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Review

Recent development in black garlic: Nutraceutical applications and health-promoting phytoconstituents

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References

  • Petrovska, B. B.; Cekovska, S. Extracts from the History and Medical Properties of Garlic. Pharmacogn. Rev. 2010, 4(7), 106–110. DOI: 10.4103/0973-7847.65321.
  • Bayan, L.; Koulivand, P. H.; Gorji, A. Garlic: A Review of Potential Therapeutic Effects. Avicenna J. Phytomed. 2014, 4(1), 1–14.
  • Pedisić, S.; Zorić, Z.; Miljanović, A.; Šimić, D.; Repajić, M.; Dragović-Uzelac, V. Retention of Bioactive Compounds during Domestic Processing of Croatian Domestic Garlic (Allium Sativum L.). Food Technol. Biotechnol. 2018, 56(4), 590–596. DOI: 10.17113/ftb.56.04.18.5709.
  • Qiu, Z.; Zheng, Z.; Zhang, B.; Sun‐Waterhouse, D.; Qiao, X. Formation, Nutritional Value, and Enhancement of Characteristic Components in Black Garlic: A Review for Maximizing the Goodness to Humans. Compr. Rev. Food Sci. Food Saf. 2020, 19(2), 801–834. DOI: 10.1111/1541-4337.12529.
  • Ryu, J. H.; Kang, D. Physicochemical Properties, Biological Activity, Health Benefits, and General Limitations of Aged Black Garlic: A Review. Molecules. 2017, 22(6), 919. DOI: 10.3390/molecules22060919.
  • Kimura, S.; Tung, Y.-C.; Pan, M.-H.; Su, N.-W.; Lai, Y.-J.; Cheng, K.-C. Black Garlic: A Critical Review of Its Production, Bioactivity, and Application. J. Food Drug Anal. 2017, 25(1), 62–70. DOI: 10.1016/j.jfda.2016.11.003.
  • Choi, I. S.; Cha, H. S.; Lee, Y. S. Physicochemical and Antioxidant Properties of Black Garlic. Molecules. 2014, 19(10), 16811–16823. DOI: 10.3390/molecules191016811.
  • Kim, J. H.; Nam, S. H.; Rico, C. W.; Kang, M. Y. A Comparative Study on the Antioxidative and Anti‐allergic Activities of Fresh and Aged Black Garlic Extracts. Int. J. Food Sci. Technol. 2012, 47(6), 1176–1182. DOI: 10.1111/j.1365-2621.2012.02957.x.
  • Jack, D. B. Keep Takingthe Tomatoes—the Exciting World of Nutraceuticals. Mol. Med. Today. 1995, 1(3), 118–121. DOI: 10.1016/S1357-4310(95)80088-3.
  • Mannion, M. Nutraceutical Revolution Continues at Foundation for Innovation in Medicine Conference Am. J. Nat. Med . 1998, 5 (), 30–33.
  • Brower, V. Nutraceuticals: Poised for a Healthy Slice of the Healthcare Market? Nat. Biotechnol. 1998, 16(8), 728–731. DOI: 10.1038/nbt0898-728.
  • Jiang, -L.-L.; Gong, X.; Ji, M.-Y.; Wang, -C.-C.; Wang, J.-H.; Li, M.-H. Bioactive Compounds from Plant-Based Functional Foods: A Promising Choice for the Prevention and Management of Hyperuricemia. Foods. 2020, 9(8), 973. DOI: 10.3390/foods9080973.
  • Pandey, K. B.; Rizvi, S. I. Plant Polyphenols as Dietary Antioxidants in Human Health and Disease. Oxid. Med. Cell. Longev. 2009, 2(5), 270–278. DOI: 10.4161/oxim.2.5.9498.
  • Vinyagam, R.; Kumar, P.; Lee, K. E.; Xu, B.; Matin, M. N.; Kang, S. G. Biological and Functional Properties of Wedelolactone in Human Chronic Diseases. Phyton. 2021, 90(1), 1. DOI: 10.32604/phyton.2020.013388.
  • Lobo, V.; Patil, A.; Phatak, A.; Chandra, N. Free Radicals, Antioxidants and Functional Foods: Impact on Human Health. Pharmacogn. Rev. 2010, 4(8), 118–126. DOI: 10.4103/0973-7847.70902.
  • Cornier, M.-A.; Dabelea, D.; Hernandez, T. L.; Lindstrom, R. C.; Steig, A. J.; Stob, N. R.; Van Pelt, R. E.; Wang, H.; Eckel, R. H. The Metabolic Syndrome. Endocrine Rev. 2008, 29(7), 777–822. DOI: 10.1210/er.2008-0024.
  • Lorzadeh, E.; Sangsefidi, Z. S.; Mirzaei, M.; Hosseinzadeh, M. Dietary Habits and Their Association with Metabolic Syndrome in A Sample of Iranian Adults: A Population-based Study. Food Sci. Nutr. 2020, 8(11), 6217–6225. DOI: 10.1002/fsn3.1918.
  • Frota, K. D. M. G.; Matias, A. C. G.; Arêas, J. A. G. Influence of Food Components on Lipid Metabolism: Scenarios and Perspective on the Control and Prevention of Dyslipidemias. Food Sci. Technol. 2010, 30, 7–14. DOI: 10.1590/S0101-20612010000500002.
  • Siwach, R.; Tokas, J.; Seth, R. Use of Lycopene as a Natural Antioxidant in Extending the Shelf-life of Anhydrous Cow Milk Fat. Food Chem. 2016, 199, 541–546. DOI: 10.1016/j.foodchem.2015.12.009.
  • Yuan, H.; Sun, L.; Chen, M.; Wang, J. The Comparison of the Contents of Sugar, Amadori, and Heyns Compounds in Fresh and Black Garlic. J. Food Sci. 2016, 81(7), C1662–C1668. DOI: 10.1111/1750-3841.13365.
  • Hwang, I. G.; Kim, H. Y.; Woo, K. S.; Lee, J.; Jeong, H. S. Biological Activities of Maillard Reaction Products (Mrps) in a Sugar–amino Acid Model System. Food Chem. 2011, 126(1), 221–227. DOI: 10.1016/j.foodchem.2010.10.103.
  • Toledano-Medina, M. A.; Pérez-Aparicio, J.; Moreno-Rojas, R.; Merinas-Amo, T. Evolution of Some Physicochemical and Antioxidant Properties of Black Garlic Whole Bulbs and Peeled Cloves. Food Chem. 2016, 199, 135–139. DOI: 10.1016/j.foodchem.2015.11.128.
  • Molina-Calle, M.; ; ; , de Medina, V.S., Priego-Capote, F., de Castro, M.D.L. Establishing compositional differences between fresh and black garlic by a metabolomics approach based on LC–QTOF MS/MS analysis. J. Food Compost. Anal. 2017, 62(62), 155–163. DOI: 10.1016/j.jfca.2017.05.004.
