Low expression of lncRNA UCA1 assists the diagnosis of type 2 diabetes mellitus and predicts an increased risk of cardiovascular complications

References

• Aikens RC, Zhao W, Saleheen D, Reilly MP, Epstein SE, Tikkanen E, Salomaa V, Voight BF. 2017. Systolic blood pressure and risk of type 2 diabetes: a Mendelian randomization study. Diabetes. 66(2):543–550.
   PubMed Web of Science ®Google Scholar
• Alberti KG, Zimmet PZ. 1998. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabetic Med 15:539–553.
   PubMed Web of Science ®Google Scholar
• Bayomy O, Rao AD, Garg R, Vaidya A, Kotin AR, Reiber B, Nijmeijer S, Di Carli MF, Jerosch-Herold M, Kwong RY, Adler GK. 2017. Plasminogen activator inhibitor-1 and pericardial fat in individuals with type 2 diabetes mellitus. Metab Syndr Relat Disord. 15(6):269–275.
   PubMed Web of Science ®Google Scholar
• Bosun-Arije FS, Ling J, Graham Y, Hayes C. 2020. Organisational factors influencing non-pharmacological management of type 2 diabetes mellitus (T2DM) in public hospitals across Lagos, Nigeria: a qualitative study of nurses’ perspectives. Diabetes Res Clin Pract. 166:108288.
   PubMed Web of Science ®Google Scholar
• Chen L, Qin L, Liu X, Meng X. 2019. CTRP3 alleviates Ox-LDL-induced inflammatory response and endothelial dysfunction in mouse aortic endothelial cells by activating the PI3K/Akt/eNOS pathway. Inflammation. 42(4):1350–1359.
   PubMed Web of Science ®Google Scholar
• Chen L, Sun X, Xiao H, Xu F, Yang Y, Lin Z, Chen Z, Quan S, Huang H. 2019. PAQR3 regulates phosphorylation of FoxO1 in insulin-resistant HepG2 cells via NF-κB signaling pathway. Exp Cell Res. 381(2):301–310.
   PubMed Web of Science ®Google Scholar
• Chen L, Zheng J, Xue Q, Zhao Y. 2019. YKL-40 promotes the progress of atherosclerosis independent of lipid metabolism in apolipoprotein E−/− mice fed a high-fat diet. Heart Vessels. 34(11):1874–1881.
   PubMed Web of Science ®Google Scholar
• Cheng C, Liu Y, Sun X, Yin Z, Li H, Zhang M, Zhang D, Wang B, Ren Y, Zhao Y, et al. 2019. Dose-response association between the triglycerides: high-density lipoprotein cholesterol ratio and type 2 diabetes mellitus risk: the rural Chinese cohort study and meta-analysis. J Diabetes. 11(3):183–192.
   PubMed Web of Science ®Google Scholar
• Cheng CF, Lin YJ, Lin MC, Liang WM, Chen CC, Chen CH, Wu JY, Lin TH, Liao CC, Huang SM, et al. 2021. Genetic risk score constructed from common genetic variants is associated with cardiovascular disease risk in type 2 diabetes mellitus. J Gene Med. 23(2):e3305.
   PubMed Web of Science ®Google Scholar
• Choi KM, Hwang SY, Hong HC, Yang SJ, Choi HY, Yoo HJ, Lee KW, Nam MS, Park YS, Woo JT, et al. 2012. C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome. Diabetes. 61(11):2932–2936.
   PubMed Web of Science ®Google Scholar
• Cui J, Ma P, Sun JP, Baloch Z, Yin F, Xin HL, Ren J, Tan JB, Wang BL. 2019. The ability of baseline triglycerides and total cholesterol concentrations to predict incidence of type 2 diabetes mellitus in Chinese men and women: a longitudinal study in Qingdao, China. Biomed Environ Sci. 32(12):905–913.
   PubMed Web of Science ®Google Scholar
• Deerochanawong C, Chan SP, Matawaran BJ, Sheu WH, Chan J, Man NH, Suastika K, Khoo CM, Yoon KH, Luk A, et al. 2019. Use of sodium-glucose co-transporter-2 inhibitors in patients with type 2 diabetes mellitus and multiple cardiovascular risk factors: an Asian perspective and expert recommendations. Diabetes Obes Metab. 21(11):2354–2367.
