Technological and Bioactive Functionalities of Canola Meal Proteins and Hydrolysates

References

• Tan , S.H. , Mailer , R.J. , Blanchard , C.L. and Agboola , S.O. 2011 . Canola proteins for human consumption: Extraction, profile, and functional properties . J. Food Sci. , 76 : R16 – R28 .
   PubMed Web of Science ®Google Scholar
• United States Department of Agriculture (USDA) . 2010 . Soybeans and Oil Crops: Canola , Washington , DC : USDA Economic Research Service .
   Google Scholar
• Howard , B . 1993 . Oils and Oilseeds to 1996: The New Patterns of Supply and Demand , New York and London : Economist Intelligence Unit .
   Google Scholar
• Van Etten , C.H. , Daxenbichler , M.E. and Wolff , I.A. 1969 . Natural glucosinolates (thioglucosides) in foods and feeds . J. Agric. Food Chem. , 17 : 483 – 491 .
   Web of Science ®Google Scholar
• Khattab , R.Y. and Arntfield , S.D. 2009 . Functional properties of raw and processed canola meal . LWT Food Sci. Technol. , 42 : 1119 – 1124 .
   Web of Science ®Google Scholar
• Pastuszewska , B. , Jablecki , G. , Swiech , E. , Buraczewska , L. and Ochtabinska , A. 2000 . Nutritional value of rapeseed meal containing lecithin gums precipitated with citric acid . Anim. Feed Sci. Technol. , 86 : 117 – 123 .
   Web of Science ®Google Scholar
• Kumar , V. , Sinha , A.K. , Makkar , H.P.S. and Becker , K. 2010 . Dietary roles of phytate and phytase in human nutrition: A review . Food Chem. , 120 : 945 – 959 .
   Web of Science ®Google Scholar
• Vucenik , I. , Sakamoto , K. , Bansal , M. and Shamsuddin , A.M. 1993 . Inhibition of rat mammary carcinogenesis by inositol hexaphosphate (phytic acid). A pilot study . Cancer Lett , 75 : 95 – 102 .
   PubMed Web of Science ®Google Scholar
• Matthäus , B. 2002 . Antioxidant activity of extracts obtained from residues of different oilseeds. J. Agric . Food Chem. , 50 : 3444 – 3452 .
   Web of Science ®Google Scholar
• Aider , M. and Barbana , C. 2011 . Canola proteins: Composition, extraction, functional properties, bioactivity, applications as a food ingredient and allergenicity: A practical and critical review . Trends Food Sci. Technol. , 22 : 21 – 39 .
   Web of Science ®Google Scholar
• Jensen , S.K. , Liu , Y.B. and Eggum , B.O. 1995 . The effect of heat treatment on glucosinolates and nutritional value of rapeseed meal in rats . Anim. Feed Sci. Technol. , 53 : 17 – 28 .
   Web of Science ®Google Scholar
• Naczk , M. , Diosady , L.L. and Rubin , L.J. 1986 . The phytate and complex phenol content of meals produced by alkanol-ammonia/hexane extraction of canola . Lebensm.-Wiss. U. Technol. , 19 : 13 – 16 .
   Google Scholar
• Schwenke , K.D. , Kroll , J. , Lange , R. , Kujawa , M. , Schnaak , W. and Steinert , A. 1990 . Preparation of detoxified high functional rapeseed flours . J. Sci. Food Agric. , 51 : 391 – 405 .
   Web of Science ®Google Scholar
• Zhou , B. , He , Z.Q. , Yu , H.M. and Mukherjee , K.D. 1990 . Proteins from double-zero rapeseed . J. Agric. Food Chem. , 38 : 690 – 694 .
   Web of Science ®Google Scholar
• Jensen , S.K. , Olsen , H.S. and Sørensen , H. 1990 . “ Aqueous enzymatic processing of rapeseed for production of high quality products ” . In Rapeseed/Canola: Production, Chemistry, Nutrition and Processing TechnologyVan Nostrand Reinhold Publisher Edited by: Shahidi , F. 331 – 343 . New York
   Google Scholar
• Cosgrove , D.J. 1980 . “ Inositol Phosphates: Their Chemistry, Biochemistry and Physiology ” . In Elsevier Science 191 New York
   Google Scholar
• Vioque , J. , Sánchez-Vioque , R. , Clemente , A. , Pedroche , J. and Millán , F. 2000 . Partially hydrolyzed rapeseed protein isolates with improved functional properties . J. Am. Oil Chem. Soc. , 77 : 447 – 450 .
