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Articles

Association between polychlorinated biphenyl exposure and thyroid hormones: a systematic review and meta-analysis

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References

  • Kabir ER, Rahman MS, Rahman I. A review on endocrine disruptors and their possible impacts on human health. Environ Toxicol Pharmacol. 2015;40(1):241–258. doi:10.1016/j.etap.2015.06.009
  • Wolff MS, Camann D, Gammon M, Stellman SD. Proposed PCB congener groupings for epidemiological studies. Environ Health Perspect. 1997;105(1):13–14. doi:10.1289/ehp.9710513
  • ATSDR A. Toxicological Profile for Polychlorinated Biphenyls (PCBs). Atlanta, GA: Agency for Toxic Substances and Disease Registry; 2000.
  • Djordjevic AB, Antonijevic E, Curcic M, Milovanovic V, Antonijevic B. Endocrine-disrupting mechanisms of polychlorinated biphenyls. Curr Opin Toxicol. 2020;19:42–49. doi:10.1016/j.cotox.2019.10.006
  • Wang J, Li X, Li P, et al. Porous microplastics enhance polychlorinated biphenyls-induced thyroid disruption in juvenile Japanese flounder (Paralichthys olivaceus). Mar Pollut Bull. 2022;174:113289. doi:10.1016/j.marpolbul.2021.113289
  • Schnitzler JG, Celis N, Klaren PH, et al. Thyroid dysfunction in sea bass (Dicentrarchus labrax): underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism. Aquat Toxicol. 2011;105(3–4):438–447. doi:10.1016/j.aquatox.2011.07.019
  • Kato Y, Ikushiro S, Haraguchi K, et al. A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats. Toxicol Sci. 2004;81(2):309–315. doi:10.1093/toxsci/kfh225
  • Hallgren S, Sinjari T, Hakansson H, Darnerud PO. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch Toxicol. 2001;75(4):200–208. doi:10.1007/s002040000208
  • Gu JY, Qian CH, Tang W, et al. Polychlorinated biphenyls affect thyroid function and induce autoimmunity in Sprague-Dawley rats. Horm Metab Res. 2009;41(6):471–474. doi:10.1055/s-0029-1220768
  • Collins WT, Jr., Capen CC, Kasza L, Carter C, Dailey RE. Effect of polychlorinated biphenyl (PCB) on the thyroid gland of rats. Ultrastructural and biochemical investigations. Am J Pathol. 1977;89(1):119–136.
  • Kiliç N, Sandal S, Colakoğlu N, Kutlu S, Seyran A, Yilmaz B. Endocrine disruptive effects of polychlorinated biphenyls on the thyroid gland in female rats. Tohoku J Exp Med. 2005;206(4):327–332. doi:10.1620/tjem.206.327
  • Hsu PC, Guo YL, Li MH. Effects of acute postnatal exposure to 3,3',4,4'-tetrachlorobiphenyl on sperm function and hormone levels in adult rats. Chemosphere. 2004;54(5):611–618. doi:10.1016/j.chemosphere.2003.09.006
  • Gaum PM, Lang J, Esser A, et al. Exposure to polychlorinated biphenyls and the thyroid gland – examining and discussing possible longitudinal health effects in humans. Environ Res. 2016;148:112–121. doi:10.1016/j.envres.2016.03.022
  • Han X, Meng L, Li Y, et al. Associations between exposure to persistent organic pollutants and thyroid function in a case-control study of East China. Environ Sci Technol. 2019;53(16):9866–9875. doi:10.1021/acs.est.9b02810
  • Persky V, Piorkowski J, Turyk M, et al. Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant. Environ Health. 2012;11(1):1–11. doi:10.1186/1476-069X-11-57
  • Hagmar L, Rylander L, Dyremark E, Klasson-Wehler E, Erfurth EM. Plasma concentrations of persistent organochlorines in relation to thyrotropin and thyroid hormone levels in women. Int Arch Occup Environ Health. 2001;74(3):184–188. doi:10.1007/s004200000213
  • Nomiyama K, Yonehara T, Yonemura S, et al. Determination and characterization of hydroxylated polychlorinated biphenyls (OH-PCBs) in serum and adipose tissue of Japanese women diagnosed with breast cancer. Environ Sci Technol. 2010;44(8):2890–2896. doi:10.1021/es9012432
