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Articles

Effect of urinary pH upon the renal toxicity of melamine and cyanuric acid

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References

  • Melamine. National Institutes of Health. (NIH) PubChem. Accessed 22 December 2020
  • WHO. Toxicological and Health Aspects of Melamine and Cyanuric Acid. Report of a WHO Expert Meeting in Collaboration with FAO, Supported by Health Canada. Geneva, Switzerland: World Health Organization; 2009.
  • Brown CA, Jeong K-S, Poppenga RH, et al. Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007. J Vet Diagn Invest. 2007;19(5):525–531. doi:10.1177/104063870701900510.
  • Puschner B, Poppenga RH, Lowenstine LJ, Filigenzi MS, Pesavento PA. Assessment of melamine and cyanuric acid toxicity in cats. J Vet Diagn Invest. 2007;19(6):616–624. doi:10.1177/104063870701900602.
  • Dobson RLM, Motlagh S, Quijano M, et al. Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs. Toxicol Sci. 2008;106(1):251–262. doi:10.1093/toxsci/kfn160.
  • Choi L, Kwak MY, Kwak EH, et al. Comparative nephrotoxicitiy induced by melamine, cyanuric acid, or a mixture of both chemicals in either Sprague-Dawley rats or renal cell lines. J Toxicol Environ Health A. 2010;73(21-22):1407–1419. doi:10.1080/15287394.2010.511540.
  • Xie G, Zheng X, Qi X, et al. Metabonomic evaluation of melamine-induced acute renal toxicity in rats. J Proteome Res. 2010;9(1):125–133. doi:10.1021/pr900333h.
  • Jacob CC, Reimschuessel R, Von Tungeln LS, et al. Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats. Toxicol Sci. 2011;119(2):391–397. doi:10.1093/toxsci/kfq333.
  • Gamboa da Costa G, Jacob CC, Von Tungeln LS, et al. Dose-response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats. Toxicol Appl Pharmacol. 2012;262(2):99–106. doi:10.1016/j.taap.2012.04.031.
  • Son JY, Kang YJ, Kim KS, Kim TH, et al. Evaluation of renal toxicity by combination exposure to melamine and cyanuric acid in male Sprague-Dawley rats. Toxicol Res. 2014;30(2):99–107. doi:10.5487/tr.2014.30.2.099.
  • Yasui T, Kobayashi T, Okada A, et al. Long-term follow-up of nephrotoxicity in rats administered both melamine and cyanuric acid. BMC Res Notes. 2014;7:87. doi:10.1186/1756-0500-7-87.
  • Peng J, Li D, Chan YK, et al. Effects of water uptake on melamine renal stone formation in mice. Nephrol Dial Transplant. 2012;27(6):2225–2231. doi:10.1093/ndt/gfr577.
  • Chang L, Yue Z, She R, Sun Y, Zhu J. The toxic effect of a mixture of melamine and cyanuric acid on the gastrointestinal tract and liver in mice. Res Vet Sci. 2015;102:234–237. doi:10.1016/j.rvsc.2015.08.018.
  • Reimschuessel R, Gieseker CM, Miller RA, et al. Evaluation of the renal effects of experimental feeding of melamine and cyanuric acid to fish and pigs. Am J Vet Res. 2008;69(9):1217–1228. doi:10.2460/ajvr.69.9.1217.
  • Stine CB, Reimschuessel R, Gieseker CM, et al. A No Observable Adverse Effects Level (NOAEL) for pigs fed melamine and cyanuric acid. Regul Toxicol Pharmacol. 2011;60(3):363–372. doi:10.1016/j.yrtph.2011.05.004.
  • IARC. Melamine. In: H. Mattock (Ed.), IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 119. Some Chemicals That Cause Tumours of the Urinary Tract in Rodents. Lyon, France: International Agency for Research on Cancer; 2019:115–172.
