Progress in the mechanism of mitochondrial dysfunction in septic cardiomyopathy

References

• Ahumada-Castro U, Silva-Pavez E, Lovy A, Pardo E, Molgomicron J, Cardenas C. 2019. MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca(2+) communication: a dead end in cancer cells. Autophagy. 15(2):358–361.
   PubMed Web of Science ®Google Scholar
• Aki T, Unuma K, Uemura K. 2017. Emerging roles of mitochondria and autophagy in liver injury during sepsis. Cell Stress. 1(2):79–89.
   PubMedGoogle Scholar
• Alvarez S, Vico T, Vanasco V. 2016. Cardiac dysfunction, mitochondrial architecture, energy production, and inflammatory pathways: interrelated aspects in endotoxemia and sepsis. Int J Biochem Cell Biol. 81(Pt B):307–314.
   PubMedGoogle Scholar
• Anderson DP, Allen WJ, Barcroft H, Edholm OG, Manning GW. 1946. Circulatory changes during fainting and coma caused by oxygen lack. J Physiol. 104(4):426–434.
   Web of Science ®Google Scholar
• Antonucci E, Fiaccadori E, Donadello K, Taccone FS, Franchi F, Scolletta S. 2014. Myocardial depression in sepsis: from pathogenesis to clinical manifestations and treatment. J Crit Care. 29(4):500–511.
   PubMed Web of Science ®Google Scholar
• Arany Z, He H, Lin J, Hoyer   K, Handschin   C, Toka  O, Ahmad  F, Matsui  T, Chin   S, Wu  PH , et al. 2005. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab. 1(4):259–271.
   PubMed Web of Science ®Google Scholar
• Beesley SJ, Weber G, Sarge T, et al. 2018. Septic cardiomyopathy. Crit Care Med. 46(4):625–634.
   PubMed Web of Science ®Google Scholar
• Belcher E, Mitchell J, Evans T. 2002. Myocardial dysfunction in sepsis: no role for NO? Heart. 87(6):507–509.
   PubMed Web of Science ®Google Scholar
• Bernardi P, Von Stockum S. 2012. The permeability transition pore as a Ca(2+) release channel: new answers to an old question. Cell Calcium. 52(1):22–27.
   PubMed Web of Science ®Google Scholar
• Bouillaud F, Alves-Guerra M C, Ricquier D. 2016. UCPs, at the interface between bioenergetics and metabolism. Biochim Biophys Acta. 1863(10):2443–2456.
   PubMed Web of Science ®Google Scholar
• Boyman L, Karbowski M, Lederer WJ. 2019. Regulation of mitochondrial ATP production: Ca(2+) signaling and quality control. Trends Mol Med. 26(1):21–39.
   PubMed Web of Science ®Google Scholar
• Bravo-San Pedro JM, Kroemer G, Galluzzi L. 2017. Autophagy and mitophagy in cardiovascular disease. Circ Res. 120(11):1812–1824.
   PubMed Web of Science ®Google Scholar
• Brealey D, Brand M, Hargreaves I, et al. 2002. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet. 360(9328):219–223.
   PubMed Web of Science ®Google Scholar
• Bruni FD, Komwatana P, Soulsby ME, et al. 1978. Endotoxin and myocardial failure: role of the myofibril and venous return. Am J Physiol. 235(2):H150–H156.
   PubMedGoogle Scholar
• Cadenas S. 2018. Mitochondrial uncoupling, ROS generation and cardioprotection. Biochim Biophys Acta Bioenerg. 1859(9):940–950.
   PubMed Web of Science ®Google Scholar
• Cao F, Maguire ML, Mcandrew DJ, et al. 2020. Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure. Basic Res Cardiol. 115(2):12.
   PubMed Web of Science ®Google Scholar
• Carre JE, Orban JC, Re L, et al. 2010. Survival in critical illness is associated with early activation of mitochondrial biogenesis. Am J Respir Crit Care Med. 182(6):745–751.
   PubMed Web of Science ®Google Scholar
• Carreras-Sureda A, Jana F, Urra H, et al. 2019. Non-canonical function of IRE1alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nat Cell Biol. 21(6):755–767.
