Aerosol-based Pulmonary Delivery of Therapeutic Molecules from Food Sources: Delivery Mechanism, Research Trends, and the Way Forward

References

• Otvos, R. A.; Still, K. B. M.; Somsen, G. W.; Smit, A. B.; Kool, J. Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays. SLAS Discov Adv Life Sci R&D. 2019, 24, 362–385.
   PubMed Web of Science ®Google Scholar
• Ackova, D. G.; Smilkov, K.; Bosnakovski, D. Contemporary Formulations for Drug Delivery of Anticancer Bioactive Compounds. Recent Pat Anticancer Drug Discov. 2019, 14(1), 19–31. DOI: 10.2174/1574892814666190111104834.
   PubMed Web of Science ®Google Scholar
• Dias, D. A.; Urban, S.; Roessner, U. A Historical Overview of Natural Products in Drug Discovery. Metabolites. 2012, 2(2), 303–336. DOI: 10.3390/metabo2020303.
   PubMedGoogle Scholar
• Veeresham, C.;. Natural Products Derived from Plants as a Source of Drugs. Journal of Advanced Pharmaceutical Technology & Research. 2012, 3(4), 200. DOI: 10.4103/2231-4040.104709.
   PubMedGoogle Scholar
• Davison, E. K.; Brimble, M. A. Natural Product Derived Privileged Scaffolds in Drug Discovery. Curr. Opin. Chem. Biol. 2019, 52, 1–8. DOI: 10.1016/j.cbpa.2018.12.007.
   PubMed Web of Science ®Google Scholar
• Morozov, V. N.; Kanev, I. L.; Mikheev, A. Y.; Shlyapnikova, E. A.; Shlyapnikov, Y. M.; Nikitin, M. P.; Nwabueze, A. O.; van Hoek, M. L. Generation and Delivery of Nanoaerosols from Biological and Biologically Active Substances. J. Aerosol Sci. 2014, 69, 48–61. DOI: 10.1016/j.jaerosci.2013.12.003.
   Web of Science ®Google Scholar
• Kandil, R.; Merkel, O. M. Pulmonary Delivery of siRNA as a Novel Treatment for Lung Diseases. Therapeutic delivery. 2019, 10(4), DOI: 10.4155/tde-2019-0009
   Google Scholar
• Salomon, C.; Goycoolea, F. M.; Moerschbacher, B. Recent Trends in the Development of Chitosan-based Drug Delivery Systems, 2017, 18, 933–935. DOI: 10.1208/s12249-017-0764-72017.
   Google Scholar
• Sakagami, M.;. In Vivo, in Vitro and Ex Vivo Models to Assess Pulmonary Absorption and Disposition of Inhaled Therapeutics for Systemic Delivery. Adv. Drug Deliv. Rev. 2006, 58(9–10), 1030–1060. DOI: 10.1016/j.addr.2006.07.012.
   PubMed Web of Science ®Google Scholar
• Ungaro, F.; Di Villa Bianca, R. D. E.; Giovino, C.; Miro, A.; Sorrentino, R.; Quaglia, F.; La Rotonda, M. I. Insulin-loaded PLGA/cyclodextrin Large Porous Particles with Improved Aerosolization Properties: In Vivo Deposition and Hypoglycaemic Activity after Delivery to Rat Lungs. J. Control. Release. 2009, 135, 25–34. DOI: 10.1016/j.jconrel.2008.12.011.
   PubMed Web of Science ®Google Scholar
• Tewes, F.; Gobbo, O. L.; Ehrhardt, C.; Healy, A. M. Amorphous Calcium Carbonate Based-microparticles for Peptide Pulmonary Delivery. ACS Appl. Mater. Interfaces. 2016, 8(2), 1164–1175. DOI: 10.1021/acsami.5b09023.
   PubMed Web of Science ®Google Scholar
• Wu, W. H.; Yuan, P.; Zhang, S. J.; Jiang, X.; Wu, C.; Li, Y.; Liu, S. F.; Liu, Q. Q.; Li, J. H.; Pudasaini, B.; Hu, Q. H. Impact of Pituitary–Gonadal Axis Hormones on Pulmonary Arterial Hypertension in Men. Hypertension. 2018, 72(1), 151–158.
   PubMed Web of Science ®Google Scholar
• Schrom, E.; Huber, M.; Aneja, M.; Dohmen, C.; Emrich, D.; Geiger, J.; Hasenpusch, G.; Herrmann-Janson, A.; Kretzschmann, V.; Mykhailyk, O.; Pasewald, T. Translation of Angiotensin-converting Enzyme 2 upon Liver-and Lung-targeted Delivery of Optimized Chemically Modified mRNA. Mol Ther Acids. 2017, 7, 350–365. DOI: 10.1016/j.omtn.2017.04.006.
   PubMedGoogle Scholar
• Wu, L.; Miao, X.; Shan, Z.; Huang, Y.; Li, L.; Pan, X.; Yao, Q.; Li, G.; Wu, C. Studies on the Spray Dried Lactose as Carrier for Dry Powder Inhalation. Asian J. Pharm. Sci. 2014, 9, 336–341. DOI: 10.1016/j.ajps.2014.07.006.
   Google Scholar
• Biesalski, H.; Reifen, R.; Fürst, P.; Edris, M. Retinyl Palmitate Supplementation by Inhalation of an Aerosol Improves Vitamin A Status of Preschool Children in Gondar (Ethiopia). Br. J. Nutr. 1999, 82(3), 179–182. DOI: 10.1017/S000711459900135X.
   PubMed Web of Science ®Google Scholar
• Yu, H.; Tran, -T.-T.; Teo, J.; Hadinoto, K. Dry Powder Aerosols of Curcumin-chitosan Nanoparticle Complex Prepared by Spray Freeze Drying and Their Antimicrobial Efficacy against Common Respiratory Bacterial Pathogens. Colloids Surfaces A Physicochem. Eng. Asp. 2016, 504, 34–42. DOI: 10.1016/j.colsurfa.2016.05.053.
   Web of Science ®Google Scholar
• Xia, Y.; Su, Y.; Wang, Q.; Yang, C.; Tang, B.; Zhang, Y.; Tu, J.; Shen, Y. Preparation, Characterization, and Pharmacodynamics of Insulin-loaded Fumaryl Diketopiperazine Microparticle Dry Powder Inhalation. Drug. Deliv. 2019, 26(1), 650–660.
   PubMed Web of Science ®Google Scholar
• AFREZZA® n.d. https://www.afrezza.com/afrezza-life (accessed April 13, 2020).
   Google Scholar
• Secor Jr, E. R.; Carson IV, W. F.; Cloutier, M. M.; Guernsey, L.A.; Schramm, C. M.; Wu, C. A.; Thrall, R. S. Bromelain Exerts Anti-inflammatory Effects in an Ovalbumin-induced Murine Model of Allergic Airway Disease. Cell. Immunol. 2005, 237, 68–75. DOI: 10.1016/j.cellimm.2005.10.002.
   PubMed Web of Science ®Google Scholar
• Omenn, G. S.; Goodman, G. E.; Thornquist, M. D.; Balmes, J.; Cullen, M. R.; Glass, A.; Keogh, J. P.; Meyskens Jr, F. L.; Valanis, B.; Williams Jr, J. H.; et al. Effects of A Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease. N. Engl. J. Med. 1996, 334(18), 1150–1155.
   PubMed Web of Science ®Google Scholar
• Ungaro, F.; De Rosa, G.; Miro, A.; Quaglia, F.; La Rotonda, M. I. Cyclodextrins in the Production of Large Porous Particles: Development of Dry Powders for the Sustained Release of Insulin to the Lungs. Eur. J. Pharm. Sci. 2006, 28(5), 423–432. DOI: 10.1016/j.ejps.2006.05.005.
   PubMed Web of Science ®Google Scholar
• Liang, W.; Kwok, P. C.; Chow, M. Y.; Tang, P.; Mason, A. J.; Chan, H. K.; Lam, J. K. Formulation of pH Responsive Peptides as Inhalable Dry Powders for Pulmonary Delivery of Nucleic Acids. Eur. J. Pharm. Biopharm. 2014, 86(1), 64–73.
   PubMed Web of Science ®Google Scholar
• Liang, W.; Chan, A. Y.; Chow, M. Y.; Lo, F. F.; Qiu, Y.; Kwok, P. C.; Lam, J. K. Spray Freeze Drying of Small Nucleic Acids as Inhaled Powder for Pulmonary Delivery. Asian J. Pharm. Sci. 2018, 13(2), 163–172. DOI: 10.1016/j.ajps.2017.10.002.
   PubMed Web of Science ®Google Scholar
• Bouche, M. P. L. A.; Vanlandschoot, P.; Sablon, E.; Depla, E.; De Buck, S.; Saelens, X.; Schepens, B.; Silence, K.; Vaeck, M.; Henegouwen, P. M. V. B. E.; et al. Pulmonary Administration of Immunoglobulin Single Variable Domains and Constructs Thereof. U.S. Patent No. 9,320,792. July 22, 2010.
   Google Scholar
• Hoboken, N.;. Pulmonary Delivery of Drugs for Bone Disorders. 42. 2005. DOI: 10.1016/S0169-409X(00)00064-8.
   Google Scholar
• Patil-Gadhe, A. A.; Kyadarkunte, A. Y.; Pereira, M.; Jejurikar, G.; Patole, M. S.; Risbud, A.; Pokharkar, V. B. Rifapentine-proliposomes for Inhalation: In Vitro and in Vivo Toxicity. Toxicol. Int. 2014, 21, 275. DOI: 10.4103/0971-6580.155361.
   PubMedGoogle Scholar
• Zhu, L.; Li, M.; Liu, X.; Jin, Y. Drug-loaded PLGA Electrospraying Porous Microspheres for the Local Therapy of Primary Lung Cancer via Pulmonary Delivery. ACS Omega. 2017, 2(5), 2273–2279. DOI: 10.1021/acsomega.7b00456.
   PubMed Web of Science ®Google Scholar
• Thakur, A. K.; Chellappan, D. K.; Dua, K.; Mehta, M.; Satija, S.; Singh, I. Patented Therapeutic Drug Delivery Strategies for Targeting Pulmonary Diseases. Expert Opin. Ther. Pat. 2020, 30(5), 375–387. DOI: 10.1080/13543776.2020.1741547.