  • Tolleson WH, Diachenko GW, Folmer D, Doell D, Heller D. Background paper on the chemistry of melamine alone and in combination with related compounds. Prepared for the WHO Expert Meeting on Toxicological and Health Aspects of Melamine and Cyanuric Acid, in Collaboration with FAO, Supported by Health Canada. Geneva, Switzerland: World Health Organization; 2009.
  • Xie Y, Huang Y, Wang W, Liu G, Zhao R. Dynamic interaction between melamine and cyanuric acid in artificial urine investigated by quartz crystal microbalance. Analyst. 2011;136(12):2482–2488. doi:10.1039/c1an15119c.
  • Kadlubar FF, Unruh LE, Flammang TJ, Sparks D, Mitchum RK, Mulder GJ. Alteration of urinary levels of the carcinogen, N-hydroxy-2-naphthylamine, and its N-glucuronide in the rat by control of urinary pH, inhibition of metabolic sulfation, and changes in biliary excretion. Chem Biol Interact. 1981;33(2-3):129–147. doi:10.1016/0009-2797(81)90036-3.
  • Jacob CC, Gamboa da Costa G. Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011;879(9-10):652–656. doi:10.1016/j.jchromb.2011.01.035.
  • Kok DJ, Iestra JA, Doorenbos CJ, Papapoulos SE. The effects of dietary excesses in animal protein and in sodium on the composition and the crystallization kinetics of calcium oxalate monohydrate in urines of healthy men. J Clin Endocrinol Metab. 1990;71(4):861–867. doi:10.1210/jcem-71-4-861.
  • Siener R, Hesse A. The effect of different diets on urine composition and the risk of calcium oxalate crystallisation in healthy subjects. Eur Urol. 2002;42(3):289–296. doi:10.1016/S0302-2838(02)00316-0.
  • Siener R, Schade N, Nicolay C, von Unruh GE, Hesse A. The efficacy of dietary intervention on urinary risk factors for stone formation in recurrent calcium oxalate stone patients. J Urol. 2005;173(5):1601–1605. doi:10.1097/01.ju.0000154626.16349.d3.
  • Ren S-T, Du Y-X, Xu C-F, et al. Preventive and therapeutic effects of sodium bicarbonate on melamine-induced bladder stones in mice. Urolithiasis. 2014;42(5):409–414. doi:10.1007/s00240-014-0689-5.
  • Lu X, Wang J, Cao X, et al. Gender and urinary pH affect melamine-associated kidney stone formation risk. Urol Ann. 2011;3(2):71–74. doi:10.4103/0974-7796.82171.
  • Zhang L, Wu L-L, Wang Y-P, Liu A-M, Zou C-C, Zhao Z-Y. Melamine-contaminated milk products induced urinary tract calculi in children. World J Pediatr. 2009;5(1):31–35. doi:10.1007/s12519-009-0005-6.
  • Sun Q, Shen Y, Sun N, et al. Diagnosis, treatment and follow-up of 25 patients with melamine-induced kidney stones complicated by acute obstructive renal failure in Beijing Children's Hospital. Eur J Pediatr. 2010;169(4):483–489. doi:10.1007/s00431-009-1093-y.
  • Dominguez-Estevez M, Constable A, Mazzatorta P, Renwick AG, Schilter B. Using urinary solubility data to estimate the level of safety concern of low levels of melamine (MEL) and cyanuric acid (CYA) present simultaneously in infant formulas. Regul Toxicol Pharmacol. 2010;57(2-3):247–255. doi:10.1016/j.yrtph.2010.03.002.
  • Chen Y-T, Hsuan S-L, Jiann B-P, et al. Effects of sodium citrate on melamine-cyanuric acid mixture-induced urolithiasis in rats. Clin Chim Acta. 2013;424:76–82. doi:10.1016/j.cca.2013.05.016.
  • Welch AA, Mulligan A, Bingham SA, Khaw K-t. Urine pH is an indicator of dietary acid-base load, fruit and vegetables and meat intakes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk population study. Br J Nutr. 2008;99(6):1335–1443. doi:10.1017/S0007114507862350.

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