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Review

Probiotics in treating with alcoholic liver disease and nonalcoholic fatty liver disease

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References

  • Toshikuni,N.; Tsutsumi, M.; Arisawa, T. Clinical Differences between Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease. World J. Gastroenterol. 2014, 20(26), 8393–8406.10.3748/wjg.v20.i26.8393.
  • José, A.; Ramón, B. Alcoholic Liver Disease: Pathogenesis and New Targets for Therapy. Nat. Rev. Gastroenterol. Hepatol. 2011, 8(9), 491–501.10.1038/nrgastro.2011.134.
  • Teli, M. R.; Day, C. P.; James, O. F. W. Determinants of Progression to Cirrhosis or Fibrosis in Pure Alcoholic Fatty Liver. The Lancet. 1995, 346(8981), 987–990.10.1016/S0140-6736(95)91685-7.
  • Bellentani, S.; Saccoccio, G.; Costa, G. Drinking Habits as Cofactors of Risk for Alcohol Induced Liver Damage. Gut. 1997, 41(6), 845–850.10.1136/41.6.845.
  • Corrao, G.; Aricò, S.; Zambon, A. Is Alcohol a Risk Factor for Liver Cirrhosis in HBsAg and anti-HCV Negative Subjects? J. Hepatol. 1997, 27(3), 470–476.10.1016/S0168-8278(97)80350-9.
  • Naghavi, M.; Abajobir, A. A.; Abbafati, C. Global, Regional, and National Age-sex Specific Mortality for 264 Causes of Death, 1980–2016: A Systematic Analysis for the Global Burden of Disease Study 2016. Lancet. 2017, 390,(10100) ,1151–1210.10.1016/S0140-6736(17)32152-9.
  • Akinyemiju, T.; Abera, S.; Ahmed, M. M. The Burden of Primary Liver Cancer and Underlying Etiologies from 1990 to 2015 at the Global, Regional, and National Level: Results from the Global Burden of Disease Study 2015. JAMA Oncol. 2017, 3(12), 1683–1691.10.1001/jamaoncol.2017.3055.
  • Rehm, J.; Samokhvalov, A. V.; Shield, K. D. Global Burden of Alcoholic Liver Diseases. J. Hepatol. 2013, 59(1), 160–168.10.1016/j.jhep.2013.03.007.
  • Duseja, A.; Chawla, Y. K. Obesity and NAFLD. Clin. Liver Dis. 2014, 18(1), 59–71.10.1016/j.cld.2013.09.002.
  • Xiao-Chen, W.; Xiao-Rong, Z.; Xin-Yu, L, L. Identification and Validation Co-differentially Expressed Genes with NAFLD and Insulin Resistance. Endocrine. 2015, 48(1), 143–151.10.1007/s12020-014-0247-5.
  • Fan, H.; Ma, X.; Lin, P. Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-derived 2)-Like 2 (Nrf2) in Rats. Medical Science Monitor. 2017, 23(1), 5599–5612. 10.12659/MSM.907530.
  • Melania, G.; Mariangela, M.; Emma, B. Non-alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease. Nutrients. 2013, 5(5), 1544–1560. DOI: 10.3390/nu5051544.
  • R, W. S.; Wendy, L.; Rose, M. Racial and Ethnic Distribution of Nonalcoholic Fatty Liver in Persons with Newly Diagnosed Chronic Liver Disease. Hepatol. (Baltimore, Md.). 2005, 41(2). DOI:10.1002/hep.20554.
  • Schwimmer, J. B.; Deutsch, R.; Kahen, T. Prevalence of Fatty Liver in Children and Adolescents. Pediatrics. 2006, 118(4), 1388–1393. DOI: 10.1542/peds.2006-1212.
  • Cornier, M. A.; Dabelea, D.; Hernandez, T. L.The Metabolic Syndrome. Endocrine Rev. 2008, 29(7), 777–822. DOI:10.4319/1o.1997.42.2.0250.
  • McCullough, A. J;. The Clinical Features, Diagnosis and Natural History of Nonalcoholic Fatty Liver Disease. Clin. Liver Dis. 2004, 8(3), 521–533. DOI: 10.1016/j.cld.2004.04.004.
  • Blachier, M.; Leleu, H.; Peck-Radosavljevic, M.; Valla, D. C. The Burden of Liver Disease in Europe: A Review of Available Epidemiological Data. Journal of Hepatology. 2013, 58(3), 593–608. DOI: 10.1016/j.jhep.2012.12.005.
  • Soresi, M.; Noto, D.; Cefalù, A. B.Nonalcoholic Fatty Liver and Metabolic Syndrome in Italy: Results from a Multicentric Study of the Italian Arteriosclerosis Society. Acta Diabetologica; 2013;50(2). DOI:10.1007/s00592-012-0406-1.
  • Bergheim, I.; Mcclain, C. J.; Arteel, G. E. Treatment of Alcoholic Liver Disease. Digestive Dis. 2005, 23(3–4), 275–284. DOI: 10.1159/000090175.
  • Bluemel, S.; Williams, B.; Knight, R. Precision Medicine in Alcoholic and Nonalcoholic Fatty Liver Disease via Modulating the Gut Microbiota. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2016, 311(6), G1018–36. DOI: 10.1152/ajpgi.00245.2016.