   PubMed Web of Science ®Google Scholar
• Sonia, T. A.; Sharma, C. P. Oral Delivery of Insulin; Elsevier Science: Netherlands, 2014; 59-112.
   Google Scholar
• Smith, M. J.; Thurm, C.; Shah, S. S.; Patel, S. J.; Kronman, M. P.; Gerber, J. S.; Courter, J. D.; Lee, B. R.; Newland, J. G.; Hersh, A. L. Route of Administration for Antibiotics with High Oral Bioavailability. Infect Control Hosp Epidemiol. 2019, 40(2), 248–249.
   PubMed Web of Science ®Google Scholar
• Lavanya, M. N.; Preethi., R.; Moses, J. A.; Anandharamakrishnan, C. Production of Bromelain Aerosols Using Spray-freeze-drying Technique for Pulmonary Supplementation. Dry. Technol. 2020, 1–13. doi:10.1080/07373937.2020.1832514.
   Web of Science ®Google Scholar
• Kim, Y.; Pritts, T. A. The Gastrointestinal Tract. In Geriatr. Trauma Crit. Care; Springer: New York, 2017; pp 35–43.
   Google Scholar
• Homayun, B.; Lin, X.; Choi, H.-J. Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals. Pharmaceutics. 2019, 11(3), 129. DOI: 10.3390/pharmaceutics11030129.
   PubMed Web of Science ®Google Scholar
• Aggarwal, B.; Knight, J. Aerosol Delivery of Curcumin. US 2005/0181036A1, 2005.
   Google Scholar
• Lowry, M.;. Rectal Drug Administration in Adults: How, When, Why. Nurs Times. 2016, 112, 12–14.
   Google Scholar
• Havaldar, V. D.; Yadav, A. V.; Dias, R. J.; Mali, K. K.; Ghorpade, V. S.; Salunkhe, N. H. Rectal Suppository as an Effective Alternative for Oral Administration. Res. J. Pharm. Technol. 2015, 8(6), 759–766. DOI: 10.5958/0974-360X.2015.00122.5.
   Google Scholar
• Weers, J.; Lipid-based Compositions of Antiinfectives for Treating Pulmonary Infections and Methods of Use Thereof 2017.
   Google Scholar
• Bind, A. K.; Gnanarajan, G.; Kothiyal, P. A Review: Sublingual Route for Systemic Drug Delivery. Int J Drug Res Technol. 2017, 3, 5.
   Google Scholar
• Prittie, J.; Barton, L. Route of Nutrient Delivery. Clin Tech Small Anim Pract. 2004, 19(1), 6–8. DOI: 10.1053/S1096-2867(03)00078-1.
   PubMedGoogle Scholar
• Kaur, I. P.; Verma, M. K. Process for Preparing Solid Lipid Sustained Release Nanoparticles for Delivery of Vitamins. US 9, 907, 758 B2, 2018.
   Google Scholar
• Ho, D.-K.; Nichols, B. L. B.; Edgar, K. J.; Murgia, X.; Loretz, B.; Lehr, C.-M. Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections. Eur. J. Pharm. Biopharm. 2019, 144, 110–124. DOI: 10.1016/j.ejpb.2019.09.002.
   PubMed Web of Science ®Google Scholar
• Tanwar, H.; Sachdeva, R. Transdermal Drug Delivery System: A Review. Int. J. Pharm. Sci. Res. 2016, 7, 2274–2290.
   Web of Science ®Google Scholar
• Gupta, K. C.; Haider, A.; Choi, Y.; Kang, I. Nanofibrous Scaffolds in Biomedical Applications. Biomater. Res. 2014, 18(1), 5. DOI: 10.1186/2055-7124-18-5.
   PubMedGoogle Scholar
• Stinson, J. A.; Raja, W. K.; Lee, S,; Kim, H. B.; Diwan, I.; Tutunjian, S.; Panilaitis, B.; Omenetto, F. G.; Tzipori, S.; Kaplan, D.L. Silk Fibroin Microneedles for Transdermal Vaccine Delivery. ACS Biomater. Sci. Eng. 2017, 3(3), 360–369.
   PubMed Web of Science ®Google Scholar
• Mangal, S.; Gao, W.; Li, T.; Zhou, Q. T. Pulmonary Delivery of Nanoparticle Chemotherapy for the Treatment of Lung Cancers: Challenges and Opportunities. Acta Pharmacol. Sin. 2017, 38, 782–797.
   PubMed Web of Science ®Google Scholar
• Chen, L.; Zhao, X. Characterization of Air Flow and Lung Function in the Pulmonary Acinus by Fluid-structure Interaction in Idiopathic Interstitial Pneumonias. PLoS One. 2019, 14(3), e0214441. DOI: 10.1371/journal.pone.0214441.
   PubMed Web of Science ®Google Scholar
• Deb, P. K.; Al-Attraqchi, O.; Chandrasekaran, B.; Paradkar, A.; Tekade, R. K. Protein/Peptide Drug Delivery Systems: Practical Considerations in Pharmaceutical Product Development. In Basic Fundam. Drug Deliv.; Elsevier Science: United Kingdom, 2019; pp 651–684.
   Google Scholar
• Ensign, L. M.; Cone, R.; Hanes, J. Oral Drug Delivery with Polymeric Nanoparticles: The Gastrointestinal Mucus Barriers. Adv. Drug Deliv. Rev. 2012, 64(6), 557–570. DOI: 10.1016/j.addr.2011.12.009.
   PubMed Web of Science ®Google Scholar
• Battaglia, L.; Panciani, P. P.; Muntoni, E.; Capucchio, M. T.; Biasibetti, E.; De Bonis, P.; Mioletti, S.; Fontanella, M.; Swaminathan, S. Lipid Nanoparticles for Intranasal Administration: Application to Nose-to-brain Delivery. Expert Opin. Drug Deliv. 2018, 15(4), 369–378.
   PubMed Web of Science ®Google Scholar
• Goldberg, M.; Gomez-Orellana, I. Challenges for the Oral Delivery of Macromolecules. Nat. Rev. Drug Discov. 2003, 2(4), 289–295. DOI: 10.1038/nrd1067.
   PubMed Web of Science ®Google Scholar
• Donovan, M. D.; Flynn, G. L.; Amidon, G. L. Absorption of Polyethylene Glycols 600 through 2000: The Molecular Weight Dependence of Gastrointestinal and Nasal Absorption. Pharm. Res. 1990, 7(8), 863–868. DOI: 10.1023/A:1015921101465.
   PubMed Web of Science ®Google Scholar
• Camenisch, G.; Alsenz, J.; Van De Waterbeemd, H.; Folkers, G. Estimation of Permeability by Passive Diffusion through Caco-2 Cell Monolayers Using the Drugs’ Lipophilicity and Molecular Weight. Eur. J. Pharm. Sci. 1998, 6(4), 313–319. DOI: 10.1016/S0928-0987(97)10019-7.
   Web of Science ®Google Scholar
• Griffin, B. T.; O’Driscoll, C. M. Opportunities and Challenges for Oral Delivery of Hydrophobic versus Hydrophilic Peptide and Protein-like Drugs Using Lipid-based Technologies. Ther Deliv. 2011, 2(12), 1633–1653. DOI: 10.4155/tde.11.128.
   PubMedGoogle Scholar
• Sudareva, N.; Suvorova, O.; Saprykina, N.; Vilesov, A.; Bel'tiukov, P.; Petunov, S.; Radilov, A. Two-level Delivery Systems for Oral Administration of Peptides and Proteins Based on Spore Capsules of Lycopodium Clavatum. J. Mater. Chem. B. 2017, 5(37), 7711–7720.
   PubMed Web of Science ®Google Scholar
• He, S.; Liu, Z.; Xu, D. Advance in Oral Delivery Systems for Therapeutic Protein. J. Drug Target. 2019, 27(3), 283–291. DOI: 10.1080/1061186X.2018.1486406.
   PubMed Web of Science ®Google Scholar
• Koziolek, M.; Carrière, F.; Porter, C. J. H. Lipids in the Stomach–implications for the Evaluation of Food Effects on Oral Drug Absorption. Pharm. Res. 2018, 35, 55. DOI: 10.1007/s11095-017-2289-x.
   PubMed Web of Science ®Google Scholar
• Amara, S.; Bourlieu, C.; Humbert, L.; Rainteau, D.; Carrière, F. Variations in Gastrointestinal Lipases, pH and Bile Acid Levels with Food Intake, Age and Diseases: Possible Impact on Oral Lipid-based Drug Delivery Systems. Adv. Drug Deliv. Rev. 2019, 142, 3–15. DOI: 10.1016/j.addr.2019.03.005.
   PubMed Web of Science ®Google Scholar
• Gul, K.; Tak, A.; Singh, A. K.; Singh, P.; Yousuf, B.; Wani, A. A. Chemistry, Encapsulation, and Health Benefits of β-carotene - A Review. Cogent Food Agric. 2015, 1(1), 1018696. DOI: 10.1080/23311932.2015.1018696.
   Google Scholar
• Purohit, T. J.; Hanning, S. M.; Wu, Z. Advances in Rectal Drug Delivery Systems. Pharm. Dev. Technol. 2018, 23(10), 942–952. DOI: 10.1080/10837450.2018.1484766.
   PubMed Web of Science ®Google Scholar
• Ruiz, M. E.; Montoto, S. S. Routes of Drug Administration. In ADME Process. Pharm. Sci.; Springer International Publishing: Germany, 2018; pp 97–133.
   Google Scholar
• Singh, C. K.; Saxena, S.; Yadav, M.; Samson, A. L. A Review on Novel Approaches for Colon Targeted Drug Delivery Systems. PharmaTutor. 2018, 6(7), 11–22. DOI: 10.29161/PT.v6.i7.2018.11.
   Google Scholar
• Hua, S.;. Physiological and Pharmaceutical Considerations for Rectal Drug Formulations. Front. Pharmacol. 2019, 10, 1196. DOI: 10.3389/fphar.2019.01196.
