References
- Alizadeh S, Mazloom H, Sadeghi A, Emamgholipour S, Golestani A, Noorbakhsh F, Khoshniatnikoo M, Meshkani R. 2018. Evidence for the link between defective autophagy and inflammation in peripheral blood mononuclear cells of type 2 diabetic patients. J Physiol Biochem. 74(3):369–379. doi:https://doi.org/10.1007/s13105-018-0624-2.
- American Diabetes Association (ADA). 2018. Classification and diagnosis of diabetes: standards of medical care in diabetes. Diabetes Care. 41:S13–S27. doi:https://doi.org/10.2337/dc18-S002.
- Casillas-Ramírez A, Alfany-Fernández I, Massip-Salcedo M, Juan ME, Planas JM, Serafín A, Pallàs M, Rimola A, Rodés J, Peralta C. 2011. Retinol-bindingprotein 4 and peroxisome proliferator-activated receptor-cin steatotic liver transplantation. J Pharmacol Exp Ther. 338:143–153. doi: https://doi.org/10.1124/jpet.110.177691
- Catalano KJ, Maddux BA, Szary J, Youngren JF, Goldfine ID, Schaufele F. 2014. Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain. PLoS One. 9(9):e108693. doi:https://doi.org/10.1371/journal.pone.0108693.
- Codoner-Franch P, Carrasco-Luna J, Allepuz P, Codoner-Alejos A, Guillem V. 2016. Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors. Pediatr Diabetes. 17(8):576–583. doi:https://doi.org/10.1111/pedi.12339.
- Daniele G, Guardado Mendoza R, Winnier D, Fiorentino TV, Pengou Z, Cornell J, Andreozzi F, Jenkinson C, Cersosimo E, Federici M, et al. 2014. The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus. Acta Diabetol. 51(1):123–131. doi:https://doi.org/10.1007/s00592-013-0543-1.
- De Leon ER, Brinkman JA, Fenske RJ, Gregg T, Schmidt BA, Sherman DS, Cummings NE, Peter DC, Kimple ME, Lamming DW, et al. 2018. Age-dependent protection of insulin secretion in diet-induced obese mice. Sci Rep. 8:17814. doi: https://doi.org/10.1038/s41598-018-36289-0
- Donia SS, Abd El Gayed EM, El-Hefnawy SM, Ragheb A. 2016. The association between interleukin-10 gene promoter polymorphism and insulin resistance in type 2 diabetes mellitus. Am J Clin Exp Med. 4(3):81–87. doi: https://doi.org/10.11648/j.ajcem.20160403.18
- Duca FA, Clemence DC, Rasmussen BA, Zadeh-Tahmasebi M, Rutter GA, Filippi BM, Lam TK. 2015. Metformin activates a duodenal Ampk-dependant pathway to lower hepatic glucose production in rats. Nat Med. 21:506–511. doi: https://doi.org/10.1038/nm.3787
- Grosjean F, Esposito P, Maccarrone R, Libetta C, Dal Canton A, Rampino T. 2017. RBP4: a culprit for insulin resistance in the end-stage renal disease that can be cleared by hemodiafiltration. BioMed Res Int. 7270595. doi:https://doi.org/10.1155/2017/7270595.
- Hong Y, Michael V, Jacek B. 2014. Fenretinide inhibited de novo ceramide synthesis and pro-inflammatory cytokines induced by A. actinomycetemcomitans. J Lipid Res. 54(1):189–201.
- Hu H, Xu M, Qi R, Wang Y, Wang C, Liu J, Luo L, Xia L, Fang Z. 2015. Sitagliptin downregulates retinol-binding protein4 and upregulates glucose transporter type 4 expression in type 2 diabetes mellitus rat models. Int J Clin Exp Med. 8(10):17902–17911.
- International Diabetes Federation (IDF). 2019. Diabetes atlas. 7th ed. [accessed 2019 Dec 16]http://www.diabetesatlas.org.
- Ip WKE, Hoshi N, Shouval DS, Snapper S, Medzhitov R. 2017. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 356(6337):513–519. doi:https://doi.org/10.1126/science.aal3535.
