References
- Booth NL, Overk CR, Yao P, Burdette JE, Nikolic D, Chen S-N, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR. 2006. The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract. J Altern Complement Med. 12(2):133–139. doi: https://doi.org/10.1089/acm.2006.12.133
- Cao PC, Xiao WX, Yan YB, Zhao X, Liu S, Feng J, Zhang W, Wang J, Feng YF, Lei W. 2014. Preventive effect of crocin on osteoporosis in an ovariectomized rat model. Evid Based Complement Alternat Med. 2014:825181.
- Chen WF, Wong MS. 2006. Genistein modulates the effects of parathyroid hormone in human osteoblastic SaOS-2 cells. Br J Nutr. 95(6):1039–1047. doi: https://doi.org/10.1079/BJN20061735
- Denizot F, Lang R. 1986. Rapid colorimetric assay for cell growth and survival: Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Methods. 89:271–277. doi: https://doi.org/10.1016/0022-1759(86)90368-6
- Dog TL. 2008. Smart talk on supplements and botanicals. Altern Complement Ther. 14(5):227–230. doi: https://doi.org/10.1089/act.2008.14502
- Gautam AK, Bhargavan B, Tyagi AM, Srivastava K, Yadav DK, Kumar M, Singh A, Mishra JS, Singh AB, Sanyal S, et al. 2011. Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats. J Nutr Biochem. 22(4):318–327. doi: https://doi.org/10.1016/j.jnutbio.2010.02.010
- Han J, Wang W. 2017. Effects of tanshinol on markers of bone turnover in ovariectomized rats and osteoblast cultures. Plos One. 12(7):e0181175. doi: https://doi.org/10.1371/journal.pone.0181175
- Heinonen SM, Wahala K, Adlercreutz H. 2004. Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjects. J Agric Food Chem. 52(22):6802–6809. doi: https://doi.org/10.1021/jf0492767
- Infante M, Fabi A, Cognetti F, Gorini S, Caprio M, Fabbri A. 2019. RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives. J Exp Clin Cancer Res. 38(1):12. doi: https://doi.org/10.1186/s13046-018-1001-2
- Kaczmarczyk-Sedlak I, Wojnar W, Zych M, Ozimina-Kaminska E, Taranowicz J, Siwek A. 2013. Effect of formononetin on mechanical properties and chemical composition of bones in rats with ovariectomy-induced osteoporosis. Evid Based Complement Alternat Med. 2013:457052. doi: https://doi.org/10.1155/2013/457052
- Kawakita S, Marotta F, Naito Y, Gumaste U, Jain S, Tsuchiya J, Minelli E. 2009. Effect of an isoflavones-containing red clover preparation and alkaline supplementation on bone metabolism in ovariectomized rats. Clin Interv Aging. 4:91–100.
- Kobayashi Y, Udagawa N, Takahashi N. 2009. Action of RANKL and OPG for osteoclastogenesis. Crit Rev Eukaryot Gene Expr. 19(1):61–72. doi: https://doi.org/10.1615/CritRevEukarGeneExpr.v19.i1.30
- Lee KH, Choi EM. 2005. Biochanin A stimulates osteoblastic differentiation and inhibits hydrogen peroxide-induced production of inflammatory mediators in MC3T3-E1 cells. Biol Pharm Bull. 28:1948–1953. doi: https://doi.org/10.1248/bpb.28.1948
- Lems WF, Raterman HG. 2017. Critical issues and current challenges in osteoporosis and fracture prevention. An overview of unmet needs. Ther Adv Musculoskel. 9(12):299–316. doi: https://doi.org/10.1177/1759720X17732562
- Li X, Wang YY, Acero A. 2008. Learning query intent from regularized click graphs. Proceedings of the 31st Annual International ACM SIGIR Conference on Research and Development in Information Retrieval; Singapore.
- Prideaux M, Wijenayaka AR, Kumarasinghe DD, Ormsby RT, Evdokiou A, Findlay DM, Atkins GJ. 2014. SaOS2 osteosarcoma cells as an In vitro model for studying the transition of human osteoblasts to osteocytes. Calcif Tissue Int. 95(2):183–193. doi: https://doi.org/10.1007/s00223-014-9879-y
- Ramos GP, Apel MA, Morais C, Ceolato PC, Schapoval EES, Dall'Agnol M, Zuanazzi JAS. 2012. In vivo and in vitro anti-inflammatory activity of red clover Trifolium pratense dry extract. Rev Bras Farmacogn. 22:176–180. doi: https://doi.org/10.1590/S0102-695X2011005000200
- Sasaki Y. 2007. The truth of the f-measure. Teach Tutor Mater. 1(5):1–5.
- Su SJ, Yeh YT, Shyu HW. 2013. The preventive effect of biochanin a on bone loss in ovariectomized rats: Involvement in regulation of growth and activity of osteoblasts and osteoclasts. Evid Based Complement Alternat Med. 2013:594857.
- Wende K, Krenn L, Unterrieder I, Lindequist U. 2004. Red clover extracts stimulate differentiation of human osteoblastic osteosarcoma HOS58 cells. Planta Med. 70(10):1003–1005. doi: https://doi.org/10.1055/s-2004-832629
- Zakłos-Szyda M, Budryn G, Grzelczyk J, Pérez-Sánchez H, Żyżelewicz D. 2020. Evaluation of isoflavones as bone resorption inhibitors upon interactions with receptor activator of nuclear factor-κb ligand (RANKL). Molecules. 25(1):206. doi: https://doi.org/10.3390/molecules25010206
- Zhang Y, Shen L, Mao Z, Wang N, Wang X, Huang X, Hu Y, Shou D, Wen C. 2017. Icariin enhances bone repair in rabbits with bone infection during post-infection treatment and prevents inhibition of osteoblasts by vancomycin. Front Pharmacol. 8:784. doi: https://doi.org/10.3389/fphar.2017.00784
- Zhang Z, Song C, Fu X, Liu M, Li Y, Pan J, Liu H, Wang S, Xiang L, Xiao GG, et al. 2014. High-dose diosgenin reduces bone loss in ovariectomized rats via attenuation of the RANKL/OPG ratio. Int J Mol. 15(9):17130–17147. doi: https://doi.org/10.3390/ijms150917130
- Zheng X, Lee SK, Chun OK. 2016. Soy isoflavones and osteoporotic bone loss: a review with an emphasis on modulation of bone remodeling. J Med Food. 19(1):1–14. doi: https://doi.org/10.1089/jmf.2015.0045