  • Jung, Y.-M.; Lee, S.-H.; Lee, D.-S.; You, M.-J.; Chung, I. K.; Cheon, W. H.; Kwon, Y.-S.; Lee, Y.-J.; Ku, S.-K. Fermented Garlic Protects Diabetic, Obese Mice When Fed a High-fat Diet by Antioxidant Effects. Nutr. Res. 2011, 31(5), 387–396. DOI: 10.1016/j.nutres.2011.04.005.
  • Sato, E.; Kohno, M.; Niwano, Y. Increased Level of Tetrahydro-beta-carboline Derivatives in Short-term Fermented Garlic. Plant Foods Hum. Nutr. 2006, 61(4), 175–178. DOI: 10.1007/s11130-006-0028-2.
  • Zhang, X.; Li, N.; Lu, X.; Liu, P.; Qiao, X. Effects of Temperature on the Quality of Black Garlic. J. Sci. Food Agric. 2016, 96(7), 2366–2372. DOI: 10.1002/jsfa.7351.
  • Lu, X.; Li, N.; Qiao, X.; Qiu, Z.; Liu, P. Composition Analysis and Antioxidant Properties of Black Garlic Extract. J. Food Drug Anal. 2017, 25(2), 340–349. DOI: 10.1016/j.jfda.2016.05.011.
  • Toledano Medina, M. Á.; Merinas-Amo, T.; Fernández-Bedmar, Z.; Font, R.; Del Río-celestino, M.; Pérez-Aparicio, J.; Moreno-Ortega, A.; Alonso-Moraga, Á.; Moreno-Rojas, R. Physicochemical Characterization and Biological Activities of Black and White Garlic: In Vivo and in Vitro Assays. Foods. 2019, 8(6), 220. DOI: 10.3390/foods8060220.
  • Kang, O.-J. Physicochemical Characteristics of Black Garlic after Different Thermal Processing Steps. Preventive Nutr. Food Sci. 2016, 21(4), 348. DOI: 10.3746/pnf.2016.21.4.348.
  • Nakagawa, K.; Maeda, H.; Yamaya, Y.; Tonosaki, Y. Maillard Reaction Intermediates and Related Phytochemicals in Black Garlic Determined by EPR and HPLC Analyses Molecules . 2020, 25(19), 4578 doi:10.3390/molecules25194578.
  • Zhang, Z.; Lei, M.; Liu, R.; Gao, Y.; Xu, M.; Zhang, M. Evaluation of Alliin, Saccharide Contents and Antioxidant Activities of Black Garlic during Thermal Processing. J. Food Biochem. 2015, 39(1), 39–47. DOI: 10.1111/jfbc.12102.
  • Purev, U.; Chung, M. J.; Oh, D.-H. Individual Differences on Immunostimulatory Activity of Raw and Black Garlic Extract in Human Primary Immune Cells. Immunopharmacol. Immunotoxicol 2012, 34(4), 651–660. DOI: 10.3109/08923973.2011.649288.
  • Najman, K.; Sadowska, A.; Hallmann, E. Evaluation of Bioactive and Physicochemical Properties of White and Black Garlic (Allium Sativum L.) From Conventional and Organic Cultivation. Appl. Sci. 2021, 11(2), 874. DOI: 10.3390/app11020874.
  • Sun, Y. E.; Wang, W. Changes in Nutritional and Bio-functional Compounds and Antioxidant Capacity during Black Garlic Processing. J. Food Sci. Technol. 2018, 55(2), 479–488. DOI: 10.1007/s13197-017-2956-2.
  • Yuan, H.; Sun, L.; Chen, M.; Wang, J. An Analysis of the Changes on Intermediate Products during the Thermal Processing of Black Garlic. Food Chem. 2018, 239, 56–61. DOI: 10.1016/j.foodchem.2017.06.079.
  • Kang, M.-J.; Lee, S.-J.; Shin, J.-H.; Kang, S.-K.; Kim, J.-G.; Sung, N.-J. Effect of Garlic with Different Processing on Lipid Metabolism in 1% Cholesterol Fed Rats. J. Korean Soc. Food Sci. Nutr. 2008, 37(2), 162–169. DOI: 10.3746/jkfn.2008.37.2.162.
  • Corzo-Martínez, M.; Corzo, N.; Villamiel, M. Biological Properties of Onions and Garlic. Trends Food Sci. Technol. 2007, 18(12), 609–625. DOI: 10.1016/j.tifs.2007.07.011.
  • Li, N.; Lu, X.; Pei, H.; Qiao, X. Effect of Freezing Pretreatment on the Processing Time and Quality of Black Garlic. J. Food Process Eng. 2015, 38(4), 329–335. DOI: 10.1111/jfpe.12156.
  • Liang, T.; Wei, F.; Lu, Y.; Kodani, Y.; Nakada, M.; Miyakawa, T.; Tanokura, M. Comprehensive NMR Analysis of Compositional Changes of Black Garlic during Thermal Processing. J. Agric. Food Chem. 2015, 63(2), 683–691. DOI: 10.1021/jf504836d.
  • Kim, J.-S.; Kang, O.-J.; Gweon, O.-C. Comparison of Phenolic Acids and Flavonoids in Black Garlic at Different Thermal Processing Steps. J. Funct. Foods. 2013, 5(1), 80–86. DOI: 10.1016/j.jff.2012.08.006.
  • Kim, J. H.; Yu, S. H.; Cho, Y. J.; Pan, J. H.; Cho, H. T.; Kim, J. H.; Bong, H.; Lee, Y.; Chang, M. H.; Jeong, Y. J. Preparation of S-allylcysteine-enriched Black Garlic Juice and Its Antidiabetic Effects in Streptozotocin-induced Insulin-deficient Mice. J. Agric. Food Chem. 2017, 65(2), 358–363. DOI: 10.1021/acs.jafc.6b04948.
  • Choi, D.-J.; Lee, S.-J.; Kang, M.-J.; Cho, H.-S.; Sung, N.-J.; Shin, J.-H. Physicochemical Characteristics of Black Garlic (Allium Sativum L.). J. Korean Soc. Food Sci. Nutr. 2008, 37(4), 465–471. DOI: 10.3746/jkfn.2008.37.4.465.
  • Beato, V. M.; Orgaz, F.; Mansilla, F.; Montaño, A. Changes in Phenolic Compounds in Garlic (Allium Sativum L.) Owing to the Cultivar and Location of Growth. Plant Foods Human Nutr. 2011, 66(3), 218–223. DOI: 10.1007/s11130-011-0236-2.
  • Kim, W. Y.; Kim, J. M.; Han, S. B.; Lee, S. K.; Kim, N. D.; Park, M. K.; Kim, C. K.; Park, J. H. Steaming of Ginseng at High Temperature Enhances Biological Activity. J. Nat. Prod. 2000, 63(12), 1702–1704. DOI: 10.1021/np990152b.
  • Ríos-Ríos, K. L.; Montilla, A.; Olano, A.; Villamiel, M. Physicochemical Changes and Sensorial Properties during Black Garlic Elaboration: A Review. Trends Food Sci. Technol. 2019, 88, 459–467. DOI: 10.1016/j.tifs.2019.04.016.
