Diet and Health: Apple Polyphenols as Antioxidants

References

• Van Duyn , M.A.S. and Pivonka , E. 2000 . Overview of the health benefits of fruit and vegetable consumption for the dietetics professional: Selected literature . J. Am. Diet. Ass. , 100 ( 12 ) : 1511 – 1521 .
   PubMed Web of Science ®Google Scholar
• Steinmetz , K.A. and Potter , J.D. 1996 . Vegetables, fruit, and cancer prevention: A review . J. Am. Diet. Assoc. , 96 : 1027 – 1039 .
   PubMed Web of Science ®Google Scholar
• Fulker , M.J. 2001 . The role of fruit in the diet . J. Environ. Radioactiv. , 52 : 147 – 157 .
   PubMed Web of Science ®Google Scholar
• Vinson , J.A. , Su , X. , Zubik , L. and Bose , P. 2001 . Phenol antioxidant quantity and quality in foods: fruits . J. Agric. Food Chem. , 49 : 5315 – 5321 .
   PubMed Web of Science ®Google Scholar
• Shoji , T. , Akazome , Y. , Kanda , T. and Ikeda , M. 2004 . The toxicology and safety of apple polyphenol extract . Food Chem. Toxicol. , 42 : 959 – 967 .
   PubMed Web of Science ®Google Scholar
• Scalbert , A. and Williamson , G. 2000 . Dietary intake and bioavailability of polyphenols . J. Nutr. , 130 : 2073S – 2085S .
   PubMed Web of Science ®Google Scholar
• Rice-Evans , C.A. , Miller , N.J. and Paganga , G. 1997 . Antioxidant properties of phenolic compounds . Trends Plant Sci. , 2 : 152 – 159 .
   Web of Science ®Google Scholar
• Kombrink , E. and Somssich , I.E. 1995 . Defense responses of plants to pathogens . Adv. Bot. Res. , 21 : 1 – 34 .
   Web of Science ®Google Scholar
• Imeh , U. and Khokhar , S. 2002 . Distribution of conjugated and free phenols in fruits: antioxidant activity and cultivar variations . J. Agric. Food Chem. , 50 : 6301 – 6306 .
   PubMed Web of Science ®Google Scholar
• Wolfe , K. , Wu , X. and Liu , R.H. 2003 . Antioxidant activity of apple peels . J. Agric. Food Chem. , 51 : 609 – 614 .
   PubMed Web of Science ®Google Scholar
• McGhie , T.K. , Hunt , M. and Barnett , L.E. 2005 . Cultivar and growing region determine the antioxidant polyphenolic concentration and composition of apples grown in New Zealand . J. Agric. Food Chem. , 53 : 3065 – 3070 .
   PubMed Web of Science ®Google Scholar
• Tsao , R. , Yang , R. , Xie , S. , Sockovie , S. and Khanizadeh , S. 2005 . Which polyphenolic compounds contribute to the total antioxidant activities of apple? . J. Agric. Food Chem. , 53 : 4989 – 4995 .
   PubMed Web of Science ®Google Scholar
• Vrhovsek , U. , Rigo , A. , Tonon , D. and Mattivi , F. 2004 . Quantitation of polyphenols in different apple varieties . J. Agric. Food Chem. , 52 : 6532 – 6538 .
   PubMed Web of Science ®Google Scholar
• Manach , C. and Donovan , J.L. 2004 . Pharmacokinetics and metabolism of dietary flavonoids in humans . Free Radic. Res. , 38 : 771 – 785 .
   PubMed Web of Science ®Google Scholar
• Cowan , M.M. 1999 . Plant products as antimicrobial agents . Clin. Microbiol. Rev. , 12 : 564 – 582 .
   PubMed Web of Science ®Google Scholar
• Harborne , J.B. and Williams , Ch.A. 2000 . Advances in flavonoid research since 1992 . Phytochem. , 55 : 481 – 504 .
   PubMed Web of Science ®Google Scholar
• Hunter , M.D. and Hull , L.A. 1993 . Variation in concentration of phloridzin and phloretin in apple foliage . Phytochem. , 34 : 1251 – 1254 .
   Web of Science ®Google Scholar
• Basaran , N. , Quintero-Ramos , A. , Moake , M.M. , Churey , J.J. and Worobo , R.W. 2004 . Influence of apple cultivars on inactivation of different strains of Escherichia coli O157:H7 in apple cider by UV irradiation . Appl. Environ. Microbiol. , 70 : 6061 – 6165 .
