A bioinformatics approach to study the role of calcium phosphate properties in bone regeneration

References

• Anselme, K., & Bigerelle, M. (2011). Role of materials surface topography on mammalian cell response. International Materials Reviews, 56(4), 243–266. doi:10.1179/1743280411Y.0000000001
   Web of Science ®Google Scholar
• Arimochi, H., Sasaki, Y., Kitamura, A., & Yasutomo, K. (2016). Differentiation of preadipocytes and mature adipocytes requires PSMB8. Scientific Reports, 6, 26791. doi:10.1038/srep26791
   PubMed Web of Science ®Google Scholar
• Bai, J., Wioland, H., Advedissian, T., Cuvelier, F., Romet-Lemonne, G., & Echard, A. (2020). Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy. Proceedings of the National Academy of Sciences of the United States of America, 117(8), 4169–4179. doi:10.1073/pnas.1911629117
   PubMed Web of Science ®Google Scholar
• Baker, B. A., Pine, P. S., Chatterjee, K., Kumar, G., Lin, N. J., McDaniel, J. H., … Simon, C. G. (2014). Ontology analysis of global gene expression differences of human bone marrow stromal cells cultured on 3D scaffolds or 2D films. Biomaterials, 35(25), 6716–6726. doi:10.1016/j.biomaterials.2014.04.075
   PubMed Web of Science ®Google Scholar
• Barradas, A. M. C., Fernandes, H. A. M., Groen, N., Chai, Y. C., Schrooten, J., van de Peppel, J., … de Boer, J. (2012). A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells. Biomaterials, 33(11), 3205–3215. doi:10.1016/j.biomaterials.2012.01.020
   PubMed Web of Science ®Google Scholar
• Barrère-de Groot, F., Yuan, H., & de Bruijn, J. D. (2018). Clinical relevance of sub-micron textured calcium phosphates for bone tissue regeneration. Materials Today: Proceedings, 5(7), 15501–15505.
   Google Scholar
• Batra, U., Kapoor, S., & Sharma, S. (2013). Influence of Magnesium Ion Substitution on Structural and Thermal Behavior of Nanodimensional Hydroxyapatite. Journal of Materials Engineering and Performance, 22(6), 1798–1806. doi:10.1007/s11665-012-0462-2
   Web of Science ®Google Scholar
• Bennett, J., & Weeds, A. (1986). Calcium and the cytoskeleton. British Medical Bulletin, 42(4), 385–390. doi:10.1093/oxfordjournals.bmb.a072156
   PubMed Web of Science ®Google Scholar
• Birgani, Z. T. (2016). Synthetic growth factors for bone regeneration. Enschede, the Netherlands: University of Twente.
   Google Scholar
• Birgani, Z. T., Malhotra, A., van Blitterswijk, C. A., & Habibovic, P. (2016). Human mesenchymal stromal cells response to biomimetic octacalcium phosphate containing strontium. Journal of Biomedical Materials Research. Part A, 104(8), 1946–1960. doi:10.1002/jbm.a.35725
   PubMed Web of Science ®Google Scholar
• Bohner, M., & Miron, R. J. (2019). A proposed mechanism for material-induced heterotopic ossification. Materials Today, 22, 132–141. doi:10.1016/j.mattod.2018.10.036
   Web of Science ®Google Scholar
• Bu, W., & Su, L.-K. (2001). Regulation of microtubule assembly by human EB1 family proteins. Oncogene, 20(25), 3185–3192. doi:10.1038/sj.onc.1204429
   PubMed Web of Science ®Google Scholar
• Cai, S., Wu, C., Yang, W., Liang, W., Yu, H., & Liu, L. (2020). Recent advance in surface modification for regulating cell adhesion and behaviors. Nanotechnology Reviews, 9(1), 971–989. doi:10.1515/ntrev-2020-0076
   Web of Science ®Google Scholar
• Chande, S., & Bergwitz, C. (2018). Role of phosphate sensing in bone and mineral metabolism. Nature Reviews. Endocrinology, 14(11), 637–655. doi:10.1038/s41574-018-0076-3