  • Bae, S. E.; Cho, S. Y.; Won, Y. D.; Lee, S. H.; Park, H. J. Changes in S-allyl Cysteine Contents and Physicochemical Properties of Black Garlic during Heat Treatment. LWT Food Sci. Technol. 2014, 55(1), 397–402. DOI: 10.1016/j.lwt.2013.05.006.
  • Shin, J.-H.; Choi, D.-J.; Lee, S.-J.; Cha, J.-Y.; Kim, J.-G.; Sung, N.-J. Changes of Physicochemical Components and Antioxidant Activity of Garlic during Its Processing. J. Life Sci. 2008, 18(8), 1123–1131. DOI: 10.5352/JLS.2008.18.8.1123.
  • Wang, W. D.; Wang, Y.; Wang, C.; Sun, Y. E.; Gao, M. X. Effect of Maillard Reaction on Nutrients and Antioxidant Activities of Garlic. Food Sci. Technol. 2013, 4, 011.
  • Jung, I.-C.; Sohn, H.-Y. Antioxidation, Antimicrobial and Antithrombosis Activities of Aged Black Garlic (Allium Sativum L.). Microbiol. Biotechnol. Lett 2014, 42(3), 285–292. DOI: 10.4014/kjmb.1407.07002.
  • Jang, E.-K.; Seo, J.-H.; Lee, S.-P. Physiological Activity and Antioxidative Effects of Aged Black Garlic (Allium Sativum L.) Extract. Korean J. Food Sci. Tech. 2008, 40(4), 443–448.
  • Bae, S. E.; Cho, S. Y.; Won, Y. D.; Lee, S. H.; Park, H. J. A Comparative Study of the Different Analytical Methods for Analysis of S-allyl Cysteine in Black Garlic by HPLC. LWT Food Sci. Technol. 2012, 46(2), 532–535. DOI: 10.1016/j.lwt.2011.11.013.
  • Sasaki, J. I.; Lu, C.; Machiya, E.; Tanahashi, M.; Hamada, K. Processed Black Garlic (Allium Sativum) Extracts Enhance Anti-tumor Potency against Mouse Tumors. Med. Aromatic J. Plant Sci Biotech 2007, 1 (2), 278–281.
  • Shin, J.-H.; Choi, D.-J.; Lee, S.-J.; Cha, J.-Y.; Sung, N.-J. Antioxidant Activity of Black Garlic (Allium Sativum L.). J. Korean Soc. Food Sci. Nutr. 2008, 37(8), 965–971. DOI: 10.3746/jkfn.2008.37.8.965.
  • Dong, M.; Yang, G.; Liu, H.; Liu, X.; Lin, S.; Sun, D.; Wang, Y. Aged Black Garlic Extract Inhibits HT29 Colon Cancer Cell Growth via the PI3K/Akt Signaling Pathway. Biomed. Rep. 2014, 2(2), 250–254. DOI: 10.3892/br.2014.226.
  • Wang, X.; Jiao, F.; Wang, Q.-W.; Wang, J.; Yang, K.; Hu, -R.-R.; Liu, H.-C.; Wang, H.-Y.; Wang, Y.-S. Aged Black Garlic Extract Induces Inhibition of Gastric Cancer Cell Growth in Vitro and in Vivo. Mol. Med. Rep. 2012, 5(1), 66–72. DOI: 10.3892/mmr.2011.588.
  • Park, C.; Park, S.; Chung, Y. H.; Kim, G.-Y.; Choi, Y. W.; Kim, B. W.; Choi, Y. H. Induction of Apoptosis by a Hexane Extract of Aged Black Garlic in the Human Leukemic U937 Cells. Nutr. Res. Pract. 2014, 8(2), 132. DOI: 10.4162/nrp.2014.8.2.132.
  • Yang, G. Q.; Wang, D.; Wang, Y. S.; Wang, Y. Y.; Yang, K. Radiosensitization Effect of Black Garlic Extract on Lung Cancer Cell Line Lewis Cells. Zhongguo Zhong Xi Yi Jie He Za Zhi 2013, 33(8), 1093–1097.
  • Shin, D.-Y.; Yoon, M.-K.; Choi, Y.-W.; Gweon, O.-C.; Kim, J.-I.; Choi, T.-H.; Choi, Y.-H. Effects of Aged Black Garlic Extracts on the Tight Junction Permeability and Cell Invasion in Human Gastric Cancer Cells. J. Life Sci. 2010, 20(4), 528–534. DOI: 10.5352/JLS.2010.20.4.528.
  • Jikihara, H.; Qi, G.; Nozoe, K.; Hirokawa, M.; Sato, H.; Sugihara, Y.; Shimamoto, F. Aged Garlic Extract Inhibits 1, 2-dimethylhydrazine-induced Colon Tumor Development by Suppressing Cell Proliferation. Oncol. Rep. 2015, 33(3), 1131–1140. DOI: 10.3892/or.2014.3705.
  • Permatasari, E.; Farida, W. S. AIP Conf. Proc 2260 ; , 2020 Cytotoxic Effects and Apoptosis of Solo Black Garlic (Allium Sativum L.) Extract on T47D Breast Cancer Cell Line ; pp 060001-1-8 doi:10.1063/5.0015736.
  • Lee, Y.-M.; Gweon, O.-C.; Seo, Y.-J.; Im, J.; Kang, M.-J.; Kim, M.-J.; Kim, J.-I. Antioxidant Effect of Garlic and Aged Black Garlic in Animal Model of Type 2 Diabetes Mellitus. Nutr. Res. Pract. 2009, 3(2), 156. DOI: 10.4162/nrp.2009.3.2.156.
  • Seo, Y.-J.; Gweon, O.-C.; Im, J.-E.; Lee, Y.-M.; Kang, M.-J.; Kim, J.-I. Effect of Garlic and Aged Black Garlic on Hyperglycemia and Dyslipidemia in Animal Model of Type 2 Diabetes Mellitus. Preventive Nutr. Food Sci. 2009, 14(1), 1–7. DOI: 10.3746/jfn.2009.14.1.001.
  • Prihanti, G. S.; Faradilla, A.; Rahman, M. The Effect of Single Type Black Garlic (Allium Sativum L.) Extract on the Cell of Langerhans Islets and the Kidney Tubular Microscopy in Male Wistar Rats (Rattus Norvegicus) Modles of Diabetes Mellitus. Sys. Rev. Pharm 2020, 11(6 290–296 doi:10.31838/srp.2020.6.46).
  • Si, L.; Lin, R.; Jia, Y.; Jian, W.; Yu, Q.; Wang, M.; Yang, S. Lactobacillus Bulgaricus Improves Antioxidant Capacity of Black Garlic in the Prevention of Gestational Diabetes Mellitus: A Randomized Control Trial. Biosci. Rep. 2019, 39(8). DOI: 10.1042/BSR20182254.
  • Chen, Y.-C.; Kao, T.-H.; Tseng, C.-Y.; Chang, W.-T.; Hsu, C.-L. Methanolic Extract of Black Garlic Ameliorates Diet-induced Obesity via Regulating Adipogenesis, Adipokine Biosynthesis, and Lipolysis. J. Funct. Foods. 2014, 9, 98–108. DOI: 10.1016/j.jff.2014.02.019.