   Web of Science ®Google Scholar
• Bos , C. , Airinei , G. , Mariotti , F. , Benamouzig , R. , Bérot , S. , Evrard , J. , Fénart , E. , Tomé , D. and Gaudichon , C. 2007 . The poor digestibility of rapeseed protein is balanced by its very high metabolic utilization in humans . J. Nutr. , 137 : 594 – 600 .
   PubMed Web of Science ®Google Scholar
• Paulson , A.T. and Tung , M.A. 1989 . Thermally induced gelation of succinylated canola protein isolate . J. Agric. Food Chem. , 37 : 319 – 326 .
   Web of Science ®Google Scholar
• Vioque , J. , Sánchez-Vioque , R. , Clemente , A. , Pedroche , J. , Bautista , J. and Millan , F. 1999 . Production and characterization of an extensive rapeseed protein hydrolysate . J. Am. Oil Chem. Soc. , 76 : 819 – 823 .
   Web of Science ®Google Scholar
• Cumby , N. , Zhong , Y. , Naczk , M. and Shahidi , F. 2008 . Antioxidant activity and water-holding capacity of canola protein hydrolysates . Food Chem. , 109 : 144 – 148 .
   PubMed Web of Science ®Google Scholar
• Farges-Haddani , B. , Tessier , B. , Chenu , S. , Chevalot , I. , Harscoat , C. , Marc , I. , Goergen , J.L. and Marc , A. 2006 . Peptide fractions of rapeseed hydrolysates as an alternative to animal proteins in CHO cell culture media . Process Biochem. , 41 : 2297 – 2304 .
   Web of Science ®Google Scholar
• Pinterits , A. and Arntfield , S.D. 2007 . The effect of limited proteolysis on canola protein gelation . Food Chem. , 102 : 1337 – 1343 .
   Web of Science ®Google Scholar
• Panyam , D. and Kilara , A. 1996 . Enhancing the functionality of food proteins by enzymatic modification . Trends Food Sci. Technol. , 7 : 120 – 125 .
   Web of Science ®Google Scholar
• Wu , J. , Aluko , R.E. and Muir , A.D. 2008 . Purification of angiotensin I converting enzyme-inhibitory peptides from the enzymatic hydrolysate of defatted canola meal . Food Chem. , 111 : 942 – 950 .
   Web of Science ®Google Scholar
• Rutherfurd-Markwick , K.J. and Moughan , P.J. 2005 . Bioactive peptides derived from food . J. Am. Oil Chem. Soc. Int. , 88 : 955 – 966 .
   Google Scholar
• Moure , A. , Sineiro , J. , Domínguez , H. and Parajó , J.C. 2006 . Functionality of oilseed protein products: A review . Food Res. Int , 39 : 945 – 963 .
   Web of Science ®Google Scholar
• Moure , A. , Domínguez , H. and Parajó , J.C. 2005 . Fractionation and enzymatic hydrolysis of soluble protein present in waste liquors from soy processing . J. Agric. Food Chem. , 53 : 7600 – 7608 .
   PubMed Web of Science ®Google Scholar
• Pinciroli , M. , Vidal , A.A. , Añón , M.C. and Martínez , E.N. 2009 . Comparison between protein functional properties of two rice cultivars . LWT Food Sci. Technol. , 42 : 1605 – 1610 .
   Web of Science ®Google Scholar
• Tan , S.H. , Mailer , R.J. , Blanchard , C.L. and Agboola , S.O. 2011 . Extraction and characterisation of proteins fractions from Australian canola meals . Food Res Int. , 44 : 1075 – 1082 .
   Web of Science ®Google Scholar
• Höglund , A.S. , Rodin , J. , Larsson , E. and Rask , L. 1992 . Distribution of napin and cruciferin in developing rape seed embryos . Plant Physiol. , 98 : 509 – 515 .
   PubMed Web of Science ®Google Scholar
• Pour-El , A. 1981 . Protein functionality: Classification, definition, and methodology of protein functionality in foods . Am. Chem. Soc. , 147 : 1 – 19 .
   Google Scholar
• Kinsella , J.E. and Whitehead , D.M. 1989 . Proteins in whey: Chemical, physical, and functional properties . Adv. Food Nutr. Res. , 33 : 343 – 438 .
