Investigation of two ferroptosis-related molecular subtypes and biomarkers in the progression of gastric adenocarcinoma

References

• Abdi H, Williams LJ. 2010. Principal component analysis. Wiley Interdisciplinary Rev: Comput Stat. 2:433–459.
   Google Scholar
• Ajani JA, Lee J, Sano T, Janjigian YY, Fan D, Song S. 2017. Gastric adenocarcinoma. Nat Rev Dis Primers. 3:1–19.
   Web of Science ®Google Scholar
• Angeli JPF, Krysko DV, Conrad M. 2019. Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion. Nat Rev Cancer. 19:405–414.
   PubMed Web of Science ®Google Scholar
• Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al. 2000. Gene Ontology: tool for the unification of biology. Nat Genet. 25:25–29.
   PubMed Web of Science ®Google Scholar
• Banks M, Graham D, Jansen M, Gotoda T, Coda S, Di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ. 2019. British society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma. Gut. 68:1545–1575.
   PubMed Web of Science ®Google Scholar
• Chang C, Worley BL, Phaëton R, Hempel N. 2020. Extracellular glutathione peroxidase GPx3 and its role in cancer. Cancers (Basel). 12:2197.
   PubMed Web of Science ®Google Scholar
• Correa P. 2013. Gastric cancer: overview. Gastroenterol Clin North Am. 42:211.
   PubMed Web of Science ®Google Scholar
• Dias AR, Azevedo BC, Alban LBV, Yagi OK, Ramos M, Jacob CE, Barchi LC, Cecconello I, Ribeiro U, Jr., Zilberstein B. 2017. Gastric neuroendocrine tumoe: review and update. Arquivos Brasileiros de Cirurgia Digestiva: ABCD = Brazilian Archives of Digestive Surgery. 30:150–154.
   PubMed Web of Science ®Google Scholar
• Dicken BJ, Bigam DL, Cass C, Mackey JR, Joy AA, Hamilton SM. 2005. Gastric adenocarcinoma: review and considerations for future directions. Ann Surg. 241:27.
   PubMed Web of Science ®Google Scholar
• Gu Y, Li T, Kapoor A, Major P, Tang D. 2020. Contactin 1: An important and Emerging oncogenic protein promoting cancer progression and metastasis. Genes (Basel). 11:874.
   PubMed Web of Science ®Google Scholar
• Hänzelmann S, Castelo R, Guinney J. 2013. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 14:7.
   PubMed Web of Science ®Google Scholar
• Hu W, Li S, Zhang S, Xie B, Zheng M, Sun J, Yang X, Zang L. 2020. GJA1 is a prognostic biomarker and correlated with immune infiltrates in colorectal cancer. Cancer Manag. Res. 12:11649–11661.
   PubMed Web of Science ®Google Scholar
• Ichihara F, Kono K, Takahashi A, Kawaida H, Sugai H, Fujii H. 2003. Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin Cancer Res. 9:4404–4408.
   PubMed Web of Science ®Google Scholar
• Kanehisa M, Goto S. 2000. KEGG: Kyoto Encyclopedia of Genes and genomes. Nucleic Acids Res. 28:27–30.
   PubMed Web of Science ®Google Scholar
• Kang BW, Kim JG, Lee IH, Bae HI, Seo AN. 2017. Clinical significance of tumor-infiltrating lymphocytes for gastric cancer in the era of immunology. World J Gastrointest Oncol. 9:293.
   PubMed Web of Science ®Google Scholar
• Kwong MLM, Denham L, Selleck MJ, Kim C, Kunihira K, Kubba R, Rojas R, Garberoglio C, Senthil M. 2019. Response to neoadjuvant treatment Is influenced by grade in gastric cancer. Am Surg. 85:1419–1422.
   PubMed Web of Science ®Google Scholar
• Lee J-Y, Nam M, Son HY, Hyun K, Jang SY, Kim JW, Kim MW, Jung Y, Jang E, Yoon S-J. 2020. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci USA. 117:32433–32442.
   PubMed Web of Science ®Google Scholar
• Li J, Cao F, Yin H-L, Huang Z-J, Lin Z-T, Mao N, Sun B, Wang G. 2020. Ferroptosis: past, present and future. Cell Death Dis. 11:1–13.
   PubMed Web of Science ®Google Scholar
• Liang J-Y, Wang D-S, Lin H-C, Chen X-X, Yang H, Zheng Y, Li Y-H. 2020. A novel ferroptosis-related gene signature for overall survival prediction in patients with hepatocellular carcinoma. Int J Biol Sci. 16:2430.
   PubMed Web of Science ®Google Scholar
• Liberzon A, Subramanian A, Pinchback R, Thorvaldsdóttir H, Tamayo P, Mesirov JP. 2011. Molecular signatures database (MSigDB) 3.0. Bioinformatics. 27:1739–1740.
   PubMed Web of Science ®Google Scholar
• Li-fang SHI, Shu-fang2A ZHENG, Yong-gang ZHAO, Jian-wei WANG, Xiao-hong ZHAN. 2011. Expressions of SNCG in gastric adenocarcinoma and its clinical significances. Prog Mod Biomed. 11:1532–1535.
