Small RNA sequencing highlights potential functions of tsRNAs in regulating pyroptosis in trigeminal neuralgia

References

• Chen ML, Lin K, Lin SK. 2018. NLRP3 inflammasome signaling as an early molecular response is negatively controlled by miR-186 in CFA-induced prosopalgia mice. Braz J Med Biol Res. 51(9):e7602. doi:10.1590/1414-431X20187602.
   PubMed Web of Science ®Google Scholar
• Chen NF, Huang SY, Chen WF, Chen CH, Lu CH, Chen CL, Yang SN, Wang HM, Wen ZH. 2013. TGF-beta1 attenuates spinal neuroinflammation and the excitatory amino acid system in rats with neuropathic pain. J Pain. 14(12):1671–1685. doi:10.1016/j.jpain.2013.08.010.
   PubMed Web of Science ®Google Scholar
• Du J, Huang T, Zheng Z, Fang S, Deng H, Liu K. 2023. Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology. Cell Commun Signal. 21(1):302. doi:10.1186/s12964-023-01341-8.
   PubMed Web of Science ®Google Scholar
• Fagan SG, Helm M, Prehn JHM. 2021. tRNA-derived fragments: a new class of non-coding RNA with key roles in nervous system function and dysfunction. Prog Neurobiol. 205:102118. doi:10.1016/j.pneurobio.2021.102118.
   PubMed Web of Science ®Google Scholar
• Guo Y, Bai D, Liu W, Liu Y, Zhang Y, Kou X, Chen J, Wang H, Teng X, Zuo J, et al. 2021. Altered sperm tsRNAs in aged male contribute to anxiety-like behavior in offspring. Aging Cell. 20(9):e13466. doi:10.1111/acel.13466.
   PubMed Web of Science ®Google Scholar
• Jehn J, Treml J, Wulsch S, Ottum B, Erb V, Hewel C, Kooijmans RN, Wester L, Fast I, Rosenkranz D. 2020. 5’ tRNA halves are highly expressed in the primate hippocampus and might sequence-specifically regulate gene expression. RNA. 26(6):694–707. doi:10.1261/rna.073395.119.
   PubMed Web of Science ®Google Scholar
• Li PF, Guo SC, Liu T, Cui H, Feng D, Yang A, Cheng Z, Luo J, Tang T, Wang Y. 2020. Integrative analysis of transcriptomes highlights potential functions of transfer-RNA-derived small RNAs in experimental intracerebral hemorrhage. Aging (Albany NY). 12(22):22794–22813. doi:10.18632/aging.103938.
   PubMedGoogle Scholar
• Liu M, Wang Y, Li S, Hou X, Li T, Xu Z, Chen F, Zhou Y, Xia L, Wang W. 2023. Attenuates reactive oxygen species: induced pyroptosis via activation of the Nrf2/HO-1 signal pathway in models of trigeminal neuralgia. Sci Rep. 13(1):18111. doi:10.1038/s41598-023-44013-w.
   PubMed Web of Science ®Google Scholar
• Liu MX, Zhong J, Xia L, Dou NN, Li ST. 2019. A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm. Neurol Res. 41(4):335–340. doi:10.1080/01616412.2018.1564188.
   PubMed Web of Science ®Google Scholar
• Liu Y, Dong Y, Liu Z, Wang Y, Chai Y, Han Z, Wei W, Chen M. 2022. RIPK1-mediated NLRP3 activation via MAPK signaling pathway in the pathogenesis of trigeminal neuralgia. Res Square. PREPRINT (Version 1) available at Research Square. doi:10.21203/rs.3.rs-2158508/v1.
   Google Scholar
• Luo D, Lin R, Luo L, Li Q, Chen T, Qiu R, Li Y. 2019. Glial plasticity in the trigeminal root entry zone of a rat trigeminal neuralgia animal model. Neurochem Res. 44(8):1893–1902. doi:10.1007/s11064-019-02824-2.
   PubMed Web of Science ®Google Scholar
• Magee R, Londin E, Rigoutsos I. 2019. TRNA-derived fragments as sex-dependent circulating candidate biomarkers for Parkinson's disease. Parkinsonism Relat Disord. 65:203–209. doi:10.1016/j.parkreldis.2019.05.035.
   PubMed Web of Science ®Google Scholar
• Martini AC, Berta T, Forner S, Chen G, Bento AF, Ji RR, Rae GA. 2016. Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection. J Neuroinflammation. 13(1):75. doi:10.1186/s12974-016-0540-8.
   PubMedGoogle Scholar
• Mu G, Wu D, Jiang Q, Wang L, Li Q, Lu B, Yu X. 2022. Hydrogen-producing silicon-based agent inhibits microglial pyroptosis to improves nerve demyelination in trigeminal neuralgia rats.
   Google Scholar
• Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, et al. 2020. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol. 18(7):e3000410. doi:10.1371/journal.pbio.3000410.
   PubMed Web of Science ®Google Scholar
• Rao Z, Zhu Y, Yang P, Chen Z, Xia Y, Qiao C, Liu W, Deng H, Li J, Ning P, et al. 2022. Pyroptosis in inflammatory diseases and cancer. Theranostics. 12(9):4310–4329. doi:10.7150/thno.71086.