  • Amor, S.; González-Hedström, D.; Martín-Carro, B.; Inarejos-García, A. M.; Almodóvar, P.; Prodanov, M.; García-Villalón, A. L.; Granado, M. Beneficial Effects of an Aged Black Garlic Extract in the Metabolic and Vascular Alterations Induced by a High Fat/sucrose Diet in Male Rats. Nutrients 2019, 11(1), 153. DOI: 10.3390/nu11010153.
  • Wu, J.; Liu, Y.; Dou, Z.; Wu, T.; Liu, R.; Sui, W.; Jin, Y.; Zhang, M. Black Garlic Melanoidins Prevent Obesity, Reduce Serum LPS Levels and Modulate the Gut Microbiota Composition in High-fat Diet-induced Obese C57BL/6J Mice. Food Funct. 2020, 11(11), 9585–9598. DOI: 10.1039/D0FO02379E.
  • Kim, I.; Kim, J.-Y.; Hwang, Y.-J.; Hwang, K.-A.; Om, A.-S.; Kim, J.-H.; Cho, K.-J. The Beneficial Effects of Aged Black Garlic Extract on Obesity and Hyperlipidemia in Rats Fed a High-fat Diet. J. Med. Plants Res. 2011, 5(14), 3159–3168.
  • Ghorbani, A.; Zarvandi, M.; Rakhshandeh, H. A Randomized Controlled Trial of A Herbal Compound for Improving Metabolic Parameters in Diabetic Patients with Uncontrolled Dyslipidemia. Endocrine Metabol. Immu. Disord. Drug Target. 2019, 19(7), 1075–1082. DOI: 10.2174/1871530319666190206213420.
  • Shin, J. H.; Lee, C. W.; Oh, S. J.; Yun, J.; Kang, M. R.; Han, S.-B.; Park, H.; Jung, J. C.; Chung, Y. H.; Kang, J. S. Hepatoprotective Effect of Aged Black Garlic Extract in Rodents. Toxicol. Res 2014, 30(1), 49–54. DOI: 10.5487/TR.2014.30.1.049.
  • Kang, M.-J.; Lee, S. J.; Sung, N. J.; Shin, J.-H. The Effect of Extract Powder from Fresh and Black Garlic on Main Components in Serum and Organs of Streptozotocin-induced Diabetic Rats. J. Life Sci. 2013, 23(3), 432–442. DOI: 10.5352/JLS.2013.23.3.432.
  • Ah, A. A. Effect of Nigella Sativa and Allium Sativum Coadminstered with Simvastatin in Dyslipidemia Patients: A Prospective, Randomized, Double-blind Trial. Anti-Inflammatory Anti-Allergy Agents Med. Chem. 2014, 13(1), 68–74. DOI: 10.2174/18715230113129990013.
  • Czompa, A.; Szoke, K.; Prokisch, J.; Gyongyosi, A.; Bak, I.; Balla, G.; Tosaki, A.; Lekli, I. Aged (Black) versus Raw Garlic against Ischemia/reperfusion-induced Cardiac Complications. Int. J. Mol. Sci. 2018, 19(4), 1017. DOI: 10.3390/ijms19041017.
  • Liu, J.; Zhang, G.; Cong, X.; Wen, C. Black Garlic Improves Heart Function in Patients with Coronary Heart Disease by Improving Circulating Antioxidant Levels. Front. Physiol. 2018, 9, 1435. DOI: 10.3389/fphys.2018.01435.
  • You, B. R.; Yoo, J.-M.; Baek, S. Y.; Kim, M. R. Anti-inflammatory Effect of Aged Black Garlic on 12-O-tetradecanoylphorbol-13-acetate-induced Dermatitis in Mice. Nutr. Res. Pract. 2019, 13(3), 189. DOI: 10.4162/nrp.2019.13.3.189.
  • Kim, D. G.; Kang, M. J.; Hong, S. S.; Choi, Y. H.; Shin, J. H. Antiinflammatory Effects of Functionally Active Compounds Isolated from Aged Black Garlic. Phytotherapy Res. 2017, 31(1), 53–61. DOI: 10.1002/ptr.5726.
  • Jeong, Y. Y.; Ryu, J. H.; Shin, J.-H.; Kang, M. J.; Kang, J. R.; Han, J.; Kang, D. Comparison of Anti-oxidant and Anti-inflammatory Effects between Fresh and Aged Black Garlic Extracts. Molecules 2016, 21(4), 430. DOI: 10.3390/molecules21040430.
  • Lee, T. W.; Bae, E.; Kim, J. H.; Jang, H. N.; Cho, H. S.; Chang, S.-H.; Park, D. J. The Aqueous Extract of Aged Black Garlic Ameliorates Colistin-induced Acute Kidney Injury in Rats. Renal Failure 2019, 41(1), 24–33. DOI: 10.1080/0886022X.2018.1561375.
  • Yoo, J.-M.; Sok, D.-E.; Kim, M. R. Anti-allergic Action of Aged Black Garlic Extract in RBL-2H3 Cells and Passive Cutaneous Anaphylaxis Reaction in Mice. J. Med. Food. 2014, 17(1), 92–102. DOI: 10.1089/jmf.2013.2927.
  • Kim, K.-H.; Park, J. K.; Choi, Y.-W.; Kim, Y.-H.; Lee, E. N.; Lee, J.-R.; Kim, H.-S.; Baek, S.-Y.; Kim, B.-S.; Lee, K.-S. Hexane Extract of Aged Black Garlic Reduces Cell Proliferation and Attenuates the Expression of ICAM-1 and VCAM‑1 in TNF-α-activated Human Endometrial Stromal Cells. Int.J. Mol. Med. 2013, 32(1), 67–78. DOI: 10.3892/ijmm.2013.1362.
  • Li, F.; Kim, M. R. Effect of Aged Garlic Ethyl Acetate Extract on Oxidative Stress and Cholinergic Function of Scopolamine-Induced Cognitive Impairment in Mice. Preventive Nutr. Food Sci. 2019, 24(2), 165. DOI: 10.3746/pnf.2019.24.2.165.
  • Nurmasitoh, T.; Sari, D. C. R.; Partadiredja, G. The Effects of Black Garlic on the Working Memory and Pyramidal Cell Number of Medial Prefrontal Cortex of Rats Exposed to Monosodium Glutamate. Drug Chem. Toxicol. 2018, 41(3), 324–329. DOI: 10.1080/01480545.2017.1414833.
  • Shi, H.; Jing, X.; Wei, X.; Perez, R. G.; Ren, M.; Zhang, X.; Lou, H. S‐allyl Cysteine Activates the Nrf2‐dependent Antioxidant Response and Protects Neurons against Ischemic Injury in Vitro and in Vivo. J. Neurochem. 2015, 133(2), 298–308. DOI: 10.1111/jnc.12986.