   Google Scholar
• Liu H-J, Hu H-M, Li G-Z, Zhang Y, Wu F, Liu X, Wang K-Y, Zhang C-B, Jiang T. 2020a. Ferroptosis-related gene signature predicts glioma cell death and glioma patient progression. Front Cell Dev Biol. 8:538.
   PubMed Web of Science ®Google Scholar
• Liu T, Sun H, Liu S, Yang Z, Li L, Yao N, Cheng S, Dong X, Liang X, Chen C. 2018. The suppression of DUSP5 expression correlates with paclitaxel resistance and poor prognosis in basal-like breast cancer. Int J Med Sci. 15:738.
   PubMed Web of Science ®Google Scholar
• Liu Z, Zhao Q, Zuo Z-X, Yuan S-Q, Yu K, Zhang Q, Zhang X, Sheng H, Ju H-Q, Cheng H. 2020b. Systematic analysis of the aberrances and functional implications of ferroptosis in cancer. Iscience. 23:101302.
   PubMed Web of Science ®Google Scholar
• Logan M, Anderson PD, Saab ST, Hameed O, Abdulkadir SA. 2013. RAMP1 is a direct NKX3.1 target gene up-regulated in prostate cancer that promotes tumorigenesis. Am J Pathol. 183:951–963.
   PubMed Web of Science ®Google Scholar
• Luo Z, Wang W, Li F, Songyang Z, Feng X, Xin C, Dai Z, Xiong Y. 2019. Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes. Mol Cancer. 18:1–15.
   PubMed Web of Science ®Google Scholar
• Lyu JH, Park DW, Huang B, Kang SH, Lee SJ, Lee C, Bae YS, Lee JG, Baek SH. 2015. RGS2 suppresses breast cancer cell growth via a MCPIP1-dependent pathway. J Cell Biochem. 116:260–267.
   PubMed Web of Science ®Google Scholar
• Mhawech-Fauceglia P, Wang D, Syriac S, Godoy H, Dupont N, Liu S, Odunsi K. 2012. Synuclein-γ (SNCG) protein expression is associated with poor outcome in endometrial adenocarcinoma. Gynecol Oncol. 124:148–152.
   PubMed Web of Science ®Google Scholar
• Moreira AM, Pereira J, Melo S, Fernandes MS, Carneiro P, Seruca R, Figueiredo J. 2020. The extracellular matrix: an accomplice in gastric cancer development and progression. Cells. 9:394.
   PubMed Web of Science ®Google Scholar
• Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, Hoang CD, Diehn M, Alizadeh AA. 2015. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 12:453–457.
   PubMed Web of Science ®Google Scholar
• Nie J, Lin B, Zhou M, Wu L, Zheng T. 2018. Role of ferroptosis in hepatocellular carcinoma. J Cancer Res Clin Oncol. 144:2329–2337.
   PubMed Web of Science ®Google Scholar
• Nirgude S, Choudhary B. 2021. Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer. Biochem. Pharmacol. 184:114365.
   PubMed Web of Science ®Google Scholar
• Niu G, Zhang X, Hong R, Yang X, Gu J, Song T, Hu Z, Chen L, Wang X, Xia J, et al. 2021. GJA1 promotes hepatocellular carcinoma progression by mediating TGF-β-induced activation and the epithelial-mesenchymal transition of hepatic stellate cells. Open Medicine (Warsaw, Poland). 16:1459–1471.
   PubMedGoogle Scholar
• Peng Z, Wang C-X, Fang E-H, Wang G-B, Tong Q. 2014. Role of epithelial-mesenchymal transition in gastric cancer initiation and progression. World J Gastroenterol. 20:5403.
   PubMed Web of Science ®Google Scholar
• Pernot S, Terme M, Radosevic-Robin N, Castan F, Badoual C, Marcheteau E, Penault-Llorca F, Bouche O, Bennouna J, Francois E. 2020. Infiltrating and peripheral immune cell analysis in advanced gastric cancer according to the lauren classification and its prognostic significance. Gastric Cancer. 23:73–81.
   PubMed Web of Science ®Google Scholar
• Pils D, Hager G, Tong D, Aust S, Heinze G, Kohl M, Schuster E, Wolf A, Sehouli J, Braicu I. 2012. Validating the impact of a molecular subtype in ovarian cancer on outcomes: a study of the OVCAD consortium. Cancer Sci. 103:1334–1341.
   PubMed Web of Science ®Google Scholar
• Rosso D, Rigueiro MP, Kassab P, Ilias EJ, Castro O, Novo NF, Lourenço LG. 2012. Correlation of natural killer cells with the prognosis of gastric adenocarcinoma. Arquivos Brasileiros de Cirurgia Digestiva: ABCD = Brazilian Archives of Digestive Surgery. 25:114–117.