   PubMed Web of Science ®Google Scholar
• Dalby, M. J., Gadegaard, N., Tare, R., Andar, A., Riehle, M. O., Herzyk, P., … Oreffo, R. O. C. (2007). The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. Nature Materials, 6(12), 997–1003. doi:10.1038/nmat2013
   PubMed Web of Science ®Google Scholar
• Danoux, C. B. S. S., Bassett, D. C., Othman, Z., Rodrigues, A. I., Reis, R. L., Barralet, J. E., … Habibovic, P. (2015). Elucidating the individual effects of calcium and phosphate ions on hMSCs by using composite materials. Acta Biomaterialia, 17, 1–15. doi:10.1016/j.actbio.2015.02.003
   PubMed Web of Science ®Google Scholar
• Danoux, C., Pereira, D., Döbelin, N., Stähli, C., Barralet, J., van Blitterswijk, C., & Habibovic, P. (2016). The effects of crystal phase and particle morphology of calcium phosphates on proliferation and differentiation of human mesenchymal stromal cells. Advanced Healthcare Materials, 5(14), 1775–1785. doi:10.1002/adhm.201600184
   PubMed Web of Science ®Google Scholar
• Danoux, C., Sun, L., Koçer, G., Birgani, Z. T., Barata, D., Barralet, J., … Habibovic, P. (2016). Development of highly functional biomaterials by decoupling and recombining material properties. Advanced Materials (Deerfield Beach, Fla.), 28(9), 1803–1808. doi:10.1002/adma.201504589
   PubMed Web of Science ®Google Scholar
• Dasgupta, S., Tarafder, S., Bandyopadhyay, A., & Bose, S. (2013). Effect of grain size on mechanical, surface and biological properties of microwave sintered hydroxyapatite. Materials Science & Engineering. C, Materials for Biological Applications, 33(5), 2846–2854. doi:10.1016/j.msec.2013.03.004
   PubMed Web of Science ®Google Scholar
• Davison, N. L., Luo, X., Schoenmaker, T., Everts, V., Yuan, H., Barrère-de Groot, F., & de Bruijn, J. D. (2014). Submicron-scale surface architecture of tricalcium phosphate directs osteogenesis in vitro and in vivo. European Cells & Materials, 27, 281–297; discussion 296–297. doi:10.22203/ecm.v027a20
   PubMed Web of Science ®Google Scholar
• Davison, N., Yuan, H., de Bruijn, J. D., & Barrere-de Groot, F. (2012). In vivo performance of microstructured calcium phosphate formulated in novel water-free carriers. Acta Biomaterialia, 8(7), 2759–2769. doi:10.1016/j.actbio.2012.04.007
   PubMed Web of Science ®Google Scholar
• Deligianni, D. D., Katsala, N. D., Koutsoukos, P. G., & Missirlis, Y. F. (2000). Efect of surface roughness of hydroxyapatite on human bone marrowcell adhesion, proliferation, differentiation and detachment strength. Biomaterials, 22(1), 87–96. doi:10.1016/S0142-9612(00)00174-5
   Web of Science ®Google Scholar
• Doebelin, N., & Kleeberg, R. (2015). Profex: A graphical user interface for the Rietveld refinement program BGMN. Journal of Applied Crystallography, 48(Pt 5), 1573–1580. doi:10.1107/S1600576715014685
   PubMed Web of Science ®Google Scholar
• dos Santos, E. A., Farina, M., Soares, G. A., & Anselme, K. (2009). Chemical and topographical influence of hydroxyapatite and beta-tricalcium phosphate surfaces on human osteoblastic cell behavior. Journal of Biomedical Materials Research. Part A, 89(2), 510–520. doi:10.1002/jbm.a.31991
   PubMed Web of Science ®Google Scholar
• Duan, R., Barbieri, D., Luo, X., Weng, J., Bao, C., de Bruijn, J. D., & Yuan, H. (2017). Variation of the bone forming ability with the physicochemical properties of calcium phosphate bone substitutes. Biomaterials Science, 6(1), 136–145. doi:10.1039/c7bm00717e
