A Review on Mechanistic Overview on the Formation of Toxic Substances during the Traditional Fermented Food Processing

References

• Zang, J.; Xu, Y.; Xia, W.; Regenstein, J. M. Quality, Functionality, and Microbiology of Fermented Fish: A Review. Crit. Rev. Food Sci. Nutr. 2020, 60(7), 1228–1242. DOI: 10.1080/10408398.2019.1565491.
   PubMed Web of Science ®Google Scholar
• Čakar, U.; Grozdanić, N.; Pejin, B.; Vasić, V.; Čakar, M.; Petrović, A.; Djordjević, B. Impact of Vinification Procedure on Fruit Wine Inhibitory Activity against α-glucosidase. Food Biosci. 2018, 25, 1–7. DOI: 10.1016/j.fbio.2018.06.00.
   Web of Science ®Google Scholar
• Lu, T.; Shi, W. Current Situation Analysis and Development Strategy of Biological Fermentation Industry in China. Biotechnology&Business. 2019, 70, 6–9.
   Google Scholar
• Shabbir, M. A.; Raza, A.; Anjum, F. M.; Khan, M. R.; Suleria, H. A. R. Effect of Thermal Treatment on Meat Proteins with Special Reference to Heterocyclic Aromatic Amines (Haas). Crit. Rev. Food Sci. Nutr. 2015, 55(1), 82–93. DOI: 10.1080/10408398.2011.647122.
   PubMed Web of Science ®Google Scholar
• Van Hylckama Vlieg, J. E.; Veiga, P.; Zhang, C.; Derrien, M.; Zhao, L. Impact of Microbial Transformation of Food on Health—from Fermented Foods to Fermentation in the Gastro-intestinal Tract. Curr. Opin. Biotechnol. 2011, 22(2), 211–219. DOI: 10.1016/j.copbio.2010.12.004.
   PubMed Web of Science ®Google Scholar
• Komprda, T.; Sládková, P.; Dohnal, V. Biogenic Amine Content in Dry Fermented Sausages as Influenced by a Producer, Spice Mix, Starter Culture, Sausage Diameter and Time of Ripening. Meat Sci. 2009, 83(3), 534–542. DOI: 10.1016/j.meatsci.2009.07.002.
   PubMed Web of Science ®Google Scholar
• Ladero, V.; Linares, D. M.; Pérez, M.; del Rio, B.; Fernández, M.; Alvarez, M. A. Biogenic Amines in Dairy Products. Crit. Rev. Food Sci. Nutr. 2011, 51(7), 691–703. DOI: 10.1002/9781118823095.ch4.
   PubMed Web of Science ®Google Scholar
• Lu, S.; Wu, D.; Li, G.; Lv, Z.; Gong, P.; Xia, L.; Sun, Z.; Chen, G.; Chen, X.; You, J. Facile and Sensitive Determination of N-nitrosamines in Food Samples by High-performance Liquid Chromatography via Combining Fluorescent Labeling with Dispersive Liquid-liquid Microextraction. Food Chem. 2017, 234, 408–415. DOI: 10.1016/j.foodchem.2017.05.032.
   PubMed Web of Science ®Google Scholar
• Yurchenko, S.; Mölder, U. Volatile N-nitrosamines in Various Fish Products. Food Chem. 2006, 96(2), 325–333. DOI: 10.1016/j.foodchem.2005.04.009.
   Web of Science ®Google Scholar
• Zhu, Y.; Wang, P.P.; Zhao, J.; Green, R.; Sun, Z.; Roebothan, B.; Squires, J.; Buehler, S.; Dicks, E.; Zhao, J.; et al. Dietary N -nitroso Compounds and Risk of Colorectal Cancer: A Case–control Study in Newfoundland and Labrador and Ontario, Canada. Br. J. Nutr. 2014, 111(6), 1109–1117. DOI: 10.1017/s0007114513003462.
   PubMed Web of Science ®Google Scholar
• Song, P.; Wu, L.; Guan, W. Dietary Nitrates, Nitrites, and Nitrosamines Intake and the Risk of Gastric Cancer: A Meta-analysis. Nutrients. 2015, 7(12), 9872–9895. DOI: 10.3390/nu7125505.
   PubMed Web of Science ®Google Scholar
• Keszei, A. P.; Goldbohm, R. A.; Schouten, L. J.; Jakszyn, P.; van den Brandt, P. A. Dietary N-nitroso Compounds, Endogenous Nitrosation, and the Risk of Esophageal and Gastric Cancer Subtypes in the Netherlands Cohort Study. Am. J. Clin. Nutr. 2013, 97(1), 135–146. DOI: 10.3945/ajcn.112.043885.
   PubMed Web of Science ®Google Scholar
• Gowd, V.; Su, H.; Karlovsky, P.; Chen, W.Ethyl Carbamate: An Emerging Food and Environmental Toxicant. Food Chem. 2018, 248, 312–321. DOI: 10.1016/j.foodchem.2017.12.072.