   PubMedGoogle Scholar
• Seibt TM, Proneth B, Conrad M. 2019. Role of GPX4 in ferroptosis and its pharmacological implication. Free Radical Biol Med. 133:144–152.
   PubMed Web of Science ®Google Scholar
• Shen H, Wang L, Chen Q, Xu J, Zhang J, Fang L, Wang J, Fan W. 2020. The prognostic value of COL3A1/FBN1/COL5A2/SPARC-mir-29a-3p-H19 associated ceRNA network in gastric cancer through bioinformatic exploration. J Cancer. 11:4933.
   PubMed Web of Science ®Google Scholar
• Shen J, Zhang Y, Yu H, Shen B, Liang Y, Jin R, Liu X, Shi L, Cai X. 2016. Role of DUSP1/MKP1 in tumorigenesis, tumor progression and therapy. Cancer Med. 5:2061–2068.
   PubMed Web of Science ®Google Scholar
• Tai Y-L, Chen L-C, Shen T-L. 2015. Emerging roles of focal adhesion kinase in cancer. BioMed Res Int. 2015:690690.
   PubMed Web of Science ®Google Scholar
• Teng F, Xu Z, Chen J, Zheng G, Zheng G, Lv H, Wang Y, Wang L, Cheng X. 2018. DUSP1 induces apatinib resistance by activating the MAPK pathway in gastric cancer. Oncol Rep. 40:1203–1222.
   PubMed Web of Science ®Google Scholar
• Tomczak K, Czerwińska P, Wiznerowicz M. 2015. The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge. Contemp Oncol. 19:A68.
   Google Scholar
• Utsunomiya T, Ogawa K, Yoshinaga K, Ohta M, Yamashita K, Mimori K, Inoue H, Ezaki T, Yoshikawa Y, Mori M. 2005. Clinicopathologic and prognostic values of apolipoprotein D alterations in hepatocellular carcinoma. Int J Cancer. 116:105–109.
   PubMed Web of Science ®Google Scholar
• Van Loon K, Yemelyanenko-Lyalenko J, Margadant C, Griffioen AW, Huijbers EJM. 2020. Role of fibrillin-2 in the control of TGF-β activation in tumor angiogenesis and connective tissue disorders. Biochimica et Biophysica Acta. Reviews on Cancer. 1873:188354.
   PubMed Web of Science ®Google Scholar
• Walker C, Mojares E. 2018. Del Río hernández A. 2018.role of extracellular matrix in development and cancer progression. Int J Mol Sci. 19:3028.
   PubMed Web of Science ®Google Scholar
• Wenta T, Zurawa-Janicka D, Rychlowski M, Jarzab M, Glaza P, Lipinska A, Bienkowska-Szewczyk K, Herman-Antosiewicz A, Skorko-Glonek J, Lipinska B. 2018. Htra3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin. J Proteomics. 177:88–111.
   PubMed Web of Science ®Google Scholar
• Wickham H, Chang W, Wickham MH. 2016. Package ‘ggplot2’. create elegant data visualisations using the grammar of graphics. Version. 2:1–189.
   Google Scholar
• Worley BL, Kim YS, Mardini J, Zaman R, Leon KE, Vallur PG, Nduwumwami A, Warrick JI, Timmins PF, Kesterson JP. 2019. GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment. Redox Biol. 25:101051.
   PubMed Web of Science ®Google Scholar
• Xie Y, Kuang F, Liu J, Tang D, Kang R. 2020. DUSP1 blocks autophagy-dependent ferroptosis in pancreatic cancer. J Pancreatology. 3:154–160.
   Google Scholar
• Yang D, Zhao D, Chen X. 2017. MiR-133b inhibits proliferation and invasion of gastric cancer cells by up-regulating FBN1 expression. Cancer Biomark. 19:425–436.
   PubMed Web of Science ®Google Scholar
• Yang S, Shin J, Park KH, Jeung H-C, Rha SY, Noh SH, Yang WI, Chung HC. 2007. Molecular basis of the differences between normal and tumor tissues of gastric cancer. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 1772:1033–1040.
   PubMed Web of Science ®Google Scholar
• Zhang J, Liu XH, Li C, Wu XX, Chen YL, Li WW, Li X, Gong F, Tang Q, Jiang D. 2020. SNCG promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathway. J Exp Clin Cancer Res. 39:79.
   PubMed Web of Science ®Google Scholar
• Zhang X, Du L, Qiao Y, Zhang X, Zheng W, Wu Q, Chen Y, Zhu G, Liu Y, Bian Z. 2019. Ferroptosis is governed by differential regulation of transcription in liver cancer. Redox Biol. 24:101211.
   PubMed Web of Science ®Google Scholar
• Zheng S, Shi L, Zhang Y, He T. 2014. Expression of SNCG, MAP2, SDF-1 and CXCR4 in gastric adenocarcinoma and their clinical significance. Int J Clin Exp Pathol. 7:6606.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK. 2019. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 10:1523.
   PubMed Web of Science ®Google Scholar
• Zou W. 2006. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol. 6:295–307.
   PubMed Web of Science ®Google Scholar