   PubMed Web of Science ®Google Scholar
• Chen W, Luo S, Xie P, et al. 2018. Overexpressed UCP2 regulates mitochondrial flashes and reverses lipopolysaccharide-induced cardiomyocytes injury. Am J Transl Res. 10(5):1347–1356.
   PubMed Web of Science ®Google Scholar
• Cimolai MC, Alvarez S, Bode C, et al. 2015. Mitochondrial mechanisms in septic cardiomyopathy. Int J Mol Sci. 16(8):17763–17778.
   PubMed Web of Science ®Google Scholar
• Coopersmith CM, DE BACKER D, Deutschman CS, et al. 2018. Surviving sepsis campaign: research priorities for sepsis and septic shock. Crit Care Med. 46(8):1334–1356.
   PubMed Web of Science ®Google Scholar
• Dorn GW 2nd, Kitsis RN. 2015. The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble. Circ Res. 116(1):167–182.
   PubMed Web of Science ®Google Scholar
• Dromparis P, Paulin R, Sutendra G, et al. 2013. Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary vascular remodeling and pulmonary hypertension. Circ Res. 113(2):126–136.
   PubMed Web of Science ®Google Scholar
• Durand A, Duburcq T, Dekeyser T, et al. 2017. Involvement of mitochondrial disorders in septic cardiomyopathy. Oxid Med Cell Longev. 2017:4076348.
   PubMed Web of Science ®Google Scholar
• Ehrman RR, Sullivan AN, Favot MJ, et al. 2018. Pathophysiology, echocardiographic evaluation, biomarker findings, and prognostic implications of septic cardiomyopathy: a review of the literature. Crit Care. 22(1):112.
   PubMedGoogle Scholar
• Elrod JW, Wong R, Mishra S, et al. 2010. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest. 120(10):3680–3687.
   PubMed Web of Science ®Google Scholar
• Escames G, Lopez LC, Tapias V, et al. 2006. Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice. J Pineal Res. 40(1):71–78.
   PubMed Web of Science ®Google Scholar
• Eyenga P, Roussel D, Morel J, et al. 2018. Time course of liver mitochondrial function and intrinsic changes in oxidative phosphorylation in a rat model of sepsis. Intensive Care Med Exp. 6(1):31.
   PubMedGoogle Scholar
• Fang X, Wang J. 2018. [Role of mitochondrial dysfunction in the pathogenesis of septic cardiomyopathy]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 30(2):189–192.
   PubMedGoogle Scholar
• Fattahi F, Frydrych LM, Bian G, et al. 2018. Role of complement C5a and histones in septic cardiomyopathy. Mol Immunol. 102:32–41.
   PubMed Web of Science ®Google Scholar
• Fedson DS. 2009. Meeting the challenge of influenza pandemic preparedness in developing countries. Emerg Infect Dis. 15(3):365–371.
   PubMed Web of Science ®Google Scholar
• Fender AC, Kleeschulte S, Stolte S, et al. 2020. Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart. Basic Res Cardiol. 115(2):10.
   PubMed Web of Science ®Google Scholar
• Finck BN, Kelly DP. 2007. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation. 115(19):2540–2548.
   PubMed Web of Science ®Google Scholar
• Fink MP. 2001. Cytopathic hypoxia. mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit Care Clin. 17(1):219–237.
   PubMed Web of Science ®Google Scholar
• Fink MP, Warren HS. 2014. Strategies to improve drug development for sepsis. Nat Rev Drug Discov. 13(10):741–758.
   PubMed Web of Science ®Google Scholar
• Friedman JR, Lackner LL, West M, et al. 2011. ER tubules mark sites of mitochondrial division. Science. 334(6054):358–362.
   PubMed Web of Science ®Google Scholar
• Friedman JR, Nunnari J. 2014. Mitochondrial form and function. Nature. 505(7483):335–343.
   PubMed Web of Science ®Google Scholar
• Gureev AP, Shaforostova EA, Popov VN. 2019. Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1alpha signaling pathways. Front Genet. 10:435.