  • Akriviadis, E.; Botla, R.; Briggs, W. Pentoxifylline Improves Short-term Survival in Severe Acute Alcoholic Hepatitis: A Double-Blind, Placebo-Controlled Trial. Gastroenterology. 2000, 119(6), 1637–1648. DOI: 10.1053/gast.2000.20189.
  • Saunders, J. B;. Treatment of Alcoholic Liver Disease. Baillière’s Clinical Gastroenterology. 1989, 3(1), 39–65. DOI: 10.1016/0950-3528(89)90045-6.
  • Reid, G;. The Importance of Guidelines in the Development and Application of Probiotics. Curr. Pharm. Des. 2005, 11(1), 11–16. DOI: 10.2174/1381612053382395.
  • Allen, S. J.; Okoko, B.; Martinez, E. G. Probiotics for Treating Infectious Diarrhea. Cochrane Database Syst. Rev. 2004, 2(2), CD003048. DOI:10.1002/14651858.CD003048.pub2.
  • Zhong, Y.; Huang, C. Y.; He, T. [Effect of Probiotics and Yogurt on Colonic Microflora in Subjects with Lactose Intolerance]. J. Hyg. Res. 2006, 5(35), 587–591. DOI:10.1360/yc-006-1337.
  • Elsa, J.; Florian, C.; Harry, S.Probiotic Strain Lactobacillus Casei BL23 Prevents Colitis-Associated Colorectal Cancer. Front. Immunol. 2017, 8(2017), 1553. DOI: 10.3389/fimmu.2017.01553.
  • L, L. K.; Lorraine, B.; Km, A. Impact of Probiotics in Women with Gestational Diabetes Mellitus on Metabolic Health: A Randomized Controlled Trial. Am. J. Obstet. Gynecol. 2015, 212(4), 491–496. DOI:10.1016/j.ajog.2015.02.008.
  • Kobyliak, N.; Conte, C.; Cammarota, G.Probiotics in Prevention and Treatment of Obesity: A Critical View. Nutr. Metab. 2016, 13(1), 14. DOI:10.1186/s12986-016-0067-0.
  • Hart, A. L.; Stagg, A. J.; Kamm, M. A. Use of Probiotics in the Treatment of Inflammatory Bowel Disease. J. Clin. Gastroenterol. 2003, 36(2), 111–119. DOI: 10.1097/00004836-200302000-00005.
  • Naderi, A.; Kasra-Kermanshahi, R.; Gharavi, S.Study of Antagonistic Effects of Lactobacillus Strains as Probiotics on Multi Drug Resistant (MDR) Bacteria Isolated from Urinary Tract Infections (Utis). Iran. J. Basic Med. Sci. 2014, 17(3), 201–208. DOI:10.5414/CP202043.
  • Tian, Y. W.; Zhuang, J. L.; Rong-Yu, X. U. Effects of Probiotics on Suppression of Chronic Intestinal Inflammation and Maintenance of Intestinal Steady-state. Chin. J. Microecol. 2009, 12(21), 1136–1139. DOI:10.1063/1.2980046.
  • Mingming, Y.; Yanhong, S.; Rongrong, S. Probiotics Reduce Inflammation and Improve Intestinal Mucosal Barrier in Patients with Inflammatory Bowel Disease. Chin. J. Microecol. 2017, 4(29), 427–430. DOI:10.13381/j.cnki.cjm.201704012.
  • Gu, Z.; Liu, Y.; Hu, S.Probiotics for Alleviating Alcoholic Alcoholic Liver Injury. Gastroenterol. Res. Pract. 2019, 2019,(4) 1–8. DOI: 10.1155/2019/9097276.
  • Lavekar, A. S.; Raje, D. V.; Manohar, T. Role of Probiotics in the Treatment of Nonalcoholic FattyLiver Disease: A Meta-analysis. Euroasian Journal of Hepato-Gastroenterology. 2017, 7(2), 130–137. DOI: 10.5005/jp-journals-10018-1233.
  • Backhed, F;. Host Responses to the Human Microbiome. Nutrition Reviews. 2012, 70(Suppl 1), S14–7. DOI: 10.1111/j.1753-4887.2012.00496.x.
  • Berg, R. D;. The Indigenous Gastrointestinal Microflora. Trends Microbiol. 1996, 4(11), 430–435. DOI: 10.1016/0966-842X(96)10057-3.
  • Tap, J.; Mondot, S.; Levenez, F. Towards the Human Intestinal Microbiota Phylogenetic Core. Environmental Microbiology. 2009, 11(10), 2574–2584. DOI:10.1111/j.1462-2920.2009.01982.x.
  • Henao-Mejia, J.; Elinav, E.; Thaiss, C. A.-Role of the Intestinal Microbiome in Liver Disease. J. Autoimmun. 2013, 46(2013), 66–73. DOI: 10.1016/j.jaut.2013.07.001.
  • Jan Lata, J. J. M. K.; Lata, J. J. J. K. M.; Pdwv, I. Probiotics in Hepatology. World J. Gastroenterol. 2011, 24(v.17), 16–22. DOI:10.3748/wjg.v17.i24.2890.