   PubMed Web of Science ®Google Scholar
• Cerreti, M.; Fidaleo, M.; Benucci, I.; Liburdi, K.; Tamborra, P.; Moresi, M.; et al. Assessing the Potential Content of Ethyl Carbamate in White, Red, and Rosé Wines as a Key Factor for Pursuing Urea Degradation by Purified Acid Urease. J. Food Sci. 2016, 81(7), C1603–C1612.
   PubMed Web of Science ®Google Scholar
• Sakano, K.; Oikawa, S.; Hiraku, Y.; Kawanishi, S. Metabolism of Carcinogenic Urethane to Nitric Oxide Is Involved in Oxidative DNA Damage. Free Radical Biol. Med. 2002, 33(5), 703–714.
   PubMed Web of Science ®Google Scholar
• Baan, R.; Straif, K.; Grosse, Y.; Secretan, B.; El Ghissassi, F.; Bouvard, V.; Altieri, A.; Cogliano, V. Carcinogenicity of Alcoholic Beverages. Lancet Oncology. 2007, 8(4), 292–293. DOI: 10.1016/S1470-2045(07)70099-2
   Google Scholar
• Tekkeli, S. E. K.; Önal, C.; Önal, A. A Review of Current Methods for the Determination of Acrylamide in Food Products. Food Anal. Methods. 2012, 5(1), 29–39.
   Web of Science ®Google Scholar
• Jozinović, A.; Ačkar, Đ.; Babić, J.; Miličević, B.; Panak, J.; Šarkanj, B.; Šubarić, D. Drago in Development of LC-MS/MS Method for Determination of Acrylamide and 5-hydroxymethylfurfural in Extruded Products. International Congress “flour–Bread” 15 & Croatian Congress of Cereal Technologists “brašno-kru” 15. 2015.
   Google Scholar
• Mo, W.; He, H.; Xu, X.; Huang, B.; Ren, Y. Simultaneous Determination of Ethyl Carbamate, Chloropropanols and Acrylamide in Fermented Products, Flavoring and Related Foods by Gas Chromatography–triple Quadrupole Mass Spectrometry. Food Control 2014, 43, 251–257. DOI: 10.1016/j.foodcont.2014.03.033.
   Web of Science ®Google Scholar
• Jayakody, L. N.; Lane, S.; Kim, H.; Jin, Y.-S. Mitigating Health Risks Associated with Alcoholic Beverages through Metabolic Engineering. Curr. Opin. Biotechnol. 2016, 37, 173–181. DOI: 10.1016/j.copbio.2015.12.001.
   PubMed Web of Science ®Google Scholar
• Awad, M.; Abdel-Rahman, M.; Hassan, S. Acrylamide Toxicity in Isolated Rat Hepatocytes. Toxicol. In Vitro. 1998, 12(6), 699–704.
   PubMed Web of Science ®Google Scholar
• Alturfan, A. A.; Tozan-Beceren, A.; Şehirli, A. Ö.;, et al. Resveratrol Ameliorates Oxidative DNA Damage and Protects against Acrylamide-induced Oxidative Stress in Rats. Mol. Biol. Rep. 2012, 39(4), 4589–4596.
   PubMed Web of Science ®Google Scholar
• Hu, H.; Kan, H.; Kearney, G. D.; Xu, X. Associations between Exposure to Polycyclic Aromatic Hydrocarbons and Glucose Homeostasis as Well as Metabolic Syndrome in Nondiabetic Adults. Sci. Total Environ. 2015, 505, 56–64. DOI: 10.1016/j.scitotenv.2014.09.085.
   PubMed Web of Science ®Google Scholar
• Xia, Z.; Duan, X.; Tao, S.; Qiu, W.; Liu, D.; Wang, Y.; Wei, S.; Wang, B.; Jiang, Q.; Lu, B.; et al. Pollution Level, Inhalation Exposure and Lung Cancer Risk of Ambient Atmospheric Polycyclic Aromatic Hydrocarbons (Pahs) in Taiyuan, China. Environ. Pollut. 2013, 173, 150–156. DOI: 10.1016/j.envpol.2012.10.009.
   PubMed Web of Science ®Google Scholar
• Gibis, M.Heterocyclic Aromatic Amines in Cooked Meat Products: Causes, Formation, Occurrence, and Risk Assessment. Compr. Rev. Food Sci. Food Saf. 2016, 15, 269–302.
   PubMed Web of Science ®Google Scholar
• Alaejos, M. S.; Ayala, J.; González, V.; Afonso, A. M. Analytical Methods Applied to the Determination of Heterocyclic Aromatic Amines in Foods. J. Chromatogr. B.2008, 862(1–2), 15–42. DOI: 10.1016/j.jchromb.2007.11.040.