   PubMedGoogle Scholar
• Kinsella , J.E. and Condon , J.J. 1982 . “ Relationship between structure and functional properties of food proteins ” . In Food Proteins , Edited by: Fox , P.F. 51 – 103 . New York : Applied Science Publishers .
   Google Scholar
• Damodaran , S. and Paraf , A. 1997 . Food Proteins and Their Applications , 1 – 24 . New York : New York: Marcel Dekker .
   Google Scholar
• Mattos , C. 2002 . Protein-water interactions in a dynamic world . Trends Biochem. Sci. , 27 : 203 – 208 .
   PubMed Web of Science ®Google Scholar
• Mohamed , I.M. 1994 . Physiochemical and functional properties of protein hydrolysates in nutritional products . Food Technol. Champaign , 48 : 50 – 60 .
   Google Scholar
• Kinsella , J.E. 1979 . Fuctional properties of soy proteins . J. Am. Oil Chem. Soc. , 56 : 242 – 258 .
   Web of Science ®Google Scholar
• Bigelow , C. C. 1967 . On the average hydrophobicity of proteins and the relation between it and protein structure . J. Theor. Biol. , 16 : 187 – 211 .
   PubMed Web of Science ®Google Scholar
• Pedroche , J. , Megías , C. , Yust , M.D.M. , Lqari , H. , Alaíz Barragán , M. , Girón-Calle , J , Alaíz , M. , Vioque , J. and Millán , F. 2004 . Utilisation of rapeseed protein isolates for production of peptides with angiotensin-I-converting enzyme inhibitory activity . Grasas Aceites , 55 : 354 – 358 .
   Web of Science ®Google Scholar
• Ghodsvali , A. , Khodaparast , M.H. , Vosoughi , M. and Diosady , L.L. 2005 . Preparation of canola protein materials using membrane technology and evaluation of meals functional properties . Food Res. Int. , 38 : 223 – 231 .
   Web of Science ®Google Scholar
• Aluko , R.E. , McIntosh , T. and Katepa-Mupondwa , F. 2005 . Comparative study of the polypeptide profiles and functional properties of Sinapis alba and Brassica juncea seed meals and protein concentrates . J. Sci. Food Agric. , 85 : 1937 – 1937 .
   Web of Science ®Google Scholar
• Kroll , J. 1991 . Selected functional properties of detoxified rapeseed protein preparations effected by phytic acid . Food/Nahrung , 35 : 619 – 624 .
   Google Scholar
• Yoshie-Stark , Y. , Wada , Y. and Wäsche , A. 2008 . Chemical composition, functional properties, and bioactivities of rapeseed protein isolates . Food Chem. , 107 : 32 – 39 .
   Web of Science ®Google Scholar
• Dev , D.K. and Mukherjee , K.D. 1986 . Functional properties of rapeseed protein products with varying phytic acid contents . J. Agric. Food Chem. , 34 : 775 – 780 .
   Web of Science ®Google Scholar
• Damodaran , S. 1986 . “ Interrelationship of molecular and functional properties of food proteins ” . In Food Proteins , Edited by: Kinsella , J.E. and Soucie , W.G. 21 – 52 . Champaign , IL : American Oil Chemists' Society .
   Google Scholar
• Ferry , J.D. 1980 . Viscoelastic Properties of Polymers , New York : John Wiley & Sons .
   Google Scholar
• Oakenfull , D. , Pearce , J. and Burley , R.W. 1997 . “ Protein gelation ” . In Food Proteins And Their Applications , Edited by: Damodaran , S. and Paraf , A. 111 – 142 . New York : Marcel Decker .
   Google Scholar
• Pinterits , A. and Arntfield , S.D. 2008 . Improvement of canola protein gelation properties through enzymatic modification with transglutaminase . LWT Food Sci. Technol , 41 : 128 – 138 .
   Web of Science ®Google Scholar
• Hyun , H.E. and Kang , Y.J. 1999 . Gelation of rapeseed protein induced with microbial transglutaminase . Korean J. Food Sci. Technol. , 31 : 1262 – 1267 .
   Google Scholar
• Arntfield , S.D. , Murray , E.D. and Ismond , M.A.H. 1999 . Dependance of thermal properteis as well as network microstructure and rheology on protien concentration for ovalbumin and vicilin . J. Texture Stud. , 21 : 191 – 212 .
