exp Rheumatol. 2020;38:85–94.
   Web of Science ®Google Scholar
• Takeshita M, Suzuki K, Kaneda Y, et al. Antigen-driven selection of antibodies against SSA, SSB and the centromere 'complex', including a novel antigen, MIS12 complex, in human salivary glands. Ann Rheum Dis. 2020;79(1):150–158.
   Web of Science ®Google Scholar
• Katano K, Kawano M, Koni I, et al. Clinical and laboratory features of anticentromere antibody positive primary Sjögren's syndrome. J Rheumatol. 2001;28:2238–2244.
   PubMed Web of Science ®Google Scholar
• Nakamura H, Kawakami A, Hayashi T, et al. Anti-centromere antibody-seropositive Sjögren's syndrome differs from conventional subgroup in clinical and pathological study. BMC Musculoskelet Disord. 2010;11(1):140.
   PubMedGoogle Scholar
• Brito-Zerón P, Acar-Denizli N, Ng WF, for the Sjögren Big Data Consortium, et al. Epidemiological profile and north-south gradient driving baseline systemic involvement of primary Sjögren's syndrome. Rheumatology (Oxford). 2020;59(9):2350–2359.
   PubMed Web of Science ®Google Scholar
• Mekinian A, Nicaise-Roland P, Chollet-Martin S, et al. Anti-SSA Ro52/Ro60 antibody testing by immunodot could help the diagnosis of Sjogren's syndrome in the absence of anti-SSA/SSB antibodies by ELISA. Rheumatology (Oxford). 2013;52(12):2223–2228.
   Web of Science ®Google Scholar
• Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31(3):315–324.
   PubMed Web of Science ®Google Scholar
• Aletaha D, Neogi T, Silman AJ, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;69(9):1580–1588.
   PubMed Web of Science ®Google Scholar
• Chisholm DM, Mason DK. Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol. 1968;21(5):656–660.
   PubMed Web of Science ®Google Scholar
• Greenspan JS, Daniels TE, Talal N, et al. The histopathology of Sjögren's syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol. 1974;37(2):217–229.
   PubMedGoogle Scholar
• Seror R, Ravaud P, Bowman SJ, et al. EULAR Sjogren's syndrome disease activity index: Development of a consensus systemic disease activity index for primary Sjogren's syndrome. Ann Rheum Dis. 2010;69(6):1103–1109.
   PubMed Web of Science ®Google Scholar
• Seror R, Bowman SJ, Brito-Zeron P, on behalf of the EULAR Sjogren's Task Force, el al. EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide. RMD Open. 2015;1(1):e000022–e000022.
   PubMed Web of Science ®Google Scholar
• Fisher BA, Jonsson R, Daniels T, et al. Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren's syndrome. Ann Rheum Dis. 2017;76(7):1161–1168.
   PubMed Web of Science ®Google Scholar
• Koller M, Stahel WA. Stahel. Sharpening Wald-type inference in robust regression for small samples. Comput. Stat. Data Anal. 2011;55(8):2504–2515.
   Web of Science ®Google Scholar
• Buuren S, van Groothuis-Oudshoorn K. mice: multivariate imputation by chained equations in R. J. Stat. Softw. 2010;45:1–68.
   Web of Science ®Google Scholar
• Venables WN, Ripley BD. Modern applied statistics with S (Statistics and Computing). New York (NY): Springer; 2002.
   Google Scholar
• Reshef DN, Reshef YA, Finucane HK, et al. Detecting novel associations in large data sets. Science. 2011;334(6062):1518–1524.
   PubMed Web of Science ®Google Scholar
• R Core Team. R: a language and environment for statistical computing. Vienna, Austria; 2018.
   Google Scholar
• Maechler M, Rousseeuw P, Croux C, et al. Robustbase: basic robust statistics. R package version 0.93-7. 2019.
   Google Scholar
• Robin X, Turck N, Hainard A, et al. pROC: An open-source package for R and S + to analyze and compare ROC curves. BMC Bioinf . 2011;12(1):77.
   PubMed Web of Science ®Google Scholar
• Menéndez A, Gómez J, Escanlar E, et al. Clinical associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies: Diagnostic utility of their separate detection. Autoimmunity. 2013;46(1):32–39.
   PubMed Web of Science ®Google Scholar
• Hennig J, Bresell A, Sandberg M, et al. The fellowship of the RING: The RING-B-box linker region interacts with the RING in TRIM21/Ro52, contains a native autoantigenic epitope in Sjögren syndrome, and is an integral and conserved region in TRIM proteins. J Mol Biol. 2008;377(2):431–449.
   Web of Science ®Google Scholar
• Espinosa A, Zhou W, Ek M, et al. The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death. J Immunol. 2006;176(10):6277–6285.
   PubMed Web of Science ®Google Scholar
• Strandberg L, Ambrosi A, Espinosa A, et al. Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies. J Clin Immunol. 2008;28(3):220–231.
   PubMed Web of Science ®Google Scholar
• Itoh Y, Kriet JD, Reichlin M. Organ distribution of the Ro (SS-A) antigen in the guinea pig. Arthritis Rheum. 1990;33(12):1815–1821.
   Google Scholar
• Itoh Y, Reichlin M. Ro/SS-A antigen in human platelets. Different distributions of the isoforms of Ro/SS-A protein and the Ro/SS-A-binding RNA. Arthritis Rheum. 1991;34(7):888–893.
   Google Scholar
• Strandberg L, Salomonsson S, Bremme K, et al. Ro52, Ro60 and La IgG autoantibody levels and Ro52 IgG subclass profiles longitudinally throughout pregnancy in congenital heart block risk pregnancies. Lupus. 2006;15(6):346–353.
   Web of Science ®Google Scholar
• Praprotnik S, Bozic B, Kveder T, et al. Fluctuation of anti-Ro/SS-A antibody levels in patients with systemic lupus erythematosus and Sjögren's syndrome: A prospective study. Clin Exp Rheumatol. 1999;17:63–68.
   PubMed Web of Science ®Google Scholar
• Ramos-Casals M, Brito-Zerón P, Solans R, on behalf of the SS Study Group, et al. Systemic involvement in primary Sjogren's syndrome evaluated by the EULAR-SS disease activity index: Analysis of 921 Spanish patients (GEAS-SS Registry). Rheumatology (Oxford). 2014;53(2):321–331.,
   Web of Science ®Google Scholar
• Retamozo S, Acar-Denizli N, Rasmussen A, et al. Systemic manifestations of primary Sjögren's syndrome out of the ESSDAI classification: Prevalence and clinical relevance in a large international, multi-ethnic cohort of patients. Clin Exp Rheumatol. 2019;37 (Suppl 118):97–106.
   Google Scholar
• Moree B, Meyer CB, Fuller CJ, et al. CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly. J Cell Biol. 2011;194(6):855–871.
   Web of Science ®Google Scholar
• Hudson M, Pope J, Mahler M, Canadian Scleroderma Research Group (CSRG), et al. Clinical significance of antibodies to Ro52/TRIM21 in systemic sclerosis. Arthritis Res Ther. 2012;14(2):R50.
   PubMed Web of Science ®Google Scholar