  • Neish, A. S;. Microbes in Gastrointestinal Health and Disease. Gastroenterology. 2009, 136(1), 65–80. DOI: 10.1053/j.gastro.2008.10.080.
  • Visvanathan, K.; Skinner, N. A.; Thompson, A. J-. Regulation of Toll-like Receptor-2 Expression in Chronic Hepatitis B by the Precore Protein. Hepatology. 2007, 45(1), 102–110.10.1002/.21482.
  • Zang, Y.; Wang, S.; Liu, N. Alcoholic Liver Disease: Gut Microbiota and Therapeutic Perspectives.Chinese Pharmacological Bullletin.2016,32(04):451-455. 10.3969/j.issn.1001-1978.2016.04.002.
  • Peng, C.; Torralba, M.; Tan, J.Supplementation of Saturated Long-Chain Fatty Acids Maintains Intestinal Eubiosis and Reduces Ethanol-induced Liver Injury in Mice. In Gastroenterology, 2014; pp 148(1). 10.1053/j.gastro.2014.09.014.
  • Bull-Otterson, L.; Feng, W.; Kirpich, I. Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus Rhamnosus GG Treatment. Plos One. 2013, 8(1), e53028. 10.1371/journal.pone.0053028.
  • Yan, A. W.; Fouts, D. E.; Brandl, J.Enteric Dysbiosis Associated with a Mouse Model of Alcoholic Liver Disease. Hepatology. 2011, 53(1), 96–105.10.1002/hep.24018.
  • Endo, H.; Niioka, M.; Kobayashi, N. Butyrate-producing Probiotics Reduce Nonalcoholic Fatty Liver Disease Progression in Rats: New Insight into the Probiotics for the Gut-liver Axis. PLoS One. 2013, 8(5), e63388. DOI:10.1371/journal.pone.0063388.
  • Loguercio, C.; Simone, T. D.; Federico, A. Gut-liver Axis: A New Point of Attack to Treat Chronic Liver Damage? Am. J. Gastroenterol. 2002, 34(8), A53. DOI:10.1016/S1590-8658(02)90205-7.
  • Aller, R.; De Luis, D. A.; Izaola, O. Effect of A Probiotic on Liver Aminotransferases in Nonalcoholic Fatty Liver Disease Patients: A Double Blind Randomized Clinical Trial. Europ. Rev. Med. Pharmacol. Sci. 2011, 15(9), 1090–1095. DOI:10.1016/j.ejpb.2011.02.015.
  • Pietro, V.; Claudia, M.; Maria Rosaria, L. Effects of Lactobacillus Rhamnosus Strain GG in Pediatric Obesity-related Liver Disease. J. Pediatr. Gastroenterol. Nutr. 2011, 52(6), 740–743. DOI:10.1097/MPG.0b013e31821f9b85.
  • Ma, X.; Baraona, E.; Lieber, C. S. Alcohol Consumption Enhances Fatty Acid ??-oxidation, with a Greater Increase in Male than in Female Rats. Hepatology. 1993, 18(5), 1247–1253. DOI: 10.1002/hep.1840180534.
  • You, M.; Fischer, M.; Deeg, M. A. Ethanol Induces Fatty Acid Synthesis Pathways by Activation of Sterol Regulatory Element-binding Protein (SREBP). J. Biol. Chem. 2002, 277(32), 29342–29347. DOI: 10.1074/jbc.M202411200.
  • Songtao Yu, S. R. J. K.; Rao, S.; Reddy, J. K. Peroxisome Proliferator-Activated Receptors, Fatty Acid Oxidation, Steatohepatitis and Hepatocarcinogenesis. Curr. Mol. Med. 2003, 3(6), 561–572. DOI: 10.2174/1566524033479537.
  • Wagner, M.; Zollner, G.; Trauner, M. Nuclear Receptors in Liver Disease. Hepatology.2011, 53(3), 1023–1034. DOI:10.1002/hep.24148.
  • Björntorp, P.; Depergola, G.; Sjöberg, C. Alcohol Consumption and Synthesis of Ethyl Esters of Fatty Acids in Adipose Tissue. J. Internal Med. 1990, 228(6), 557–562. DOI: 10.1111/j.1365-2796.1990.tb00279.x.
  • A, A. F.; J, S.; G, R. K. Murein Lipoprotein Is a Critical Outer Membrane Component Involved in Salmonella Enterica Serovar Typhimurium Systemic Infection. Infect. Immun. 2005, 73(2), 1081–1096. DOI: 10.1128/IAI.73.2.1081-1096.2005.
  • Szabo, G.; Bala, S. Alcoholic Liver Disease and the Gut-liver Axis. World J. Gastroenterol. 2010, 16(11), 1321–1329. DOI: 10.3748/wjg.v16.i11.1321.
  • Bradham, C. A.; Plümpe, J.; Manns, M. P. Mechanisms of Hepatic Toxicity. I. TNF-induced Liver Injury. Am. J. Physiol. 1998, 275(3 pt 1), G387. 10.1080/09608788.2012.730982.
  • Tsukamoto, H;. Why Do Hepatic Macrophages and Stellate Cells Become Dysregulated in Alcoholic Liver Disease? cell. 2004, 36(8), 19–23.