   PubMed Web of Science ®Google Scholar
• Canales, R.; Guiñez, M.; Bazán, C.; Reta, M.; Cerutti, S.Determining Heterocyclic Aromatic Amines in Aqueous Samples: A Novel Dispersive Liquid-liquid Micro-extraction Method Based on Solidification of Floating Organic Drop and Ultrasound Assisted Back Extraction Followed by UPLC-MS/MS. Talanta 2017, 174, 548–555. DOI: 10.1016/j.talanta.2017.06.065.
   PubMed Web of Science ®Google Scholar
• Muckel, E.; Frandsen, H.; Glatt, H. Heterologous Expression of Human N-acetyltransferases 1 and 2 and Sulfotransferase 1A1 in Salmonella Typhimurium for Mutagenicity Testing of Heterocyclic Amines. Food Chem. Toxicol. 2002, 40(8), 1063–1068.
   PubMed Web of Science ®Google Scholar
• Oz, F.; Kaya, M. Heterocyclic Aromatic Amines in Meat. J. Food Process. Preserv. 2011, 35(6), 739–753.
   Web of Science ®Google Scholar
• Santos, M. S. Biogenic Amines: Their Importance in Foods. Int. J. Food Microbiol. 1996, 29(2–3), 213–231. DOI: 10.1016/0168-1605(95)00032-1.
   PubMed Web of Science ®Google Scholar
• Sciancalepore, A. G.; Mele, E.; Arcadio, V.; Reddavide, F.; Grieco, F.; Spano, G.; Lucas, P.; Mita, G.; Pisignano, D.Microdroplet-based Multiplex PCR on Chip to Detect Foodborne Bacteria Producing Biogenic Amines. Food Microbiol. 2013, 35(1), 10–14. DOI: 10.1016/j.fm.2013.02.010.
   PubMed Web of Science ®Google Scholar
• Liu, F.; Xu, W.; Du, L.; Wang, D.; Zhu, Y.; Geng, Z.; Zhang, M.; Xu, W. Heterologous Expression and Characterization of Tyrosine Decarboxylase from Enterococcus Faecalis R612Z1 and Enterococcus Faecium R615Z1. J. Food Prot. 2014, 77(4), 592–598.
   PubMed Web of Science ®Google Scholar
• Bartkiene, E.; Zavistanaviciute, P.; Lele, V.; Ruzauskas, M.; Bartkevics, V.; Bernatoniene, J.; Gallo, P.; Tenore, G. C.; Santini, A.Lactobacillus Plantarum LUHS135 and Paracasei LUHS244 as Functional Starter Cultures for the Food Fermentation Industry: Characterisation, Mycotoxin-reducing Properties, Optimisation of Biomass Growth and Sustainable Encapsulation by Using Dairy By-products. LWT. 2018, 93, 649–658. DOI: 10.1016/j.lwt.2018.04.017.
   Web of Science ®Google Scholar
• Bartkiene, E.; Lele, V.; Starkute, V.; Zavistanaviciute, P. ; Zokaityte, E.; Varinauskaite, I.; Pileckaite, G.; Paskeviciute, L.; Rutkauskaite, G.; Kanaporis, T.; et al. Plants and Lactic Acid Bacteria Combination for New Antimicrobial and Antioxidant Properties Product Development in a Sustainable Manner. Foods. 2020, 9(4), 433. DOI: 10.3390/foods9040433.
   PubMed Web of Science ®Google Scholar
• Bartkiene, E.; Bartkevics, V.; Mozuriene, E.;Krungleviciute, V.; Novoslavskij, A.; Santini, A.; Rozentale, I.; Juodeikiene, G.; Cizeikiene, D.The Impact of Lactic Acid Bacteria with Antimicrobial Properties on Biodegradation of Polycyclic Aromatic Hydrocarbons and Biogenic Amines in Cold Smoked Pork Sausages. Food Control. 2017, 71, 285–292. DOI: 10.1016/j.foodcont.2016.07.010.
   Web of Science ®Google Scholar
• Danilović, B.; Joković, N.; Petrović, L.; Veljović, K.; Tolinački, M.; Savić, D. The Characterisation of Lactic Acid Bacteria during the Fermentation of an Artisan Serbian Sausage (Petrovská Klobása). Meat Sci. 2011, 88(4), 668–674. DOI: 10.1016/j.meatsci.2011.02.026.
   PubMed Web of Science ®Google Scholar
• Dapkevicius, M. L. E.; Nout, M. R.; Rombouts, F. M.;Houben, J. H.; Wymenga, W.Biogenic Amine Formation and Degradation by Potential Fish Silage Starter Microorganisms. Int. J. Food Microbiol. 2000, 57(1–2), 107–114.
   Web of Science ®Google Scholar
• Masson, F.; Talon, R.; Montel, M.-C. Histamine and Tyramine Production by Bacteria from Meat Products. Int. J. Food Microbiol. 1996, 32(1–2), 199–207.
   PubMed Web of Science ®Google Scholar
• Lorenzo, J. M.; Cachaldora, A.; Fonseca, S.;, et al. Production of Biogenic Amines “In Vitro” in Relation to the Growth Phase by Enterobacteriaceae Species Isolated from Traditional Sausages. Meat Sci. 2010, 86(3), 684–691.