   PubMed Web of Science ®Google Scholar
• Ren C, Chen M, Mu G, Peng S, Liu X, Ou C. 2021. NLRP3 inflammasome mediates neurodegeneration in rats with chronic neuropathic pain. Shock. 56(5):840–849. doi:10.1097/SHK.0000000000001832.
   PubMed Web of Science ®Google Scholar
• Sun B, Chen Z, Chi Q, Zhang Y, Gao B. 2021b. Endogenous tRNA-derived small RNA (tRF3-Thr-AGT) inhibits ZBP1/NLRP3 pathway-mediated cell pyroptosis to attenuate acute pancreatitis (AP). J Cell Mol Med. 25(22):10441–10453. doi:10.1111/jcmm.16972.
   PubMed Web of Science ®Google Scholar
• Sun X, Cao L, Ge JL, Ge JY, Yang XF, Du BX, Song J. 2021a. The NLRP3-related inflammasome modulates pain behavior in a rat model of trigeminal neuropathic pain. Life Sci. 277:119489. doi:10.1016/j.lfs.2021.119489.
   PubMed Web of Science ®Google Scholar
• Tao R, Huang F, Lin K, Lin SW, Wei DE, Luo DS. 2021. Using RNA-Seq to explore the Hub genes in the trigeminal root entry zone of rats by compression injury. Pain Physician. 24(5):E573–e581.
   PubMed Web of Science ®Google Scholar
• Wang Q, Lee I, Ren J, Ajay SS, Lee YS, Bao X. 2013. Identification and functional characterization of tRNA-derived RNA fragments (tRFs) in respiratory syncytial virus infection. Mol Ther. 21(2):368–379. doi:10.1038/mt.2012.237.
   PubMed Web of Science ®Google Scholar
• Wu W, Lee I, Spratt H, Fang X, Bao X. 2021. tRNA-Derived fragments in Alzheimer's disease: implications for new disease biomarkers and neuropathological mechanisms. J Alzheimers Dis. 79(2):793–806. doi:10.3233/JAD-200917.
   PubMed Web of Science ®Google Scholar
• Xiao L, Wang J, Ju S, Cui M, Jing R. 2022. Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer. J Med Genet. 59(7):623–631. doi:10.1136/jmedgenet-2021-108327.
   PubMed Web of Science ®Google Scholar
• Xiong W, Tan M, Tong Z, Yin C, He L, Liu L, Shen Y, Guan S, Ge H, Li G, et al. 2019. Effects of long non-coding RNA uc.48 + on pain transmission in trigeminal neuralgia. Brain Res Bull. 147:92–100. doi:10.1016/j.brainresbull.2019.02.009.
   PubMed Web of Science ®Google Scholar
• Xu M, Yan Y, Zhu M, Wang Z, Zhang X, Zhang D. 2020. Effects of long non-coding RNA Gm14461 on pain transmission in trigeminal neuralgia. J Inflamm (Lond). 17:1. doi:10.1186/s12950-019-0231-1.
   PubMed Web of Science ®Google Scholar
• Yao Y, Chang B, Li S. 2020. Relationship of inflammation with trigeminal neuralgia. J Craniofac Surg. 31(2):e110–e113. doi:10.1097/scs.0000000000005879.
   PubMed Web of Science ®Google Scholar
• Yu P, Zhang X, Liu N, Tang L, Peng C, Chen X. 2021. Pyroptosis: mechanisms and diseases. Signal Transduct Target Ther. 6(1):128. doi:10.1038/s41392-021-00507-5.
   PubMed Web of Science ®Google Scholar
• Zhang S, Li H, Zheng L, Li H, Feng C, Zhang W. 2019. Identification of functional tRNA-derived fragments in senescence-accelerated mouse prone 8 brain. Aging (Albany NY). 11(22):10485–10498. doi:10.18632/aging.102471.
   PubMedGoogle Scholar
• Zhang X, Trebak F, Souza LAC, Shi J, Zhou T, Kehoe PG, Chen Q, Feng Earley Y. 2020. Small RNA modifications in Alzheimer's disease. Neurobiol Dis. 145:105058. doi:10.1016/j.nbd.2020.105058.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Ren L, Sun X, Zhang Z, Liu J, Xin Y, Yu J, Jia Y, Sheng J, Hu GF, et al. 2021. Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs. Nat Commun. 12(1):6673. doi:10.1038/s41467-021-26909-1.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Li X, Ye C, Huang C, Lv X, Li J. 2023. The biogenesis, mechanism and function of the tRNA-derived small RNA (tsRNA): a review compared with microRNA. Am J Cancer Res. 13(5):1656–1666.
   PubMed Web of Science ®Google Scholar
• Zhu J, Wen Y, Zhang Q, Nie F, Cheng M, Zhao X. 2022. The monomer TEC of blueberry improves NASH by augmenting tRF-47-mediated autophagy/pyroptosis signaling pathway. J Transl Med. 20(1):128. doi:10.1186/s12967-022-03343-5.
   PubMed Web of Science ®Google Scholar
• Zong T, Yang Y, Zhao H, Li L, Liu M, Fu X, Tang G, Zhou H, Aung LHH, Li P, et al. 2021. tsRNAs: novel small molecules from cell function and regulatory mechanism to therapeutic targets. Cell Prolif. 54(3):e12977. doi:10.1111/cpr.12977.
   PubMed Web of Science ®Google Scholar