  • Lieber, C. S;. Role of Oxidative Stress and Antioxidant Therapy in Alcoholic and Nonalcoholic Liver Diseases. Adv Pharmacol. 1997, 38(38), 601–62810.1016/51054-3589(08)61001-7.
  • Patsenker, W.; Millonig, M.; Stoll. 973 Cannabinoid Receptor Type 1 Expression Modulates Alcohol-induced Liver Fibrosis: Role of Acetaldehyde. Zeitschrift Für Gastroenterologie. 2010, 52(52), S376 10.1055/s-0029-1246364.
  • Wang, J. H.; Batey, R. G.; George, J. Role of Ethanol in the Regulation of Hepatic Stellate Cell Function.World Journal of Gastroenterology2006, 012(43), 6926–6932108810031915515314101.
  • Albano, E;. Oxidative Mechanisms in the Pathogenesis of Alcoholic Liver Disease. Mol Aspects Med. 2008, 29(1–2), 9–1610.1016/j.mam.2007.09.004.
  • Parola, M.; Robino, G. Oxidative Stress-related Molecules and Liver Fibrosis. J. Hepatol. 2001, 35(2), 297–306. DOI: 10.1016/S0168-8278(01)00142-8.
  • Devanshi, S.; Paul, S. H.; Wing-Kin, S.Pathogenesis of Alcohol-induced Liver Disease: Classical Concepts and Recent Advances. J. Gastroenterol. Hepatol. 2011, 26(7), 1089–1105. DOI: 10.1111/j.1440-1746.2011.06756.x.
  • Wang, S.; Pacher, P.; De Lisle, R. C. A Mechanistic Review of Cell Death in Alcohol‐Induced Liver Injury. Alcohol. Clin. Exp. Res. 2016, 40(6), 1215–1223. DOI: 10.1111/acer.13078.
  • Cubero, F.; Urtasun, R.; Nieto, N. Alcohol and Liver Fibrosis. Seminars in Liver Disease .2009, 29(2): 211–221. DOI:10.1055/s-0029-1214376.
  • Li, F.; Duan, K.; Wang, C. Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms. Gastroenterol. Res. Pract. 2015, 2016(6), 1–11. DOI:10.1155/2016/5491465.
  • Nanji, A. A.; Khettry, U.; Sadrzadeh, S. M. Lactobacillus Feeding Reduces Endotoxemia and Severity of Experimental Alcoholic Liver (Disease). Proceedings of the Society for Experimental Biology & Medicine Society for Experimental Biology & Medicine. 1994, 205(3), 243–247. DOI: 10.3181/00379727-205-43703.
  • Wang, Y.; Kirpich, I.; Liu, Y. Lactobacillus Rhamnosus GG Treatment Potentiates Intestinal Hypoxia-inducible Factor, Promotes Intestinal Integrity and Ameliorates Alcohol-induced Liver Injury. The American Journal of Pathology. 2011, 179(6), 2866–2875. DOI:10.1016/j.ajpath.2011.08.039.
  • Forsyth, C.; Farhadi, A. S.; Tang, Y. Lactobacillus GG Treatment Ameliorates Alcohol-induced Intestinal Oxidative Stress, Gut Leakiness, and Liver Injury in a Rat Model of Alcoholic Steatohepatitis. Alcohol. 2009, 43(2), 163–172. DOI:10.1016/j.alcohol.2008.12.009.
  • Kirpich, I. A.; Solovieva, N. V.; Leikhter, S. N. Probiotics Restore Bowel Flora and Improve Liver Enzymes in Human Alcohol-induced Liver Injury: A Pilot Study. Alcohol. 2008, 42(8), 675–682. DOI:10.1016/j.alcohol.2008.08.006.
  • Rui-Cong, C.; Lan-Man, X.; Shan-Jie, D. Lactobacillus Rhamnosus GG Supernatant Promotes Intestinal Barrier Function, Balances Treg and TH17 Cells and Ameliorates Hepatic Injury in a Mouse Model of Chronic-binge Alcohol Feeding. Toxicol. Lett. 2016, 241(241), 103–110. DOI: 10.1016/j.toxlet.2015.11.019.
  • Min, Z.; Chunhong, W.Enhanced AMPK Phosphorylation Contributes to the Beneficial Effects of Lactobacillus Rhamnosus GG Supernatant on Chronic-alcohol-induced Fatty Liver Disease. J. Nutr. Biochem. 2015, 26(4), 337–344. DOI:10.1016/j.nutbio.2014.10.016.
  • Zelin, G.; Yanfeng, W; Yu, W.Lactobacillus Rhamnosus Granules Dose-Dependently Balance Intestinal Microbiome Disorders and Ameliorate Chronic Alcohol-Induced Liver Injury. J. Med. Food. 2020, 23(2), 114–124. DOI:10.1089/jmf.2018.4357.
  • Forsyth, C. B.; Farhadi, A.; Jakate, S. M. Lactobacillus GG Treatment Ameliorates Alcohol-induced Intestinal Oxidative Stress, Gut Leakiness, and Liver Injury in a Rat Model of Alcoholic Steatohepatitis. Alcohol. 2009, 43(2), 163–172. DOI: 10.1016/j.alcohol.2008.12.009.