   PubMed Web of Science ®Google Scholar
• Dieset I, Morch RH, Hope S, Hoseth EZ, Reponen EJ, Gran JM, Aas M, Michelsen AE, Reichborn-Kjennerud T, Nesvag R, et al. 2019. An association between YKL-40 and type 2 diabetes in psychotic disorders. Acta Psychiatr Scand. 139(1):37–45.
   PubMed Web of Science ®Google Scholar
• Erfanian Omidvar M, Ghaedi H, Kazerouni F, Kalbasi S, Shanaki M, Miraalamy G, Zare A, Rahimipour A. 2019. Clinical significance of long noncoding RNA VIM-AS1 and CTBP1-AS2 expression in type 2 diabetes. J Cell Biochem. 120(6):9315–9323.
   PubMed Web of Science ®Google Scholar
• Freitas Lima LC, Braga VA, do Socorro de Franca Silva M, Cruz JC, Sousa Santos SH, de Oliveira Monteiro MM, Balarini CM. 2015. Adipokines, diabetes and atherosclerosis: an inflammatory association. Front Physiol. 6:304.
   PubMed Web of Science ®Google Scholar
• Garcia-Fontana B, Morales-Santana S, Longobardo V, Reyes-Garcia R, Rozas-Moreno P, Garcia-Salcedo JA, Munoz-Torres M. 2015. Relationship between proinflammatory and antioxidant proteins with the severity of cardiovascular disease in type 2 diabetes mellitus. Int J Mol Sci. 16(5):9469–9483.
   PubMed Web of Science ®Google Scholar
• Gu L, Cao C, Fu J, Li Q, Li DH, Chen MY. 2018. Serum adiponectin in breast cancer: a meta-analysis. Medicine (Baltimore). 97(29):e11433.
   PubMed Web of Science ®Google Scholar
• Guo C, Qin P, Li Q, Zhang D, Tian G, Liu D, Liu L, Cheng C, Chen X, Qie R, et al. 2020. Association between mean arterial pressure and risk of type 2 diabetes mellitus: the Rural Chinese Cohort Study. Prim Care Diabetes. 14(5):448–454.
   PubMed Web of Science ®Google Scholar
• Hu W, Ding Y, Wang S, Xu L, Yu H. 2020. The construction and analysis of the aberrant lncRNA-miRNA-mRNA network in adipose tissue from type 2 diabetes individuals with obesity. J Diabetes Res. 2020:3980742.
   PubMed Web of Science ®Google Scholar
• Jaiswal S, Libby P. 2020. Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease. Nat Rev Cardiol. 17(3):137–144.
   PubMed Web of Science ®Google Scholar
• Javeed N, Matveyenko AV. 2018. Circadian etiology of type 2 diabetes mellitus. Physiology (Bethesda). 33(2):138–150.
   PubMed Web of Science ®Google Scholar
• Kazerouni F, Bayani A, Asadi F, Saeidi L, Parvizi N, Mansoori Z. 2020. Type2 diabetes mellitus prediction using data mining algorithms based on the long-noncoding RNAs expression: a comparison of four data mining approaches. BMC Bioinformatics. 21(1):372.
   PubMed Web of Science ®Google Scholar
• Kousaxidis A, Petrou A, Lavrentaki V, Fesatidou M, Nicolaou I, Geronikaki A. 2020. Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus. Eur J Med Chem. 207:112742.
   PubMed Web of Science ®Google Scholar
• Li J, Wang C, Liu J, Yu Y, Liu Y, Peng Q, Liu H, Guan X. 2021. A feedback loop: interactions between inflammatory signals and clonal hematopoiesis in cardiovascular disease. Mol Biol Rep. 48(4):3785–3798.
   PubMed Web of Science ®Google Scholar
• Li M, Duan L, Li Y, Liu B. 2019. Long noncoding RNA/circular noncoding RNA-miRNA-mRNA axes in cardiovascular diseases. Life Sci. 233:116440.
   PubMed Web of Science ®Google Scholar
• Liu HE, Shi HH, Luo XJ. 2020. Upregulated long noncoding RNA UCA1 enhances warburg effect via miR-203/HK2 axis in esophagal cancer. J Oncol. 2020:8847687.