   PubMed Web of Science ®Google Scholar
• Haileselassie B, Mukherjee R, Joshi AU, et al. 2019. Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy. J Mol Cell Cardiol. 130:160–169.
   PubMed Web of Science ®Google Scholar
• Handschin C, Spiegelman BM. 2006. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev. 27(7):728–735.
   PubMed Web of Science ®Google Scholar
• Hardeland R. 2018. Melatonin and inflammation-story of a double-edged blade. J Pineal Res. 65(4):e12525.
   PubMed Web of Science ®Google Scholar
• Harris J, Lang T, Thomas JPW, et al. 2017. Autophagy and inflammasomes. Mol Immunol. 86:10–15.
   PubMed Web of Science ®Google Scholar
• Hasnat M, Yuan Z, Naveed M, et al. 2019. Drp1-associated mitochondrial dysfunction and mitochondrial autophagy: a novel mechanism in triptolide-induced hepatotoxicity. Cell Biol Toxicol. 35(3):267–280.
   PubMed Web of Science ®Google Scholar
• Hoppins S, Nunnari J. 2009. The molecular mechanism of mitochondrial fusion. Biochim Biophys Acta. 1793(1):20–26.
   PubMed Web of Science ®Google Scholar
• Horak J, Martinkova V, Radej J, et al. 2019. Back to basics: recognition of sepsis with new definition. J Clin Med. 8(11):1838.
   PubMed Web of Science ®Google Scholar
• Hotchkiss RS, Karl IE. 1992. Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. Jama. 267(11):1503–1510.
   PubMed Web of Science ®Google Scholar
• Huang J, Peng W, Zheng Y, et al. 2019. Upregulation of UCP2 expression protects against LPS-induced oxidative stress and apoptosis in cardiomyocytes. Oxid Med Cell Longev. 2019:2758262.
   PubMed Web of Science ®Google Scholar
• Jiang BM, Liang PF, Tang YT, et al. 2019. [Study on the expression and roles of nucleolin in cardiac injury in septic mice]. Zhonghua yi xue za zhi. 99(1):57–61.
   PubMedGoogle Scholar
• Jiang X, Cai S, Jin Y, et al. 2021. Irisin attenuates oxidative stress, mitochondrial dysfunction, and apoptosis in the H9C2 cellular model of septic cardiomyopathy through augmenting Fundc1-dependent mitophagy. Oxid Med Cell Longev. 2021:2989974.
   PubMed Web of Science ®Google Scholar
• Jiang ZM, Yang QH, Zhu CQ. 2017. UCP2 in early diagnosis and prognosis of sepsis. Eur Rev Med Pharmacol Sci. 21(3):549–553.
   PubMed Web of Science ®Google Scholar
• Jin Q, Li R, Hu N, et al. 2018. DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways. Redox Biol. 14:76–87.
   Web of Science ®Google Scholar
• Joseph LC, Kokkinaki D, Valenti MC, et al. 2017. Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function. JCI Insight. 2(17):e94248.
   PubMed Web of Science ®Google Scholar
• Kalbitz M, Grailer JJ, Fattahi F, et al. 2015. Role of extracellular histones in the cardiomyopathy of sepsis. FASEB J. 29(5):2185–2193.
   PubMed Web of Science ®Google Scholar
• Kerkhofs M, Bittremieux M, Morciano G, et al. 2018. Emerging molecular mechanisms in chemotherapy: Ca(2+) signaling at the mitochondria-associated endoplasmic reticulum membranes. Cell Death Dis. 9(3):334.
   PubMedGoogle Scholar
• Kim MJ, Bae SH, Ryu JC, et al. 2016. SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages. Autophagy. 12(8):1272–1291.
   PubMed Web of Science ®Google Scholar
• Kulikova TG, Stepanova OV, Voronova AD, et al. 2018. Pathological remodeling of the myocardium in chronic heart failure: role of PGC-1alpha. Bull Exp Biol Med. 164(6):794–797.