   PubMed Web of Science ®Google Scholar
• Engel, E., Del Valle, S., Aparicio, C., Altankov, G., Asin, L., Planell, J. A., & Ginebra, M.-P. (2008). Discerning the role of topography and ion exchange in cell response of bioactive tissue engineering scaffolds. Tissue Engineering. Part A, 14(8), 1341–1351. doi:10.1089/ten.tea.2007.0287
   PubMed Web of Science ®Google Scholar
• Eyckmans, J., Roberts, S. J., Bolander, J., Schrooten, J., Chen, C. S., & Luyten, F. P. (2013). Mapping calcium phosphate activated gene networks as a strategy for targeted osteoinduction of human progenitors. Biomaterials, 34(19), 4612–4621. doi:10.1016/j.biomaterials.2013.03.011
   PubMed Web of Science ®Google Scholar
• Faia-Torres, A. B., Guimond-Lischer, S., Rottmar, M., Charnley, M., Goren, T., Maniura-Weber, K., … Neves, N. M. (2014). Differential regulation of osteogenic differentiation of stem cells on surface roughness gradients. Biomaterials, 35(33), 9023–9032. doi:10.1016/j.biomaterials.2014.07.015
   PubMed Web of Science ®Google Scholar
• Fang, Y., Zekiy, A. O., Ghaedrahmati, F., Timoshin, A., Farzaneh, M., Anbiyaiee, A., & Khoshnam, S. E. (2021). Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions. Cell Communication and Signaling: CCS, 19(1), 41. doi:10.1186/s12964-021-00725-y
   PubMed Web of Science ®Google Scholar
• Farzadi, A., Bakhshi, F., Solati-Hashjin, M., Asadi-Eydivand, M., & Osman, NAa. (2014). Magnesium incorporated hydroxyapatite: Synthesis and structural properties characterization. Ceramics International, 40(4), 6021–6029. doi:10.1016/j.ceramint.2013.11.051
   Web of Science ®Google Scholar
• Franceschi, R. T., & Xiao, G. (2003). Regulation of the osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways. Journal of Cellular Biochemistry, 88(3), 446–454. doi:10.1002/jcb.10369
   PubMed Web of Science ®Google Scholar
• Galvan-Chacon, V. P., & Habibovic, P. (2017). Deconvoluting the bioactivity of calcium phosphate-based bone graft substitutes: Strategies to understand the role of individual material properties. Advanced Healthcare Materials, 6(13), 1478.
   Web of Science ®Google Scholar
• Gibson, I. R., & Bonfield, W. (2002). Preparation and characterization of magnesium/carbonate co-substituted hydroxyapatites. Journal of Materials Science. Materials in Medicine, 13(7), 685–693.
   PubMed Web of Science ®Google Scholar
• Gillman, C. E., & Jayasuriya, A. C. (2021). FDA-approved bone grafts and bone graft substitute devices in bone regeneration. Materials Science & Engineering. C, Materials for Biological Applications, 130, 112466. doi:10.1016/j.msec.2021.112466
   PubMed Web of Science ®Google Scholar
• Govoni, M., Vivarelli, L., Mazzotta, A., Stagni, C., Maso, A., & Dallari, D. (2021). Commercial bone grafts claimed as an alternative to autografts: Current trends for clinical applications in orthopaedics. Materials (Basel), 14(12), 3290. doi:10.3390/ma14123290
   PubMed Web of Science ®Google Scholar
• Green, J., Nusse, R., & van Amerongen, R. (2014). The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction. Cold Spring Harbor Perspectives in Biology, 6(2), a009175.
   PubMed Web of Science ®Google Scholar
• Groen, N., Yuan, H., Hebels, D. G., Kocer, G., Mbuyi, F., & LaPointe, V. (2017). Linking the transcriptional landscape of bone induction to biomaterial design parameters. Advanced Materials, 29(10), 3259.