   PubMed Web of Science ®Google Scholar
• Zaman, M. Z. Isolation of Staphylococcus Carnosus and Bacillus Amyloliquefaciens as Potential Biogenic Amine Degraders in Fish Sauce. Serdang: Universiti Putra Malaysia
   Google Scholar
• Roseiro, L.; Gomes, A.; Gonçalves, H.;Sol, M.; Cercas, R.; Santos, C.  Effect of Processing on Proteolysis and Biogenic Amines Formation in a Portuguese Traditional Dry-fermented Ripened Sausage “Chouriço Grosso De Estremoz E Borba PGI”. Meat Sci. 2010, 84(1), 172–179.
   PubMed Web of Science ®Google Scholar
• Zhong, J.; Ye, X.; Fang, Z.; Xie, G.; Liao, N.; Shu, J.; Liu, D.Determination of Biogenic Amines in Semi-dry and Semi-sweet Chinese Rice Wines from the Shaoxing Region. Food Control.2012, 28(1), 151–156. DOI: 10.1016/j.foodcont.2012.05.011.
   Web of Science ®Google Scholar
• Bjornsdottir, K.; Bolton, G. E.; McClellan-Green, P. D.; et al. Detection of Gram-negative Histamine-producing Bacteria in Fish: A Comparative Study. J. Food Prot. 2009, 72(9), 1987–1991.
   PubMed Web of Science ®Google Scholar
• Landete, J. M.; de las Rivas, B.; Marcobal, A.; Muñoz, R. Molecular Methods for the Detection of Biogenic Amine-producing Bacteria on Foods. Int. J. Food Microbiol. 2007, 117(3), 258–269. DOI: 10.1016/j.ijfoodmicro.2007.05.001.
   PubMed Web of Science ®Google Scholar
• Satomi, M.; Furushita, M.; Oikawa, H.; Yoshikawa-Takahashi, M.; Yano, Y. Analysis of a 30 Kbp Plasmid Encoding Histidine Decarboxylase Gene in Tetragenococcus Halophilus Isolated from Fish Sauce. Int. J. Food Microbiol. 2008, 126(1–2), 202–209. DOI: 10.1016/j.ijfoodmicro.2008.05.025.
   PubMed Web of Science ®Google Scholar
• Calles-Enríquez, M.; Eriksen, B. H.; Andersen, P. S.;, et al. Sequencing and Transcriptional Analysis of the Streptococcus Thermophilus Histamine Biosynthesis Gene Cluster: Factors that Affect Differential hdcA Expression. Appl. Environ. Microbiol. 2010, 76(18), 6231–6238.
   PubMed Web of Science ®Google Scholar
• Granvogl, M.; Schieberle, P. Thermally Generated 3-aminopropionamide as a Transient Intermediate in the Formation of Acrylamide. J. Agric. Food Chem. 2006, 54(16), 5933–5938. DOI: 10.1021/jf061150.
   PubMed Web of Science ®Google Scholar
• Hidalgo, F. J.; Navarro, J. L.; Delgado, R. M.; Zamora, R. Histamine Formation by Lipid Oxidation Products. Food Res. Int. 2013, 52(1), 206–213. DOI: 10.1016/j.foodres.2013.03.031.
   Web of Science ®Google Scholar
• Lundberg, J. O.; Weitzberg, E. Biology of Nitrogen Oxides in the Gastrointestinal Tract. Gut. 2013, 62(4), 616–629.
   PubMed Web of Science ®Google Scholar
• Krul, C. A.; Zeilmaker, M. J.; Schothorst, R. C.; Havenaar, R. Intragastric Formation and Modulation of N-nitrosodimethylamine in a Dynamic in Vitro Gastrointestinal Model under Human Physiological Conditions. Food Chem. Toxicol. 2004, 42(1), 51–63. DOI: 10.1016/j.fct.2003.08.005.
   PubMed Web of Science ®Google Scholar
• Li, L.; Wang, P.; Xu, X.;, et al. Influence of Various Cooking Methods on the Concentrations of Volatile N‐nitrosamines and Biogenic Amines in Dry‐cured Sausages. J. Food Sci. 2012, 77(5), C560–C565
   PubMed Web of Science ®Google Scholar
• Alahakoon, A. U.; Jayasena, D. D.; Ramachandra, S.; Jo, C. Alternatives to Nitrite in Processed Meat: Up to Date. Trends Food Sci. Technol. 2015, 45(1), 37–49. DOI: 10.1016/j.tifs.2015.05.008.
   Web of Science ®Google Scholar
• Sannino, A.; Bolzoni, L. GC/CI–MS/MS Method for the Identification and Quantification of Volatile N-nitrosamines in Meat Products. Food Chem. 2020, 60(4), 3925–3930. DOI: 10.1016/j.foodchem.2013.06.070.
