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Original Articles

Biological Properties and Characterization of Lectin from Red Kidney Bean (Phaseolus Vulgaris)

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Pages 12-27 | Published online: 24 Dec 2008

References

  • Kocourek , J. and Horejsi , V. 1981 . Defining a lectin . Nature , 290 ( 5803 ) : 188 – 193 .
  • Rudiger , H. and Gabius , H.J. 2001 . Plant lectins: Occurrence, biochemistry, functions, and applications . Glycoconj J. , 18 ( 8 ) : 589 – 613 .
  • Wong , J.H. and Ng , T.B. 2003 . Purification of a trypsin-stable lectin with antiproliferative and HIV-1 reverse transcriptase inhibitory activity . Biochem. Biophys. Rs. Commun. , 301 : 545 – 550 .
  • Barrientos , L.G. and Gronenborn , A.M. 2005 . The highly specific carbohydrate-binding protein cyanovirin-N: Structure, anti-HIV/Ebola activity and possibilities for therapy . Mini. Rev. Med. Chem. , 5 : 21 – 31 .
  • Xia , L. and Ng , T.B. 2006 . Ahemagglutinin with mitogenic activity from dark red kidney beans . J. Chroma. B. , 844 : 213 – 216 .
  • Rudiger , H. , Siebert , H.C. , Solis , D. , Jimenez-Barbero , J. , Romero , A. von der Lieth , C.W. 2000 . Medicinal chemistry based on the sugar code: Fundamentals of lectinology and experimental strategies with lectins as targets . Curr. Med. Chem. , 7 ( 4 ) : 389 – 416 .
  • Ma , Z.Y. , Guan , Y.P. and Liu , H.Z. 2006 . Affinity adsorption of albumin on Cibacro Blue F3GA-couples non-porous micrometer-sized magnetic polymer microspheres . Reactive and Functional Polymers , 66 : 618 – 624 .
  • Tetala , K.K.R. , Chen , B. , Visser , G.M. , Maruska , A. , Kornysova , O. , Beek , T.A. and Sudholter , E.J.R. 2007 . Preparation of a monolithic capillary column with immobilized α-mannose for affinity chromatography of lectins . J. Biochem. Biophys. Methods , 70 : 63 – 69 .
  • Latha , V.L. , Rao , R.N. and Nadimpalli , S.K. 2006 . Affinity purification, physicochemical and immunological characterization fo a galactose-specific lectin from the seeds of Dolichos Lablab (Indian lablab beans) . Protein Expression and Purification , 45 : 296 – 306 .
  • Ye , X.Y. , Ng , T.B. , Tsang , P.W.K. and Wang , J. 2001 . Isolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (phaseolus vulgaris) seeds . J. Protein Chem. , 20 ( 5 ) : 367 – 375 .
  • Wong , J.H. and Ng , T.B. 2003 . Purification of a trypsin-stable lectin with antiproliferative and HIV-1 reverse transcriptase inhibitory activity . Biochem Biophys Res Commun. , 301 ( 2 ) : 545 – 550 .
  • Ye , X.Y. and Ng , T.B. 2001 . Peptides from pinto bean and red bean with sequence homology to cowpea 10-kDa protein precursor exhibit antifungal, mitogenic, and HIV-1 reverse transcriptase-inhibitory activities . Biochem. Biophys. Res. Commun. , 285 ( 2 ) : 424 – 249 .
  • Adeparusi , E.O. 2001 . Effect of processing on the nutrients and anti-nutrients of lima bean (Phaseolus Lunatus L.) flour . Nahrung. , 45 : 94 – 96 .
  • Vasconcelos , I.M. , Siebra , E.A. , Maia , A.A.B. , Moreira , R.A. , Neto , A.F. , Campelo , G.J.A. and Oliveira , J.T.A. 1997 . Composition, toxic and antinutritional factors of newly developed cultivars of Brazilan soybean (Glycine max) . J. Sci. Food Agric. , 75 : 419 – 426 .