  • Ahmed, R. A. Hepatoprotective and Antiapoptotic Role of Aged Black Garlic against Hepatotoxicity Induced by Cyclophosphamide. J. Basic and Applied Zool. 2018, 79(1), 1–8. DOI: 10.1186/s41936-018-0017-7.
  • Kim, M. H.; Kim, M. Y.; Son, C. W.; Cheong, S. H.; Kim, M. R. Effect of Black Garlic on Acute Alcohol‐induced Hangover and Chronic Alcohol‐induced Liver Injury in Rats. FASEB. J. 2009, 23, 111–116.
  • Lee, K. C.; Teng, C. C.; Shen, C. H.; Huang, W. S.; Lu, C. C.; Kuo, H. C.; Tung, S. Y. Protective Effect of Black Garlic Extracts on tert-Butyl Hydroperoxide-induced Injury in Hepatocytes via a c-Jun N-terminal Kinase-dependent Mechanism. Exp. Ther. Med. 2018, 15(3), 2468–2474. DOI: 10.3892/etm.2018.5719.
  • Tran, G.-B.; Dam, S.-M.; Le, N.-T.-T. Amelioration of Single Clove Black Garlic Aqueous Extract on Dyslipidemia and Hepatitis in Chronic Carbon Tetrachloride Intoxicated Swiss Albino Mice. Int. J. hepatol 2018, 2018 9383950 . DOI: 10.1155/2018/9383950.
  • Ku, S.; Dong-seop, F. L.; Seonha, L.; Youngmi, J. Composition for Treating or Alleviating Obesity or Hyperlipidemia Comprising Black Garlic Extract. KR100990260B1 2010.
  • Namho, J. Y.; Famous, J.; Lee, D.; Seonha, L. Composition for Treating or Alleviating Obesity or Hyperlipidemia Comprising Black Garlic Extract. WO2012128461A3 2011.
  • Ren, G.; Z. W. D. X. L. H. L. W., Z. L. Black Garlic Yoghourt and Preparation Method Thereof. CN105145833A 2015.
  • Liu, Y. S.; Ji, J.; Wang, Y.; Liu, Y.; Zhang, Y.; Gao, Z.; Dong, Y.; Yu, Y.; Yang, Z.; Q. Garlic Endophyte for Accelerating Black Garlic Fermentation Process. CN102936573B 2012.
  • Miri, K. C.; Hyun-jung, S.; S. Method for Producing Maturing Black Garlic with Anti-oxidation Ability. KR100983213B1 2008.
  • Namho, J. Y.; Famous, J.; Lee, D.; Seonha, L. Pharmaceutical Composition for Treating or Alleviating Obesity or Hyperlipidemia Comprising Black Garlic Extract and Garcinia Cambogia Extract. KR101350217B1 2011.
  • Liu, F. X.; He, N.; Zhao, J.; B. Method for Producing Concentrated Black Garlic Juice and Application Thereof. CN102240010A 2011.
  • Zhu, J.; Duanqing, D. S.; Haifeng, Z.; G., P. Application of Black Garlic Extract in Adjusting Animal Intestinal Flora. CN104415214A 2013.
  • Kim, S. R.; Shin, H.; Choi, J.; Shim, M.; Kang, H.; M. Method for Manufacturing of Vinegar Using Black Garlic. KR101731180B1 2015.
  • Lai, Y. Z.; Liu, W.; Lai, K. A Kind of Black Garlic Fermented Milk for Antioxidant Ability/free Radical Scavenging Capacity with Its Manufacture Method. TWI593352B 2015.
  • Fan, S. Black Garlic Extract and Application Thereof in Preventing and Curing Breast Cancer. CN105596674A 2016.
  • Liu, Y. W.; Wu, Y.; Yang, C.; Yang, S.; H. Black Garlic Polyphenol Oral Liquid Containing Eurycoma Longifolia Extract Product and Preparation Method Thereof. CN106474322A 2016.
  • Ryu, J. H.; Kang, D. Physicochemical Properties, Biological Activity, Health Benefits, and General Limitations of Aged Black Garlic: A Review. Molecules. 2017, 22(6). DOI: 10.3391/molecules22060919.
  • Berginc, K.; Milisav, I.; Kristl, A. Garlic Flavonoids and Organosulfur Compounds: Impact on the Hepatic Pharmacokinetics of Saquinavir and Darunavir. Drug Metab. Pharmacokinet 2010, 25(6), 521–530. DOI: 10.2133/dmpk.DMPK-10-RG-053.
  • Nagae, S.; Ushijima, M.; Hatono, S.; Imai, J.; Kasuga, S.; Matsuura, H.; Itakura, Y.; Higashi, Y. Pharmacokinetics of the Garlic Compound S-allylcysteine. Planta Med. 1994, 60(3), 214–217. DOI: 10.1055/s-2006-959461.
  • Park, T; Oh, J.H, Lee, J.H, Park, S.C, Jang, Y.P, Lee, Y.J. Oral administration of (S)-Allyl-l-cysteine and aged garlic extract to rats: determination of metabolites and their pharmacokinetics. Planta. Med 2017, 83 17 , 1351–1360 doi:10.1055/s-0043-111895.
  • Amano, H.; Kazamori, D.; Itoh, K.; Kodera, Y. Metabolism, Excretion, and Pharmacokinetics of S-allyl-L-cysteine in Rats and Dogs. Drug. Metab. Dispos 2015, 43(5), 749–755. DOI: 10.1124/dmd.115.063230.
  • Amano, H.; Kazamori, D.; Itoh, K. Pharmacokinetics of S-allyl-l-cysteine in Rats Is Characterized by High Oral Absorption and Extensive Renal Reabsorption. J. Nutr. 2016, 146(2), 456S–459S. DOI: 10.3945/jn.114.201749.
  • Lee, S.; In Chang, N.; Yoo, M.; Hoon Choi, J.; Shin, D. Development and Validation of S-Allyl-L-Cysteine in Rat Plasma Using a Mixed-Mode Reversed-Phase and Cation-Exchange LC–ESI–MS/MS Method: Application to Pharmacokinetic Studies. J. Chromatogr. Sci. 2015, 53(1), 54–59. DOI: 10.1093/chromsci/bmu013.
  • Sharifi-Rad, M.; Anil Kumar, N. V.; Zucca, P.; Varoni, E. M.; Dini, L.; Panzarini, E.; Rajkovic, J.; Tsouh Fokou, P. V.; Azzini, E.; Peluso, I. Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. Front. Physiol. 2020, 11, 694. DOI: 10.3389/fphys.2020.00694.
  • Marie, A. M. A.; Wijayanti, N. Proc. Int. Conf. Sci. Eng 3 , 2020 The Antioxidant Properties of Black Garlic Aqueous Extract in Vero Cell Line ; pp 85–89 doi:10.14421/icse.v3.474.
  • Colín-González, A. L.; Santana, R. A.; Silva-Islas, C. A.; Chánez-Cárdenas, M. E.; Santamaría, A.; Maldonado, P. D. The Antioxidant Mechanisms Underlying the Aged Garlic Extract-and S-allylcysteine-induced Protection. Oxid. Med. Cell. Longev. 2012, 2012. DOI: 10.1155/2012/907162.