- Jia Y, Lao Y, Zhu H, Li N, Leung SW. 2019. Is metformin still the most efficacious first-line oral hypoglycaemic drug in treating type 2 diabetes? A network meta-analysis of randomized controlled trials. Obes Rev. 20(1):1–12. doi:https://doi.org/10.1111/obr.12753.
- Kotnik P, Keuper M, Wabitsch M, Fisher-Posovszky P. 2013. Interleukin-1b downregulates RBP4 secretion in human adipocytes. PLoS One. 8(2):e57796. doi: https://doi.org/10.1371/journal.pone.0057796
- Kravchuk E, Grineva E, Bairamov A, Galagudza M, Vlasov T. 2011. The effect of metformin on the myocardial tolerance to ischemia-reperfusion injury in the rat model of diabetes mellitus type II. Exp Diabetes Res. 2011:1–5. doi:https://doi.org/10.1155/2011/907496.
- Krhac M, Lovrencic MV. 2019. Update on biomarkers of glycemic control. World J Diabetes. 10(1):1–15. doi:https://doi.org/10.4239/wjd.v10.i1.1.
- Kumar M, Sukumar D, Manoranjan PS, Kumar A, Raipat BS. 2017. Different blood collection methods from rats: A review. Balneo Res. J. 8(1):46–50. doi: https://doi.org/10.12680/balneo.2017.141
- Kwanbunjan K, Panprathip P, Phosat C, Chumpathat N, Wechjakwen N, Puduang S, Auyyuenyong R, Henkel I, Schweigert FJ. 2018. Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural Thais with high type 2 diabetes risk. BMC Endocr Dis. 18(1). doi:https://doi.org/10.1186/s12902-018-0254-2.
- Liu Y, Wang D, Li D, Sun R, Xia M. 2014. Associations of retinol-binding protein 4 with oxidative stress, inflammatory markers, and metabolic syndrome in a middle-aged and elderly Chinese population. Diabetol Metab Syndr. 6:25. doi: https://doi.org/10.1186/1758-5996-6-25
- Ma X, Zhou Z, Chen Y, Wu Y, Liu Y. 2016. RBP4 function as a hepatokine in the regulation of glucose metabolism by the circadian clock in mice. Diabetologia. 59(2):354–362. doi: https://doi.org/10.1007/s00125-015-3807-1
- Mather K. 2009. Surrogate measures of insulin resistance: of rats, mice, and men. Am J Physiol Endocrinol Metab. 296:E398–E399. doi: https://doi.org/10.1152/ajpendo.90889.2008
- Mauer J, Denson JL, Bruning JC. 2015. Versatile function of IL-6 in metabolism and cancer. Trends Immunol. 36(2):92–101. doi: https://doi.org/10.1016/j.it.2014.12.008
- Mcilroy GD, Delibegovic M, Owen C, Stoney PN, Shearer KD, McCaffery PJ, Mody N. 2013. Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose liver and hypothalamus. Diabetes. 62:825–836. doi: https://doi.org/10.2337/db12-0458
- Mertler CA, Reinhart RV. 2017. Advanced and multivariate statistical methods – practical application and interpretation. 6th ed. New York: Routledge. p. 71–96.
- Mody N, Mcilroy GD. 2014. The mechanism of fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes. Biochem Pharmacol. 91:277–286. doi: https://doi.org/10.1016/j.bcp.2014.07.012
- Moraes-Vieira PM, Saghatelian A, Kahn BB. 2016. GLUT4 expression in adipocytes regulates de novo lipogenesis and levels of a novel class o lipids with antidiabetic and anti-inflammatory effects. Diabetes. 65(7):1808–1815. doi:https://doi.org/10.2337/db16-0221.
- Morrice N, Mcilroy GD, Tammireddy SR, Reekie J, Shearer KD, Doherty MK. 2017. Elevated fibroblast growth factor 21 (FGF21) in obese, insulin resistance states is normalized by the synthetic retinoid, Fenretinide in mice. Sci Rep. 7(7):43782. doi:https://doi.org/10.1038/srep43782.