   Google Scholar
• Zhang, J.; Fang, F.; Chen, J.; et al. The Arginine Deiminase Pathway of Koji Bacteria Is Involved in Ethyl Carbamate Precursor Production in Soy Sauce. FEMS Microbiol. Lett. 2014, 358(1), 91–97.
   PubMed Web of Science ®Google Scholar
• Weber, J. V.; Sharypov, V. I. Ethyl Carbamate in Foods and Beverages: A Review. Environ. Chem. Lett. 2008, 7(3), 233–247. DOI: 10.1007/s10311-008-0168-8.
   Web of Science ®Google Scholar
• Vujovic, D.; Pejin, B.; Popovic Djordjevic, J.; Velickovic, M.; Tesevic, V. Phenolic Natural Products of the Wines Obtained from Three New Merlot Clone Candidates. Nat. Prod. Res. 2015, 30(8), 987–990. DOI: 10.1080/14786419.2015.1079191.
   PubMed Web of Science ®Google Scholar
• Francis, P. S.; Lewis, S. W.; Lim, K. F. Analytical Methodology for the Determination of Urea: Current Practice and Future Trends. TrAC Trends Anal. Chem. 2002, 21(5), 389–400.
   Web of Science ®Google Scholar
• Tate, J. J.; Georis, I.; Dubois, E.;Cooper, T. G. Distinct Phosphatase Requirements and GATA Factor Responses to Nitrogen Catabolite Repression and Rapamycin Treatment in Saccharomyces Cerevisiae. J. Biol. Chem. 2010, 285(23), 17880–17895. DOI: 10.1074/jbc.m109.085712.
   PubMed Web of Science ®Google Scholar
• Azevedo, Z.; Couto, J.; Hogg, T. Citrulline as the Main Precursor of Ethyl Carbamate in Model Fortified Wines Inoculated with Lactobacillus Hilgardii: A Marker of the Levels in a Spoiled Fortified Wine. Lett Appl. Microbiol. 2002, 34(1), 32–36.
   PubMed Web of Science ®Google Scholar
• Romero, S. V.; Reguant, C.; Bordons, A.;, et al. Potential Formation of Ethyl Carbamate in Simulated Wine Inoculated with Oenococcus Oeni and Lactobacillus Plantarum. Int. J. Food Sci. Technol. 2009, 44(6), 1206–1213.
   Web of Science ®Google Scholar
• Ough, C. S. Ethyl Carbamate in Fermented Beverages and Foods. I. Naturally occurring ethylcarbamate. J. Agricul Food Chem. 1976, 242, 323–328. DOI:10.1021/jf60204a033.
   Google Scholar
• Adams, C.; van Vuuren, H. J. Effect of Timing of Diammonium Phosphate Addition to Fermenting Grape Must on the Production of Ethyl Carbamate in Wine. Am. J. Enol. Vitic. 2010, 61, 125–129.
   Web of Science ®Google Scholar
• Polychroniadou, E.; et al. Grape and Apple Wines Volatile Fermentation Products and Possible Relation to Spoilage. Bioresour. Technol. 2003, 87(3), 337–339.
   PubMed Web of Science ®Google Scholar
• Bruno, S. N. F.; Vaitsman, D. S.; Kunigami, C. N.; BRASIL, M. Influence of the Distillation Processes from Rio De Janeiro in the Ethyl Carbamate Formation in Brazilian Sugar Cane Spirits. Food Chem. 2007, 104(4), 1345–1352. DOI: 10.1016/j.foodchem.2007.01.048.
   Web of Science ®Google Scholar
• Olafsdottir, E. S.; Jørgensen, L. B.; Jaroszewski, J. W.; Jørgensen, L. B.; Jaroszewski, J. W.; Jaroszewski, J. W. Cyanogenesis in Glucosinolate-producing Plants: Carica Papaya and Carica Quercifolia. Phytochemistry. 2002, 60(3), 269–273.
   PubMed Web of Science ®Google Scholar
• Riachi, L.; Santos, A.; Moreira, R.; De Maria, C. A Review of Ethyl Carbamate and Polycyclic Aromatic Hydrocarbon Contamination Risk in Cachaça and Other Brazilian Sugarcane Spirits. Food Chem. 2014, 149, 159–169. DOI: 10.1016/j.foodchem.2013.10.088.
   PubMed Web of Science ®Google Scholar
• Singla, R. K.; Dubey, A. K.; Ameen, S. M.;Montalto, S.; Parisi, S. The Analytical Evaluation of Acrylamide in Foods as a Maillard Reaction Product. in Analytical Methods for the Assessment of Maillard Reactions in Foods; Springer International Publishing: New York; 2018, pp. 37–45.
   Google Scholar
• Zyzak, D. V.; Stojanovic, M. Method for Reducing Acrylamide in Foods, Foods Having Reduced Levels of Acrylamide, and Article of Commerce; United States, 2009. Google Patents. US7524519B2.