   Web of Science ®Google Scholar
• Léger , L.W. and Arntfield , S.D. 1993 . Thermal gelation of the 12s canola globulin. J. Am. Oil Chem. Soc , 70 : 853 – 861 .
   Web of Science ®Google Scholar
• Barnes , H.A. , Hutton , K.F. and Walters , K. 1989 . An introduction to rheology . J. Fluid Mech. , 228 : 694 – 695 .
   Google Scholar
• Mahajan , A. and Dua , S. 1994 . Physicochemical properties of rapeseed (var. Toria) seed proteins: Viscosity and ionizable groups . J. Agric. Food Chem. , 42 : 1411 – 1414 .
   Web of Science ®Google Scholar
• Schwenke , K.D. , Linow , K.J. and Zirwer , D. 1986 . Modification of the oligomeric structure of 11S globulin from sunflower (Helianthus annuus L.) and rape (Brassica napus L.) seeds by succinylation . Food/Nahrung , 30 : 263 – 270 .
   Google Scholar
• Paulson , A.T. and Tung , M.A. 1988 . Rheology and microstructure of succinylated canola protein isolate . J. Food Sci. , 53 : 821 – 825 .
   Web of Science ®Google Scholar
• Friberg , S. , Larsson , K. and Sjöblom , J. 2004 . Food Emulsions , 4th , 2 – 3 . New York : Marcel Dekker .
   Google Scholar
• Dalgleish , D.G. 1997 . Adsorption of protein and the stability of emulsions. Trends Food Sci. Technol , 8 : 1 – 6 .
   Web of Science ®Google Scholar
• Eke , O.S. and Akobundu , E.N.T. 1993 . Functional properties of african yam bean (Sphenostylis stenocarpa) seed flour as affected by processing . Food Chem. , 48 : 337 – 340 .
   Web of Science ®Google Scholar
• Halling , P.J. 1981 . Protein-stabilised foams and emulsions . CRC Crit. Rev Food Sci. Nutr. , 15 : 155 – 203 .
   Google Scholar
• Aluko , R.E. and McIntosh , T. 2001 . Polypeptide profile and functional properties of defatted meals and protein isolates of canola seeds . J. Sci. Food Agric. , 81 : 391 – 396 .
   Web of Science ®Google Scholar
• Kinsella , J.E. , Damodaran , S. and German , B. 1985 . Physicochemical and functional properties of oilseed proteins with emphasis on soy proteins . New Protein Foods , 5 : 107 – 179 .
   Google Scholar
• Lakkis , J. and Villota , R. 1992 . Comparative performance of chemically and enzymatically modified whey proteins . Food Chem. , 43 : 93 – 105 .
   Web of Science ®Google Scholar
• Mahajan , A. and Dua , S. 1998 . Improvement of functional properties of rapeseed (var Toria) meal by reducing antinutritional factors employing enzymatic modification . Food Hydrocoll. , 12 : 349 – 355 .
   Web of Science ®Google Scholar
• Jiang , J. , Chen , J. and Xiong , Y.L. 2009 . Structural and emulsifying properties of soy protein isolate subjected to acid and alkaline pH-shifting processes . J. Agric. Food Chem. , 57 : 7576 – 7583 .
   PubMed Web of Science ®Google Scholar
• Mahajan , A. , Dua , S. and Bhardwaj , S. 2002 . Simple physical treatment as an effective tool to improve the functional properties of rapeseed (Brassica campestris var. Toria) and sesame seed (Sesamum indicum) meals . Int. J. Food Sci. Nutr. , 53 : 455 – 463 .
   PubMed Web of Science ®Google Scholar
• Darmodaran , S. , Hettiarachchy , N.S. and Zeigler , G.R. 1994 . Protein Functionality in Food Systems , 20 – 22 . New York : Marcel Dekker .
   Google Scholar
• Mahajan , A. and Dua , S. 1998 . Role of enzymatic treatments in modifying the functional properties of rapeseed (Brassica campestris var. Toria) meal . Int. J. Food Sci. Nutr. , 49 : 435 – 440 .
   Web of Science ®Google Scholar
• Richert , S.H. , Morr , C.V. and Cooney , C.M. 1974 . Effect of heat and other factors upon foaming properties of whey protein concentrates . J. Food Sci. , 39 : 42 – 48 .