   Web of Science ®Google Scholar
• Guadarrama Bello, D., Fouillen, A., Badia, A., & Nanci, A. (2017). A nanoporous titanium surface promotes the maturation of focal adhesions and formation of filopodia with distinctive nanoscale protrusions by osteogenic cells. Acta Biomaterialia, 60, 339–349. doi:10.1016/j.actbio.2017.07.022
   PubMed Web of Science ®Google Scholar
• Habibovic, P., & Barralet, J. E. (2011). Bioinorganics and biomaterials: Bone repair. Acta Biomaterialia, 7(8), 3013–3026. doi:10.1016/j.actbio.2011.03.027
   PubMed Web of Science ®Google Scholar
• Habibovic, P., Yuan, H., van den Doel, M., Sees, T. M., van Blitterswijk, C. A., & de Groot, K. (2006). Relevance of osteoinductive biomaterials in critical-sized orthotopic defect. Journal of Orthopaedic Research, 24(5), 867–876. doi:10.1002/jor.20115
   PubMed Web of Science ®Google Scholar
• Hahn, M., Vogel, M., Pompesius-Kempa, M., & Delling, G. (1992). Trabecular bone pattern factor – a new parameter for simple quantification of bone microarchitecture. Bone, 13(4), 327–330. doi:10.1016/8756-3282(92)90078-b
   PubMed Web of Science ®Google Scholar
• He, D., Liu, F., Cui, S., Jiang, N., Yu, H., Zhou, Y., … Kou, X. (2020). Mechanical load-induced H2S production by periodontal ligament stem cells activates M1 macrophages to promote bone remodeling and tooth movement via STAT1. Stem Cell Research & Therapy, 11(1), 112. doi:10.1186/s13287-020-01607-9
   PubMed Web of Science ®Google Scholar
• Hoai, T. T., & Nga, N. K. (2018). Effect of pore architecture on osteoblast adhesion and proliferation on hydroxyapatite/poly(D,L) lactic acid-based bone scaffolds. Journal of the Iranian Chemical Society, 15(7), 1663–1671. doi:10.1007/s13738-018-1365-4
   Web of Science ®Google Scholar
• Hornez, J. C., Chai, F., Monchau, F., Blanchemain, N., Descamps, M., & Hildebrand, H. F. (2007). Biological and physico-chemical assessment of hydroxyapatite (HA) with different porosity. Biomolecular Engineering, 24(5), 505–509. doi:10.1016/j.bioeng.2007.08.015
   PubMedGoogle Scholar
• Kannan, S., Ventura, J. M., & Ferreira, J. M. F. (2007). Aqueous precipitation method for the formation of Mg-stabilized β-tricalcium phosphate: An X-ray diffraction study. Ceramics International, 33(4), 637–641. doi:10.1016/j.ceramint.2005.11.014
   Web of Science ®Google Scholar
• Kano, S., Miyajima, N., Fukuda, S., & Hatakeyama, S. (2008). Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2. Cancer Research, 68(14), 5572–5580. doi:10.1158/0008-5472.CAN-07-6231
   PubMed Web of Science ®Google Scholar
• Kean, M. J., Williams, K. C., Skalski, M., Myers, D., Burtnik, A., Foster, D., & Coppolino, M. G. (2009). VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. Journal of Cell Science, 122(Pt 22), 4089–4098. doi:10.1242/jcs.052761
   PubMed Web of Science ®Google Scholar
• Landi, E., Logroscino, G., Proietti, L., Tampieri, A., Sandri, M., & Sprio, S. (2008). Biomimetic Mg-substituted hydroxyapatite: From synthesis to in vivo behaviour. Journal of Materials Science. Materials in Medicine, 19(1), 239–247. doi:10.1007/s10856-006-0032-y
   PubMed Web of Science ®Google Scholar
• Lapczyna, H., Galea, L., Wüst, S., Bohner, M., Jerban, S., Sweedy, A., … von Rechenberg, B. (2014). Effect of grain size and microporosity on the in vivo behaviour of beta-tricalcium phosphate scaffolds. European Cells and Materials, 28, 299–319. doi:10.22203/eCM.v028a21
   PubMed Web of Science ®Google Scholar
• Le, B. Q., Vasilevich, A., Vermeulen, S., Hulshof, F., Stamatialis, D. F., van Blitterswijk, C. A., & de Boer, J. (2017). Micro-Topographies Promote Late Chondrogenic Differentiation Markers in the ATDC5 Cell Line. Tissue Engineering. Part A, 23(9–10), 458–469. doi:10.1089/ten.TEA.2016.0421
   PubMed Web of Science ®Google Scholar
• Lee, W. H., Zavgorodniy, A. V., Loo, C. Y., & Rohanizadeh, R. (2012). Synthesis and characterization of hydroxyapatite with different crystallinity: Effects on protein adsorption and release. Journal of Biomedical Materials Research. Part A, 100(6), 1539–1549. doi:10.1002/jbm.a.34093
   PubMed Web of Science ®Google Scholar
• Li, S., De Wijn, J. R., Li, J., Layrolle, P., & De Groot, K. (2003). Macroporous biphasic calcium phosphate scaffold with high permeability/porosity ratio. Tissue Engineering, 9(3), 535–548. doi:10.1089/107632703322066714
   PubMedGoogle Scholar
• Li, Y.-F., Gregersen, H., Nygaard, J. V., Cheng, W., Yu, Y., Huang, Y., … Chen, M. (2015). Ultraporous nanofeatured PCL-PEO microfibrous scaffolds enhance cell infiltration, colonization and myofibroblastic differentiation. Nanoscale, 7(36), 14989–14995. doi:10.1039/c5nr04244e
   PubMed Web of Science ®Google Scholar
• Liang, T., Gao, W., Zhu, L., Ren, J., Yao, H., & Wang, K. (2019). TIMP-1 inhibits proliferation and osteogenic differentiation of hBMSCs through Wnt/beta-catenin signaling. Bioscience Reports, 39(1), BSR20181290.