  • Pusztai , A. 2003 . “ Effects of lectin ingestion on animal growth and internal organs, in lectin methods and protocols ” . In Lectin Methods and Protocols , Edited by: Rhodes , J.M. and Milton , J.D. 485 – 514 . Totowa, New Jersey : Humana Press .
  • Pusztai , A. and Bardocz , S. 1996 . Biological effects of plant lectins on the gastrointestinal tract: Metabolic consequences and applications . Trends in Glycoscience and Glycotechnology , 8 ( 41 ) : 149 – 165 .
  • Sturm , A. and Chrispeels , M.J. 1986 . The high manose ologosaccharide of phytohemagglutinin is attached to asparagine-12 and the modified oligosaccharide to asparagine-60 . Plant Physiol. , 81 ( 1 ) : 320 – 322 .
  • Leavitt , RD , Felsted , RL and Bachur , NR. 1997 . Biological and biochemical properties of Phaseolus Vulgaris Isolctins . J. Biolog. Chemi. , 252 : 2961 – 2966 .
  • Lectin (homepage on the Internet). Teikyo University, Faculty of Pharmaceutical Sciences, Teikyo, 1997 December 15, 1997 http://www.glycoforum.gr.jp/science/word/lectin/LEA00E.html (Accessed: 28 November 2004 ).
  • Thomas , W. , Hamelryck , T.W. , Minh-Hoa Dao-Thi , M.H. , Poortmans , F. , Chrispeels , M.J. Wyns , L. 1996 . The crystallographic structure of phytohemagglutinin-L . J. Biolog. Chemi. , 27 ( 34 ) : 20479 – 20485 .
  • Sharon , N. and Lis , H. 2003 . Lectins , 2nd , Dordrecht, , Netherlands : Kluwer Academic Publishers .
  • Kilpatrick , D.C. , Pusztai , A. , Grant , G. , Graham , C. and Ewan , S.W.B. 1985 . Tomato lectin resists digestion in the mammalian alimentary tract and binds to intestinal villi without deleterious effects . FEBS lett. , 185 : 299 – 305 .
  • Sharon , N. and Lis , H. 1989 . Lectins , 1st , New York : Chapman and Hall .
  • Bardocz , S. , Grant , G. , Ewen , S.W.B. , Duguid , T.J. , Brown , D.S. Englyst , K. 1995 . Reversible effect of phytohemagglutinin on the growth and metabolism of rat gastrointestinal-tract . Gut. , 37 ( 3 ) : 353 – 360 .
  • Reynoso-Camacho , R. , Gaozales de Mejia , E. and Loarca-Pina , G. 2003 . Purification and acute toxicity of a lectin extract from tepory bean (phaseolus acetifoluis) . Food and Chemical Toxicology , 41 : 21 – 27 .
  • Van Damme , E.J.M. , Peumans , W.J. , Pusztai , A. and Bardocz , S. 1998 . Handbook of plant lectins: Properties and biomedical applications , Chichester, , UK : John Wiley & Sons .
  • Augustin , J. and Klein , B.P. 1989 . “ Nutrient composition of raw, cooked, canned and sprouted legumes ” . In Legumes: chemistry, technology, and human nutrition , Edited by: Matthews , R.H. 187 – 217 . New York : Marcel Dekker Inc .
  • Wang , H.D. , lu-Gang , Y. , Campbell , B.J. , Milton , J.D. and Rhodes , J.M. 1999 . Identification of intact peanut lectin in peripheral venous blood . Lancet. , 352 : 1831 – 1832 .
  • Wang , H.X. and Ng , T.B. 2003 . Alocasin, an anti-fungal protein from rhizomes of the giant taro alocasia macrorrhiza . Protein Expr Purif. , 28 ( 1 ) : 9 – 14 .
  • D'Costa , S.S. and Hurwitz , J.L. 2003 . Phytohemagglutinin inhibits lymphoid tumor growth in votro and in vivo . Leukemia & Lymphoma , 44 ( 10 ) : 1785 – 1791 .