   Web of Science ®Google Scholar
• Chobert , J.M. , Sitohy , M.Z. and Whitaker , J.R. 1988 . Solubility and emulsifying properties of caseins modified enzymatically by Staphylococcus aureus V8 protease . J. Agric. Food Chem. , 36 : 220 – 224 .
   Web of Science ®Google Scholar
• Howell , N.K. 1996 . “ Chemical and enzymatic modifications ” . In Food Proteins Properties and Characterization , Edited by: Nakai , S. and Modler , H.W. 235 – 280 . New York : Wiley-VCH .
   Google Scholar
• Dua , S. , Mahajan , A. and Mahajan , A. 1996 . Improvement of functional properties of rapeseed (Brassica campestris var. Toria) preparations by chemical modification . J. Agric. Food Chem. , 44 : 706 – 710 .
   Web of Science ®Google Scholar
• Ponnaampalam , R. , Deslie , J. , Gagne , Y. and Amiot , J. 1990 . The functional and nutritional properties of acylated rapeseed proteins . J. Am. Oil Chem. Soc. , 67 : 531 – 536 .
   Web of Science ®Google Scholar
• Paulson , A.T. and Tung , M.A. 1988 . Emulsification properties of succinylated canola protein isolate . J. Food Sci. , 53 : 817 – 820 .
   Web of Science ®Google Scholar
• Adler-Nissen , J. 1986 . “ A review of food protein hydrolysis-specific areas ” . In Enzymatic Hydrolysis of Food Proteins , Edited by: Adler-Nissen , J. 57 – 109 . London : Elsevier Applied Science Publishers .
   Google Scholar
• Marczak , E.D. , Usui , H. , Fujita , H. , Yang , Y. , Ykoo , M. , Lipkowski , A.W. and Yoshikawa , M. 2003 . New antihypertensive peptides isolated from rapeseed . Peptides , 24 : 791 – 798 .
   PubMed Web of Science ®Google Scholar
• Pan , M. , Jiang , T.S. and Pan , J.L. 2009 . Antioxidant activities of rapeseed protein hydrolysates . Food Bioprocess Technol. , 4 : 1114 – 1152 .
   Google Scholar
• Schwenke , K.D. 1994 . “ Rapeseed proteins ” . In New and Developing Sources of Food Proteins , Edited by: Hudson , B.J.F. 281 – 306 . London : Chapman & Hall .
   Google Scholar
• Tkachuk , R. 1981 . Oil and protein analysis of whole rapeseed kernels by near infrared reflectance spectroscopy . J. Am. Oil Chem. Soc. , 58 : 819 – 822 .
   Web of Science ®Google Scholar
• Rape Requirement Fund (RRF) . 1986 . Rapes of New Varieties. In Breeding, Cultivation, and Use. Gelseukirchen-assessment , Germany : Bonn .
   Google Scholar
• Ohlson , R. and Anjou , K. 1979 . Rapeseed protein products . J. Am. Food Chem. Soc. , 56 : 431 – 437 .
   Web of Science ®Google Scholar
• Sawar , G. , Blair , R. , Friedman , M. , Gumbmann , M.R. , Hackler , L.R. , Pellett , P.L. and Smith , T.K. 1984 . Inter- and intra-laboratory variability in rat growth assays for estimating protein quality in foods . J. Agric. Food Chem. , 67 : 974 – 976 .
   Google Scholar
• Mnzava , N.A. and Olsson , K. 1990 . Studies on tropical vegetables seeds, amino, fatty acid and glucosinolate profile of ethiopian mustards (Brassica carinata Braun) . Food Chem. , 35 : 229 – 235 .
   Web of Science ®Google Scholar
• Klockeman , D.M. , Toledo , R. and Sims , K.A. 1997 . Isolation and characterization of defatted canola meal protein . J. Agric. Food Chem. , 45 : 3867 – 3870 .
   Web of Science ®Google Scholar
• Shahidi , F. 1990 . Canola and Rapeseed: Production, Chemistry, Nutrition and Processing , 18 London : Chapman and Hall .
   Google Scholar
• Friedman , M. 1996 . Nutritional value of proteins from different food sources: A review . J. Agric. Food Chem. , 44 : 6 – 29 .