   Google Scholar
• Keramat, J.; LeBail, A.; Prost, C.; et al.Acrylamide in Foods: Chemistry and Analysis. A review. Food Bioproc. Technol. 2011, 4(3), 340–363
   Google Scholar
• Iriondo-DeHond, A.; Elizondo, A. S.; Iriondo-DeHond, M.;Ríos, M. B.; Mufari, R.; Mendiola, J. A.; Ibañez, E.; Castillo, M. D. E.  Assessment of Healthy and Harmful Maillard Reaction Products in a Novel Coffee Cascara Beverage: Melanoidins and Acrylamide. Foods. 2020, 9(5), 620. DOI: 10.3390/foods9050620.
   PubMed Web of Science ®Google Scholar
• Visvanathan, K. T.;. Acrylamide in Food Products: A Review. J. Food Process. Technol. 2014, 5(07), 344.
   Google Scholar
• Yaylayan, V. A.; Wnorowski, A.; Perez Locas, C. Why Asparagine Needs Carbohydrates to Generate Acrylamide. J. Agric. Food Chem. 2003, 51(6), 1753–1757. DOI: 10.1021/jf0261506.
   PubMed Web of Science ®Google Scholar
• Teng, J.; Hu, X.; Tao, N.;; et al. 2018. Impact and Inhibitory Mechanism of Phenolic Compounds on the Formation of Toxic Maillard Reaction Products in Food. Front. Agricul. Sci. Eng. 5(3)
   Google Scholar
• Maan, A. A.; Anjum, M. A.; Khan, M. K. I.; Nazir, A.; Saeed, F.; Aadil, R. M. Acrylamide Formation and Different Mitigation Strategies during Food Processing–A Review. Food Rev. Int. 2020, 1–18. DOI: 10.1080/87559129.2020.1719505.
   Google Scholar
• Ehling, S.; Hengel, M.; Shibamoto, T. Formation of acrylamide from lipids, in Chemistry and safety of acrylamide in food; Springer: Boston, MA, 2015; p. 223-233. https://doi.org/10.1007/0-387-24980-X_17.
   Google Scholar
• Vattem, D. A.; Shetty, K. Acrylamide in Food: A Model for Mechanism of Formation and Its Reduction. Innovative Food Sci. Emerg. Technol. 2003, 4(3), 331–338.
   Google Scholar
• Knol, J. J.; Linssen, J. P.; van Boekel, M. A. Unravelling the Kinetics of the Formation of Acrylamide in the Maillard Reaction of Fructose and Asparagine by Multiresponse Modelling. Food Chem. 2010, 120(4), 1047–1057. DOI: 10.1016/j.foodchem.2009.11.049.
   Web of Science ®Google Scholar
• Chen, B. H.; Chen, Y. C. Formation of Polycyclic Aromatic Hydrocarbons in the Smoke from Heated Model Lipids and Food Lipids. J. Agric. Food Chem. 2001, 49(11), 5238–5243. DOI: 10.1021/jf0106906.
   PubMed Web of Science ®Google Scholar
• Farhadian, A.; Jinap, S.; Abas, F.; Sakar, Z. I. Determination of Polycyclic Aromatic Hydrocarbons in Grilled Meat. Food Control.2010, 21(5), 606–610. DOI: 10.1016/j.foodcont.2009.09.002.
   Web of Science ®Google Scholar
• Stumpe-Vīksna, I.; Bartkevičs, V.; Kukāre, A.;Morozovs, A. Polycyclic Aromatic Hydrocarbons in Meat Smoked with Different Types of Wood. Food Chem. 2008, 110(3), 794–797. DOI: 10.1016/j.foodchem.2008.03.004.
   Web of Science ®Google Scholar
• Tanaka, N.; Ohtake, K.; Tsuzaki, M.; Miyazaki, A. Analysis of Polycyclic Aromatic Hydrocarbons in Oil-mist Emitted from Food Grilling. Bunseki Kagaku. 2012, 61(2), 77–86. DOI: 10.2116/bunsekikagaku.61.77.
   Web of Science ®Google Scholar
• Britt, P. F.; Buchanan, A.; Owens, C. V. Jr, Et Al. Fuel 2004, 83, 1417–1432. DOI: 10.1016/j.fuel.2004.02.009.
   Web of Science ®Google Scholar
• Saito, E.; Tanaka, N.; Miyazaki, A.; Tsuzaki, M. Concentration and Particle Size Distribution of Polycyclic Aromatic Hydrocarbons Formed by Thermal Cooking. Food Chem. 2014, 153, 285–291. DOI: 10.1016/j.foodchem.2013.12.055.
   PubMed Web of Science ®Google Scholar
• Murkovic, M. Formation of Heterocyclic Aromatic Amines in Model Systems. J. Chromatogr. B. 2004, 802(1), 3–10. DOI: 10.1016/j.jchromb.2003.09.026.