   PubMed Web of Science ®Google Scholar
• Kwong JQ, Molkentin JD. 2015. Physiological and pathological roles of the mitochondrial permeability transition pore in the heart. Cell Metab. 21(2):206–214.
   PubMed Web of Science ®Google Scholar
• Lancel S, Hassoun S M, Favory R, et al. 2009. Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis. J Pharmacol Exp Ther. 329(2):641–648.
   PubMed Web of Science ®Google Scholar
• Lee JE, Westrate LM, Wu H, et al. 2016. Multiple dynamin family members collaborate to drive mitochondrial division. Nature. 540(7631):139–143.
   PubMed Web of Science ®Google Scholar
• Lehman JJ, Barger PM, Kovacs A, et al. 2000. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest. 106(7):847–856.
   PubMed Web of Science ®Google Scholar
• Lemasters JJ, Theruvath TP, Zhong Z, et al. 2009. Mitochondrial calcium and the permeability transition in cell death. Biochim Biophys Acta. 1787(11):1395–1401.
   PubMed Web of Science ®Google Scholar
• Levy RJ. 2007. Mitochondrial dysfunction, bioenergetic impairment, and metabolic down-regulation in sepsis. Shock. 28(1):24–28.
   PubMed Web of Science ®Google Scholar
• Li J, Zhang B, Chang X, et al. 2020. Silver nanoparticles modulate mitochondrial dynamics and biogenesis in HepG2 cells. Environ Pollut. 256:113430.
   PubMed Web of Science ®Google Scholar
• Li S, Wu H, Han D, et al. 2018. A novel mechanism of mesenchymal stromal cell-mediated protection against sepsis: restricting inflammasome activation in macrophages by increasing mitophagy and decreasing mitochondrial ROS. Oxid Med Cell Longev. 2018:3537609.
   PubMed Web of Science ®Google Scholar
• Li Y, Feng YF, Liu XT, et al. 2021. Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis. Redox Biol. 38:101771.
   PubMed Web of Science ®Google Scholar
• Mao JY, Su LX, Li DK, et al. 2021. The effects of UCP2 on autophagy through the AMPK signaling pathway in septic cardiomyopathy and the underlying mechanism. Ann Transl Med. 9(3):259.
   PubMed Web of Science ®Google Scholar
• Michalska B, Duszynski J, Szymanski J. 2016. [Mechanism of mitochondrial fission - structure and function of Drp1 protein]. Postepy Biochem. 62(2):127–137.
   PubMedGoogle Scholar
• Moncada S, Erusalimsky JD. 2002. Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat Rev Mol Cell Biol. 3(3):214–220.
   PubMed Web of Science ®Google Scholar
• Moon JS, Lee S, Park MA, et al. 2015. UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J Clin Invest. 125(2):665–680.
   PubMed Web of Science ®Google Scholar
• Morales PE, Arias-Duran C, Avalos-Guajardo Y, et al. 2019. Emerging role of mitophagy in cardiovascular physiology and pathology. Mol Aspects Med. 71:100822.
   PubMed Web of Science ®Google Scholar
• Naon D, Scorrano L. 2014. At the right distance: ER-mitochondria juxtaposition in cell life and death. Biochim Biophys Acta. 1843(10):2184–2194.
   PubMed Web of Science ®Google Scholar
• Ouyang H, Li Q, Zhong J, et al. 2020. Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways. J Cell Physiol. 235(10):6647–6659.
   PubMed Web of Science ®Google Scholar
• Pan P, Wang X, Liu D. 2018. The potential mechanism of mitochondrial dysfunction in septic cardiomyopathy. J Int Med Res. 46(6):2157–2169.
   PubMed Web of Science ®Google Scholar
• Pan P, Zhang H, Su L, et al. 2018. Melatonin balance the autophagy and apoptosis by regulating UCP2 in the LPS-induced cardiomyopathy. Molecules. 23(3):675 .
   PubMed Web of Science ®Google Scholar
• Parikh SM, Yang Y, He L, et al. 2015. Mitochondrial function and disturbances in the septic kidney. Semin Nephrol. 35(1):108–119.
   PubMed Web of Science ®Google Scholar
• Piantadosi CA, Suliman HB. 2012. Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. Biochim Biophys Acta. 1820(4):532–541.