   Web of Science ®Google Scholar
• Larbier , Z.M. , Chagneau , A.M. and Lessire , M. 1991 . Bioavailability of lysine in rapeseed and soyabean meals determined by digestibility trial in cockerels and chick growth assay . Anim. Feed Sci. Technol. , 35 : 237 – 246 .
   Web of Science ®Google Scholar
• Wu , W. , Williams , W.P. , Kunkel , M.E. , Acton , J.C. , Huang , Y. , Wardlaw , F.B. and Grimes , L.W. 1996 . Amino acid availability and availability-corrected amino acid score of red kidney beans (Phaseolus vulgaris L.) . J. Agric. Food Chem , 44 : 1296 – 1301 .
   Web of Science ®Google Scholar
• Delisle , J. , Amiot , J. , Brisson , G.J. and Lacroix , M. 1983 . Improvement of rapeseed protein nutritional value . Plant Food. Human Nutr. , 33 : 173 – 177 .
   Web of Science ®Google Scholar
• Delisle , J. , Amiot , J , Dauphin , F. , Roy , A. , Brisson , G.J. and Jones , J.D. 1987 . Nutritive value of rapeseed proteins and fractions supplemented with methionine and tyrosine in rats . Plant Food. Human Nutr. , 37 : 109 – 116 .
   Web of Science ®Google Scholar
• Mwachireya , S.A. , Beames , R.M. , Higgs , D.A. and Dosanjh , B.S. 1999 . Digestibility of canola protein products derived from the physical, enzymatic and chemical processing of commercial canola meal in rainbow trout . Oncorhynchus mykiss (walbaum) held in fresh water. Aquacult. Nutr. , 5 : 73 – 82 .
   Web of Science ®Google Scholar
• Mariscal-Landín , G. , Reis de Souza , T.C. , Parra , S. and Aguilera , B. 2008 . Ileal digestibility of protein and amino acids from canola meal in weaned piglets and growing pigs . Livestock Sci. , 116 : 53 – 62 .
   Web of Science ®Google Scholar
• Anderson , J.S. , Higgs , D.A. , Beames , R.M. and Rowshandeli , M. 1997 . Fish meal quality assessment for atlantic salmon (Salmo salar L.) reared in sea water . Aquacult. Nutr. , 3 : 25 – 38 .
   Web of Science ®Google Scholar
• Parsons , C.M. , Hashimoto , K. , Wedekind , K.J. , Han , Y. and Baker , D.H. 1992 . Effect of overprocessing on availabilty of amino acids and energy in soybean meal . Poult. Sci. , 71 : 133 – 150 .
   Web of Science ®Google Scholar
• Krissansen , G.W. 2007 . Emerging health properties of whey proteins and their clinical implications . J. Am. Coll. Nutr. , 26 : 713S – 723S .
   PubMed Web of Science ®Google Scholar
• Shahidi , F. and Zhong , Y. 2008 . Bioactive peptides . J. Am. Oil Chem. Soc. Int. , 91 : 914 – 931 .
   Google Scholar
• Adler-Nissen , J. 1976 . Enzymic hydrolysis of proteins for increased solubility . J. Agric. Food Chem. , 24 : 1090 – 1093 .
   PubMed Web of Science ®Google Scholar
• Robinson , D.S. 1987 . “ Enzyme catalysed hydrolysis of proteins ” . In Food Biochemistry and Nutritional Values , Edited by: Robinson , D.S. 152 – 179 . London : Longman Scientific and Technical .
   Google Scholar
• Pedroche , J. , Yust , M.D.M. , Giron-Calle , J. , Alaiz , M. , Millan , F. and Vioque , J. 2002 . Utilisation of chickpea protein isolates for production of peptides with angiotensin I converting enzyme ACE-inhibitory activity . J. Sci. Food Agric. , 82 : 960 – 965 .
   Web of Science ®Google Scholar
• Meisel , H. 1998 . Overview on milk protein-derived peptides . Int. Dairy J. , 8 : 363 – 373 .
   Web of Science ®Google Scholar
• Wu , J. , Aluko , R.E. and Muir , A.D. 2009 . Production of angiotensin I converting enzyme inhibitory peptides from defatted canola meal . Bioresour. Technol. , 100 : 5283 – 5287 .