  • Jastrzebski, Z.; Leontowicz, H.; Leontowicz, M.; Namiesnik, J.; Zachwieja, Z.; Barton, H.; Pawelzik, E.; Arancibia-Avila, P.; Toledo, F.; Gorinstein, S. The Bioactivity of Processed Garlic (Allium Sativum L.) As Shown in Vitro and in Vivo Studies on Rats. Food Chem. Toxicol 2007, 45(9), 1626–1633. DOI: 10.1016/j.fct.2007.02.028.
  • Wang, D.; Feng, Y.; Liu, J.; Yan, J.; Wang, M.; Sasaki, J.-I.; Lu, C. Black Garlic (Allium Sativum) Extracts Enhance the Immune System. Med. Aromatic J. Plant Sci Biotech 2010, 4(1), 37–40.
  • Avula, P. R.; Asdaq, S. M.; Asad, M. Effect of Aged Garlic Extract and S-allyl Cysteine and Their Interaction with Atenolol during Isoproterenol Induced Myocardial Toxicity in Rats. Indian J. Pharmacol. 2014, 46(1), 94. DOI: 10.4103/0253-7613.125185.
  • Jang, H.-J.; Lee, H.-J.; Yoon, D.-K.; Ji, D.-S.; Kim, J.-H.; Lee, C.-H. Antioxidant and Antimicrobial Activities of Fresh Garlic and Aged Garlic By-products Extracted with Different Solvents. Food Sci. Biotechnol. 2018, 27(1), 219–225. DOI: 10.1007/s10068-017-0246-4.
  • Wang, W.-D.; Sun, Y.-E.; Chen, H.-W. Characterization of Antioxidant Activity of Sulfur Compounds in Black Garlic. Cell. Mol. Biol 2018, 64(12), 76–80. DOI: 10.14715/cmb/2018.64.12.15.
  • Chang, T.-C.; Jang, H.-D.; Lin, W.-D. Biochemical Properties of Black Garlic Aged under Different Temperatures of Commercial Rice Wine Extracts in Taiwan. Food Measure 15 2021, 509–518 doi:10.1007/s11694-020-00648-1.
  • Setiawan, A. A.; Safitri, M.; Armiyani, D. T.; Herianto, G.; Marwanta, E. Adv. Health Sci. Res 33 ; , 2021 Formulation and Antioxidant Effectivity Test of Single Bulb Black Garlic Lotion with DPPH Method (1, 1-diphenyl-2-picrylhydrazyl) ; pp 1–7 doi:10.2991/ahsr.k.210115.001.
  • Karnjanapratum, S.; Supapvanich, S.; Kaewthong, P.; Takeungwongtrakul, S. Impact of Steaming Pretreatment Process on Characteristics and Antioxidant Activities of Black Garlic (Allium Sativum L.). J. Food Sci. Technol. 58 5 2021, 1869–1876.
  • Yu, J.; Shan, Y.; Li, S.; Zhang, L. Potential Contribution of Amadori Compounds to Antioxidant and Angiotensin I Converting Enzyme Inhibitory Activities of Raw and Black Garlic. LWT 2020, 129, 109553. DOI: 10.1016/j.lwt.2020.109553.
  • Wu, J.; Jin, Y.; Zhang, M. Evaluation on the Physicochemical and Digestive Properties of Melanoidin from Black Garlic and Their Antioxidant Activities in Vitro. Food Chem. 2021, 340, 127934. DOI: 10.1016/j.foodchem.2020.127934.
  • Shin, J.-H.; Lee, H.-G.; Kang, M.-J.; Lee, S.-J.; Sung, N.-J. Antioxidant Activity of Solvent Fraction from Black Garlic. J. Korean Soc. Food Sci. Nutr. 2010, 39(7), 933–940. DOI: 10.3746/jkfn.2010.39.7.933.
  • Kim, H. K.; Choi, Y. W.; Lee, E. N.; Park, J. K.; Kim, S. G.; Park, D. J.; Kim, B. S.; Lim, Y. T.; Yoon, S. 5‐Hydroxymethylfurfural from Black Garlic Extract Prevents TNFα‐induced Monocytic Cell Adhesion to HUVECs by Suppression of Vascular Cell Adhesion Molecule‐1 Expression, Reactive Oxygen Species Generation and NF‐κB Activation. Phytotherapy Res. 2011, 25(7), 965–974. DOI: 10.1002/ptr.3351.
  • Sato, E.; Kohno, M.; Hamano, H.; Niwano, Y. Increased Anti-oxidative Potency of Garlic by Spontaneous Short-term Fermentation. Plant Foods Human Nutr. 2006, 61(4), 157–160. DOI: 10.1007/s11130-006-0017-5.
  • Setiyoningrum, F.; Priadi, G.; Afiati, F.; Herlina, N.; Solikhin, A. Composition of Spontaneous Black Garlic Fermentation in a Water Bath. Food Sci. Technol. 2021. (AHEAD). DOI:10.1590/fst.28720.
  • Wang, W.; Sun, Y. In Vitro and in Vivo Antioxidant Activities of Polyphenol Extracted from Black Garlic. Food Sci. Technol. 2017, 37(4), 681–685. DOI: 10.1590/1678-457x.30816.
  • Ha, A. W.; Kim, W. K. Antioxidant Mechanism of Black Garlic Extract Involving Nuclear Factor Erythroid 2-like Factor 2 Pathway. Nutr. Res. Pract. 2017, 11(3), 206–213. DOI: 10.4162/nrp.2017.11.3.206.
  • Liu, C.; Cao, F.; Tang, Q.-Z.; Yan, L.; Dong, Y.-G.; Zhu, L.-H.; Wang, L.; Bian, Z.-Y.; Li, H. Allicin Protects against Cardiac Hypertrophy and Fibrosis via Attenuating Reactive Oxygen Species-dependent Signaling Pathways. J. Nutr. Biochem. 2010, 21(12), 1238–1250. DOI: 10.1016/j.jnutbio.2009.11.001.
  • Chan, J.Y., Jr, Yuen, A.C., Chan, R.Y., Chan, S.W. Phytother. Res 27 5 637–46 doi:10.1002/ptr.4796 , 2013 A review of the cardiovascular benefits and antioxidant properties of allicin. .
  • Saravanan, G.; Ponmurugan, P. Beneficial Effect of S-allylcysteine (SAC) on Blood Glucose and Pancreatic Antioxidant System in Streptozotocin Diabetic Rats. Plant Foods Hum. Nutr. 2010, 65(4), 374–378. DOI: 10.1007/s11130-010-0192-2.
  • Nurafiani, W.; Widiyanto, S. AIP Conf. Proc. 2260 ; , 2020 Cytotoxic of Ethanol Extract & N-hexane Fraction of Solo Black Garlic (Allium Sativum L.) To Breast Cancer Cell Line T47D ; pp 040001-1–10 doi:10.1063/5.0015739.