   PubMed Web of Science ®Google Scholar
• Linakis, M. W.; Roberts, J. K.; Lala, A. C.; Spigarelli, M. G.; Medlicott, N. J.; Reith, D. M.; Ward, R. M.; Sherwin, C. M. Challenges Associated with Route of Administration in Neonatal Drug Delivery. Clin Pharmacokinet. 2016, 55, 185–196. DOI: 10.1007/s40262-015-0313-z.
   PubMed Web of Science ®Google Scholar
• Nunes, R.; Sarmento, B.; Das Neves, J. Formulation and Delivery of anti-HIV Rectal Microbicides: Advances and Challenges. J. Control. Release. 2014, 194, 278–294. DOI: 10.1016/j.jconrel.2014.09.013.
   PubMed Web of Science ®Google Scholar
• Mathur, P.; Rana, A.; Saroha, K.; Mathur, K. Sublingual Route: An Approach to Administered Drugs in Systemic Circulation. Int J Pharma Res Heal Sci. 2019, 7, 2869–2873. DOI: 10.21276/ijprhs.2019.01.01.
   Google Scholar
• Pawar, P. P.; Ghorpade, H. S.; Kokane, B. A. Sublingual Route for Systemic Drug Delivery. J Drug Deliv Ther. 2018, 8(6–s), 340–343. DOI: 10.22270/jddt.v8i6-s.2097.
   Google Scholar
• Morales, J. O.; Fathe, K. R.; Brunaugh, A.; Ferrati, S.; Li, S.; Montenegro-Nicolini, M.; Mousavikhamene, Z.; McConville, J.T.; Prausnitz, M. R.; Smyth, H. D. Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes. Aaps J. 2017, 19(3), 652–668.
   PubMed Web of Science ®Google Scholar
• Doyle, G. R.; McCutcheon, J. A. Clinical Procedures for Safer Patient Care. Campus Manitoba. 2016, 225, 979-980.
   Google Scholar
• Khan, A. R.; Liu, M.; Khan, M. W.; Zhai, G. Progress in Brain Targeting Drug Delivery System by Nasal Route. J. Control. Release. 2017, 268, 364–389.
   PubMed Web of Science ®Google Scholar
• Ozsoy, Y.; Güngör, S. Nasal Route: An Alternative Approach for Antiemetic Drug Delivery. Expert Opin. Drug Deliv. 2011, 8(11), 1439–1453. DOI: 10.1517/17425247.2011.607437.
   PubMed Web of Science ®Google Scholar
• Fasiolo, L. T.; Manniello, M. D.; Tratta, E.; Buttini, F.; Rossi, A.; Sonvico, F.; Bortolotti, F.; Russo, P.; Colombo, G. Opportunity and Challenges of Nasal Powders: Drug Formulation and Delivery. Eur. J. Pharm. Sci. 2018, 113, 2–17. DOI: 10.1016/j.ejps.2017.09.027.
   PubMed Web of Science ®Google Scholar
• Ghori, M. U.; Mahdi, M. H.; Smith, A. M.; Conway, B. R. Nasal Drug Delivery Systems: An Overview. Am. J. Pharmacol. Sci. 2015, 3, 110–119.
   Google Scholar
• Martignoni, I.; Trotta, V.; Lee, W. H.; Loo, C. Y.; Pozzoli, M.; Young, P. M.; Scalia, S.; Traini, D. Resveratrol Solid Lipid Microparticles as Dry Powder Formulation for Nasal Delivery, Characterization and in Vitro Deposition Study. J. Microencapsul. 2016, 33(8), 735–742.
   PubMed Web of Science ®Google Scholar
• Sosnowski, T. R.; Rapiejko, P.; Sova, J.; Dobrowolska, K. Impact of Physicochemical Properties of Nasal Spray Products on Drug Deposition and Transport in the Pediatric Nasal Cavity Model. Int. J. Pharm. 2020, 574, 118911. DOI: 10.1016/j.ijpharm.2019.118911.
   PubMed Web of Science ®Google Scholar
• Gizurarson, S.;. The Effect of Cilia and the Mucociliary Clearance on Successful Drug Delivery. Biol. Pharm. Bull. 2015, 38(4), 497-506.
   PubMed Web of Science ®Google Scholar
• Brunaugh, A. D.; Smyth, H. D. C.; Williams, R. O. Essential Pharmaceutics; Springer International Publishing: Germany, 2019.
   Google Scholar
• Agu, R. U.;. Challenges in Nasal Drug Absorption: How Far Have We Come? Ther Deliv. 2016, 7(7), 495–510. DOI: 10.4155/tde-2016-0022.
   PubMed Web of Science ®Google Scholar
• Warnken, Z. N.; Smyth, H. D. C.; Davis, D. A.; Weitman, S.; Kuhn, J. G.; Williams III, R. O. Personalized Medicine in Nasal Delivery: The Use of Patient-specific Administration Parameters to Improve Nasal Drug Targeting Using 3D-printed Nasal Replica Casts. Mol. Pharm. 2018, 15, 1392–1402. DOI: 10.1021/acs.molpharmaceut.7b00702.
   PubMedGoogle Scholar
• Illum, L.;. Nasal Drug Delivery—possibilities, Problems and Solutions. J. Control. Release. 2003, 87(1–3), 187–198. DOI: 10.1016/S0168-3659(02)00363-2.
   PubMed Web of Science ®Google Scholar
• Alkilani, A.; McCrudden, M. T.; Donnelly, R. Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum. Pharmaceutics. 2015, 7(4), 438–470. DOI: 10.3390/pharmaceutics7040438.
   PubMed Web of Science ®Google Scholar
• Han, S. B.; Kwon, S. S.; Jeong, Y. M.; Yu, E. R.; Park, S. N. Physical Characterization and in Vitro Skin Permeation of Solid Lipid Nanoparticles for Transdermal Delivery of Quercetin. Int. J. Cosmet. Sci. 2014, 36(6), 588–597. DOI: 10.1111/ics.12160.
   PubMed Web of Science ®Google Scholar
• Alsaqr, A.; Rasoully, M.; Musteata, F. M. Investigating Transdermal Delivery of Vitamin D 3. AAPS PharmSciTech. 2015, 16(4), 963–972. DOI: 10.1208/s12249-015-0291-3.
   PubMed Web of Science ®Google Scholar
• Park, S. N.; Jo, N. R.; Jeon, S. H. Chitosan-coated Liposomes for Enhanced Skin Permeation of Resveratrol. J. Ind. Eng. Chem. 2014, 20(4), 1481–1485. DOI: 10.1016/j.jiec.2013.07.035.
   Web of Science ®Google Scholar
• Prausnitz, M. R.; Langer, R. Transdermal Drug Delivery. Nat. Biotechnol. 2008, 26(11), 1261. DOI: 10.1038/nbt.1504.
   PubMed Web of Science ®Google Scholar
• Ashim K.; Mitra.; Cholkar K.; Mandal A. In Micro and Nano Technologies, Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices, Elsevier Science: Netherlands, 2017; 331-353. DOI: 10.1016/B978-0-323-42978-8.00013-9.
   Google Scholar
• Das Kurmi, B.; Tekchandani, P.; Paliwal, R.; Rai Paliwal, S. Transdermal Drug Delivery: Opportunities and Challenges for Controlled Delivery of Therapeutic Agents Using Nanocarriers. Curr. Drug Metab. 2017, 18(5), 481–495. DOI: 10.2174/1389200218666170222150555.
   PubMed Web of Science ®Google Scholar
• Van Gele, M.; Geusens, B.; Brochez, L.; Speeckaert, R.; Lambert, J. Three-dimensional Skin Models as Tools for Transdermal Drug Delivery: Challenges and Limitations. Expert Opin. Drug Deliv. 2011, 8(6), 705–720. DOI: 10.1517/17425247.2011.568937.
   PubMed Web of Science ®Google Scholar
• Bhowmick, M.; Sengodan, T.; Thangavel, S. Challenges Facing Transdermal Drug Delivery Systems: A Conceptual Approach. Res J Sci Technol. 2012, 4(5), 197-200.
   Google Scholar
• Geusens, B.; Sanders, N.; Prow, T.; Van Gele, M.; Lambert, J. Cutaneous Short-interfering RNA Therapy. Expert Opin. Drug Deliv. 2009, 6(12), 1333–1349. DOI: 10.1517/17425240903304032.
   PubMed Web of Science ®Google Scholar
• Javadzadeh, Y.; Yaqoubi, S. Therapeutic Nanostructures for Pulmonary Drug Delivery. In Nanostructures Drug Deliv.; Elsevier: Netherlands, 2017; pp 619–638.
   Google Scholar
• Patil, T. S.; Deshpande, A. S.; Deshpande, S.; Shende, P. Targeting Pulmonary Tuberculosis Using Nanocarrier-based Dry Powder Inhalation: Current Status and Futuristic Need. J. Drug Target. 2019, 27(1), 12–27. DOI: 10.1080/1061186X.2018.1455842.
   PubMed Web of Science ®Google Scholar
• Machira, E. P. M.; Obimbo, E. M.; Wamalwa, D.; Gachare, L. N. Assessment of Inhalation Technique among Asthmatic Children and Their Carers at the Kenyatta National Hospital, Kenya. African J Respir Med, 2011, 7, 19–22.
   Google Scholar
• Deng, Q.; Deng, L.; Miao, Y.; Guo, X.; Li, Y. Particle Deposition in the Human Lung: Health Implications of Particulate Matter from Different Sources. Environ. Res. 2019, 169, 237–245. DOI: 10.1016/j.envres.2018.11.014.
   PubMed Web of Science ®Google Scholar
• Edwards, D. A.; Ben-Jebria, A.; Langer, R. Recent Advances in Pulmonary Drug Delivery Using Large, Porous Inhaled Particles. J. Appl. Physiol. 1998, 85, 379–385. DOI: 10.1152/jappl.1998.85.2.379.
   PubMed Web of Science ®Google Scholar
• Ungaro, F.; Giovino, C.; Coletta, C.; Sorrentino, R.; Miro, A.; Quaglia, F. Engineering Gas-foamed Large Porous Particles for Efficient Local Delivery of Macromolecules to the Lung. Eur. J. Pharm. Sci. 2010, 41, 60–70.
   PubMed Web of Science ®Google Scholar
• Watanabe, J.; Watanabe, M. Anatomical Factors of Human Respiratory Tract Influencing Volume Flow Rate and Number of Particles Arriving at Each Bronchus. Biocybern Biomed Eng. 2019. DOI: 10.1016/j.bbe.2019.03.004.