  • Selden AI, Lundholm C, Johansson N, Wingfors H. Polychlorinated biphenyls (PCB), thyroid hormones and cytokines in construction workers removing old elastic sealants. Int Arch Occup Environ Health. 2008;82(1):99–106. doi:10.1007/s00420-008-0313-5
  • Zani C, Magoni M, Speziani F, et al. Polychlorinated biphenyl serum levels, thyroid hormones and endocrine and metabolic diseases in people living in a highly polluted area in North Italy: a population-based study. Heliyon. 2019;5(6):e01870. doi:10.1016/j.heliyon.2019.e01870
  • Hagmar L. Polychlorinated biphenyls and thyroid status in humans: a review. Thyroid. 2003;13(11):1021–1028. doi:10.1089/105072503770867192
  • Salay E, Garabrant D. Polychlorinated biphenyls and thyroid hormones in adults: a systematic review appraisal of epidemiological studies. Chemosphere. 2009;74(11):1413–1419. doi:10.1016/j.chemosphere.2008.11.031
  • Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi:10.1136/bmj.n71
  • Centers for Disease Control and Prevention. Laboratory procedure manual: polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs), polychlorinated biphenyls (PCBs) and persistent pesticides (PPs). 2016. https://wwwn.cdc.gov/nchs/data/nhanes/2013-2014/labmethods/PCBPOL_H_MET.pdf.
  • Moleti M, Trimarchi F, Vermiglio F. Thyroid physiology in pregnancy. Endocr Pract. 2014;20(6):589–596. doi:10.4158/EP13341.RA
  • Yu Y, Li X, Jiang S, et al. Serum thyroid hormone levels among Chinese pregnant women. Gynecol Endocrinol. 2017;33(10):774–778. doi:10.1080/09513590.2017.1320375
  • Corcoran JM, Eastman CJ, Carter JN, Lazarus L. Circulating thyroid hormone levels in children. Arch Dis Child. 1977;52(9):716–720. doi:10.1136/adc.52.9.716
  • Elmlinger MW, Kuhnel W, Lambrecht HG, Ranke MB. Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH). Clin Chem Lab Med. 2001;39(10):973–979. doi:10.1515/CCLM.2001.158
  • Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5:13. doi:10.1186/1471-2288-5-13
  • Melo G, Dutra KL, Rodrigues Filho R, et al. Association between psychotropic medications and presence of sleep bruxism: a systematic review. J Oral Rehabil. 2018;45(7):545–554. doi:10.1111/joor.12633
  • Martins JN, Marques D, Silva EJNL, Caramês J, Mata A, Versiani MA. Influence of demographic factors on the prevalence of a second root canal in mandibular anterior teeth–a systematic review and meta-analysis of cross-sectional studies using cone beam computed tomography. Arch Oral Biol. 2020;116:104749. doi:10.1016/j.archoralbio.2020.104749
  • Rupinski MT, Dunlap WP. Approximating Pearson product-moment correlations from Kendall’s tau and Spearman’s rho. Educ Psychol Meas. 1996;56(3):419–429. doi:10.1177/0013164496056003004
  • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–1558. doi:10.1002/sim.1186
  • Ioannidis JP, Patsopoulos NA, Evangelou E. Uncertainty in heterogeneity estimates in meta-analyses. BMJ. 2007;335(7626):914–916. doi:10.1136/bmj.39343.408449.80
  • Bella D, Carpenter DO, Akwesasne Task Force on the Environment. Interactions among thyroid hormones and serum lipid levels in association with PCB exposure in the Mohawk Akwesasne population. Environ Res. 2021;200:111334. doi:10.1016/j.envres.2021.111334
  • Bloom MS, Vena JE, Olson JR, Kostyniak PJ. Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York state anglers. Int J Hyg Environ Health. 2009;212(6):599–611. doi:10.1016/j.ijheh.2009.04.005
  • Turyk ME, Anderson HA, Freels S, Great Lakes Consortium, et al. Associations of organochlorines with endogenous hormones in male Great Lakes fish consumers and nonconsumers. Environ Res. 2006;102(3):299–307. doi:10.1016/j.envres.2006.01.009
  • Langer P, Kocan A, Tajtakova M, et al. Possible effects of persistent organochlorinated pollutants cocktail on thyroid hormone levels and pituitary-thyroid interrelations. Chemosphere. 2007;70(1):110–118. doi:10.1016/j.chemosphere.2007.06.046