   PubMed Web of Science ®Google Scholar
• Piel DA, Deutschman CS, Levy RJ. 2008. Exogenous cytochrome C restores myocardial cytochrome oxidase activity into the late phase of sepsis. Shock. 29(5):612–616.
   PubMed Web of Science ®Google Scholar
• Piquereau J, Godin R, Deschenes S, et al. 2013. Protective role of PARK2/parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction. Autophagy. 9(11):1837–1851.
   PubMed Web of Science ®Google Scholar
• Poggi C, Dani C. 2018. Sepsis and oxidative stress in the newborn: from pathogenesis to novel therapeutic targets. Oxid Med Cell Longev. 2018:9390140.
   PubMed Web of Science ®Google Scholar
• Pyle A, Ibbett I M, Gordon C, et al. 2009. A common UCP2 polymorphism predisposes to stress hyperglycaemia in severe sepsis. J Med Genet. 46(11):773–775.
   PubMed Web of Science ®Google Scholar
• Qiao Y, Wang L, Hu T, et al. 2021. Capsaicin protects cardiomyocytes against lipopolysaccharide-induced damage via 14-3-3γ-mediated autophagy augmentation. Front Pharmacol. 12:659015.
   PubMed Web of Science ®Google Scholar
• Rieusset J. 2018. The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update. Cell Death Dis. 9(3):388.
   PubMedGoogle Scholar
• Roshon MJ, Kline JA, Thornton LR, et al. 2003. Cardiac UCP2 expression and myocardial oxidative metabolism during acute septic shock in the rat. Shock. 19(6):570–576.
   PubMed Web of Science ®Google Scholar
• Rowland AA, Voeltz GK. 2012. Endoplasmic reticulum-mitochondria contacts: function of the junction. Nat Rev Mol Cell Biol. 13(10):607–625.
   PubMed Web of Science ®Google Scholar
• Russell LK, Mansfield CM, Lehman JJ, et al. 2004. Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res. 94(4):525–533.
   PubMed Web of Science ®Google Scholar
• Ryter SW. 2019. Heme oxygenase-1/carbon monoxide as modulators of autophagy and inflammation. Arch Biochem Biophys. 678:108186.
   PubMed Web of Science ®Google Scholar
• Saito T, Sadoshima J. 2015. Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circ Res. 116(8):1477–1490.
   PubMed Web of Science ®Google Scholar
• Sato R, Kuriyama A, Takada T, et al. 2016. Prevalence and risk factors of sepsis-induced cardiomyopathy: a retrospective cohort study. Medicine (Baltimore). 95(39):e5031.
   PubMed Web of Science ®Google Scholar
• Scarpulla RC. 2008. Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator. Ann N Y Acad Sci. 1147:321–334.
   PubMed Web of Science ®Google Scholar
• Scarpulla RC. 2011. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta. 1813(7):1269–1278.
   PubMed Web of Science ®Google Scholar
• Sciarretta S, Maejima Y, Zablocki D, et al. 2018. The role of autophagy in the heart. Annu Rev Physiol. 80:1–26.
   PubMed Web of Science ®Google Scholar
• Shang X, Li J, Yu R, et al. 2019. Sepsis-related myocardial injury is associated with Mst1 upregulation, mitochondrial dysfunction and the Drp1/F-actin signaling pathway. J Mol Histol. 50(2):91–103.
   PubMed Web of Science ®Google Scholar
• Shang X, Lin K, Zhang Y, et al. 2020. Mst1 deletion reduces septic cardiomyopathy via activating parkin-related mitophagy. J Cell Physiol. 235(1):317–327.
   PubMed Web of Science ®Google Scholar
• Sharp WW, Fang YH, Han M, et al. 2014. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. Faseb J. 28(1):316–326.
   PubMed Web of Science ®Google Scholar
• Shen YL, Shi Y Z, Chen GG, et al. 2018. TNF-α induces Drp1-mediated mitochondrial fragmentation during inflammatory cardiomyocyte injury. Int J Mol Med. 41(4):2317–2327.