   Web of Science ®Google Scholar
• Amulya, C.; Gupta, M. E.; Babu, I. S. A Review on Alternative Routes for Insulin Administration. World J. Pharm. Res, 2019, 8, 1471-1479.
   Google Scholar
• Tena, A. F.; Clarà, P. C. Deposition of Inhaled Particles in the Lungs. Curr Biol. 2019, 27(14), 713-715.
   Google Scholar
• Nahar, K.; Gupta, N.; Gauvin, R.; Absar, S.; Patel, B.; Gupta, V.; Khademhosseini, A.; Ahsan, F. In Vitro, in Vivo and Ex Vivo Models for Studying Particle Deposition and Drug Absorption of Inhaled Pharmaceuticals. Eur. J. Pharm. Sci. 2013, 49(5), 805–818.
   PubMed Web of Science ®Google Scholar
• Verma, R. K.; Ibrahim, M.; Garcia-Contreras, L. Lung Anatomy and Physiology and Their Implications for Pulmonary Drug Delivery. In Pulm Drug Deliv Adv Challenges, Wiley: United Kingdom, 2015; pp 1–18.
   Google Scholar
• Puisney, C.; Baeza-Squiban, A.; Boland, S. Mechanisms of Uptake and Translocation of Nanomaterials in the Lung. In Cell. Mol. Toxicol. Nanoparticles; Springer: Germany, 2018; pp 21–36.
   Google Scholar
• Sosnowski, T. R.;. Particles on the Lung Surface-physicochemical and Hydrodynamic Effects. Curr. Opin. Colloid Interface Sci. 2018, 36, 1–9. DOI: 10.1016/j.cocis.2017.12.003.
   Web of Science ®Google Scholar
• Sosnowski, T. R.;. Influence of Insoluble Aerosol Deposits on the Surface Activity of the Pulmonary Surfactant: A Possible Mechanism of Alveolar Clearance Retardation? Aerosol Sci. Technol. 2000, 32(1), 52–60. DOI: 10.1080/027868200303920.
   Web of Science ®Google Scholar
• Rogueda, P. G. A.; Traini, D. The Nanoscale in Pulmonary Delivery. Part 1: Deposition, Fate, Toxicology and Effects. Expert Opin. Drug Deliv. 2007, 4(6), 595–606. DOI: 10.1517/17425247.4.6.595.
   PubMed Web of Science ®Google Scholar
• Chen, Q.; Hu, C.; Yu, H.; Shen, K.; Assam, P.N.; Gillen, M.; Liu, Y.; Dorinsky, P. Pharmacokinetics and Tolerability of Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate and Glycopyrronium/Formoterol Fumarate Dihydrate Metered Dose Inhalers in Healthy Chinese Adults: A Randomized, Double-Blind, Parallel-Group Study. Clin. Ther. 2019, 41(5), 897-909.
   Web of Science ®Google Scholar
• Clark, S.; Pawlyn, J. Inhaler and Nebuliser Technique for People with a Learning Disability. Learn Disabil Res Pract. 2019, 22(1), 58384. DOI: 10.7748/ldp.2019.e1941.
   Google Scholar
• Cheng, Y. S.;. Mechanisms of Pharmaceutical Aerosol Deposition in the Respiratory Tract. AAPS PharmSciTech. 2014, 15(3), 630–640. DOI: 10.1208/s12249-014-0092-0.
   PubMed Web of Science ®Google Scholar
• Khan, I.; Elhissi, A.; Shah, M.; Alhnan, M. A.; Ahmed, W. Liposome-based Carrier Systems and Devices Used for Pulmonary Drug Delivery. In Biomater. Med. Tribol.; Elsevier Science: United Kingdom, 2013; pp 395–443.
   Google Scholar
• Sinsuebpol, C.; Chatchawalsaisin, J.; Kulvanich, P. Preparation and in Vivo Absorption Evaluation of Spray Dried Powders Containing Salmon Calcitonin Loaded Chitosan Nanoparticles for Pulmonary Delivery. Drug Des. Devel. Ther. 2013, 7, 861. DOI: 10.2147/DDDT.S47681.
   PubMed Web of Science ®Google Scholar
• Falcon-Rodriguez, C. I.; Osornio-Vargas, A. R.; Sada-Ovalle, I.; Segura-Medina, P. Aeroparticles, Composition, and Lung Diseases. Front. Immunol. 2016, 7, 3. DOI: 10.3389/fimmu.2016.00003.
   PubMed Web of Science ®Google Scholar
• Chen, X.; Feng, Y.; Zhong, W.; Sun, B.; Tao, F. Numerical Investigation of Particle Deposition in a Triple Bifurcation Airway Due to Gravitational Sedimentation and Inertial Impaction. Powder Technol. 2018, 323, 284–293. DOI: 10.1016/j.powtec.2017.09.050.
   Web of Science ®Google Scholar
• Khajeh-Hosseini-Dalasm, N.; Longest, P. W. Deposition of Particles in the Alveolar Airways: Inhalation and Breath-hold with Pharmaceutical Aerosols. J. Aerosol Sci. 2015, 79, 15–30. DOI: 10.1016/j.jaerosci.2014.09.003.
   PubMed Web of Science ®Google Scholar
• Darquenne, C.;. Aerosol Deposition in Health and Disease. J Aerosol Med Pulm Drug Deliv. 2012, 25(3), 140–147. DOI: 10.1089/jamp.2011.0916.
   PubMed Web of Science ®Google Scholar
• Hickey, A. J.; Pharmaceutical Inhalation Aerosol Technology. 2003. DOI: 10.1201/9780203912898.
   Google Scholar
• Hofemeier, P.; Sznitman, J. Revisiting Pulmonary Acinar Particle Transport: Convection, Sedimentation, Diffusion, and Their Interplay. J. Appl. Physiol. 2015, 118(11), 1375–1385. DOI: 10.1152/japplphysiol.01117.2014.
   PubMed Web of Science ®Google Scholar
• Murgia, X.; Pawelzyk, P.; Schaefer, U. F.; Wagner, C.; Willenbacher, N.; Lehr, C.-M. Size-limited Penetration of Nanoparticles into Porcine Respiratory Mucus after Aerosol Deposition. Biomacromolecules. 2016, 17(4), 1536–1542. DOI: 10.1021/acs.biomac.6b00164.
   PubMed Web of Science ®Google Scholar
• Asgharian, B.; Owen, T. P.; Kuempel, E. D.; Jarabek, A. M. Dosimetry of Inhaled Elongate Mineral Particles in the Respiratory Tract: The Impact of Shape Factor. Toxicol. Appl. Pharmacol. 2018, 361, 27–35. DOI: 10.1016/j.taap.2018.05.001.
   PubMed Web of Science ®Google Scholar
• Asgharian, B.; Yu, C. P. Deposition of Inhaled Fibrous Particles in the Human Lung. J Aerosol Med. 1988, 1(1), 37–50. DOI: 10.1089/jam.1988.1.37.
   Google Scholar
• Koullapis, P. G.; Kassinos, S. C.; Bivolarova, M. P.; Melikov, A. K. Particle Deposition in a Realistic Geometry of the Human Conducting Airways: Effects of Inlet Velocity Profile, Inhalation Flowrate and Electrostatic Charge. J. Biomech. 2016, 49(11), 2201–2212. DOI: 10.1016/j.jbiomech.2015.11.029.
   PubMed Web of Science ®Google Scholar
• Johnson, T. J.; Irwin, M.; Symonds, J. P. R.; Olfert, J. S.; Boies, A. M. Measuring Aerosol Size Distributions with the Aerodynamic Aerosol Classifier. Aerosol Sci. Technol. 2018, 52, 655–665. DOI: 10.1080/02786826.2018.1440063.
   Web of Science ®Google Scholar
• Wilson, E. M.; Luft, J. C.; DeSimone, J. M. Formulation of High-Performance Dry Powder Aerosols for Pulmonary Protein Delivery. Pharm. Res. 2018, 35(10), 195. DOI: 10.1007/s11095-018-2452-z.
   PubMed Web of Science ®Google Scholar
• Longest, P. W.; Jr, M.; James, T.; Hindle, M. Characterization of Nano-aerosol Size Change during Enhanced Condensational Growth. Aerosol Sci. Technol. 2010, 44, 473–483. DOI: 10.1080/02786821003749525.
   PubMed Web of Science ®Google Scholar
• Chalvatzaki, E.; Lazaridis, M. A Dosimetry Model of Hygroscopic Particle Growth in the Human Respiratory Tract. Air Qual Atmos Heal. 2018, 11, 471–482. DOI: 10.1007/s11869-018-0555-7.
   Web of Science ®Google Scholar
• Ching, J.; Kajino, M. Aerosol Mixing State Matters for Particles Deposition in Human Respiratory System. Sci. Rep. 2018, 8(1), 8864. DOI: 10.1038/s41598-018-27156-z.
   PubMed Web of Science ®Google Scholar
• Kadota, K.; Imanaka, A.; Shimazaki, M.; Takemiya, T.; Kubo, K.; Uchiyama, H.; Tozuka, Y. Effects of Inhalation Procedure on Particle Behavior and Deposition in the Airways Analyzed by Numerical Simulation. J. Taiwan Inst. Chem. Eng. 2018, 90, 44–50. DOI: 10.1016/j.jtice.2017.11.008.
   Web of Science ®Google Scholar
• Yang, Y.; Martonen, T.; Caillibotte, G.; Katz, I.; Sbirlea-Apiou, G. Deposition Mechanics of Pharmaceutical Particles in Human Airways. In Inhal. Aerosols; CRC Press: United States, 2006; pp 27–56.
   Google Scholar
• Martins, V.; Minguillón, M. C.; Moreno, T.; Querol, X.; de Miguel, E.; Capdevila, M.; Centelles, S.; Lazaridis, M. Deposition of Aerosol Particles from a Subway Microenvironment in the Human Respiratory Tract. J. Aerosol Sci. 2015, 90, 103–113. DOI: 10.1016/j.jaerosci.2015.08.008.