   PubMed Web of Science ®Google Scholar
• Lien, S. M., Ko, L. Y., & Huang, T. J. (2009). Effect of pore size on ECM secretion and cell growth in gelatin scaffold for articular cartilage tissue engineering. Acta Biomaterialia, 5(2), 670–679. doi:10.1016/j.actbio.2008.09.020
   PubMed Web of Science ®Google Scholar
• Lincks, J., Boyan, B. D., Blanchard, C. R., Lohmann, C. H., Liu, Y., & Cochran, D. L. (1998). Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition. Biomaterials, 19(23), 2219–2232. doi:10.1016/S0142-9612(98)00144-6
   PubMed Web of Science ®Google Scholar
• Linez-Bataillon, P., Monchau, F., Bigerelle, M., & Hildebrand, H. F. (2002). In vitro MC3T3 osteoblast adhesion with respect to surface roughness of Ti6Al4V substrates. Biomolecular Engineering, 19(2–6), 133–141. doi:10.1016/S1389-0344(02)00024-2
   PubMedGoogle Scholar
• Luftman, K., Hasan, N., Day, P., Hardee, D., & Hu, C. (2009). Silencing of VAMP3 inhibits cell migration and integrin-mediated adhesion. Biochemical and Biophysical Research Communications, 380(1), 65–70. doi:10.1016/j.bbrc.2009.01.036
   PubMed Web of Science ®Google Scholar
• Maazouz, Y., Chizzola, G., Dobelin, N., & Bohner, M. (2021). Cell-free, quantitative mineralization measurements as a proxy to identify osteoinductive bone graft substitutes. Biomaterials, 275, 120912. doi:10.1016/j.biomaterials.2021.120912
   PubMed Web of Science ®Google Scholar
• Maazouz, Y., Rentsch, I., Lu, B., Santoni, B. L. G., Doebelin, N., & Bohner, M. (2020). In vitro measurement of the chemical changes occurring within beta-tricalcium phosphate bone graft substitutes. Acta Biomaterialia, 102, 440–457. doi:10.1016/j.actbio.2019.11.035
   PubMed Web of Science ®Google Scholar
• Mailer, R. K., Allende, M., Heestermans, M., Schweizer, M., Deppermann, C., Frye, M., … Renné, T. (2021). Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate. Blood, 137(10), 1392–1405. doi:10.1182/blood.2019004617
   PubMed Web of Science ®Google Scholar
• Mandal, B. B., & Kundu, S. C. (2009). Cell proliferation and migration in silk fibroin 3D scaffolds. Biomaterials, 30(15), 2956–2965. doi:10.1016/j.biomaterials.2009.02.006
   PubMed Web of Science ®Google Scholar
• Mazón, P., García-Bernal, D., Meseguer-Olmo, L., Cragnolini, F., & De Aza, P. N. (2015). Human mesenchymal stem cell viability, proliferation and differentiation potential in response to ceramic chemistry and surface roughness. Ceramics International, 41(5), 6631–6644. doi:10.1016/j.ceramint.2015.01.110
   Web of Science ®Google Scholar
• Mehrjoo, M., Javadpour, J., Shokrgozar, M. A., Farokhi, M., Javadian, S., & Bonakdar, S. (2015). Effect of magnesium substitution on structural and biological properties of synthetic hydroxyapatite powder. Materials Express, 5(1), 41–48. doi:10.1166/mex.2015.1205
   Web of Science ®Google Scholar
• Mizuno, N., Iwata, T., Ohsawa, R., Ouhara, K., Matsuda, S., Kajiya, M., … Kurihara, H. (2020). Optineurin regulates osteoblastogenesis through STAT1. Biochemical and Biophysical Research Communications, 525(4), 889–894. doi:10.1016/j.bbrc.2020.03.028
   PubMed Web of Science ®Google Scholar