  • Yuhua, W.; Irina, K.; Yanlong, L.Lactobacillus Rhamnosus GG Treatment Potentiates Intestinal Hypoxia-inducible Factor, Promotes Intestinal Integrity and Ameliorates Alcohol-induced Liver Injury. Am. J. Pathol. 2011, 179(6), 2875. DOI:10.1016/j.ajpath.2011.08.039.
  • Bang, C. S.; Hong, S. H.; Suk, K. T. Effects of Korean Red Ginseng (Panax Ginseng), Urushiol (Rhus Vernicifera Stokes), and Probiotics (Lactobacillus Rhamnosus R0011 and Lactobacillus Acidophilus R0052) on the Gut–liver Axis of Alcoholic Liver Disease. J. Ginseng Res. 2014, 38(3), 167–172. DOI:10.1016/j.jgr.2014.04.002.
  • Hong, M.; Woo, K. S.; Han, S. H. Probiotics (Lactobacillus Rhamnosus R0011 and Acidophilus R0052) Reduce the Expression of Toll-Like Receptor 4 in Mice with Alcoholic Liver Disease. Plos One. 2015, 10(2), e117451. DOI:10.1371/journal.pone.0117451.
  • McCarthy, J.; Mahony, L. O.; Callaghan, L. O.Double Blind, Placebo Controlled Trial of Two Probiotic Strains in Interleukin 10 Knockout Mice and Mechanistic Link with Cytokine Balance. Gut. 2003, 52(7), 975–980. DOI:10.1136/gut.52.7.975.
  • Shuichi, S.; Yoshihisa, W.; Hiroshi, H. Oral Administration of Heat-killed Lactobacillus Brevis SBC8803 Ameliorates Alcoholic Liver Disease in Ethanol-containing Diet-fed C57BL/6N Mice. Int. J. Food Microbiol. 2008, 128(2), 371–377. DOI: 10.1016/j.ijfoodmicro.2008.09.023.
  • Xiang, Z. T.; Lin, P. S.; Peng, T. Liver Metabolomics Reveals the Effect of Lactobacillus Reuteri on Alcoholic Liver Disease. Front. Physiol. 2020.11(59),5382. DOI:10.3389/fphys.2020.595382.
  • Spring, M. Y.; Gary, D. O.; Michael, L. G.Reduction of Escherichia Coli O157 in Finishing Beef Cattle by Various Doses of Lactobacillus Acidophilus in Direct-fed Microbials. J. Food Prot. 2005, 68(1), 6–10. DOI: 10.4315/0362-028X-68.1.6.
  • E, P. R.; J, K. T.; A, M. R Efficacy of Dose Regimen and Observation of Herd Immunity from a Vaccine against Escherichia Coli O157: H7for Feedlot Cattle. J. Food Prot. 2007, 70(11), 2561–2567. DOI:10.2134/jeq.2007.0100
  • Arora, S.; Kaur, I. P.; Chopra, K. Efficiency of Double Layered Microencapsulated Probiotic to Modulate Proinflammatory Molecular Markers for the Management of Alcoholic Liver Disease. Mediators of Inflammation. 2014, 2014(1), 715130. DOI: 10.1155/2014/715130.
  • Chang, B.; Sang, L.; Wang, Y. The Protective Effect of VSL#3 on Intestinal Permeability in a Rat Model of Alcoholic Intestinal Injury. BMC Gastroenterol. 2013, 13(1), 151. DOI: 10.1186/1471-230X-13-151.
  • Liu, Q.; Zhong, P. D.; Da, K. H.Synbiotic Modulation of Gut Flora: Effect on Minimal Hepatic Encephalopathy in Patients with Cirrhosis. Hepatology. 2004, 39(5), 1441–1449. DOI: 10.1002/hep.20194.
  • Stadlbauer, V.; Mookerjee, R. P.; Hodges, S. Effect of Probiotic Treatment on Deranged Neutrophil Function and Cytokine Responses in Patients with Compensated Alcoholic Cirrhosis. J. Hepatol. 2008, 48(6), 951. DOI: 10.1016/j.jhep.2008.02.015.
  • Loguercio, C.; Federico, A.; Tuccillo, C. Beneficial Effects of a Probiotic VSL#3 on Parameters of Liver Dysfunction in Chronic Liver Diseases. J. Clin. Gastroenterol. 2005, 39(6), 540–543. DOI:10.1097/01.mcg.0000165671.25272.0f.
  • Hironori, K.; Yoshitaka, T.; Keiichi, M. Probiotics Promote Rapid-turnover Protein Production by Restoring Gut Flora in Patients with Alcoholic Liver Cirrhosis. Hepatol. Internat. 2013, 7(2), 767–774. DOI:10.1007/s12072-012-9408-x.
  • Lata, J.; Novotný, I.; Príbramská, V. The Effect of Probiotics on Gut Flora, Level of Endotoxin and Child-Pugh Score in Cirrhotic Patients: Results of a Double-blind Randomized Study. European Journal of Gastroenterology & Hepatology. 2007, 19(12), 1111–1113. DOI:10.1097/MEG.0b013e32823fa40e.