  • Capuano, E.; Fogliano, V. Acrylamide and 5-hydroxymethylfurfural (HMF): A Review on Metabolism, Toxicity, Occurrence in Food and Mitigation Strategies. LWT Food Sci. Technol. 2011, 44(4), 793–810. DOI: 10.1016/j.lwt.2010.11.002.
  • Kim, H.-J.; Han, C.-H.; Kim, N.-Y.; Lee, E.-K.; Lee, K.-N.; Cho, H.-E.; Choi, Y.-H.; Chong, M.-S. Effect of Garlic Extracts with Extraction Conditions on Antioxidant and Anticancer Activity. J. Physiol & Pathol. Korean. Med. 2010, 24(1), 111–117. DOI: 10.4196/kjpp.2020.24.1.111.
  • Farhat, Z.; Hershberger, P. A.; Freudenheim, J. L.; Mammen, M. J.; Blair, R. H.; Aga, D. S.; Mu, L. Types of Garlic and Their Anticancer and Antioxidant Activity: A Review of the Epidemiologic and Experimental Evidence. Eur. J. Nutr. 60 7 2021, 3585–3609 doi:10.1007/s00394-021-02482-7.
  • Asmat, U.; Abad, K.; Ismail, K. Diabetes Mellitus and Oxidative stress-A Concise Review. Saudi Pharm. J. 2016, 24(5), 547–553. DOI: 10.1016/j.jsps.2015.03.013.
  • Hameed, I.; Masoodi, S. R.; Mir, S. A.; Nabi, M.; Ghazanfar, K.; Ganai, B. A. Type 2 Diabetes Mellitus: From a Metabolic Disorder to an Inflammatory Condition. World J. Diabetes. 2015, 6(4), 598–612. DOI: 10.4239/wjd.v6.i4.598.
  • Al-Qattan, K.; Thomson, M.; Ali, M. Garlic (Allium Sativum) and Ginger (Zingiber Officinale) Attenuate Structural Nephropathy Progression in Streptozotocin-induced Diabetic Rats. e-SPEN. Eur. e-J. Clin. Nutr. Metab. 2008, 3(2), e62–e71. DOI: 10.1016/j.eclnm.2007.12.001.
  • Prihanti, G. S.; Isnaini, F.; Yudistia, R.; Faradilla, A.; Rahman, M. Effect of Black Garlic Extract on Blood Glucose, Lipid Profile, and SGPT-SGOT of Wistar Rats Diabetes Mellitus Model. Majalah Kedokteran Bandung 2019, 51(2), 82–87. DOI: 10.15395/mkb.v51n2.1657.
  • Ha, A. W.; Ying, T.; Kim, W. K. The Effects of Black Garlic (Allium Satvium) Extracts on Lipid Metabolism in Rats Fed a High Fat Diet. Nutr. Res. Pract. 2015, 9(1), 30. DOI: 10.4162/nrp.2015.9.1.30.
  • Park, J.; Park, C.; Han, M.-H.; Kim, B.-W.; Chung, Y.-H.; Choi, Y.-H. Inhibition of Adipocyte Differentiation and Adipogenesis by Aged Black Garlic Extracts in 3T3-L1 Preadipocytes. J. Life Sci. 2011, 21(5), 720–728. DOI: 10.5352/JLS.2011.21.5.720.
  • Nam, H.; Jung, H.; Kim, Y.; Kim, B.; Kim, K. H.; Park, S. J.; Suh, J. G. Aged Black Garlic Extract Regulates Lipid Metabolism by Inhibiting Lipogenesis and Promoting Lipolysis in Mature 3T3-L1 Adipocytes. Food Sci. Biotechnol. 2018, 27(2), 575–579. DOI: 10.1007/s10068-017-0268-y.
  • Kim, J.; Kim, J.; Kang, M.; Han, J.; Kang, Y. Aged Black Garlic Improves Insulin Sensitivity in Fructose Fed Rats. FASEB. J. 2010, 24, 722–724.
  • Chang, W.-T.; Shiau, D.; Cheng, M.; Tseng, C.; Chen, C.; Wu, M.; Hsu, C. Black Garlic Ameliorates Obesity Induced by a High-fat Diet in Rats. J. Food Nutr. Res. 2017, 5(10), 736–741. DOI: 10.12691/jfnr-5-10-3.
  • Lee, H.-S.; Yang, S.-T.; Ryu, B.-H. Effects of Aged Black Garlic Extract on Lipid Improvement in Rats Fed with High Fat-cholesterol Diet. J. Life Sci. 2011, 21(6), 884–892. DOI: 10.5352/JLS.2011.21.6.884.
  • Nie, C.; Zhang, F.; Ma, X.; Guo, R.; Zhou, S.; Zhao, L.; Xu, H.; Xiao, X.; Wang, Z. Determination of Quality Markers of Xuezhiling Tablet for Hyperlipidemia Treatment. Phytomedicine 2018, 44, 231–238. DOI: 10.1016/j.phymed.2018.03.004.
  • Zhai, B.; Zhang, C.; Sheng, Y.; Zhao, C.; He, X.; Xu, W.; Huang, K.; Luo, Y. Hypoglycemic and Hypolipidemic Effect of S-allyl-cysteine Sulfoxide (Alliin) in DIO Mice. Sci. Rep. 2018, 8(1), 1–7. DOI: 10.1038/s41598-018-21421-x.
  • Chung, S. Y.; Han, K.-H.; Bae, S.-H.; Han, S. H.; Lee, Y. K. Effects of the Fermented Black Garlic Extract on Lipid Metabolism and Hepatoprotection in Mice. Korean J. Food Nutr. 2020, 33(1), 17–26.
  • Saryono, P. A. AIP Conf. Proc 2094 ; , 2019 The Potency of Black Garlic as Anti-atherosclerotic: Mechanisms of Action and the Prospectively ; pp 020027 doi:10.1063/1.5097496.
  • Ried, K.; Frank, O. R.; Stocks, N. P. Aged Garlic Extract Lowers Blood Pressure in Patients with Treated but Uncontrolled Hypertension: A Randomised Controlled Trial. Maturitas 2010, 67(2), 144–150. DOI: 10.1016/j.maturitas.2010.06.001.
  • Steiner, M.; Khan, A. H.; Holbert, D.; Lin, R. I. A Double-blind Crossover Study in Moderately Hypercholesterolemic Men that Compared the Effect of Aged Garlic Extract and Placebo Administration on Blood Lipids. Am. J. Clin. Nutr. 1996, 64(6), 866–870. DOI: 10.1093/ajcn/64.6.866.
  • García-Villalón, A. L.; Amor, S.; Monge, L.; Fernández, N.; Prodanov, M.; Muñoz, M.; Inarejos-García, A. M.; Granado, M. In Vitro Studies of an Aged Black Garlic Extract Enriched in S-allylcysteine and Polyphenols with Cardioprotective Effects. J. Funct. Foods. 2016, 27, 189–200. DOI: 10.1016/j.jff.2016.08.062.