• Murakami, K., Yasunaga, T., Noguchi, T. Q. P., Gomibuchi, Y., Ngo, K. X., Uyeda, T. Q. P., & Wakabayashi, T. (2010). Structural basis for actin assembly, activation of ATP hydrolysis, and delayed phosphate release. Cell, 143(2), 275–287. doi:10.1016/j.cell.2010.09.034
   PubMed Web of Science ®Google Scholar
• Nabiyouni, M., Ren, Y., & Bhaduri, S. B. (2015). Magnesium substitution in the structure of orthopedic nanoparticles: A comparison between amorphous magnesium phosphates, calcium magnesium phosphates, and hydroxyapatites. Materials Science & Engineering. C, Materials for Biological Applications, 52, 11–17. doi:10.1016/j.msec.2015.03.032
   PubMed Web of Science ®Google Scholar
• Nehlig, A., Molina, A., Rodrigues-Ferreira, S., Honore, S., & Nahmias, C. (2017). Regulation of end-binding protein EB1 in the control of microtubule dynamics. Cellular and Molecular Life Sciences: CMLS, 74(13), 2381–2393. doi:10.1007/s00018-017-2476-2
   PubMed Web of Science ®Google Scholar
• Othman, Z., Fernandes, H., Groot, A. J., Luider, T. M., Alcinesio, A., Pereira, D. d M., … Habibovic, P. (2019). The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics. Biomaterials, 210, 12–24. doi:10.1016/j.biomaterials.2019.04.021
   PubMed Web of Science ®Google Scholar
• Otsuka, M., Oshinbe, A., LeGeros, R. Z., Tokudome, Y., Ito, A., Otsuka, K., & Higuchi, W. I. (2008). Efficacy of the injectable calcium phosphate ceramics suspensions containing magnesium, zinc and fluoride on the bone mineral deficiency in ovariectomized rats. Journal of Pharmaceutical Sciences, 97(1), 421–432. doi:10.1002/jps.21131
   PubMed Web of Science ®Google Scholar
• Pamula, E., Filova, E., Bacakova, L., Lisa, V., & Adamczyk, D. (2009). Resorbable polymeric scaffolds for bone tissue engineering: The influence of their microstructure on the growth of human osteoblast-like MG 63 cells. Journal of Biomedical Materials Research. Part A, 89(2), 432–443. doi:10.1002/jbm.a.31977
   PubMed Web of Science ®Google Scholar
• Perkins, R. S., Suthon, S., Miranda-Carboni, G. A., & Krum, S. A. (2021). WNT5B in cellular signaling pathways. Seminars in Cell & Developmental Biology, 125, 11–16.
   PubMed Web of Science ®Google Scholar
• Place, D. E., Malireddi, R. K. S., Kim, J., Vogel, P., Yamamoto, M., & Kanneganti, T. D. (2021). Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins. Nature Communications, 12(1), 496. doi:10.1038/s41467-020-20807-8
   PubMed Web of Science ®Google Scholar
• Prihadi, J. C., Sugandi, S., Siregar, N. C., Soejono, G., & Harahap, A. (2018). Imbalance in extracellular matrix degradation in urethral stricture. Research and Reports in Urology, 10, 227–232. doi:10.2147/RRU.S178904
   PubMed Web of Science ®Google Scholar
• Ribeiro, C. M., Reece, J., & Putney, J. W. Jr.(1997). Role of the cytoskeleton in calcium signaling in NIH 3T3 cells. An intact cytoskeleton is required for agonist-induced [Ca2+]i signaling, but not for capacitative calcium entry. The Journal of Biological Chemistry, 272(42), 26555–26561. doi:10.1074/jbc.272.42.26555
   PubMed Web of Science ®Google Scholar
• Riggs, K. A., Hasan, N., Humphrey, D., Raleigh, C., Nevitt, C., Corbin, D., & Hu, C. (2012). Regulation of integrin endocytic recycling and chemotactic cell migration by syntaxin 6 and VAMP3 interaction. Journal of Cell Science, 125(Pt 16), 3827–3839.