- Nayak SS, Pattabiraman TN. 1981. A new colorimetric method for the estimation of glycosylated hemoglobin. Clin Chim Acta. 109:267–274. doi: https://doi.org/10.1016/0009-8981(81)90312-0
- Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, et al. 2012. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 32(10):2010–2019. doi:https://doi.org/10.1128/MCB.06193-11.
- Noy N. 2016. Vitamin A in regulation of insulin responsiveness: mini review. Proc Nutr Soc. 75(2):212–215. doi: https://doi.org/10.1017/S0029665115004322
- Ottosson-Laakso E, Krus U, Storm P, Prasad RB, Oskolkov N, Ahlqvist E. 2017. Glucose-induced changes in gene expression in human pancreatic islets – causes or consequences of chronic hyperglycemia. Diabetes. 66(12):3013–3028. doi:https://doi.org/10.2337/db17-0311.
- Rodrigues KF, Pietrani NT, Bosco AA, Campos FMF, Sandrim VC, Gomes KB. 2017. IL-10, TNF-( and IL-10 levels/polymorphisms and their association with type 2 diabetes mellitus and obesity in Brazillian individuals. Arch Endocrinol Metab. 61(5). doi:https://doi.org/10.1590/2359-3997000000254.
- Shearer KD, Morrice N, Henderson C, Reekie J, Mcilroy GD, McCaffery PJ, Delibegovic M, Mody N. 2015. Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen signaling. Obesity. 23(8):1655–1662. doi: https://doi.org/10.1002/oby.21164
- Stojsavljević S, Palčić GM, Jukić LV, Duvnjak LS, Duvnjak M. 2014. Adipokines and proinflammatory cytokines: The key mediators in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol. 20(48):18070–18091. doi:https://doi.org/10.3748/wjg.v20.i48.18070.
- Szkudelski T. 2012. Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model. Exp Biol Med. 237(5):481–490. doi:https://doi.org/10.1258/ebm.2012.011372.
- Tarnumihardjo SA, Russell RM, Stephensen CB, Gannon BM, Craft NE, Haskell MJ, Lietz G, Schulze K, Raiten DJ. 2016. Biomarkers of nutrition for development (BOND) – vitamin A review. J Nutr. 146(9):1816S–1848S. doi: https://doi.org/10.3945/jn.115.229708
- Trinder P. 1969. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol. 22(2):158–161. doi: https://doi.org/10.1136/jcp.22.2.158
- Vasques AC, Pareja JC, da Saude de Oliveira M, Novaes FS, Lima MM, Chaim EA. 2016. Long-term Outcome of biliopancreatic diversion on glycemic control, insulin sensitivity and beta cell function. Obes Surg. 26(11):2572–2580. doi: https://doi.org/10.1007/s11695-016-2159-3
- Yasuo M, Mizuno S, Allegood J, Kraskauskas D, Bogaard HJ, Spiegel S, Voelkel NF. 2013. Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate. PLoS One. 8(1):e53927. doi:https://doi.org/10.1371/journal.pone.0053927.
- Yonamine CY, Machado EP, Michalani ML, Alves-Wagner AB, Esteves JV, Freitas HS. 2017. Resveratrol improves glycemic control in type 2 diabetic obese mice by regulating glucose transporter expression in skeletal muscle and liver. Molecule. 22:1180. doi:https://doi.org/10.3390/molecules22071180.
- Zabetian-Targhi F, Mahmoudi MJ, Rezaei N, Mahmoudi M. 2015. Retinol-binding protein 4 in relation to diet, inflammation, immunity and cardiovascular diseases. Adv Nutr. 6(6):748–762. doi:https://doi.org/10.3945/an.115.008292.
- Zaccardi F, Webb DR, Yates T, Davies MJ. 2015. Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective. Postgrad Med J. 92(1084):63–69. doi:https://doi.org/10.1136/postgradmedj-2015-133281.
- Zhao H, Huang X, Jiao J, Zhang H, Liu J, Qin W. 2015. Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-α-induced hepatic insulin resistance. Sci Rep. 5(1). doi:https://doi.org/10.1038/srep18093.