   PubMed Web of Science ®Google Scholar
• Reinders , R.D. , Biesterveld , S. and Bijker , P.G. 2001 . Survival of Escherichia coli O157:H7 ATCC 43895 in a model apple juice medium with different concentrations of praline and caffeic acid . Appl. Environ. Microbiol. , 67 : 2863 – 2866 .
   PubMed Web of Science ®Google Scholar
• Mikulič Petkovšek , M. , Usenik , V. and Štampar , F. 2003 . The role of chlorogenic acid in the resistance of apples to apple scab (Venturia inaequalis (Cooke) G. Wind. Aderh . Zb. Bioteh. Fak. Univ. Ljublj. Kmet , 81 : 233 – 242 .
   Google Scholar
• Michalek , S. , Mayr , U. , Treutter , D. , Lux-Endrich , A. , Gutmann , M. , Feucht , W. and Geibel , M. 1999 . Role of flavan-3-ols in resistance of apple trees to Venturia inaequalis . Acta Horticult. , 484 : 535 – 539 .
   Google Scholar
• Burda , S. , Oleszek , W. and Lee , C.Y. 1990 . Phenolic compounds and their changes in apples during maturation and cold storage . J. Agric. Food Chem. , 38 : 945 – 948 .
   Web of Science ®Google Scholar
• Guyot , S. , Le Bourvellec , C. , Marnet , N. and Drilleau , J.F. 2002 . Procyanidins are the most abundant polyphenols in dessert apples at maturity . Lebensm.-Wiss. u.-Technol. , 35 : 289 – 291 .
   Web of Science ®Google Scholar
• Chinnici , F. , Bendini , A. , Gaiani , A. and Riponi , C. 2004 . Radical scavenging activities of peels and pulps from cv. Golden Delicious apples as related to their phenolic composition . J. Agric. Food Chem. , 52 : 4684 – 4689 .
   PubMed Web of Science ®Google Scholar
• Spanos , G.A. and Wrolstad , R.E. 1992 . Phenolics of apple, pear, and white grape juice and their changes with processing and storage: a review . J. Agric. Food Chem. , 40 : 1478 – 1487 .
   Web of Science ®Google Scholar
• Pearson , D.A. , Tan , Ch.H. , German , J.B. , Davis , P.A. and Gershwin , M.E. 1999 . Apple juice inhibits human low density lipoprotein oxidation . Life Sci. , 64 : 1913 – 1920 .
   PubMed Web of Science ®Google Scholar
• Van der Sluis , A.A. , Dekker , M. , Skrede , G. and Jongen , W.M.F. 2002 . Activity and concentration of polyphenolic antioxidants in apple juice. 1. Effect of existing production methods . J. Agric. Food Chem. , 50 : 7211 – 7219 .
   PubMed Web of Science ®Google Scholar
• Van der Sluis , A.A. , Dekker , M. , Skrede , G. and Jongen , W.M.F. 2004 . Activity and concentration of polyphenolic antioxidants in apple juice. 2. Effect of novel production methods . J. Agric. Food Chem. , 52 : 2840 – 2848 .
   PubMed Web of Science ®Google Scholar
• Van der Sluis , A.A. , Dekker , M. and van Boekel , M.A.J.S. 2005 . Activity and concentration of polyphenolic antioxidants in apple juice. 3. Stability during storage . J. Agric. Food Chem. , 53 : 1073 – 1080 .
   PubMed Web of Science ®Google Scholar
• Vanzani , P. , Rossetto , M. , Rigo , A. , Vrhovsek , U. , Mattivi , F. , D'Amato , E. and Scarpa , M. 2005 . Major phytochemicals in apple cultivars: Contribution to peroxyl radical trapping efficiency . J. Agric. Food Chem. , 53 : 3377 – 3382 .
   PubMed Web of Science ®Google Scholar
• Lee , K.W. , Kim , Y.J. , Kim , D.-O. , Lee , H.J. and Lee , Ch.Y. 2003 . Major phenolics in apple and their contribution to the total antioxidant capacity . J. Agric. Food Chem. , 51 : 6516 – 6520 .
   PubMed Web of Science ®Google Scholar
• Day , A.J. , DuPont , M.S. , Ridley , S. , Rhodes , M. , Rhodes , M.J.C. , Morgan , M.R.A. and Williamson , G. 1998 . Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver β-glucosidase activity . FEBS Lett. , 436 : 71 – 75 .
   PubMed Web of Science ®Google Scholar
• Havsteen , B.H. 2002 . The biochemistry and medical significance of the flavonoids . Pharmacol. Therapeut. , 96 : 67 – 202 .