   PubMed Web of Science ®Google Scholar
• Spellman , D. , McEvoy , E. , O'Cuinn , G. and FitzGerald , R.J. 2003 . Proteinase and exopeptidase hydrolysis of whey protein: Comparison of the TNBS, OPA and PH stat methods for quantification of degree of hydrolysis . Int. Dairy J. , 13 : 447 – 453 .
   Web of Science ®Google Scholar
• Wang , W. and De Mejia , E.G. 2005 . A new frontier in soy bioactive peptides that may prevent age-related chronic diseases . Comp. Rev. Food Sci. Food Saf. , 4 : 63 – 78 .
   PubMed Web of Science ®Google Scholar
• Udenigwe , C.C. , Lin , Y.S. , Hou , W.C. and Aluko , R.E. 2009 . Kinetics of the inhibition of renin and angiotensin I-converting enzyme by flaxseed protein hydrolysate fractions . J. Funct. Foods , 1 : 199 – 207 .
   Web of Science ®Google Scholar
• Agboola , S.O. and Aluko , R.E. 2009 . Isolation and structural properties of the major protein fraction in Australian wattle seed (Acacia victoriae Bentham) . Food Chem. , 115 : 1187 – 1193 .
   Web of Science ®Google Scholar
• Lin , F.Y. , Chen , W.Y. , Ruaan , R.C. and Huang , H.M. 2000 . Microcalorimetric studies of interactions between proteins and hydrophobic ligands in hydrophobic interaction chromatography: Effects of ligand chain length, density and the amount of bound protein . J. Chromatogr. A , 872 : 37 – 47 .
   PubMed Web of Science ®Google Scholar
• Megías , C. , Pedroche , J. , Yust , M.D.M. , Girón-Calle , J. , Alaiz , M. , Millán , F. and Vioque , J. 2007 . Affinity purification of copper-chelating peptides from sunflower protein hydrolysates. J. Agric . Food Chem. , 55 : 6509 – 6514 .
   Web of Science ®Google Scholar
• Megías , C. , Pedroche , J. , Yust , M.D.M. , Alaiz , M. , Girón-Calle , J. , Millán , F. and Vioque , J. 2006 . Affinity purification of angiotensin converting enzyme inhibitory peptides using immobilized ACE . J. Agric. Food Chem. , 54 : 7120 – 7124 .
   PubMed Web of Science ®Google Scholar
• Megías , C. , Pedroche , J. , Yust , M.D.M. , Alaiz , M. , Girón-Calle , J. , Millán , F. and Vioque , J. 2006 . Immobilization of angiotensin-converting enzyme on glyoxyl-agarose . J. Agric. Food Chem. , 54 : 4641 – 4645 .
   PubMed Web of Science ®Google Scholar
• Pouliot , Y. , Gauthier , S.F. and Groleau , P.E. 2006 . “ Nutraceutical proteins and peptides in health and disease ” . In Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals , Edited by: Shahidi , M.F. 639 – 658 . Boca Raton , FL : Taylor & Francis Group .
   Google Scholar
• Pihlanto-Leppälä , A. 2001 . Bioactive peptides derived from bovine whey proteins: Opioid and ACE inhibitory peptides . Trends Food Sci. Technol. , 11 : 347 – 356 .
   Web of Science ®Google Scholar
• Hartmann , R. and Meisel , H. 2007 . Food derived peptides with biological activity: From research to food applications . Curr. Opin. Chem. Biol. , 18 : 163 – 169 .
   Web of Science ®Google Scholar
• Pellegrini , A. 2003 . Antimicrobial peptides from food proteins . Curr. Pharm. Des. , 9 : 1225 – 1238 .
   PubMed Web of Science ®Google Scholar
• Meisel , H. 2004 . Multifunctional peptides encrypted in milk proteins. BioFactors , 21 : 55 – 61 .
   Google Scholar
• Ondetti , M. , Rubin , B. and Cushman , D. 1977 . Design of specific inhibitors of angiotensin-converting enzyme . New class of orally active antihypertensive agents. Science , 196 : 441 – 444 .
   Google Scholar
• Chen , J.R. , Yang , S.C. , Suetsuna , K. and Chao , J.C.J. 2004 . Soybean protein-derived hydrolysate affects blood pressure in spontaneously hypertensive rats . J. Food Biochem. , 28 : 61 – 73 .
   Web of Science ®Google Scholar
• Yoshie-Stark , Y. , Wada , Y. , Schott , M. and Wäsche , A. 2006 . Functional and bioactive properties of rapeseed protein concentrates and sensory analysis of food application with rapeseed protein concentrates . LWT Food Sci. Technol. , 39 : 503 – 512 .