   PubMed Web of Science ®Google Scholar
• Singer M. 2014. The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence. 5(1):66–72.
   PubMed Web of Science ®Google Scholar
• Singer M, Deutschman CS, Seymour CW, et al. 2016. The third international consensus definitions for sepsis and septic shock (sepsis-3). Jama. 315(8):801–810.
   PubMed Web of Science ®Google Scholar
• Song M, Gong G, Burelle Y, et al. 2015. Interdependence of Parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts. Circ Res. 117(4):346–351.
   PubMed Web of Science ®Google Scholar
• Sreedhar A, Zhao Y. 2017. Uncoupling protein 2 and metabolic diseases. Mitochondrion. 34:135–140.
   PubMed Web of Science ®Google Scholar
• Suliman HB, Sweeney TE, Withers CM, et al. 2010. Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis. J Cell Sci. 123(Pt 15):2565–2575.
   PubMed Web of Science ®Google Scholar
• Suliman HB, Welty-Wolf KE, Carraway M, et al. 2004. Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. Cardiovasc Res. 64(2):279–288.
   PubMed Web of Science ®Google Scholar
• Szabadkai G, Bianchi K, Varnai P, et al. 2006. Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2 + channels. J Cell Biol. 175(6):901–911.
   PubMed Web of Science ®Google Scholar
• Takasu O, Gaut JP, Watanabe E, et al. 2013. Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med. 187(5):509–517.
   PubMed Web of Science ®Google Scholar
• Tan Y, Ouyang H, Xiao X, et al. 2019. Irisin ameliorates septic cardiomyopathy via inhibiting DRP1-related mitochondrial fission and normalizing the JNK-LATS2 signaling pathway. Cell Stress Chaperones. 24(3):595–608.
   PubMed Web of Science ®Google Scholar
• Tang R, Qi PP, Liu YS, et al. 2019. Uncoupling protein 2 drives myocardial dysfunction in murine models of septic shock. Biomed Res Int. 2019:9786101.
   PubMed Web of Science ®Google Scholar
• Toda C, Kim JD, Impellizzeri D, et al. 2016. UCP2 regulates mitochondrial fission and ventromedial nucleus control of glucose responsiveness. Cell. 164(5):872–883.
   PubMed Web of Science ®Google Scholar
• Trumbeckaite S, Opalka JR, Neuhof C, et al. 2001. Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function. Eur J Biochem. 268(5):1422–1429.
   PubMedGoogle Scholar
• Tsolaki V, Makris D, Mantzarlis K, et al. 2017. Sepsis-induced cardiomyopathy: oxidative implications in the initiation and resolution of the damage. Oxid Med Cell Longev. 2017:7393525.
   PubMed Web of Science ®Google Scholar
• Turdi S, Han X, Huff AF, et al. 2012. Cardiac-specific overexpression of catalase attenuates lipopolysaccharide-induced myocardial contractile dysfunction: role of autophagy. Free Radic Biol Med. 53(6):1327–1338.
   PubMed Web of Science ®Google Scholar
• Vanasco V, Saez T, Magnani ND, et al. 2014. Cardiac mitochondrial biogenesis in endotoxemia is not accompanied by mitochondrial function recovery. Free Radical Biol Med. 77:1–9.
   PubMed Web of Science ®Google Scholar
• Van Vliet AR, Agostinis P. 2018. Mitochondria-associated membranes and ER stress. Curr Top Microbiol Immunol. 414:73–102.
   PubMed Web of Science ®Google Scholar
• Van Vliet AR, Verfaillie T, Agostinis P. 2014. New functions of mitochondria associated membranes in cellular signaling. Biochim Biophys Acta. 1843(10):2253–2262.
   PubMed Web of Science ®Google Scholar
• Vasquez-Trincado C, Garcia-Carvajal I, Pennanen C, et al. 2016. Mitochondrial dynamics, mitophagy and cardiovascular disease. J Physiol. 594(3):509–525.