   PubMed Web of Science ®Google Scholar
• Crespy , V. , Morand , Ch. , Besson , C. , Manach , C. , Demigne , Ch. and Remesy , Ch. 2002 . Quercetin, but not its glycosides, is absorbed from the rat stomach . J. Agric. Food Chem. , 50 : 618 – 621 .
   PubMed Web of Science ®Google Scholar
• Jenner , A.M. , Rafter , J. and Halliwell , B. 2005 . Human fecal water content of phenolics: The extent of colonic exposure to aromatic compounds . Free Radical Biol. Med. , 38 : 763 – 772 .
   PubMed Web of Science ®Google Scholar
• Crespy , V. , Morand , Ch. , Manach , C. , Besson , C. , Demigne , Ch. and Remesy , Ch. 1999 . Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen . Am. J. Physiol. , 277 : G120 – G126 .
   PubMed Web of Science ®Google Scholar
• Pforte , H. , Hempel , J. and Jacobasch , G. 1999 . Distribution pattern of a flavonoid extract in the gastrointestinal lumen and wall of rats . Nahrung , 43 : 205 – 208 .
   PubMedGoogle Scholar
• Scalbert , A. , Deprez , S. , Mila , I. , Albrecht , A.M. , Huneau , J.F. and Rabot , S. 2000 . Proanthocyanidins and human health: systemic effects and local effects in the gut . Biofactors , 13 : 115 – 120 .
   PubMed Web of Science ®Google Scholar
• Stahl , W. , van den Berg , H. , Arthur , J. , Bast , A. , Dainty , J. , Faulks , R. , Gartner , C. , Haenen , G. , Hallman , P. , Holst , B. , Kelly , F.J. , Polidori , M.C. , Rice-Evans , C. , Southon , S. , van Vliet , T. , Vina-Ribes , J. , Williamson , G. and Astley , S.B. 2002 . Bioavailability and metabolism . Mol. Aspects Med. , 23 : 39 – 100 .
   PubMed Web of Science ®Google Scholar
• Rechner , A.R. , Kuhnle , G. , Bremner , P. , Hubbard , G.P. , Moore , K.P. and Rice-Evans , C.A. 2002 . The metabolic fate of dietary polyphenols in humans . Free Radic. Biol. Med. , 33 : 220 – 235 .
   PubMed Web of Science ®Google Scholar
• Rechner , A.R. , Kuhnle , G. , Hu , H.L. , Roedig-Penman , A. , Braak , M.V.D. , Moore , K.P. and Rice-Evans , C. 2002 . The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites . Free Radic. Res. , 36 : 1229 – 1241 .
   PubMed Web of Science ®Google Scholar
• Scalbert , A. , Morand , C. , Manach , C. and Remesy , C. 2002 . Absorption and metabolism of polyphenols in the gut and impact on health . Biomed. Pharmacother. , 56 : 276 – 282 .
   PubMed Web of Science ®Google Scholar
• Halliwell , B. , Rafter , J. and Jenner , A.M. 2005 . Health promotion by flavonoids, tocopherols, tocotrienols and other phenols. Direct or indirect effects? Antioxidants or not? . Am. J. Clin Nutr. , 81 : 268S – 276S .
   PubMed Web of Science ®Google Scholar
• Spencer , J.P.E. , Chowrimootoo , G. , Choudhury , R. , Debnam , E. , Srai , S.K. and Rice-Evans , C. 1999 . The small intestine can both absorb and glucuronidate luminal flavonoids . FEBS Lett. , 458 : 224 – 230 .
   PubMed Web of Science ®Google Scholar
• Aura , A.M. , Martin-Lopez , P. , O'Leary , K.A. , Williamson , G. , Oksman-Caldentey , K.M. , Poutanen , K. and Santos-Buelga , C. 2005 . In vitro metabolism of anthocyanins by human gut microflora . Eur. J. Nutr. , 44 : 133 – 142 .
   PubMed Web of Science ®Google Scholar
• Aura , A.M. , O'Leary , K.A. , Williamson , G. , Ojala , M. , Bailey , M. , Puupponen-Pimia , R. , Nuutila , A.M. , Oksman-Caldentey , K.M. and Poutanen , K. 2002 . Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro . J. Agric. Food Chem. , 50 : 1725 – 1730 .
   PubMed Web of Science ®Google Scholar
• Rechner , A.R. , Smith , M.A. , Kuhnle , G. , Gibson , G.R. , Debnam , E.S. , Srai , S.K. , Moore , K.P. and Rice-Evans , C.A. 2004 . Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products . Free Radic. Biol. Med. , 36 : 212 – 225 .