   PubMed Web of Science ®Google Scholar
• Liu SX, Zheng F, Xie KL, Xie MR, Jiang LJ, Cai Y. 2019. Exercise reduces insulin resistance in type 2 diabetes mellitus via mediating the lncRNA MALAT1/MicroRNA-382-3p/Resistin Axis. Mol Ther Nucleic Acids. 18:34–44.
   PubMedGoogle Scholar
• Liu Z, Wang Y, Yuan S, Wen F, Liu J, Zou L, Zhang J. 2021. Regulatory role of long non-coding RNA UCA1 in signaling pathways and its clinical applications. Oncol Lett. 21(5):404.
   PubMed Web of Science ®Google Scholar
• Ma Q, Wang L, Yang Y, Su Y, Wang T, Hou Q, Cai R, Wang Z, Yao H. 2020. Association between lncRNA and GCKR gene in type 2 diabetes mellitus. Clin Chim Acta. 501:66–71.
   PubMed Web of Science ®Google Scholar
• Mohamadi M, Ghaedi H, Kazerouni F, Erfanian Omidvar M, Kalbasi S, Shanaki M, Miraalamy G, Rahimipour A. 2019. Deregulation of long noncoding RNA SNHG17 and TTC28-AS1 is associated with type 2 diabetes mellitus. Scand J Clin Lab Invest. 79(7):519–523.
   PubMed Web of Science ®Google Scholar
• Muszynski P, Groblewska M, Kulczynska-Przybik A, Kulakowska A, Mroczko B. 2017. YKL-40 as a potential biomarker and a possible target in therapeutic strategies of Alzheimer’s disease. Curr Neuropharmacol. 15(6):906–917.
   PubMed Web of Science ®Google Scholar
• Nagaraju GP, Rajitha B, Aliya S, Kotipatruni RP, Madanraj AS, Hammond A, Park D, Chigurupati S, Alam A, Pattnaik S. 2016. The role of adiponectin in obesity-associated female-specific carcinogenesis. Cytokine Growth Factor Rev. 31:37–48.
   PubMed Web of Science ®Google Scholar
• Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, Murray JJ, Pendergraft TB. 2004. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 113(1):59–65.
   PubMed Web of Science ®Google Scholar
• Palacios OM, Kramer M, Maki KC. 2019. Diet and prevention of type 2 diabetes mellitus: beyond weight loss and exercise. Expert Rev Endocrinol Metab. 14(1):1–12.
   PubMed Web of Science ®Google Scholar
• Peters KE, Davis WA, Beilby J, Hung J, Bruce DG, Davis TME. 2018. The relationship between circulating adiponectin, ADIPOQ variants and incident cardiovascular disease in type 2 diabetes: the Fremantle Diabetes Study. Diabetes Res Clin Pract. 143:62–70.
   PubMed Web of Science ®Google Scholar
• Petrie JR, Guzik TJ, Touyz RM. 2018. Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms. Can J Cardiol. 34(5):575–584.
   PubMed Web of Science ®Google Scholar
• Qi M, Zhou Q, Zeng W, Shen M, Liu X, Luo C, Long J, Chen W, Zhang J, Yan S. 2017. Analysis of long non-coding RNA expression of lymphatic endothelial cells in response to type 2 diabetes. Cell Physiol Biochem. 41(2):466–474.
   PubMedGoogle Scholar
• Qu H, Deng M, Wang H, Wei H, Liu F, Wu J, Deng H. 2015. Plasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance. J Clin Lipidol. 9(3):289–294.
   PubMed Web of Science ®Google Scholar
• Rathcke CN, Vestergaard H. 2006. YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis. Inflamm Res. 55(6):221–227.
   PubMed Web of Science ®Google Scholar
• Sawicka M, Janowska J, Chudek J. 2016. Potential beneficial effect of some adipokines positively correlated with the adipose tissue content on the cardiovascular system. Int J Cardiol. 222:581–589.
   PubMed Web of Science ®Google Scholar
• Shuangying L. 2016. Analysis of clinical characteristics of newly diagnosed type 2 diabetes mellitus patients complicated with cardiovascular disease. Chinese Remedies Clinics. 16(11):1667–1668.
   Google Scholar
• Strain WD, Paldanius PM. 2018. Diabetes, cardiovascular disease and the microcirculation. Cardiovasc Diabetol. 17(1):57.