  • Emmett EA, Maroni M, Jefferys J, Schmith J, Levin BK, Alvares A. Studies of transformer repair workers exposed to PCBs: II. Results of clinical laboratory investigations. Am J Ind Med. 1988;14(1):47–62. doi:10.1002/ajim.4700140107
  • Persky V, Turyk M, Anderson HA, et al. The effects of PCB exposure and fish consumption on endogenous hormones. Environ Health Perspect. 2001;109(12):1275–1283. doi:10.1289/ehp.011091275
  • Kitamura S, Jinno N, Suzuki T, et al. Thyroid hormone-like and estrogenic activity of hydroxylated PCBs in cell culture. Toxicology. 2005;208(3):377–387. doi:10.1016/j.tox.2004.11.037
  • Meerts IA, Assink Y, Cenijn PH, et al. Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. Toxicol Sci. 2002;68(2):361–371. doi:10.1093/toxsci/68.2.361
  • Cheek AO, Kow K, Chen J, McLachlan JA. Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ Health Perspect. 1999;107(4):273–278. doi:10.1289/ehp.99107273
  • Bai X, Yan L, Ji C, et al. A combination of ternary classification models and reporter gene assays for the comprehensive thyroid hormone disruption profiles of 209 polychlorinated biphenyls. Chemosphere. 2018;210:312–319. doi:10.1016/j.chemosphere.2018.07.023
  • Fisher JW, Campbell J, Muralidhara S, et al. Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat. Toxicol Sci. 2006;90(1):87–95. doi:10.1093/toxsci/kfj069
  • Hood A, Klaassen CD. Effects of microsomal enzyme inducers on outer-ring deiodinase activity toward thyroid hormones in various rat tissues. Toxicol Appl Pharmacol. 2000;163(3):240–248. doi:10.1006/taap.1999.8883
  • Liu C, Ha M, Li L, Yang K. PCB153 and p,p’-DDE disorder thyroid hormones via thyroglobulin, deiodinase 2, transthyretin, hepatic enzymes and receptors. Environ Sci Pollut Res Int. 2014;21(19):11361–11369. doi:10.1007/s11356-014-3093-3
  • Coimbra AM, Reis-Henriques MA, Darras VM. Circulating thyroid hormone levels and iodothyronine deiodinase activities in Nile tilapia (Oreochromis niloticus) following dietary exposure to Endosulfan and Aroclor 1254. Comp Biochem Physiol C Toxicol Pharmacol. 2005;141(1):8–14. doi:10.1016/j.cca.2005.04.006
  • Meeker JD, Hauser R. Exposure to polychlorinated biphenyls (PCBs) and male reproduction. Syst Biol Reprod Med. 2010;56(2):122–131. doi:10.3109/19396360903443658
  • Amir S, Shah STA, Mamoulakis C, et al. Endocrine disruptors acting on estrogen and androgen pathways cause reproductive disorders through multiple mechanisms: a review. Int J Environ Res Public Health. 2021;18(4):1464. doi:10.3390/ijerph18041464
  • Lin BG, Chen CR, Chen XC, et al. Effects of organochlorine exposure on male reproductive disorders in an electronic waste area of South China. Environ Int. 2021;147:106318. doi:10.1016/j.envint.2020.106318
  • Santin AP, Furlanetto TW. Role of estrogen in thyroid function and growth regulation. J Thyroid Res. 2011;2011:875125. doi:10.4061/2011/875125
  • Federman DD, Robbins J, Rall JE. Effects of methyl testosterone on thyroid function, thyrozine metabolism, and thyroxine-binding protein. J Clin Invest. 1958;37(7):1024–1030. doi:10.1172/JCI103683
  • Tahboub R, Arafah BM. Sex steroids and the thyroid. Best Pract Res Clin Endocrinol Metab. 2009;23(6):769–780. doi:10.1016/j.beem.2009.06.005
  • Takaguchi K, Nishikawa H, Mizukawa H, et al. Effects of PCB exposure on serum thyroid hormone levels in dogs and cats. Sci Total Environ. 2019;688:1172–1183. doi:10.1016/j.scitotenv.2019.06.300
  • Desaulniers D, Poon R, Phan W, Leingartner K, Foster WG, Chu I. Reproductive and thyroid hormone levels in rats following 90-day dietary exposure to PCB 28 (2,4,4'-trichlorobiphenyl) or PCB 77 (3,3'4,4'-tetrachlorobiphenyl). Toxicol Ind Health. 1997;13(5):627–638. doi:10.1177/074823379701300504
  • Liu J, Liu Y, Barter RA, Klaassen CD. Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a dose-response study. J Pharmacol Exp Ther. 1995;273(2):977–985.