   PubMed Web of Science ®Google Scholar
• Rosado, J. A., & Sage, S. O. (2000). The actin cytoskeleton in store­mediated calcium entry. The Journal of Physiology, 526(2), 221–229. doi:10.1111/j.1469-7793.2000.t01-2-00221.x
   PubMed Web of Science ®Google Scholar
• Semnani, D. (2017). Geometrical characterization of electrospun nanofibers. In Electrospun nanofibers (pp. 151–180). Sawston, UK: Woodhead Publishing.
   Google Scholar
• Sheikh, Z., Abdallah, M.-N., Hanafi, A., Misbahuddin, S., Rashid, H., & Glogauer, M. (2015). Mechanisms of in Vivo Degradation and Resorption of Calcium Phosphate Based Biomaterials. Materials (Basel, Switzerland), 8(11), 7913–7925. doi:10.3390/ma8115430
   PubMed Web of Science ®Google Scholar
• Stiburek, L., Cesnekova, J., Kostkova, O., Fornuskova, D., Vinsova, K., Wenchich, L., … Zeman, J. (2012). YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation. Molecular Biology of the Cell, 23(6), 1010–1023. doi:10.1091/mbc.E11-08-0674
   PubMed Web of Science ®Google Scholar
• Sun, L., Danoux, C. B., Wang, Q., Pereira, D., Barata, D., Zhang, J., … Habibovic, P. (2016). Independent effects of the chemical and microstructural surface properties of polymer/ceramic composites on proliferation and osteogenic differentiation of human MSCs. Acta Biomaterialia, 42, 364–377. doi:10.1016/j.actbio.2016.06.018
   PubMed Web of Science ®Google Scholar
• Tahmasebi Birgani, Z., Fennema, E., Gijbels, M. J., de Boer, J., van Blitterswijk, C. A., & Habibovic, P. (2016). Stimulatory effect of cobalt ions incorporated into calcium phosphate coatings on neovascularization in an in vivo intramuscular model in goats. Acta Biomaterialia, 36, 267–276. doi:10.1016/j.actbio.2016.03.031
   PubMed Web of Science ®Google Scholar
• Tamimi, F., Le Nihouannen, D., Eimar, H., Sheikh, Z., Komarova, S., & Barralet, J. (2012). The effect of autoclaving on the physical and biological properties of dicalcium phosphate dihydrate bioceramics: Brushite vs. monetite. Acta Biomaterialia, 8(8), 3161–3169. doi:10.1016/j.actbio.2012.04.025
   PubMed Web of Science ®Google Scholar
• Tran, H., Hamada, F., Schwarz-Romond, T., & Bienz, M. (2008). Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes & Development, 22(4), 528–542. doi:10.1101/gad.463208
   PubMed Web of Science ®Google Scholar
• Vasilevich, A. S., Vermeulen, S., Kamphuis, M., Roumans, N., Eroumé, S., Hebels, D. G. A. J., … de Boer, J. (2020). On the correlation between material-induced cell shape and phenotypical response of human mesenchymal stem cells. Scientific Reports, 10(1), 18988. doi:10.1038/s41598-020-76019-z
   PubMed Web of Science ®Google Scholar
• Veljović, D., Colić, M., Kojić, V., Bogdanović, G., Kojić, Z., Banjac, A., … Janaćković, D. (2012). The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics. Journal of Biomedical Materials Research. Part A, 100(11), 3059–3070. doi:10.1002/jbm.a.34225
   PubMed Web of Science ®Google Scholar
• Vermeulen, S., Roumans, N., Honig, F., Carlier, A., Hebels, D. G. A. J., Eren, A. D., … de Boer, J. (2020). Mechanotransduction is a context-dependent activator of TGF-beta signaling in mesenchymal stem cells. Biomaterials, 259, 120331. doi:10.1016/j.biomaterials.2020.120331