   PubMedGoogle Scholar
• Suwal A, Hao JL, Liu XF, Zhou DD, Pant OP, Gao Y, Hui P, Dai XX, Lu CW. 2019. NONRATT021972 long-noncoding RNA: a promising lncRNA in diabetes-related diseases. Int J Med Sci. 16(6):902–908.
   PubMed Web of Science ®Google Scholar
• Thomsen SB, Gjesing AP, Rathcke CN, Ekstrom CT, Eiberg H, Hansen T, Pedersen O, Vestergaard H. 2015. Associations of the inflammatory marker YKL-40 with measures of obesity and dyslipidaemia in individuals at high risk of type 2 diabetes. PLoS One. 10(7):e0133672.
   PubMed Web of Science ®Google Scholar
• Tian J, Zhao Y, Wang L, Li L. 2021. Role of TLR4/MyD88/NF-κB signaling in heart and liver-related complications in a rat model of type 2 diabetes mellitus. J Int Med Res. 49(3):030006052199759.
   Web of Science ®Google Scholar
• Tian S, Yuan Y, Li Z, Gao M, Lu Y, Gao H. 2018. LncRNA UCA1 sponges miR-26a to regulate the migration and proliferation of vascular smooth muscle cells. Gene. 673:159–166.
   PubMed Web of Science ®Google Scholar
• Tong HV, Luu NK, Son HA, Hoan NV, Hung TT, Velavan TP, Toan NL. 2017. Adiponectin and pro-inflammatory cytokines are modulated in Vietnamese patients with type 2 diabetes mellitus. J Diabetes Investig. 8(3):295–305.
   PubMed Web of Science ®Google Scholar
• Umapathy D, Dornadula S, Krishnamoorthy E, Mariappanadar V, Viswanathan V, Ramkumar KM. 2018. YKL-40: a biomarker for early nephropathy in type 2 diabetic patients and its association with inflammatory cytokines. Immunobiology. 223(11):718–727.
   PubMed Web of Science ®Google Scholar
• Wang J, Su Z, Lu S, Fu W, Liu Z, Jiang X, Tai S. 2018. LncRNA HOXA-AS2 and its molecular mechanisms in human cancer. Clin Chim Acta. 485:229–233.
   PubMed Web of Science ®Google Scholar
• Wang LK, Wang H, Wu XL, Shi L, Yang RM, Wang YC. 2020. Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus. J Int Med Res. 48(4):300060519870407.
   PubMedGoogle Scholar
• Wang S, Ling Y, Liang W, Shen L. 2017. Association of serum C1q/TNF-related protein-3 (CTRP-3) in patients with coronary artery disease. BMC Cardiovasc Disord. 17(1):210.
   PubMedGoogle Scholar
• Xu Z, Zuo Z, Dong D, Liu J, Tang Y, Gu Y, Liu H. 2020. Downregulated lncRNA UCA1 accelerates proliferation and migration of vascular smooth muscle cells by epigenetic regulation of MMP9. Exp Ther Med. 19(6):3589–3594.
   PubMed Web of Science ®Google Scholar
• Yang JL, Han NH. 2020. LncRNA UCA1 stimulates the repair of hyperglycemic vascular smooth muscle cells through targeting miR-582-5p. Eur Rev Med Pharmacol Sci. 24(24):12859–12866.
   PubMed Web of Science ®Google Scholar
• Youngstrom DW, Zondervan RL, Doucet NR, Acevedo PK, Sexton HE, Gardner EA, Anderson JS, Kushwaha P, Little HC, Rodriguez S, et al. 2020. CTRP3 regulates endochondral ossification and bone remodeling during fracture healing. J Orthop Res. 38(5):996–1006.
   PubMed Web of Science ®Google Scholar
• Zenno A, Nadler EP. 2021. Surgical treatment of type 2 diabetes mellitus in youth. Adv Exp Med Biol. 1307:321–330.
   PubMed Web of Science ®Google Scholar
• Zheng Y, Ley SH, Hu FB. 2018. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 14(2):88–98.
   PubMed Web of Science ®Google Scholar
• Zhou AX, Mondal T, Tabish AM, Abadpour S, Ericson E, Smith DM, Knoll R, Scholz H, Kanduri C, Tyrberg B, Althage M. 2021. The long noncoding RNA TUNAR modulates Wnt signaling and regulates human beta-cell proliferation. Am J Physiol Endocrinol Metab. 320(4):E846–E857.
   PubMed Web of Science ®Google Scholar