  • Humphrey HE, Gardiner JC, Pandya JR, et al. PCB congener profile in the serum of humans consuming Great Lakes fish. Environ Health Perspect. 2000;108(2):167–172. doi:10.1289/ehp.00108167
  • Liu C, Wang C, Yan M, Quan C, Zhou J, Yang K. PCB153 disrupts thyroid hormone homeostasis by affecting its biosynthesis, biotransformation, feedback regulation, and metabolism. Horm Metab Res. 2012;44(9):662–669. doi:10.1055/s-0032-1311569
  • LeRoy KD, Thomas P, Khan IA. Thyroid hormone status of Atlantic croaker exposed to Aroclor 1254 and selected PCB congeners. Comp Biochem Physiol C Toxicol Pharmacol. 2006;144(3):263–271. doi:10.1016/j.cbpc.2006.09.005
  • Viluksela M, Heikkinen P, van der Ven LT, et al. Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats. PLoS One. 2014;9(8):e104639. doi:10.1371/journal.pone.0104639
  • Giera S, Bansal R, Ortiz-Toro TM, Taub DG, Zoeller RT. Individual polychlorinated biphenyl (PCB) congeners produce tissue- and gene-specific effects on thyroid hormone signaling during development. Endocrinology. 2011;152(7):2909–2919. doi:10.1210/en.2010-1490
  • Chu I, Poon R, Yagminas A, et al. Subchronic toxicity of PCB 105 (2,3,3',4,4'-pentachlorobiphenyl) in rats. J Appl Toxicol. 1998;18(4):285–292. doi:10.1002/(sici)1099-1263(199807/08)18:4 < 285::aid-jat510 > 3.0.co;2-9
  • Villanger GD, Lydersen C, Kovacs KM, Lie E, Skaare JU, Jenssen BM. Disruptive effects of persistent organohalogen contaminants on thyroid function in white whales (Delphinapterus leucas) from Svalbard. Sci Total Environ. 2011;409(13):2511–2524. doi:10.1016/j.scitotenv.2011.03.014
  • Eguchi A, Nomiyama K, Minh Tue N, et al. Residue profiles of organohalogen compounds in human serum from e-waste recycling sites in North Vietnam: association with thyroid hormone levels. Environ Res. 2015;137:440–449. doi:10.1016/j.envres.2015.01.007
  • Meeker JD, Altshul L, Hauser R. Serum PCBs, p,p’-DDE and HCB predict thyroid hormone levels in men. Environ Res. 2007;104(2):296–304. doi:10.1016/j.envres.2006.11.007
  • Jacobson MH, Darrow LA, Barr DB, et al. Serum polybrominated biphenyls (PBBs) and polychlorinated biphenyls (PCBs) and thyroid function among Michigan adults several decades after the 1973-1974 PBB contamination of livestock feed. Environ Health Perspect. 2017;125(9):097020. doi:10.1289/EHP1302
  • O'Brien KM, Upson K, Cook NR, Weinberg CR. Environmental chemicals in urine and blood: improving methods for creatinine and lipid adjustment. Environ Health Perspect. 2016;124(2):220–227. doi:10.1289/ehp.1509693

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