   Web of Science ®Google Scholar
• Vermeirssen , V. , Van Camp , J. and Verstraete , W. 2005 . Fractionation of angiotensin I converting enzyme inhibitory activity from pea and whey protein in vitro gastrointestinal digests . J. Sci. Food Agric. , 85 : 399 – 405 .
   Web of Science ®Google Scholar
• Meisel , H. , Walsh , D.J. , Murray , B. and FitzGerald , R.J. 2006 . “ ACE inhibitory peptides ” . In Nutraceutical Proteins and Peptides in Health and Disease , Edited by: Mine , Y. and Shahidi , F. 269 – 315 . London : CRC–Taylor and Francis Group .
   Google Scholar
• Fujita , H. , Yokoyama , K. and Yoshikawa , M. 2000 . Classification and antihypertensive activity of angiotensin I converting enzyme inhibitory peptides derived from food proteins . J. Food Sci. , 65 : 564 – 569 .
   Web of Science ®Google Scholar
• Halliwell , B. 1990 . How to characterise a biological antioxidant . Free Radic. Resour. Commun. , 9 : 1 – 32 .
   PubMed Web of Science ®Google Scholar
• Chen , H.M. , Muramoto , K. , Yamauchi , F. , Fujimoto , K. and Nokihara , K. 1998 . Antioxidative properties of histidine-containing peptides designed from peptide fragments found in the digests of a soybean protein . J. Agric. Food Chem. , 46 : 49 – 53 .
   PubMed Web of Science ®Google Scholar
• Pena-Ramos , E.A. and Xiong , Y.L. 2001 . Antioxidative activity of whey protein hydrolysates in a liposomal system . J. Dairy Sci. , 84 : 2577 – 2583 .
   PubMed Web of Science ®Google Scholar
• Kong , B. and Xiong , Y.L. 2006 . Antioxidant activity of zein hydrolysates in a liposome system and the possible mode of action . J. Agric. Food Chem. , 54 : 6059 – 6068 .
   PubMed Web of Science ®Google Scholar
• Rice-Evans , C. and Miller , N.J. 1994 . Total antioxidant status in plasma and body fluids . Methods Enzymol. , 234 : 279 – 293 .
   PubMed Web of Science ®Google Scholar
• Brand-Williams , W. , Cuvelier , M.E. and Berset , C. 1995 . Use of a free radical method to evaluate antioxidant activity . LWT Food Sci. Technol. , 28 : 25 – 30 .
   Web of Science ®Google Scholar
• Ou , B. , Hampsch-Woodill , M. and Prior , R.L. 2001 . Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe . J. Agric. Food Chem. , 49 : 4619 – 4626 .
   PubMed Web of Science ®Google Scholar
• Benzie , I.F.F. 1996 . An automated, specific, spectrophotometric method for measuring ascorbic acid in plasma (EFTSA) . Clin. Biochem. , 29 : 111 – 116 .
   PubMed Web of Science ®Google Scholar
• Amarowicz , R. 2008 . Antioxidant activity of protein hydrolyastes . Eur. J. Lipid Sci. Technol. , 110 : 489 – 490 .
   Web of Science ®Google Scholar
• Zhang , S.B. , Wang , Z. and Xu , S.Y. 2008 . Antioxidant and antithrombotic activities of rapeseed peptides . J. Am. Oil Chem. Soc. , 85 : 521 – 527 .
   Web of Science ®Google Scholar
• Xue , Z. , Yu , W. , Liu , Z. , Wu , M. , Kou , X. and Wang , J. 2009 . Preparation and antioxidative properties of a rapeseed (Brassica napus) protein hydrolysate and three peptide fractions . J. Agric. Food Chem. , 57 : 5287 – 5293 .
   PubMed Web of Science ®Google Scholar
• Cushman , D.W. and Cheung , H.S. 1971 . Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung . Biochem. Pharmacol , 20 : 1637 – 1648 .
   PubMed Web of Science ®Google Scholar
• Hayakari , M. , Kondo , Y. and Izumi , H. 1978 . A rapid and simple spectrophotometric assay of angiotensin-converting enzyme. Anal . Biochem. , 84 : 361 – 369 .
   Web of Science ®Google Scholar