   PubMed Web of Science ®Google Scholar
• Veeresh P, Kaur H, Sarmah D, et al. 2019. Endoplasmic reticulum-mitochondria crosstalk: from junction to function across neurological disorders. Ann N Y Acad Sci. 1457(1):41–60.
   PubMed Web of Science ®Google Scholar
• Volt H, García JA, Doerrier C, et al. 2016. Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin. J Pineal Res. 60(2):193–205.
   PubMed Web of Science ®Google Scholar
• Wang GQ, Tang T, Wang ZS, et al. 2016. Overexpression of hypo-phosphorylated IkappaBbeta at Ser313 protects the heart against sepsis. PLoS One. 11(8):e0160860.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhou H. 2020. Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury. Acta Pharmaceutica Sinica B. 10(10):1866–1879.
   PubMed Web of Science ®Google Scholar
• Wang X, Liu D, Chai W, et al. 2015. The role of uncoupling protein 2 during myocardial dysfunction in a canine model of endotoxin shock. Shock. 43(3):292–297.
   PubMed Web of Science ®Google Scholar
• Wang X, Qin W, Qiu X, et al. 2014. A novel role of exogenous carbon monoxide on protecting cardiac function and improving survival against sepsis via mitochondrial energetic metabolism pathway. Int J Biol Sci. 10(7):777–788.
   PubMed Web of Science ®Google Scholar
• Wang Y, Jasper H, Toan S, et al. 2021. Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury. Redox Biol. 45:102049.
   PubMed Web of Science ®Google Scholar
• Ward PA, Fattahi F. 2019. New strategies for treatment of infectious sepsis. J Leukocyte Biol. 106(1):187–192.
   PubMed Web of Science ®Google Scholar
• Wu S, Lu Q, Ding Y, et al. 2019. Hyperglycemia-driven inhibition of AMP-activated protein kinase alpha2 induces diabetic cardiomyopathy by promoting mitochondria-associated endoplasmic reticulum membranes in vivo. Circulation. 139(16):1913–1936.
   PubMed Web of Science ®Google Scholar
• Wu S, Lu Q, Wang Q, et al. 2017. Binding of FUN14 domain containing 1 with inositol 1,4,5-trisphosphate receptor in mitochondria-associated endoplasmic reticulum membranes maintains mitochondrial dynamics and function in hearts in vivo. Circulation. 136(23):2248–2266.
   PubMed Web of Science ®Google Scholar
• Wu W, Li W, Chen H, et al. 2016. FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy. Autophagy. 12(9):1675–1676.
   PubMed Web of Science ®Google Scholar
• Xiao X, Hu Y, Quiros PM, et al. 2014. OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury. Am J Physiol Renal Physiol. 306(11):F1318–F1326.
   PubMed Web of Science ®Google Scholar
• Yang CS, Yuk JM, Kim JJ, et al. 2013. Small heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2. PLoS One. 8(5):e63435.
   PubMed Web of Science ®Google Scholar
• Yang L, Zhang H, Chen P. 2018. Sulfur dioxide attenuates sepsis-induced cardiac dysfunction via inhibition of NLRP3 inflammasome activation in rats. Nitric Oxide. 81:11–20.
   PubMed Web of Science ®Google Scholar
• Yao RQ, Ren C, Xia ZF, et al. 2020. Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles. Autophagy. 17(2):385–401.
   PubMed Web of Science ®Google Scholar
• Yarana C, Sripetchwandee J, Sanit J, et al. 2012. Calcium-induced cardiac mitochondrial dysfunction is predominantly mediated by cyclosporine A-dependent mitochondrial permeability transition pore. Arch Med Res. 43(5):333–338.
   PubMed Web of Science ®Google Scholar
• Youle RJ, Van Der Bliek AM. 2012. Mitochondrial fission, fusion, and stress. Science. 337(6098):1062–1065.
   PubMed Web of Science ®Google Scholar
• Yu JW, Lee MS. 2016. Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance. Arch Pharm Res. 39(11):1503–1518.
   PubMed Web of Science ®Google Scholar
• Yu X, Hao M, Liu Y, et al. 2019. Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy. Eur J Pharmacol. 864:172715.