   PubMed Web of Science ®Google Scholar
• Gonthier , M.-P. , Verny , M.-A. , Besson , C. , Remesy , Ch. and Scalbert , A. 2003 . Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats . J. Nutr. , 133 : 1853 – 1859 .
   PubMed Web of Science ®Google Scholar
• Williamson , G. and Manach , C. 2005 . Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies . Am. J. Clin. Nutr. , 81 : 243S – 255S .
   PubMed Web of Science ®Google Scholar
• Heo , H.J. and Lee , Ch.Y. 2004 . Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegradation . J. Agric. Food Chem. , 52 : 7514 – 7517 .
   PubMed Web of Science ®Google Scholar
• Aprikian , O. , Busserolles , J. , Manach , C. , Mazur , A. , Morand , Ch. , Davicco , M.-J. , Besson , C. , Rayssiguier , Y. , Rémésy , Ch. and Demigné , Ch. 2002 . Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese Zucker rats . J. Nutr. , 132 : 1969 – 1976 .
   PubMed Web of Science ®Google Scholar
• Leontowicz , M. , Gorinstein , S. , Leontowicz , H. , Krzeminski , R. , Lojek , A. , Katrich , E. , Číž , M. , Martin-Belloso , O. , Soliva-Fortuny , R. , Haruenkit , R. and Trakhtenberg , S. 2003 . Apple and pear peel and pulp and their influence on plasma lipids and antioxidant potentials in rats fed cholesterol-containing diets . J. Agric. Food Chem. , 51 : 5780 – 5785 .
   PubMed Web of Science ®Google Scholar
• Liu , R.H. , Liu , J. and Chen , B. 2005 . Apples prevent mammary tumors in rats . J. Agric. Food Chem. , 53 : 2341 – 2343 .
   PubMed Web of Science ®Google Scholar
• Manach , C. , Mazur , A. and Scalbert , A. 2005 . Polyphenols and prevention of cardiovascular diseases . Curr. Opin. Lipidol. , 16 : 77 – 84 .
   PubMed Web of Science ®Google Scholar
• Lotito , S.B. and Frei , B. 2004 . Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects . Free Radic. Biol. Med. , 36 ( 2 ) : 201 – 211 .
   PubMed Web of Science ®Google Scholar
• Lotito , S.B. and Frei , B. 2004 . The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate not apple-derived antioxidant flavonoids . Free Radic. Biol. Med. , 37 ( 2 ) : 251 – 258 .
   PubMed Web of Science ®Google Scholar
• Manach , C. , Scalbert , A. , Morand , Ch. , Rémésy , Ch. and Jiménez , L. 2004 . Polyphenols: food sources and bioavailability . Am. J. Clin. Nutr. , 79 : 727 – 747 .
   PubMed Web of Science ®Google Scholar
• Scalbert , A. , Manach , C. , Morand , C. , Remesy , C. and Jimenez , L. 2005 . Dietary polyphenols and the prevention of diseases . Crit. Rev. Food Sci. Nutr. , 45 : 287 – 306 .
   PubMed Web of Science ®Google Scholar
• Liu , R.H. 2004 . Potential synergy of phytochemicals in cancer prevention: Mechanism of action . J. Nutr. , 134 : 3479S – 3485S .
   PubMed Web of Science ®Google Scholar
• Liu , R.H. 2003 . Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals . Am. J. Clin. Nutr. , 78 : 517S – 520S .
   PubMed Web of Science ®Google Scholar
• Cilliers , J.J. , Singleton , V.L. and Lamuela-Raventos , R.M. 1990 . Total polyphenols in apples and ciders; Correlation with chlorogenic acid . J. Food Sci. , 55 : 1458 – 1459 .
   Web of Science ®Google Scholar
• Gardner , P.T. , White , T.A.C. , McPhail , D.B. and Duthie , G.G. 2000 . The relative contributions of vitamin C, carotenoids and phenolics to the antioxidant potential of fruit juices . Food Chem. , 68 : 471 – 474 .
   Web of Science ®Google Scholar
• Boyer, J.; Liu, R.H. Apple phytochemicals and their health benefits. Nutrition J. 2004, 3, 5 http://www.nutritionj.com/content/3/1/5
   Google Scholar
• Hamauzu , Y. , Yasui , H. , Inno , T. , Kume , Ch. and Omanyuda , M. 2005 . Phenolic profile, antioxidant property, and anti-ifluenza viral activity of Chinese quince (Pseudocydonia sinensis Schneid.), quince (Cydonia oblonga Mill.), and apple (Maalus domestica Mill.) fruits . J. Agric. Food Chem. , 53 : 928 – 934 .