  • Balzarini , J. , Neyetes , J. , Schols , D. , Hosoya , M. , Van DAmme , E. Peumans , W. 1992 . The mannose-specific plant-lectins from cymbidium hybrid and epipactis-helleborine and the (n-acetylglucosamine) n-specific plant lectin from urtica-dioica are potent and selective inhibitors of human-immunodeficiency-virus and cytomegalovirus replication in vitro . Antiviral Res. , 18 ( 2 ) : 191 – 207 .
  • Animashaun , T. , Mahmood , N. , Hay , A.J. and Hughes , R.C. 1993 . Inhibitory effect of novel mannose binding lectins on HIV-infectivity and syncytium formation . Antiviral Chemistry and Chemotherapy , 4 : 145 – 153 .
  • Mori , T. and Boyd , M.R. 2001 . Cyanovirin-N, a potent hunam immunodeficiency virus inactivation protein, bloks both CD4-dependant binding of soluble gp120 (sgp120) to target cells, inhibits sCD4-induced binding of sgp120 to cell associated CXCR4, and dissociates bound sgp120 from target cells . Antimicrob Agents Chemother. , 45 : 664 – 672 .
  • Ng , T.B. , Au , T.K. , Lam , T.L. , Ye , X.Y. and Wan , D.C.C. 2002 . Inhibitory effects of antifungal proteins on human immunodeficiency virus type 1 reverse transcriptase, protease and integrase . Life Sci. , 70 ( 8 ) : 927 – 935 .
  • Ye , X.Y. and Ng , T.B. 2002 . Delandin, a chitinase-like protein with antifungal, HIV-1 reverse transcriptase inhibitory and mitogenic activities from the rice bean delandia umbellata . Protein Expr Purif. , 24 ( 3 ) : 524 – 529 .
  • Ye , X.Y. and Ng , T.B. 2001 . Isolation of unguilin, a cyclophilin-like protein with anti-mitogenic, antiviral, and antifungal activities, from black-eyed pea . J. Protein Chem. , 20 ( 5 ) : 353 – 359 .
  • Ye , X.Y. , Wang , H.X. and Ng , T.B. 2000 . Structurally dissimilar proteins with antiviral and antifungal potency from cowpea (vigna unguiculata) seeds . Life Sci. , 67 ( 26 ) : 3199 – 3207 .
  • HIV-1 reverse transcriptase. 2004 http://www.clunet.edu/BioDev/omm/gallery.htm (Accessed: 14 July 2004 ).
  • Vaishnav , Y.N. and Wong-Staal , F. 1991 . Biochemistry of AIDS . Annu Rev Biochem. , 60 : 577 – 630 .
  • Pryme , I.F. , Bardocz , S. , Pusztai , A. and Ewen , S.W.B. 1999 . The growth of an established murine non-hodgkin lymphoma tumour is limited by switching to a phytohaemagglutinin-containing diet . Cancer Lett. , 146 ( 1 ) : 87 – 91 .
  • Pryme , I.F. , Pusztai , A. , Bardocz , S. and Ewen , S.W.B. 1999 . A combination of dietary protein depletion and PHA-induced gut growth reduce the mass of a murine non-hodgkin lymphoma . Cancer Lett. , 139 ( 2 ) : 145 – 152 .
  • Schaffrath , B. , Mengs , U. , Schwarz , T. , Hilgers , R.D. , Beuth , J. Mockel , B. 2001 . Anticancer activity of rViscumin (recombinant mistletoe lectin) in tumor colonization models with immunocompetent mice . Anticancer Res. , 21 ( 6A ) : 3981 – 3987 .
  • Hajto , T. , Berki , T. , Boldizsar , F. and Nemeth , P. 2003 . Galacto side-specific plant lectin, viscum album agglutinin-I induces enhanced proliferation and apoptosis of murine thymocytes in vivo . Immunol Lett. , 86 ( 1 ) : 23 – 27 .

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