  • Julius, B. T.; Jordana, C. Fecal Microbiota Transplantation: Techniques, Applications, and Issues. Gastroenterol Clin North Am. 2012, 41(4), 781–803. DOI: 10.1016/j.gtc.2012.08.008.
  • Han, S. H.; Suk, K. T.; Kim, D. J. Effects of Probiotics (Cultured Lactobacillus subtilis/Streptococcus Faecium) in the Treatment of Alcoholic Hepatitis. European Journal of Gastroenterology & Hepatology. 2015, 27(11), 1300–1306. DOI:10.1097/MEG.0000000000000458.
  • Kwak, D. S.; Jun, D. W.; Seo, J. G Short-term Probiotic Therapy Alleviates Small Intestinal Bacterial Overgrowth, but Does Not Improve Intestinal Permeability in Chronic Liver Disease. Eur. J. Gastroenterol. Hepatol. 2014, 26(12), 1. DOI:10.11097/MEG.0000000000000214.
  • Neuschwander-Tetri, B. A.; Caldwell, S. H. Nonalcoholic Steatohepatitis: Summary of an AASLD Single Topic Conference. Hepatology. 2003, 38(2), 536. DOI: 10.1002/hep.510380242.
  • Matteoni, C. A.; Younossi, Z. M.; Gramlich, T. Nonalcoholic Fatty Liver Disease: A Spectrum of Clinical and Pathological Severity. Gastroenterology. 1999, 116(6), 1413–1419. DOI: 10.1016/S0016-5085(99)70506-8.
  • Wanless, I. R.; Lentz, J. S. Fatty Liver Hepatitis (Steatohepatitis) and Obesity: An Autopsy Study with Analysis of Risk Factors. Hepatology. 1990, 12(5), 1106–1110. DOI: 10.1002/hep.1840120505.
  • ERIKSSON, S.; KF, E. R. I. K. S. S. O. N.; BONDESSON, L. Nonalcoholic Steatohepatitis in Obesity: A Reversible Condition. Acta Med. Scand. 1986, 220(1), 83–88. DOI:10.1111/j.0954-6820.1986.tb02733.X.
  • Ortiz-Lopez, C.; Lomonaco, R.; Orsak, B. Prevalence of Prediabetes and Diabetes and Metabolic Profile of Patients with Nonalcoholic Fatty Liver Disease (NAFLD). Diabetes Care. 2012, 35(4), 873–878. DOI:10.2337/dc11-1849.
  • Tsukanov, V. V.; Tonkikh, J. L.; Kupershtein, E. Y.870 Coronary Heart Disease and Hyperlipidemia Were Associated with Nafld in the Russian Federation.results of Open Multicenter Prospective Study DIREG_L_01903. J. Hepatol. 2011, 54(54), S347. DOI:10.1016/S0168-8278(11)60872-6.
  • Önnerhag, K.; Nilsson, P. M.; Lindgren, S. Insulin Resistance with Impaired Fasting Glucose Increases the Risk of NAFLD. Open J. Gastroenterol. 2013, 03(3), 170–176. DOI: 10.4236/ojgas.2013.33028.
  • Cani, P. D.; Bibiloni, R.; Knauf, C Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice. Diabetes. 2008, 57(6), 1470–1481. DOI:10.2337/db07-1403.
  • Adviti, N.; Rok, K.; Damjana, R. Genomic Aspects of NAFLD Pathogenesis. Genomics. 2013, 102(2). DOI:10.1016/j.ygeno.2013.03.007.
  • Day, C. P.; James, O. F. W. Steatohepatitis: A Tale of Two ‘Hits’? Gastroenterology. 1998, 114(4), 842–845. DOI: 10.1016/S0016-5085(98)70599-2.
  • Abenavoli, L.; Scarpellini, E.; Rouabhia, S. Probiotics in Non-alcoholic Fatty Liver Disease: Which and When. Ann. Hepatol. 2013, 12(3), 357–363. DOI: 10.1016/S1665-2681(19)30997-4.
  • Reaven, G. M;. Pathophysiology of Insulin Resistance in Human Disease. Physiol. Rev. 1995, 75(3), 473. DOI: 10.1152/physrev.1995.75.3.473.
  • Krentz, A. J;. Fortnightly Review: Insulin Resistance. BMJ Clin. Res. 1996, 313(7069), 1385–1389. DOI: 10.1136/bmj.313.7069.1385.
  • I, S.; Y, B.; S, I.; J, D. H.; M, S. B.; J, L. G. Insulin Selectively Increases SREBP-1c mRNA in the Livers of Rats with Streptozotocin-induced Diabetes. Proc. Natl. Acad. Sci. U. S. A. 1999, 96(24), 13656–13661. DOI: 10.1073/pnas.96.24.13656.
  • Nadeau, K. J.; Leitner, J. W.; Gurerich, I. Insulin Regulation of SREBP-1 Expression in L-6 Muscle Cells and 3T3 L1 Adipocytes. J. Biol. Chem. 2004, 279(33), 34380–34387. DOI: 10.1074/jbc.M403596200.