   Web of Science ®Google Scholar
• Fröhlich, E.; Mercuri, A.; Wu, S.; Salar-Behzadi, S. Measurements of Deposition, Lung Surface Area and Lung Fluid for Simulation of Inhaled Compounds. Front. Pharmacol. 2016, 7, 181. DOI: 10.3389/fphar.2016.00181.
   PubMed Web of Science ®Google Scholar
• Crowder, T. M.; Rosati, J. A.; Schroeter, J. D.; Hickey, A. J.; Martonen, T. B. Fundamental Effects of Particle Morphology on Lung Delivery: Predictions of Stokes’ Law and the Particular Relevance to Dry Powder Inhaler Formulation and Development. Pharm. Res. 2002, 19(3), 239–245. DOI: 10.1023/A:1014426530935.
   PubMed Web of Science ®Google Scholar
• Hickey, A. J.; Edwards, D. A. Density and Shape Factor Terms in Stokes’ Equation for Aerodynamic Behavior of Aerosols. J. Pharm. Sci. 2018, 107(3), 794–796. DOI: 10.1016/j.xphs.2017.11.005.
   PubMed Web of Science ®Google Scholar
• Davies, C. N.;. Definitive Equations for the Fluid Resistance of Spheres. Proc Phys Soc. 1945, 57, 259. DOI: 10.1088/0959-5309/57/4/301.
   Google Scholar
• Chow, K.; Tong, H. H. Y.; Lum, S.; Chow, A. H. L. Engineering of Pharmaceutical Materials: An Industrial Perspective. J. Pharm. Sci. 2008, 97(8), 2855–2877. DOI: 10.1002/jps.21212.
   PubMed Web of Science ®Google Scholar
• Hussain, M.; Madl, P.; Khan, A. Lung Deposition Predictions of Airborne Particles and the Emergence of Contemporary Diseases, Part-I. Health (Irvine Calif). 2011, 2, 51–59.
   Google Scholar
• Depreter, F.; Pilcer, G.; Amighi, K. Inhaled Proteins: Challenges and Perspectives. Int. J. Pharm. 2013, 447, 251–280.
   PubMed Web of Science ®Google Scholar
• Brown, J. S.;. Deposition of Particles. In Comp. Biol. Norm. Lung; Elsevier Science: Netherlands, 2015; pp 513–536.
   Google Scholar
• Ibrahim, M.; Garcia-Contreras, L. Mechanisms of Absorption and Elimination of Drugs Administered by Inhalation. Ther Deliv. 2013, 4(8), 1027–1045. DOI: 10.4155/tde.13.67.
   PubMedGoogle Scholar
• Frank, J. A.;. Claudins and Alveolar Epithelial Barrier Function in the Lung. Ann. N Y Acad. Sci. 2012, 1257(1), 175. DOI: 10.1111/j.1749-6632.2012.06533.x.
   PubMedGoogle Scholar
• Schneeberger, E. E.; Lynch, R. D. The Tight Junction: A Multifunctional Complex. Am J Physiol Physiol. 2004, 286, C1213–C1228. DOI: 10.1152/ajpcell.00558.2003.
   PubMed Web of Science ®Google Scholar
• Stewart, C. E.; Torr, E. E.; Jamili, M.; Nur, H.; Bosquillon, C.; Sayers, I. Evaluation of Differentiated Human Bronchial Epithelial Cell Culture Systems for Asthma Research. J Allergy. 2012, 2012. DOI:10.1155/2012/943982.
   Google Scholar
• Patton, J. S.; Byron, P. R. Inhaling Medicines: Delivering Drugs to the Body through the Lungs. Nat. Rev. Drug Discov. 2007, 6(1), 67. DOI: 10.1038/nrd2153.
   PubMed Web of Science ®Google Scholar
• Florea, B. I.; Cassara, M. L.; Junginger, H. E.; Borchard, G. Drug Transport and Metabolism Characteristics of the Human Airway Epithelial Cell Line Calu-3. J. Control. Release. 2003, 87(1–3), 131–138. DOI: 10.1016/S0168-3659(02)00356-5.
   PubMed Web of Science ®Google Scholar
• Vllasaliu, D.; Casettari, L.; Fowler, R.; Exposito-Harris, R.; Garnett, M.; Illum, L.; Stolnik, S. Absorption-promoting Effects of Chitosan in Airway and Intestinal Cell Lines: A Comparative Study. Int. J. Pharm. 2012, 430, 151–160. DOI: 10.1016/j.ijpharm.2012.04.012.
   PubMed Web of Science ®Google Scholar
• Sun, J.; Sakai, S.; Tauchi, Y.; Deguchi, Y.; Chen, J.; Zhang, R.; Morimoto, K. Determination of Lipophilicity of Two Quinolone Antibacterials, Ciprofloxacin and Grepafloxacin, in the Protonation Equilibrium. Eur. J. Pharm. Biopharm. 2002, 54(1), 51–58.
   PubMed Web of Science ®Google Scholar
• Liang, Z.; Ni, R.; Zhou, J.; Mao, S. Recent Advances in Controlled Pulmonary Drug Delivery. Drug Discov. Today. 2015, 20(3), 380–389. DOI: 10.1016/j.drudis.2014.09.020.
   PubMed Web of Science ®Google Scholar
• Forbes, B.; Ehrhardt, C. Human Respiratory Epithelial Cell Culture for Drug Delivery Applications. Eur. J. Pharm. Biopharm. 2005, 60(2), 193–205. DOI: 10.1016/j.ejpb.2005.02.010.
   PubMed Web of Science ®Google Scholar
• Bosquillon, C.;. Drug Transporters in the Lung’ Do They Play a Role in the Biopharmaceutics of Inhaled Drugs? J. Pharm. Sci. 2010, 99(5), 2240–2255. DOI: 10.1002/jps.21995.
   PubMed Web of Science ®Google Scholar
• Groneberg DA, Eynott PR, Döring F, Dinh QT, Oates T, Barnes PJ, et al. Distribution and Function of the Peptide Transporter PEPT2 in Normal and Cystic Fibrosis Human Lung. Thorax. 2002, 57(1), 55–60. doi:10.1136/thorax.57.1.55.
   PubMed Web of Science ®Google Scholar
• Roth, M.; Obaidat, A.; Hagenbuch, B. OATPs, OATs and OCTs: The Organic Anion and Cation Transporters of the SLCO and SLC22A Gene Superfamilies. Br. J. Pharmacol. 2012, 165, 1260–1287.
   PubMed Web of Science ®Google Scholar
• Zelikin, A. N.; Ehrhardt, C.; Healy, A. M. Materials and Methods for Delivery of Biological Drugs. Nat. Chem. 2016, 8(11), 997. DOI: 10.1038/nchem.2629.
   PubMed Web of Science ®Google Scholar
• Gumbleton, M.; Hollins, A. J.; Omidi, Y.; Campbell, L.; Taylor, G. Targeting Caveolae for Vesicular Drug Transport. J. Control. Release. 2003, 87(1–3), 139–151. DOI: 10.1016/S0168-3659(02)00358-9.
   PubMed Web of Science ®Google Scholar
• Bourquin, J.; Milosevic, A.; Hauser, D.; Lehner, R.; Blank, F.; Petri‐Fink, A.; Rothen‐Rutishauser. Biodistribution, Clearance, and Long-term Fate of Clinically Relevant Nanomaterials. Adv. Mater. 2018, 30, 1704307.
   PubMed Web of Science ®Google Scholar
• Parkar, N. S.; Akpa, B. S.; Nitsche, L. C.; Wedgewood, L. E.; Place, A. T.; Sverdlov, M. S.; Chaga, O.; Minshall, R. D. Vesicle Formation and Endocytosis: Function, Machinery, Mechanisms, and Modeling. Antioxid. Redox Signal. 2009, 11(6), 1301–1312.
   PubMed Web of Science ®Google Scholar
• Herd, H.; Daum, N.; Jones, A. T.; Huwer, H.; Ghandehari, H.; Lehr, C.-M. Nanoparticle Geometry and Surface Orientation Influence Mode of Cellular Uptake. ACS Nano. 2013, 7(3), 1961–1973. DOI: 10.1021/nn304439f.
   PubMed Web of Science ®Google Scholar
• Focaroli, S.; Mah, P. T.; Hastedt, J. E.; Gitlin, I.; Oscarson, S.; Fahy, J. V.; Healy, A. M. A Design of Experiment (Doe) Approach to Optimise Spray Drying Process Conditions for the Production of Trehalose/leucine Formulations with Application in Pulmonary Delivery. Int. J. Pharm. 2019. DOI:10.1016/j.ijpharm.2019.03.004.
   Google Scholar
• Basak, S.; Chen, D.-R.; Biswas, P. Electrospray of Ionic Precursor Solutions to Synthesize Iron Oxide Nanoparticles: Modified Scaling Law. Chem. Eng. Sci. 2007, 62(4), 1263–1268. DOI: 10.1016/j.ces.2006.11.029.
   Web of Science ®Google Scholar
• Mehta, P. P.; Ghoshal, D.; Pawar, A. P.; Kadam, S. S.; Dhapte-Pawar, V. S. Recent Advances in Inhalable Liposomes for Treatment of Pulmonary Diseases: Concept to Clinical Stance. In J Drug Deliv Sci Technol, 2020, 56, 101509. DOI:10.1016/j.jddst.2020.101509.
   Google Scholar
• Price, D. N.; Kunda, N. K.; Muttil, P. Challenges Associated with the Pulmonary Delivery of Therapeutic Dry Powders for Preclinical Testing. KONA Powder Part. J. 2019, 36, 129–144. DOI: 10.14356/kona.2019008.
   Google Scholar
• Mack, G. S. Pfizer Dumps Exubera. Nat. Biotechnol. 2007, 25(12), 1331–1332. DOI: 10.1038/nbt1207-1331.
   PubMed Web of Science ®Google Scholar
• Clark, A. R. Medical Aerosol Inhalers: Past, Present, and Future. Aerosol Sci. Technol. 1995, 22(4), 374–391. DOI: 10.1080/02786829408959755.
   Web of Science ®Google Scholar
• FDA issues guidance on quality considerations for inhaled drugs, Posted on 15.06.2018 n.d. http://www.gabionline.net/Guidelines/FDA-issues-guidance-on-quality-considerations-for-inhaled-drugs ( accessed April 18, 2020).