   PubMed Web of Science ®Google Scholar
• Yuan H, Perry CN, Huang C, et al. 2009. LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. Am J Physiol Heart Circ Physiol. 296(2):H470–H479.
   PubMed Web of Science ®Google Scholar
• Zhang H, Feng YW, Yao YM. 2018. Potential therapy strategy: targeting mitochondrial dysfunction in sepsis. Mil Med Res. 5(1):41.
   PubMedGoogle Scholar
• Zhang J, Wang L, Xie W, et al. 2020. Melatonin attenuates ER stress and mitochondrial damage in septic cardiomyopathy: A new mechanism involving BAP31 upregulation and MAPK-ERK pathway. J Cell Physiol. 235(3):2847–2856.
   PubMed Web of Science ®Google Scholar
• Zhang X, Yuan D, Sun Q, et al. 2017. Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis. Faseb J. 31(10):4382–4395.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xu H. 2016. Translational regulation of mitochondrial biogenesis. Biochem Soc Trans. 44(6):1717–1724.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Meszaros G, He WT, et al. 2017. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 214(9):2671–2693.
   PubMed Web of Science ®Google Scholar
• Zheng G, Lyu J, Liu S, et al. 2015. Silencing of uncoupling protein 2 by small interfering RNA aggravates mitochondrial dysfunction in cardiomyocytes under septic conditions. Int J Mol Med. 35(6):1525–1536.
   PubMed Web of Science ®Google Scholar
• Zhong J, Tan Y, Lu J, et al. 2019. Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: A novel mechanism linking Ripk3-modified mitochondrial performance and endoplasmic reticulum function. Redox Biol. 26:101287.
   PubMed Web of Science ®Google Scholar
• Zhong X, He J, Zhang X, et al. 2019. UCP2 alleviates tubular epithelial cell apoptosis in lipopolysaccharide-induced acute kidney injury by decreasing ROS production. Biomed Pharmacother. 115:108914.
   PubMed Web of Science ®Google Scholar
• Zhong Z, Sanchez-Lopez E, Karin M. 2016. Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases. Clin Exp Rheumatol. 34(4 Suppl 98):12–16.
   PubMed Web of Science ®Google Scholar
• Zhong Z, Umemura A, Sanchez-Lopez E, et al. 2016. NF-kappaB restricts inflammasome activation via elimination of damaged mitochondria. Cell. 164(5):896–910.
   PubMed Web of Science ®Google Scholar
• Zhou H, Hu S, Jin Q, et al. 2017. Mff-Dependent mitochondrial fission contributes to the pathogenesis of cardiac microvasculature ischemia/reperfusion injury via induction of mROS-mediated cardiolipin oxidation and HK2/VDAC1 disassociation-involved mPTP opening. J Am Heart Assoc. 6(3):e005328.
   PubMed Web of Science ®Google Scholar
• Zhou H, Ren J, Toan S, et al. 2021. Role of mitochondrial quality surveillance in myocardial infarction: from bench to bedside. Ageing Res Rev. 66:101250.
   PubMed Web of Science ®Google Scholar
• Zhou H, Zhu P, Wang J, et al. 2018. Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy. Cell Death Differ. 25(6):1080–1093.
   PubMed Web of Science ®Google Scholar
• Zhou R, Yazdi AS, Menu P, et al. 2011. A role for mitochondria in NLRP3 inflammasome activation. Nature. 469(7329):221–225.
   PubMed Web of Science ®Google Scholar
• Zhou T, Chang L, Luo Y, et al. 2019. Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy. Redox Biol. 21:101120.
   PubMed Web of Science ®Google Scholar
• Zhu X, Shen W, Yao K, et al. 2019. Fine-tuning of PGC1alpha expression regulates cardiac function and longevity. Circ Res. 125(7):707–719.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Kuang L, Wu Y, et al. 2021. Protective effects of inhibition of mitochondrial fission on organ function after sepsis. Front Pharmacol. 12:712489.
   PubMed Web of Science ®Google Scholar
• Zorov DB, Juhaszova M, Sollott SJ. 2014. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 94(3):909–950.
   PubMed Web of Science ®Google Scholar