  • Weyer, C.; Funahashi, T.; Tanaka, S. Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia. The Journal of Clinical Endocrinology & Metabolism. 2001, 86(5), 1930–1935. DOI:10.1210/jcem.86.5.7463.
  • Donovan, D. S.; Solomon, C. G.; Seely, E. W. Effect of Sodium Intake on Insulin Sensitivity. Am. J. Physiol. 1993, 264(5), E730–4. DOI:10.1152/ajpendo.1993.264.5E730.
  • Lombardini, S.; Loria, P.; Lonardo, A. 25 Progression of Nonalcoholic Fatty Liver Disease (NAFLD) Associates with Increased Insulin Resistance. Digest. Liver Dis. 2003, 35(03), A17. DOI: 10.1016/S1590-8658(03)90056-9.
  • Zhang, X. L.; Wu, Y. F.; Wang, Y. S. The Protective Effects of Probiotic-fermented Soymilk on High-fat Diet-induced Hyperlipidemia and Liver Injury. J. Funct. Foods. 2017, 30, 220–227. DOI: 10.1016/j.jff.2017.01.002.
  • Liong, E.; Pan, J.; Guo, R. Oxidative Stress Induced by Intermittent Hypoxia Aggravates Lipid Accumulation and Autophagy in a Cell Model of Nonalcoholic Fatty Liver Disease (NAFLD). J. Pediatr. Neurosci. 2014, 10(2), 178–180.
  • Zhang, X.; Zhang, J. H.; Chen, X. Y. ROS-induced TXNIP Drives Fructose-mediated Hepatic Inflammation and Lipid Accumulation through NLRP3 Inflammasome Activation. Antioxidants & Redox Signaling. 2015, 22(10), 848–870. DOI:10.1089/ars.2014.5658.
  • Allard, J. P.; Aghdassi, E.; Mohammed, S. Nutritional Assessment and Hepatic Fatty Acid Composition in Non-alcoholic Fatty Liver Disease (NAFLD): A Cross-sectional Study. J. Hepatol. 2008, 48(2), 307. DOI:10.1016/jep.2007.09.009.
  • Kwiecien, S.; Jasnos, K.; Magierowski, MLipid Peroxidation, Reactive Oxygen Species and Antioxidative Factors in the Pathogenesis of Gastric Mucosal Lesions and Mechanism of Protection against Oxidative Stress - Induced Gastric Injury. J. Physiol. Pharmacol. 2014, 65(5), 613–622. PMID:25371520.
  • Claudia, C.; Angelo, T.; Anna, D. P. Gut Microbiota and Probiotics in Chronic Liver Diseases. Dig Liver Dis. 2011, 43(6), 431–438. DOI:10.1016/j.did.2010.10.015.
  • Aqel, B.; Dibaise, J. K. Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease. Nutr. Clin. Pract. 2015, 30(6), 780–786. DOI: 10.1177/0884533615605811.
  • Satya Vati, R.; Surendra, S.; Jaspreet, K. Relationship of Cytokines, Oxidative Stress and GI Motility with Bacterial Overgrowth in Ulcerative Colitis Patients. Journal of Crohn’s and Colitis. 2014, 8(8), 859–865. DOI:10.1016/j.crohns.2014.01.007.
  • Yu, E. L.; Schwimmer, J. B.; Lavine, J. E. Non-alcoholic Fatty Liver Disease: Epidemiology, Pathophysiology, Diagnosis and Treatment. Paed. Child Health. 2010, 20(1), 26–29. DOI: 10.1016/j.paed.2009.09.005.
  • Esposito, E.; Iacono, A.; Bianco, G.Probiotics Reduce Inflammatory Response Induced by High Fat Diet in Liver of Young Rat: New Insights for NAFLD Treatment. Digest. Liver Dis. 2008, 40(10), A52–3. DOI:10.1016/j.crohns.2014.01.007.
  • Nardone, G.; Compare, D.; Liguori, E. Protective Effects of Lactobacillus Paracasei F19 in a Rat Model of Oxidative and Metabolic Hepatic Injury. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2010, 299(3), G669–76. DOI: 10.1152/ajpgi.00188.2010.
  • Velayudham, A.; Dolganiuc, A.; Ellis, M.VSL#3 Probiotic Treatment Attenuates Fibrosis without Changes in Steatohepatitis in a Diet-induced Nonalcoholic Steatohepatitis Model in Mice. Hepatology. 2009, 49(3), 989–997.DOI:10.1002/hep.22711.
  • Ma, X.; Hua, J.; Li, Z. Probiotics Improve High Fat Diet-induced Hepatic Steatosis and Insulin Resistance by Increasing Hepatic NKT Cells. J. Hepatol. 2008, 49(5), 821–830. DOI: 10.1016/j.jhep.2008.05.025.
  • Zhiping, L.; Shiqi, Y.; Huizhi, L. Probiotics and Antibodies to TNF Inhibit Inflammatory Activity and Improve Nonalcoholic Fatty Liver Disease. Hepatol. (Baltimore, Md.). 2003, 37(2), 343–350. DOI:10.1053/hep.2003.50048.