   Google Scholar
• Bailey, C. J.; Barnett, A. H. Why Is Exubera Being Withdrawn? Bmj. 2007, 335(7630), 1156. DOI: 10.1136/bmj.39409.507662.94.
   Google Scholar
• Experts to Consider Withdrawal of Asthma Drugs n.d. https://www.nytimes.com/2005/07/13/health/experts-to-consider-withdrawal-of-asthma-drugs.html?auth=link-dismiss-google1tap ( accessed April 19, 2020).
   Google Scholar
• Fröhlich, E.; Salar-Behzadi, S. Toxicological Assessment of Inhaled Nanoparticles: Role of in Vivo, Ex Vivo, in Vitro, and in Silico Studies. Int. J. Mol. Sci. 2014, 15(3), 4795–4822. DOI: 10.3390/ijms15034795.
   PubMed Web of Science ®Google Scholar
• Seville, P. C.; Kellaway, I. W.; Birchall, J. C. Preparation of Dry Powder Dispersions for Non-viral Gene Delivery by Freeze-drying and Spray-drying. J Gene Med, 2002, 4(4), 428-437.
   Google Scholar
• Verma, P.; Thakur, A. S.; Deshmukh, K.; Jha, A. K.; Verma, S. Routes of Drug Administration. Int J Pharm Stud Res. 2010, 1, 54–59.
   Google Scholar
• Kestenbaum, M. G.; Vilches, A. O.; Messersmith, S.; Connor, S. R.; Fine, P. G.; Murphy, B.; Davis, M.; Muir, J. C. Alternative Routes to Oral Opioid Administration in Palliative Care: A Review and Clinical Summary. Pain Med. 2014, 15(7), 1129–1153.
   PubMed Web of Science ®Google Scholar
• Tangri, P.; Road, D. Approaches to Pulmonary Drug Delivery Systems. Ijpsr. 2011, 2, 1616–1622.
   Google Scholar
• Singh, M.; Chitranshi, N.; Singh, A. P.; Arora, V.; Siddiqi, A. W. An Overview on Fast Disintegrating Sublingual Tablets. Int J Drug Deliv. 2012, 4, 407.
   Google Scholar
• Chhajed, S.; Sangale, S.; Barhate, S. D. Advantageous Nasal Drug Delivery System: A Review. Int. J. Pharm. Sci. Res. 2011, 2, 1322.
   Google Scholar
• Chowdhury, P. H.; He, Q.; Lasitza Male, T.; Brune, W. H.; Rudich, Y.; Pardo, M. Exposure of Lung Epithelial Cells to Photochemically Aged Secondary Organic Aerosol Shows Increased Toxic Effects. Environ. Sci. Technol. Lett. 2018, 5(7), 424–430. DOI: 10.1021/acs.estlett.8b00256.
   Web of Science ®Google Scholar
• Martonen, T. B.; Bell, K. A.; Phalen, R. F.; Wilson, A. F.; Ho, A. Growth Rate Measurements and Deposition Modelling of Hygroscopic Aerosols in Human Tracheobronchial Models. In Inhaled Part. V; Elsevier Science: United Kingdom, 1982; pp 93–108.
   Google Scholar
• Sansone, F.; Aquino, R. P.; Del Gaudio, P.; Colombo, P.; Russo, P. Physical Characteristics and Aerosol Performance of Naringin Dry Powders for Pulmonary Delivery Prepared by Spray-drying. Eur. J. Pharm. Biopharm. 2009, 72, 206–213.
   PubMed Web of Science ®Google Scholar
• McClure, R.; Ong, H.; Janve, V.; Barton, S.; Zhu, M.; Li, B.; Dawes, M.; Jerome, W. G.; Anderson, A.; Massion, P.; Gore, J. C. Aerosol Delivery of Curcumin Reduced amyloid-$β$ Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer’s Disease. J. Alzheimer’s Dis. 2017, 55, 797–811. DOI: 10.3233/JAD-160289.
   PubMed Web of Science ®Google Scholar
• Fu, H.; He, J.; Mei, F.; Zhang, Q.; Hara, Y.; Ryota, S.; Lubet, R. A.; Chen, R.; Chen, D. R.; You, M. Lung Cancer Inhibitory Effect of Epigallocatechin-3-gallate Is Dependent on Its Presence in a Complex Mixture (Polyphenon E). Cancer Prev. Res. 2009, 2(6), 531–537.
   PubMed Web of Science ®Google Scholar
• Gandhi, M.; Pandya, T.; Gandhi, R.; Patel, S.; Mashru, R.; Misra, A.; Tandel, H. Inhalable Liposomal Dry Powder of gemcitabine-HCl: Formulation, in Vitro Characterization and in Vivo Studies. Int. J. Pharm. 2015, 496(2), 886–895.
   PubMed Web of Science ®Google Scholar
• Chow, M. Y.; Qiu, Y.; Lo, F. F.; Lin, H. H.; Chan, H. K.; Kwok, P. C.; Lam, J. K. Inhaled Powder Formulation of Naked siRNA Using Spray Drying Technology with L-leucine as Dispersion Enhancer. Int. J. Pharm. 2017, 530, 40–52. DOI: 10.1016/j.ijpharm.2017.07.013.
   PubMedGoogle Scholar
• Tse, J. Y.; Kadota, K.; Hirata, Y.; Taniguchi, M.; Uchiyama, H.; Tozuka, Y. Characterization of Matrix Embedded Formulations for Combination Spray-dried Particles Comprising Pyrazinamide and Rifampicin. J. Drug Deliv. Sci. Technol. 2018, 48, 137–144. DOI: 10.1016/j.jddst.2018.09.013.
   Web of Science ®Google Scholar
• Poursina, N.; Vatanara, A.; Rouini, M. R.; Gilani, K.; Najafabadi, A. R. The Effect of Excipients on the Stability and Aerosol Performance of Salmon Calcitonin Dry Powder Inhalers Prepared via Spray Freeze Drying Process. Acta. Pharm. 2016, 66(2), 207–218. DOI: 10.1515/acph-2016-0012.
   PubMed Web of Science ®Google Scholar
• O’hara, P.; Hickey, A. J. Respirable PLGA Microspheres Containing Rifampicin for the Treatment of Tuberculosis: Manufacture and Characterization. Pharm. Res. 2000, 17(8), 955–961. DOI: 10.1023/A:1007527204887.
   PubMed Web of Science ®Google Scholar
• Vaidya, B.; Kulkarni, N. S.; Shukla, S. K.; Parvathaneni, V.; Chauhan, G.; Damon, J. K.; Sarode, A.; Garcia, J. V.; Kunda, N.; Mitragotri, S.; Gupta, V. Development of Inhalable Quinacrine Loaded Bovine Serum Albumin Modified Cationic Nanoparticles: Repurposing Quinacrine for Lung Cancer Therapeutics. Int. J. Pharm. 2020, 577, 118995. DOI: 10.1016/j.ijpharm.2019.118995.
   PubMedGoogle Scholar
• Piao, C.; Kim, G.; Ha, J.; Lee, M. Inhalable Gene Delivery System Using a Cationic RAGE-antagonist Peptide for Gene Delivery to Inflammatory Lung Cells. ACS Biomater. Sci. Eng. 2019, 5(5), 2247–2257. DOI: 10.1021/acsbiomaterials.9b00004.
   PubMed Web of Science ®Google Scholar
• Barandalla Sobrados, M.; Carullo, P.; Salvarani, N.; Condorelli, G.; Miragoli, M.; Catalucci, D. 3072 Myocardial Delivery of Therapeutic miR-133 via Inhalable Nanoparticles Prevents the Pathologic Development in a Model of Ventricular Pressure Overload. Eur. Heart J. 2019, 40(Supplement_1), ehz745–0028. DOI: 10.1093/eurheartj/ehz745.0028.
   Google Scholar
• Anzctr n.d. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=373982 (accessed April 13, 2020).
   Google Scholar
• Lonhala® Magnair® n.d. https://www.lonhalamagnair.com/(accessed April 13, 2020).
   Google Scholar
• Pulmozyme® n.d. https://www.pulmozyme.com/(accessed April 13, 2020).
   Google Scholar
• Symbicort® n.d. https://www.mysymbicort.com/asthma.html (accessed April 13, 2020).
   Google Scholar
• PodhalerTM n.d. https://www.cff.org/Trials/pipeline/details/14/Tobramycin-Inhaled-Powder-TOBI-Podhaler (accessed April 13, 2020).
   Google Scholar
• Gonda, I.; Blanchard, J.; Cipolla, D. C.; Bermudez, L. E. M. Liposomal Ciprofloxacin Formulations with Activity against Non-tuberculous Mycobacteria 2017.
   Google Scholar
• Wang, Y.; Nebulization of Monoclonal Antibodies for Treating Pulmonary Diseases 2017.
   Google Scholar
• Ishwarya, S. P.; Anandharamakrishnan, C.; Stapley, A. G. F. Spray-freeze-drying: A Novel Process for the Drying of Foods and Bioproducts. Trends Food Sci. Technol. 2015, 41(2), 161–181. DOI: 10.1016/j.tifs.2014.10.008.
   Web of Science ®Google Scholar
• Lavanya, M. N.; Kathiravan, T.; Moses, J. A.; Anandharamakrishnan, C. Influence of Spray-drying Conditions on Microencapsulation of Fish Oil and Chia Oil. Dry Technol. 2019, 38(3), 279-292. DOI: 10.1080/07373937.2018.1553181.
   Google Scholar
• Vehring, R.; Foss, W. R.; Lechuga-Ballesteros, D. Particle Formation in Spray Drying. J. Aerosol Sci. 2007, 38(7), 728–746. DOI: 10.1016/j.jaerosci.2007.04.005.
   Web of Science ®Google Scholar
• Vicente, J.; Pinto, J.; Menezes, J.; Gaspar, F. Fundamental Analysis of Particle Formation in Spray Drying. Powder Technol. 2013, 247, 1–7. DOI: 10.1016/j.powtec.2013.06.038.
   Web of Science ®Google Scholar
• Elversson, J.; Millqvist-Fureby, A. Particle Size and Density in Spray Drying—effects of Carbohydrate Properties. J. Pharm. Sci. 2005, 94(9), 2049–2060. DOI: 10.1002/jps.20418.