   PubMed Web of Science ®Google Scholar
• Vermeulen, S., Tahmasebi Birgani, Z., & Habibovic, P. (2022). Biomaterial-induced pathway modulation for bone regeneration. Biomaterials, 283, 121431. doi:10.1016/j.biomaterials.2022.121431
   PubMed Web of Science ®Google Scholar
• Wang, J., Wang, M., Chen, F., Wei, Y., Chen, X., Zhou, Y., … Zhang, X. (2019). Nano-hydroxyapatite coating promotes porous calcium phosphate ceramic-induced osteogenesis via BMP/Smad signaling pathway. International Journal of Nanomedicine, 14, 7987–8000. doi:10.2147/IJN.S216182
   PubMed Web of Science ®Google Scholar
• Wang, L., Barbieri, D., Zhou, H., de Bruijn, J. D., Bao, C., & Yuan, H. (2015). Effect of particle size on osteoinductive potential of microstructured biphasic calcium phosphate ceramic. Journal of Biomedical Materials Research. Part A, 103(6), 1919–1929. doi:10.1002/jbm.a.35325
   PubMed Web of Science ®Google Scholar
• Wang, Y., Pan, J., Zhang, Y., Li, X., Zhang, Z., Wang, P., … Li, J. (2019). Wnt and Notch signaling pathways in calcium phosphate-enhanced osteogenic differentiation: A pilot study. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 107(1), 149–160. doi:10.1002/jbm.b.34105
   PubMed Web of Science ®Google Scholar
• Webb, H. K., Truong, V. K., Hasan, J., Fluke, C., Crawford, R. J., & Ivanova, E. P. (2012). Roughness parameters for standard description of surface nanoarchitecture. Scanning, 34(4), 257–263. doi:10.1002/sca.21002
   PubMed Web of Science ®Google Scholar
• Wilkinson, A., Hewitt, R. N., McNamara, L. E., McCloy, D., Dominic Meek, R. M., & Dalby, M. J. (2011). Biomimetic microtopography to enhance osteogenesis in vitro. Acta Biomaterialia, 7(7), 2919–2925. doi:10.1016/j.actbio.2011.03.026
   PubMed Web of Science ®Google Scholar
• Xiao, Y., Guo, Q., Jiang, T.-J., Yuan, Y., Yang, L., Wang, G.-W., & Xiao, W.-F. (2019). miR4833p regulates osteogenic differentiation of bone marrow mesenchymal stem cells by targeting STAT1. Molecular Medicine Reports, 20(5), 4558–4566.
   PubMed Web of Science ®Google Scholar
• Xu, L., Corcoran, R. B., Welsh, J. W., Pennica, D., & Levine, A. J. (2000). WISP-1 is a Wnt-1- and β-catenin-responsive oncogene. Genes & Development, 14(5), 585–595. doi:10.1101/gad.14.5.585
   PubMed Web of Science ®Google Scholar
• Yuan, H., Fernandes, H., Habibovic, P., de Boer, J., Barradas, A. M. C., de Ruiter, A., … de Bruijn, J. D. (2010). Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. Proceedings of the National Academy of Sciences of the United States of America, 107(31), 13614–13619. doi:10.1073/pnas.1003600107
   PubMed Web of Science ®Google Scholar
• Yuan, H., van Blitterswijk, C. A., de Groot, K., & de Bruijn, J. D. (2006). A comparison of bone formation in biphasic calcium phosphate (BCP) and hydroxyapatite (HA) implanted in muscle and bone of dogs at different time periods. Journal of Biomedical Materials Research Part A, 78A(1), 139–147. doi:10.1002/jbm.a.30707
   Web of Science ®Google Scholar
• Yuan, H., Yang, Z., De Bruij, J. D., De Groot, K., & Zhang, X. (2001). Material-dependent bone induction by calcium phosphate ceramics: A 2.5 years study in dogs. Biomaterials, 22(19), 2617–2623. doi:10.1016/S0142-9612(00)00450-6
   PubMed Web of Science ®Google Scholar