  • Wang, Y.; Xu, N.; Xi, A. Effects ofLactobacillus plantarumMA2 Isolated from Tibet Kefir on Lipid Metabolism and Intestinal Microflora of Rats Fed on High-cholesterol Diet. Appl. Microbiol. Biotechnol. 2009, 84(2), 341–347. DOI: 10.1007/s00253-009-2012-x.
  • Paik, H. D.; Park, J. S.; Park, E. Effects of Bacillus Polyfermenticus SCD on Lipid and Antioxidant Metabolisms in Rats Fed a High-Fat and High-Cholesterol Diet. Biol. Pharm. Bull. 2005, 28(7), 1270–1274. DOI: 10.1248/bpb.28.1270.
  • Lee, H. Y.; Park, J. H.; Seok, S. H. Human Originated Bacteria, Lactobacillus Rhamnosus PL60, Produce Conjugated Linoleic Acid and Show Anti-obesity Effects in Diet-induced Obese Mice. Biochimica Et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2006, 1761(7), 736–744. DOI:10.1016/j.bbalip.2006.05.007.
  • Hariom, Y.; Shalini, J.; P R, S. Antidiabetic Effect of Probiotic Dahi Containing Lactobacillus Acidophilus and Lactobacillus Casei in High Fructose Fed Rats. Nutr (Burbank, Los Angeles County, Calif.). 2007, 23(1), 62–68. DOI: 10.1016/j.nut.2006.09.002.
  • Hitoshi, E.; Maki, N.; Noriko, K. Butyrate-Producing Probiotics Reduce Nonalcoholic Fatty Liver Disease Progression in Rats: New Insight into the Probiotics for the Gut-Liver Axis. Plos One. 2013, 8(5), e63388. DOI: 10.1371/journal.pone.0063388.
  • Li, C.; Nie, S.; Ding, Q. Cholesterol-lowering Effect of Lactobacillus Plantarum NCU116 in a Hyperlipidaemic Rat Model. J. Funct. Foods. 2014, 8, 340–347. DOI: 10.1016/j.jff.2014.03.031.
  • Chen, D.; Yang, Z.; Chen, X. The Effect of Lactobacillus Rhamnosus Hsryfm 1301 on the Intestinal Microbiota of a Hyperlipidemic Rat Model. Bmc Complemen. Altern. Med. 2014, 14(1), 386. DOI:10.1186/1472-6882-14-386.
  • Wang, J.; Tang, H.; Zhang, C. Modulation of Gut Microbiota during Probiotic-mediated Attenuation of Metabolic Syndrome in High Fat Diet-fed Mice. The ISME Journal. 2015, 9(1), 1–15. DOI:10.1038/ismej.2014.99.
  • Malaguarnera, M.; Vacante, M.; Antic, T. Bifidobacterium Longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis. Digestive Diseases and Sciences. 2011, 57(2), 545–553. DOI: 10.1007/s10620-011-1887-4.
  • Alisi, A.; Bedogni, G.; Baviera, G.Randomised Clinical Trial: The Beneficial Effects of VSL#3 in Obese Children with Non-alcoholic Steatohepatitis. Aliment. Pharmacol. Ther. 2014, 39(11), 1276–1285. DOI: 10.1111/apt.12758.
  • Wong, V. W.; Wong, G. L.; Chim, A. M. Treatment of Nonalcoholic Steatohepatitis with Probiotics. A Proof-of-concept Study. Ann. Hepatol. 2013, 12(2), 256–262. DOI:10.5812/hepatmon.6590.
  • Mykhal’Chyshyn, H. P.; Bodnar, P. M.; Kobyliak, N. Effect of Probiotics on Proinflammatory Cytokines Level in Patients with Type 2 Diabetes and Nonalcoholic Fatty Liver Disease. Likarska Sprava. 2013, 2(2), 56–62. PMID:24605611.
  • Shavakhi, A.; Minakari, M.; Firouzian, H.Effect of A Probiotic and Metformin on Liver Aminotransferases in Non-alcoholic Steatohepatitis: A Double Blind Randomized Clinical Trial. Int. J. Preventive Med. 2013, 4(2013), 531–537. DOI:10.1111/j.1749-6632.2002.th03065.x.
  • Abbaszadeh, S.; Parastouei, K.; Afshari, H. Effects of Multistrain Probiotic Supplementation on Glycemic and Inflammatory Indices in Patients with Nonalcoholic Fatty Liver Disease: A Double-Blind Randomized Clinical Trial. J. Am. Coll. Nutr. 2016, 35(6), 1–6. DOI:10.1080/07315724.2015.1031355.
  • Nabavi, S.; Rafraf, M.; Somi, M. H. Effects of Probiotic Yogurt Consumption on Metabolic Factors in Individuals with Nonalcoholic Fatty Liver Disease. J. Dairy Sci. 2014, 97(12), 7386–7393. DOI: 10.3168/jds.2014-8500.
  • Kobyliak, N.; Abenavoli, L.; Mykhalchyshyn, GAMulti-strain Probiotic Reduces the Fatty Liver Index, Cytokines and Aminotransferase Levels in NAFLD Patients: Evidence from A Randomized ClinicalTrial. J. Gastrointestin. Liver Dis. Jgld. 2018, 27(1), 41.10.15403/jgld.2014.1121.271.kby.

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