   PubMed Web of Science ®Google Scholar
• Schiffter, H.; Lee, G. Single-droplet Evaporation Kinetics and Particle Formation in an Acoustic Levitator. Part 1: Evaporation of Water Microdroplets Assessed Using Boundary-layer and Acoustic Levitation Theories. J. Pharm. Sci. 2007, 96, 2274–2283. DOI: 10.1002/jps.20860.
   PubMed Web of Science ®Google Scholar
• Liao, Q.; Yip, L.; Chow, M. Y.; Chow, S. F.; Chan, H. K.; Kwok, P. C.; Lam, J. K. Porous and Highly Dispersible Voriconazole Dry Powders Produced by Spray Freeze Drying for Pulmonary Delivery with Efficient Lung Deposition. Int. J. Pharm. 2019, 560, 144–154. DOI: 10.1016/j.ijpharm.2019.01.057.
   PubMed Web of Science ®Google Scholar
• Hickey, A. J.; Mansour, H. M. Inhalation Aerosols: Physical and Biological Basis for Therapy; United States: CRC press, 2019; Vol. 1.
   Google Scholar
• Taki, M.; Tagami, T.; Fukushige, K.; Ozeki, T. Fabrication of Nanocomposite Particles Using a Two-solution Mixing-type Spray Nozzle for Use in an Inhaled Curcumin Formulation. Int. J. Pharm. 2016, 511(1), 104–110. DOI: 10.1016/j.ijpharm.2016.06.134.
   PubMed Web of Science ®Google Scholar
• Trotta, V.; Lee, W.-H.; Loo, C.-Y.; Young, P. M.; Traini, D.; Scalia, S. Co-spray Dried Resveratrol and Budesonide Inhalation Formulation for Reducing Inflammation and Oxidative Stress in Rat Alveolar Macrophages. Eur. J. Pharm. Sci. 2016, 86, 20–28. DOI: 10.1016/j.ejps.2016.02.018.
   PubMed Web of Science ®Google Scholar
• Sheth, P.; Myrdal, P.B. Excipients Utilized for Modifying Pulmonary Drug Release. In Control. Pulm. Drug Deliv.; Springer: New York,2011; 237–263. DOI:10.1007/978-1-4419-9745-6.
   Google Scholar
• Bürki, K.; Jeon, I.; Arpagaus, C.; Betz, G. New Insights into Respirable Protein Powder Preparation Using a Nano Spray Dryer. Int. J. Pharm. 2011, 408, 248–256. DOI: 10.1016/j.ijpharm.2011.02.012.
   PubMed Web of Science ®Google Scholar
• Elhissi, A.;. Liposomes for Pulmonary Drug Delivery: The Role of Formulation and Inhalation Device Design. Curr. Pharm. Des. 2017, 23(3), 362–372. DOI: 10.2174/1381612823666161116114732.
   PubMed Web of Science ®Google Scholar
• D’Addio, S. M.; Chan, J. G. Y.; Kwok, P. C. L.; Benson, B. R.; Prud’homme, R. K.; Chan, H.-K. Aerosol Delivery of Nanoparticles in Uniform Mannitol Carriers Formulated by Ultrasonic Spray Freeze Drying. Pharm. Res. 2013, 30, 2891–2901. DOI: 10.1007/s11095-013-1120-6.
   PubMed Web of Science ®Google Scholar
• Arpagaus, C.; Meuri, M. Laboratory Scale Spray Drying of Inhalable Particles: A Review. 2010.
   Google Scholar
• Dutta, S.; Moses, J. A.; Anandharamakrishnan, C. Modern Frontiers and Applications of Spray‐freeze‐drying in Design of Food and Biological Supplements. J. Food Process Eng. 2018, 41, e12881. DOI: 10.1111/jfpe.12881.
   Web of Science ®Google Scholar
• Al-Hussein, A.; Gieseler, H. The Effect of Mannitol Crystallization in Mannitol–sucrose Systems on LDH Stability during Freeze-drying. J. Pharm. Sci. 2012, 101(7), 2534–2544. DOI: 10.1002/jps.23173.
   PubMed Web of Science ®Google Scholar
• Carvalho, T. C.; Peters, J. I. Influence of Particle Size on Regional Lung Deposition - What Evidence Is There? Respiratory Drug Deliv. 2010, 2, 469-476.
   Google Scholar
• Liao, X.; Krishnamurthy, R.; Suryanarayanan, R. Influence of the Active Pharmaceutical Ingredient Concentration on the Physical State of Mannitol—implications in Freeze-drying. Pharm. Res. 2005, 22(11), 1978–1985. DOI: 10.1007/s11095-005-7625-x.
   PubMed Web of Science ®Google Scholar
• Patil, J. S.; Devi, V. K.; Devi, K.; Sarasija, S. A Novel Approach for Lung Delivery of Rifampicin-loaded Liposomes in Dry Powder Form for the Treatment of Tuberculosis. Lung India Off Organ Indian Chest Soc. 2015, 32(4), 331. DOI: 10.4103/0970-2113.159559.
   PubMed Web of Science ®Google Scholar
• Nounou, M. M.; El-Khordagui, L.; Khalafallah, N.; Khalil, S. Influence of Different Sugar Cryoprotectants on the Stability and Physico-chemical Characteristics of Freeze-dried 5-fluorouracil Plurilamellar Vesicles. DARU J. Pharm. Sci. 2005, 13, 133–142.
   Google Scholar
• Kusuma, G. D.; Barabadi, M.; Tan, J. L.; Da V, M.; Frith, J. E.; Lim, R. To Protect and to Preserve: Novel Preservation Strategies for Extracellular Vesicles. Front. Pharmacol. 2018, 9, 1199. DOI: 10.3389/fphar.2018.01199.
   PubMed Web of Science ®Google Scholar
• Werly, E. F.; Bauman, E. K. Production of Submicronic Powder by Spray-freezing. Arch Environ Heal An Int J. 1964, 9(5), 567–571. DOI: 10.1080/00039896.1964.10663881.
   PubMed Web of Science ®Google Scholar
• Ali, M. E.; Lamprecht, A. Spray Freeze Drying for Dry Powder Inhalation of Nanoparticles. Eur. J. Pharm. Biopharm. 2014, 87(3), 510–517. DOI: 10.1016/j.ejpb.2014.03.009.
   PubMed Web of Science ®Google Scholar
• Wanning, S.; Sueverkruep, R.; Lamprecht, A. Pharmaceutical Spray Freeze Drying. Int. J. Pharm. 2015, 488, 136–153. DOI: 10.1016/j.ijpharm.2015.04.053.
   PubMed Web of Science ®Google Scholar
• Anandharamakrishnan, C.;. Spray-Freeze-Drying of Coffee. Caffeinated and Cocoa Based Beverages; Elsevier Science: United Kingdom, 2019; pp 337–366.
   Google Scholar
• Vishali, D. A.; Monisha, J.; Sundari, S. S. K.; Moses, J. A.; Anandharamakrishnan, C. Spray Freeze Drying: Emerging Applications in Drug Delivery. J. Control. Release. 2019, 93–101. doi:10.1016/j.jconrel.2019.02.044.
   PubMed Web of Science ®Google Scholar
• Kondo, M.; Niwa, T.; Okamoto, H.; Danjo, K. Particle Characterization of Poorly Water-soluble Drugs Using a Spray Freeze Drying Technique. Chem. Pharm. Bull. 2009, 57, 657–662. DOI: 10.1248/cpb.57.657.
   PubMed Web of Science ®Google Scholar
• Vranić, E.; Sirbubalo, M.; Tucak, A.; Hadžiabdić, J.; Rahić, O.; Elezović, A. Development of Inhalable Dry Gene Powders for Pulmonary Drug Delivery by Spray-Freeze-Drying. In Int. Conf. Med. Biol. Eng., Springer: Germany, 2019; pp 533–537.
   Google Scholar
• Santos, G. D.; Ri, N.; Rosenthal, A. Powdered Yoghurt Produced by Spray Drying and Freeze Drying: A Review. Braz. J. Food Technol. 2018, 21. DOI: 10.1590/1981-6723.12716.
   Google Scholar
• Mueannoom, W.; Srisongphan, A.; Taylor, K. M. G.; Hauschild, S.; Gaisford, S. Thermal Ink-jet Spray Freeze-drying for Preparation of Excipient-free Salbutamol Sulphate for Inhalation. Eur. J. Pharm. Biopharm. 2012, 80(1), 149–155. DOI: 10.1016/j.ejpb.2011.09.016.
   PubMed Web of Science ®Google Scholar
• Zeleny, J.;. Instability of Electrified Liquid Surfaces. Phys. Rev. 1917, 10(1), 1. DOI: 10.1103/PhysRev.10.1.
   Google Scholar
• Javanshad, R.; Venter, A. R. Ambient Ionization Mass Spectrometry: Real-time, Proximal Sample Processing and Ionization. Anal. Methods. 2017, 9(34), 4896–4907. DOI: 10.1039/C7AY00948H.
   Web of Science ®Google Scholar
• Okuyama, K.; Lenggoro, I. W. Preparation of Nanoparticles via Spray Route. Chem. Eng. Sci. 2003, 58(3–6), 537–547. DOI: 10.1016/S0009-2509(02)00578-X.
   Web of Science ®Google Scholar
• Ijsebaert, J. C.; Geerse, K. B.; Marijnissen, J. C. M.; Lammers J-WJ, Z. P. Electro-hydrodynamic Atomization of Drug Solutions for Inhalation Purposes. J. Appl. Physiol. 2001, 91(6), 2735–2741. DOI: 10.1152/jappl.2001.91.6.2735.
   PubMed Web of Science ®Google Scholar
• Xie, J.; Lim, L. K.; Phua, Y.; Hua, J.; Wang, C.-H. Electrohydrodynamic Atomization for Biodegradable Polymeric Particle Production. J. Colloid Interface Sci. 2006, 302(1), 103–112. DOI: 10.1016/j.jcis.2006.06.037.
   PubMed Web of Science ®Google Scholar
• Jayan, H.; Leena, M. M.; Sundari, S. K. S.; Moses, J. A.; Anandharamakrishnan, C. Improvement of Bioavailability for Resveratrol through Encapsulation in Zein Using Electrospraying Technique. J. Funct. Foods. 2019, 57, 417–424. DOI: 10.1016/j.jff.2019.04.007.