   PubMed Web of Science ®Google Scholar
• Koutros, S.; Cross, A. J.; Sandler, D. P.; Hoppin, J. A.; Ma, X.; Zheng, T.; Alavanja, M. C. R.; Sinha, R.;, et al. Meat and Meat Mutagens and Risk of Prostate Cancer in the Agricultural Health Study. Cancer Epidemiology Biomarkers & Prevention.2008, 17(1), 80–87.
   PubMed Web of Science ®Google Scholar
• Turesky, R. J.; Le Marchand, L. Metabolism and Biomarkers of Heterocyclic Aromatic Amines in Molecular Epidemiology Studies: Lessons Learned from Aromatic Amines. Chem. Res. Toxicol. 2011, 24, 1169–1214. DOI: 10.1021/tx200135s.
   PubMed Web of Science ®Google Scholar
• Khan, M. R.; Naushad, M.; Alothman, Z. A.; Algamdi, M. S.; Alsohaimi, I. H.; Ghfar, A. A. Effect of Natural Food Condiments on Carcinogenic/mutagenic Heterocyclic Amines Formation in Thermally Processed Camel Meat. J. Food Process. Preserv. 2017, 41(1), e12819. DOI: 10.1111/jfpp.12819.
   Web of Science ®Google Scholar
• Rönner, B.; Lerche, H.; Bergmüller, W.; Freilinger, C.; Severin, T.; Pischetsrieder, M. Formation of Tetrahydro-β-carbolines and β-Carbolines during the Reaction of l -tryptophan with d-Glucose. J. Agric. Food Chem. 2000, 48(6), 2111–2116. DOI: 10.1021/jf991237l.
   PubMed Web of Science ®Google Scholar
• Raatikainen, M.; Kronlöf, E.; Salovaara, H.; Koivisto, P. Acrylamide in Rye bread–A Risk in Finnish Diet?.Toxicology Letters. 2015, 238(2), S68.
   Google Scholar
• Crews, C. Processing Contaminants: N-nitrosamines. Encyclopedia of Food Safety; Yasmine Motarjemi. 2014; pp. 409-415. ISBN 9780123786135. https://doi.org/10.1016/B978-0-12-378612-8.00217-1
   Google Scholar
• Adımcılar, V.; Öztekin, N.; Erim, F. B. A Direct and Sensitive Analysis Method for Biogenic Amines in Dairy Products by Capillary Electrophoresis Coupled with Contactless Conductivity Detection. Food Anal. Methods. 2018, 11(5), 1374–1379.
   Web of Science ®Google Scholar
• Ščavničar, A.; Rogelj, I.; Kočar, D.; Kse, S.; Pompe, M. Determination of Biogenic Amines in Cheese by Ion Chromatography with Tandem Mass Spectrometry Detection. J. AOAC Int. 2018, 101(5), 1542–1547.
   PubMed Web of Science ®Google Scholar
• Shukla, S.; Park, H. K.; Lee, J. S.; Kim, J. K.; Kim, M. Reduction of Biogenic Amines and Aflatoxins in Doenjang Samples Fermented with Various Meju as Starter Cultures. Food Control. 2014, 42, 181-187. DOI:10.1016/j.foodcont.2014.02.006.
   Google Scholar
• Biji, K.; Ravishankar, C.; Venkateswarlu, R.;, et al. Biogenic Amines in Seafood: A Review. J. Food Sci. Technol. 2016, 53(5), 2210–2218.
   PubMed Web of Science ®Google Scholar
• Zhao, X.; Du, G.; Zou, H.; Fu, J.; Zhou, J.; Chen, J. Progress in Preventing the Accumulation of Ethyl Carbamate in Alcoholic Beverages. Trends Food Sci. Technol. 2013, 32(2), 97–107. DOI: 10.1016/j.tifs.2013.05.009.
   Web of Science ®Google Scholar
• Sun, X.; Zhou, K.; Gong, Y.;, et al. Determination of Biogenic Amines in Sichuan-style Spontaneously Fermented Sausages. Food Anal. Methods.2016, 9(8), 2299–2307.
   Web of Science ®Google Scholar
• Vale, S. R.; Glória, M. B. A. Determination of Biogenic Amines in Cheese. J. AOAC Int. 1997, 80(5), 1006–1012. DOI: 10.1093/jaoac/80.5.1006.
   PubMed Web of Science ®Google Scholar
• Lu, Y.; Chen, X.; Jiang, M.; Lv, X.; Nurgul, R.; Dong, M.; Yan, G. Biogenic Amines in Chinese Soy Sauce. Food Control. 2009, 20(6), 593–597. DOI: 10.1016/j.foodcont.2008.08.020.
   Web of Science ®Google Scholar
• Kikuchi, H.; Tsutsumi, T.; Matsuda, R. Performance Evaluation of a Fluorescamine-hplc Method for Determination of Histamine in Fish and Fish Products. J Food Hygienic Safety Sci.Soc. Japan. 2012, 53(2), 121–127. DOI:10.3358/shokueishi.53.121.