   PubMed Web of Science ®Google Scholar
• Leontowicz , M. , Gorinstein , S. , Lojek , A. , Leontowicz , H. , Číž , M. , Soliva-Fortuny , R. , Park , Y.-S. , Jung , S.-T. , Trakhtenberg , S. and Martin-Belloso , O. 2002 . Comparative content of some bioactive compounds in apples, peaches and pears and their influence on lipids and antioxidant capacity in rats . J. Nutr. Biochem. , 13 : 603 – 610 .
   PubMed Web of Science ®Google Scholar
• Hassimotto , N.M.A. , Genovese , M.I. and Lajolo , F.M. 2005 . Antioxidant activity of dietary fruits, vegetables, and commercial frozen pulps . J. Agric. Food Chem. , 53 : 2928 – 2935 .
   PubMed Web of Science ®Google Scholar
• Ju , Z. and Bramlage , W.J. 1999 . Phenolics and lipid-soluble antioxidants in fruit cuticle of apples and their antioxidant activities in model systems . Postharvest Biol. Technol. , 16 : 107 – 118 .
   Web of Science ®Google Scholar
• Leja , M. , Mareczek , A. and Ben , J. 2003 . Antioxidant properties of two cultivars during long-term storage . Food Chem. , 80 : 303 – 307 .
   Web of Science ®Google Scholar
• Olsson , M.E. , Gustavsson , K.E. , Andersson , S. , Nilsson , Å. and Duan , R.D. 2004 . Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlation with antioxidant levels . J. Agric. Food Chem. , 52 : 7264 – 7271 .
   PubMed Web of Science ®Google Scholar
• Dekker , M. , Verkerk , R. , Van der Sluis , A.A. , Khokhar , S. and Jongen , W.M.F. 1999 . Analysing the antioxidant activity of food products: Processing and matrix effects . Toxicol. in Vitro , 13 : 797 – 799 .
   PubMed Web of Science ®Google Scholar
• Garcia-Alonso , M. , de Pascual-Teresa , S. , Santos-Buelga , C. and Rivas-Gonzalo , J.C. 2004 . Evaluation of the antioxidant properties of fruits . Food Chem. , 84 : 13 – 18 .
   Web of Science ®Google Scholar
• Spanos , G.A. , Wrolstad , R.E. and Heatherbell , D. 1990 . Influence of processing and storage on the phenolic composition of apple juice . J. Agric. Food Chem. , 38 : 1572 – 1579 .
   Web of Science ®Google Scholar
• Suarez , B. , Picinelli , A. , Moreno , J. and Mangas , J.J. 1998 . Changes in phenolic composition of apple juices by HPLC with direct injection . J. Sci. Food Agric. , 78 : 461 – 465 .
   Web of Science ®Google Scholar
• Stopar , M. , Bolcina , U. , Vanzo , A. and Vrhovsek , U. 2002 . Lower crop load for cv. Jonagold apples (Malus x domestica Borkh.) increases polyphenol content and fruit quality . J. Agric. Food Chem. , 50 : 1643 – 1646 .
   PubMed Web of Science ®Google Scholar
• Chinnici , F. , Gaiani , A. , Natali , N. , Riponi , C. and Galassi , S. 2004 . Improved HPLC determination of phenolic compounds in cv. Golden Delicious apples using a monolithic column . J. Agric. Food Chem. , 52 : 3 – 7 .
   PubMed Web of Science ®Google Scholar
• Lattanzio , V. , Di Venere , D. , Linsalata , V. , Bertolini , P. , Ippolito , A. and Salerno , M. 2001 . Low temperature metabolism of apple phenolics and quiescence of Phlyctaena vagabunda . J. Agric. Food Chem. , 49 : 5817 – 5821 .
   PubMed Web of Science ®Google Scholar
• Bitsch , R. , Netzel , M. , Carle , E. , Strass , G. , Kesenheimer , B. , Herbst , M. and Bitsch , I. 2001 . Bioavailability of antioxidative compounds from Brettacher apple juice in humans . Innov. Food Sci. Emerg. Technol. , 1 : 245 – 249 .
   Google Scholar
• Sun , J. , Chu , Y.-F. , Wu , X. and Liu , R.H. 2002 . Antioxidant and antiproliferative activities of common fruits . J. Agric. Food Chem. , 50 : 7449 – 7454 .
   PubMed Web of Science ®Google Scholar
• Rababah , T.M. , Ereifej , K.I. and Howard , L. 2005 . Effect of ascorbic acid and dehydratation on concentrations of total phenolics, antioxidant capacity, anthocyanins, and color in fruits . J. Agric. Food Chem. , 53 : 4444 – 4447 .
   PubMed Web of Science ®Google Scholar