   Web of Science ®Google Scholar
• Gu, H.; Hu, B.; Li, J.; Yang, S.; Han, J.; Chen, H. Rapid Analysis of Aerosol Drugs Using Nano Extractive Electrospray Ionization Tandem Mass Spectrometry. Analyst. 2010, 135(6), 1259–1267. DOI: 10.1039/b923991j.
   PubMed Web of Science ®Google Scholar
• Morozov, V. N.;. Generation of Biologically Active Nano-aerosol by an Electrospray-neutralization Method. J. Aerosol Sci. 2011, 42(5), 341–354. DOI: 10.1016/j.jaerosci.2011.02.008.
   Web of Science ®Google Scholar
• Li, G.; Pei, J.; Yin, Y.; Huang, G. Direct Sequencing of a Disulfide-linked Peptide with Electrospray Ionization Tandem Mass Spectrometry. Analyst. 2015, 140(8), 2623–2627. DOI: 10.1039/C5AN00011D.
   PubMed Web of Science ®Google Scholar
• Almekinders, J. C.; Jones, C. Multiple Jet Electrohydrodynamic Spraying and Applications. J. Aerosol Sci. 1999, 30(7), 969–971. DOI: 10.1016/S0021-8502(98)00755-1.
   Web of Science ®Google Scholar
• Patil, S.; Mahadik, A.; Nalawade, P.; More, P. Crystal Engineering of Lactose Using Electrospray Technology: Carrier for Pulmonary Drug Delivery. Drug Dev. Ind. Pharm. 2017, 43, 2085–2091. DOI: 10.1080/03639045.2017.1371733.
   PubMed Web of Science ®Google Scholar
• Jaworek, A.; Sobczyk, A. T.; Krupa, A. Electrospray Application to Powder Production and Surface Coating. J. Aerosol Sci. 2018, 125, 57–92.
   Web of Science ®Google Scholar
• Pistel, K. F.; Kissel, T. Effects of Salt Addition on the Microencapsulation of Proteins Using W/O/W Double Emulsion Technique. J. Microencapsul. 2000, 17(4), 467–483. DOI: 10.1080/026520400405723.
   PubMed Web of Science ®Google Scholar
• Patel, B.; Gupta, V.; Ahsan, F. PEG–PLGA Based Large Porous Particles for Pulmonary Delivery of a Highly Soluble Drug, Low Molecular Weight Heparin. J. Control. Release. 2012, 162(2), 310–320. DOI: 10.1016/j.jconrel.2012.07.003.
   PubMed Web of Science ®Google Scholar
• Pistel, K. F.; Bittner, B.; Koll, H.; Winter, G.; Kissel, T. Biodegradable Recombinant Human Erythropoietin Loaded Microspheres Prepared from Linear and Star-branched Block Copolymers: Influence of Encapsulation Technique and Polymer Composition on Particle Characteristics. J. Control. Release. 1999, 59(3), 309–325. DOI: 10.1016/S0168-3659(99)00008-5.
   PubMed Web of Science ®Google Scholar
• Kaialy, W.; Nokhodchi, A. Dry Powder Inhalers: Physicochemical and Aerosolization Properties of Several Size-fractions of a Promising Alternative Carrier, Freeze-dried Mannitol. Eur. J. Pharm. Sci. 2015, 68, 56–67. DOI: 10.1016/j.ejps.2014.12.005.
   PubMed Web of Science ®Google Scholar
• Khadka, P.; Dummer, J.; Hill, P. C.; Das, S. C. Considerations in Preparing for Clinical Studies of Inhaled Rifampicin to Enhance Tuberculosis Treatment. Int. J. Pharm. 2018, 548, 244–254. DOI: 10.1016/j.ijpharm.2018.07.011.
   PubMedGoogle Scholar
• Patil, J. S.; Sarasija, S. Pulmonary Drug Delivery Strategies: A Concise, Systematic Review. Lung India Off Organ Indian Chest Soc. 2012, 29, 44. DOI: 10.4103/0970-2113.92361.
   PubMedGoogle Scholar
• Liu, J.; Gong, T.; Fu, H.; Wang, C.; Wang, X.; Chen, Q.; Zhang, Q.; He, Q.; Zhang, Z. Solid Lipid Nanoparticles for Pulmonary Delivery of Insulin. Int. J. Pharm. 2008, 356(1–2), 333–344.
   PubMed Web of Science ®Google Scholar
• Chattopadhyay, P.; Shekunov, B. Y.; Yim, D.; Cipolla, D.; Boyd, B.; Farr, S. Production of Solid Lipid Nanoparticle Suspensions Using Supercritical Fluid Extraction of Emulsions (SFEE) for Pulmonary Delivery Using the AERx System. Adv. Drug Deliv. Rev. 2007, 59(6), 444–453. DOI: 10.1016/j.addr.2007.04.010.
   PubMed Web of Science ®Google Scholar
• Sanidad, K. Z.; Sukamtoh, E.; Xiao, H.; McClements, D. J.; Zhang, G. Curcumin: Recent Advances in the Development of Strategies to Improve Oral Bioavailability. Annu Rev Food Sci Technol. 2019, 10, 597-617.
   Google Scholar
• Karaman, M.; Firinci, F.; Arıkan, Z. A.; Bahar, I. H. Effects of Imipenem, Tobramycin and Curcumin on Biofilm Formation of Pseudomonas Aeruginosa Strains. Mikrobiyol Bul. 2013, 47, 192–194. DOI: 10.5578/mb.3902.
   PubMed Web of Science ®Google Scholar
• Deljoo, S.; Rabiee, N.; Rabiee, M. Curcumin-hybrid Nanoparticles in Drug Delivery System. Asian J. Nanosci. Mater. 2019, 2, 66–91.
   Google Scholar
• Hu, L.; Kong, D.; Hu, Q.; Gao, N.; Pang, S. Evaluation of High-performance Curcumin Nanocrystals for Pulmonary Drug Delivery Both in Vitro and in Vivo. Nanoscale Res. Lett. 2015, 10(1), 381. DOI: 10.1186/s11671-015-1085-y.
   PubMedGoogle Scholar
• El-Sherbiny, I. M.; Smyth, H. D. C. Controlled Release Pulmonary Administration of Curcumin Using Swellable Biocompatible Microparticles. Mol. Pharm. 2011, 9, 269–280. DOI: 10.1021/mp200351y.
   PubMed Web of Science ®Google Scholar
• Kozlowska, J.; Kaczmarkiewicz, A. Collagen Matrices Containing Poly (Vinyl Alcohol) Microcapsules with Retinyl palmitate–Structure, Stability, Mechanical and Swelling Properties. Polym. Degrad. Stab. 2019, 161, 108–113. DOI: 10.1016/j.polymdegradstab.2019.01.019.
   Web of Science ®Google Scholar
• Esteban, J.; Serrano-Maciá, M.; Sánchez-Pérez, I.; Alonso-Magdalena, P.; de la Cruz Pellín, M.; García-Arévalo, M.; Nadal, Á.; Barril, J. In Utero Exposure to bisphenol-A Disrupts Key Elements of Retinoid System in Male Mice Offspring. Food Chem. Toxicol. 2019, 126, 142–151. DOI: 10.1016/j.fct.2019.02.023.
   PubMed Web of Science ®Google Scholar
• Schofield, J. R.; Afrin, L. B. Recognition and Management of Medication Excipient Reactivity in Patients with Mast Cell Activation Syndrome. Am. J. Med. Sci. 2019, 357(6), 507–511. DOI: 10.1016/j.amjms.2019.03.005.
   PubMed Web of Science ®Google Scholar
• Reifen, R.; Berkovich, Z.; Vitamin, M. A. A Supplementation via Aerosol Spray in Asthmatic Children. Pediatr. Allergy Immunol. 2015, 26(6), 578–579. DOI: 10.1111/pai.12443.
   PubMed Web of Science ®Google Scholar
• Wiseman, E. M.; Bar-El Dadon, S.; Reifen, R. The Vicious Cycle of Vitamin A Deficiency: A Review. Crit. Rev. Food Sci. Nutr. 2017, 57(17), 3703–3714. DOI: 10.1080/10408398.2016.1160362.
   PubMed Web of Science ®Google Scholar
• Hans, K.; Biesalski, A. Vitamin A Aerosol-Inhalation Preparations. 5,112,598, 1992.
   Google Scholar
• Lavanya, M. N.; Dutta, S.; Moses, J. A.; Chinnaswamy, A. Development of β-carotene Aerosol Formulations Using a Modified Spray Dryer. J Food Process Eng,2019, 43(3), e13233.
   Google Scholar
• Palmisano, F.; Spinelli, M. G.; Luzzago, S.; Boeri, L.; De Lorenzis, E.; Albo, G.; Gadda, F.; Gelosa, M.; Longo, F.; Dell’Orto, P. G.; Montanari, E. Medical Expulsive Therapy for Symptomatic Distal Ureter Stones: Is the Combination of Bromelain and Tamsulosin More Effective than Tamsulosin Alone? Preliminary Results of a Single-Center Study. Urol Int. 2019, 102, 145–152. DOI: 10.1159/000493158.
   PubMed Web of Science ®Google Scholar
• Pavan, R.; Jain, S.; Kumar, A. Others. Properties and Therapeutic Application of Bromelain: A Review. Biotechnol. Res. Int. 2012, 2012. doi:10.1155/2012/976203.
   Google Scholar
• Shoba, E.; Lakra, R.; Kiran, M. S.; Korrapati, P. S. Fabrication of Core–shell Nanofibers for Controlled Delivery of Bromelain and Salvianolic Acid B for Skin Regeneration in Wound Therapeutics. Biomed. Mater. 2017, 12(3), 35005. DOI: 10.1088/1748-605X/aa6684.
   PubMed Web of Science ®Google Scholar
• Taussig, S. J.; Batkin, S. Bromelain, the Enzyme Complex of Pineapple (Ananas Comosus) and Its Clinical Application. An Update. J. Ethnopharmacol. 1988, 22, 191–203. DOI: 10.1016/0378-8741(88)90127-4.
   PubMed Web of Science ®Google Scholar