   Google Scholar
• Mey, E. D.; Klerck, K. D.; Maere, H. D.; Dewulf, L.; Derdelinckx, G.; Peeters, M.; Fraeye, I.; Heyden, Y. V.; Paelinck, H. The Occurrence of N-nitrosamines in Commercial Dry Fermented Sausages in Relation to Residual Nitrite and Biogenic Amines. Meat Sci. 2014, 96(2), 821–828.
   PubMed Web of Science ®Google Scholar
• Liu, Y.; Dong, B.; Qin, Z.; Yang, N.; Lu, Y.; Yang, L.; Chang, F.; Wu, Y. Ethyl Carbamate Levels in Wine and Spirits from Markets in Hebei Province, China. Food Addit. Contam. 2011, 4(1), 1–5. DOI: 10.1080/19393210.2011.557783.
   PubMed Web of Science ®Google Scholar
• Wu, P.; Pan, X.; Wang, L.; Shen, X.; Yang, D.A Survey of Ethyl Carbamate in Fermented Foods and Beverages from Zhejiang, China. Food Control. 2012, 23(1), 286–288. DOI: 10.1016/j.foodcont.2011.07.014.
   Web of Science ®Google Scholar
• Liu, J.; Liu, X.; Man, Y.; Liu, Y. Reduction of Acrylamide Content in Bread Crust by Starch Coating. J. Sci Food Agricul. 2018, 98(1), 336–345. DOI: 10.1002/jsfa.8476.
   PubMed Web of Science ®Google Scholar
• Hamzalıoğlu, A.; Gökmen, V. Investigation of the Reactions of Acrylamide during in Vitro Multistep Enzymatic Digestion of Thermally Processed Foods. Food Funct. 2015, 6(1), 108–113. DOI: 10.1039/c4fo00884g.
   Web of Science ®Google Scholar
• Zhang, S.; Liang, G. J.; Wu, S. L.; Qin, L. K. Determination of Acrylamide in Traditional Fermented Bean Products by HPLC-MS. Food & Fermentation Industries. 2012, 38(9), 151–155. https://doi.org/10.13995/j.cnki.11-1802/ts.2012.09.019
   Google Scholar
• Shi, Y.; Wu, H.; Wang, C.; Guo, X.; Du, J.; Du, L. Determination of Polycyclic Aromatic Hydrocarbons in Coffee and Tea Samples by Magnetic Solid-phase Extraction Coupled with HPLC–FLD. Food Chem. 2016, 199, 75–80. DOI: 10.1016/j.foodchem.2015.11.137.
   PubMed Web of Science ®Google Scholar
• Udowelle, N. A.; Igweze, Z. N.; Asomugha, R. N.; Orisakwe, O. E.Health Risk Assessment and Dietary Exposure of Polycyclic Aromatic Hydrocarbons (Pahs), Lead and Cadmium from Bread Consumed in Nigeria. Roczniki Państwowego Zakładu Higieny; The National Institute of Public Health - National Institute of Hygiene; 2017, Vol. 68(3), pp. 269–280. PMID: 28895670.
   Google Scholar
• Zachara, A.; Gałkowska, D.; Juszczak, L. Contamination of Smoked Meat and Fish Products from Polish Market with Polycyclic Aromatic Hydrocarbons. Food Control. 2017, 80, 45–51. DOI: 10.1016/j.foodcont.2017.04.024.
   Web of Science ®Google Scholar
• Yang, D.; He, Z.; Gao, D.; Qin, F.; Deng, S.; Wang, P.; Xu, X.; Chen, J.; Zeng, M. Effects of Smoking or Baking Procedures during Sausage Processing on the Formation of Heterocyclic Amines Measured Using UPLC-MS/MS. Food Chem. 2019, 276, 195–201. DOI: 10.1016/j.foodchem.2018.09.160.
   PubMed Web of Science ®Google Scholar
• Shalaby, A. R.;. Significance of Biogenic Amines to Food Safety and Human Health. Food Res. Int. 1996, 29(7), 675–690
   Web of Science ®Google Scholar
• Ruiz-Capillas, C.; Jiménez-Colmenero, F. Biogenic Amines in Meat and Meat Products. Crit. Rev. Food. Sci. Nut. 2005, 44(7–8), 489–599. DOI: 10.1080/10408690490489341.
   Google Scholar
• Lynnes, T.; Horne, S.; Prüß., B. ß-phenylethylamine as a Novel Nutrient Treatment to Reduce Bacterial Contamination Due to Escherichia Coli O157: H7 on Beef Meat. Meat Sci. 2014, 96(1), 165–171. DOI: 10.1016/j.meatsci.2013.06.030.
   PubMed Web of Science ®Google Scholar
• Smit, A.; Du Toit, W.; Du Toit, M. Biogenic Amines in Wine: Understanding the Headache. S. Afr. J. Enol. Vitic. 2008, 29, 109–127.
   Web of Science ®Google Scholar