  • Lee, E. N.; Choi, Y. W.; Kim, H. K.; Park, J. K.; Kim, H. J.; Kim, M. J.; Lee, H. W.; Kim, K. H.; Bae, S. S.; Kim, B. S. Chloroform Extract of Aged Black Garlic Attenuates TNF‐α‐induced ROS Generation, VCAM‐1 Expression, NF‐κB Activation and Adhesiveness for Monocytes in Human Umbilical Vein Endothelial Cells. Phytotherapy Res. 2011, 25(1), 92–100. DOI: 10.1002/ptr.3230.
  • Zhang, X.; Shi, Y.; Wang, L.; Li, X.; Zhang, S.; Wang, X.; Jin, M.; Hsiao, C.-D.; Lin, H.; Han, L. Metabolomics for Biomarker Discovery in Fermented Black Garlic and Potential Bioprotective Responses against Cardiovascular Diseases. J. Agric. Food Chem. 2019, 67(44), 12191–12198. DOI: 10.1021/acs.jafc.9b04073.
  • Jung, E.-S.; Park, S.-H.; Choi, E.-K.; Ryu, B.-H.; Park, B.-H.; Kim, D.-S.; Kim, Y.-G.; Chae, S.-W. Reduction of Blood Lipid Parameters by a 12-wk Supplementation of Aged Black Garlic: A Randomized Controlled Trial. Nutrition 2014, 30(9), 1034–1039. DOI: 10.1016/j.nut.2014.02.014.
  • Ramli, N. K. C. M.; Ujang, S.; Ramli, N. Awareness of Black Garlic Benefits to Health: A Preliminary Study. Gading J. Sci.Tech. 2020, 3(2), 148–155.
  • Aziz, N. F.; Ramalingam, A.; Latip, J.; Zainalabidin, S. S-allylcysteine Improves Ischemia/reperfusion Alteration on Cardiac Function, Antioxidant, and Mitochondrial Permeability. Life Sci. 2021, 119080. DOI:10.1016/j.lfs.2021.119080.
  • Kim, K. J.; Kim, S. H.; Shin, M.-R.; Kim, Y. J.; Park, H.-J.; Roh, S.-S. Protective Effect of S-allyl Cysteine-enriched Black Garlic on Reflux Esophagitis in Rats via NF-κB Signaling Pathway. J. Funct. Foods. 2019, 58, 199–206. DOI: 10.1016/j.jff.2019.04.040.
  • Kim, M. J.; Yoo, Y. C.; Kim, H. J.; Shin, S. K.; Sohn, E. J.; Min, A. Y.; Sung, N. Y.; Kim, M. R. Aged Black Garlic Exerts Anti-inflammatory Effects by Decreasing No and Proinflammatory Cytokine Production with Less Cytoxicity in LPS-stimulated Raw 264.7 Macrophages and LPS-induced Septicemia Mice. J. Med. Food. 2014, 17(10), 1057–1063. DOI: 10.1089/jmf.2013.3043.
  • Tak, H.-M.; Kang, M.-J.; Kim, K. M.; Kang, D.; Han, S.; Shin, J.-H. Anti-inflammatory Activities of Fermented Black Garlic. J. Korean Soc. Food Sci. Nutr. 2014, 43(10), 1527–1534. DOI: 10.3746/jkfn.2014.43.10.1527.
  • Tsai, J.-C.; Chen, Y.-A.; Wu, J.-T.; Cheng, K.-C.; Lai, P.-S.; Liu, K.-F.; Lin, Y.-K.; Huang, Y.-T.; Hsieh, C.-W. Extracts from Fermented Black Garlic Exhibit a Hepatoprotective Effect on Acute Hepatic Injury. Molecules 2019, 24(6), 1112. DOI: 10.3390/molecules24061112.
  • Ryu, J.H; Park, H.J; Jeong, Y.Y.; Han, S., Shin, J.H, Lee, S.J, Kang, M.J, Sung, N.J, Kang, D. . In J. Med. Food 18 4 , 2015 Aged red garlic extract suppresses nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages through inhibition of NF-κB ; pp 439–45 doi:10.1089/jmf.2014.3214.
  • Zhang, Y.; Yao, H.-P.; Huang, -F.-F.; Wu, W.; Gao, Y.; Chen, Z.-B.; Liang, Z.-Y.; Liang, T.-B. Allicin, a Major Component of Garlic, Inhibits Apoptosis in Vital Organs in Rats with Trauma/hemorrhagic Shock. Crit. Care Med. 2008, 36(12), 3226–3232. DOI: 10.1097/CCM.0b013e31818f2103.
  • Lee, D. Y.; Li, H.; Lim, H. J.; Lee, H. J.; Jeon, R.; Ryu, J.-H. Anti-inflammatory Activity of Sulfur-containing Compounds from Garlic. J. Med. Food. 2012, 15(11), 992–999. DOI: 10.1089/jmf.2012.2275.
  • Abel-Salam, B. K. A. Immunomodulatory Effects of Black Seeds and Garlic on Alloxan-induced Diabetes in Albino Rat. Allergol. Immunopathol. 2012, 40(6), 336–340. DOI: 10.1016/j.aller.2011.07.002.
  • Hermawati, E.; Sari, D. C.; Partadiredja, G. The Effects of Black Garlic Ethanol Extract on the Spatial Memory and Estimated Total Number of Pyramidal Cells of the Hippocampus of Monosodium Glutamate-exposed Adolescent Male Wistar Rats. Anat. Sci. Int. 2015, 90(4), 275–286. DOI: 10.1007/s12565-014-0262-x.
  • Aminuddin, M.; Partadiredja, G.; Sari, D. C. The Effects of Black Garlic (Allium Sativum L.) Ethanol Extract on the Estimated Total Number of Purkinje Cells and Motor Coordination of Male Adolescent Wistar Rats Treated with Monosodium Glutamate. Anat. Sci. Int. 2015, 90(2), 75–81. DOI: 10.1007/s12565-014-0233-2.
  • Manikandaselvi, S.; Mahalakshmi, R.; Thinagarbabu, R.; Angumeenal, A. R. Neuroprotective Activity of S-allylcysteine on Haloperidol Induced Parkinson’s Disease in Albino Mice. Int. J. PharmTech Res. 2012, 4, 669–675.
  • Javed, H.; Khan, M. M.; Khan, A.; Vaibhav, K.; Ahmad, A.; Khuwaja, G.; Ahmed, M. E.; Raza, S. S.; Ashafaq, M.; Tabassum, R. S-allyl Cysteine Attenuates Oxidative Stress Associated Cognitive Impairment and Neurodegeneration in Mouse Model of Streptozotocin-induced Experimental Dementia of Alzheimer’s Type. Brain Res. 2011, 1389, 133–142. DOI: 10.1016/j.brainres.2011.02.072.
  • Colín-González, A. L.; Ali, S. F.; Túnez, I.; Santamaría, A. On the Antioxidant, Neuroprotective and Anti-inflammatory Properties of S-allyl Cysteine: An Update. Neurochem. Int. 2015, 89, 83–91. DOI: 10.1016/j.neuint.2015.06.011.
  • Gupta, V. B.; Rao, K. S. J. Anti-amyloidogenic Activity of S-allyl-l-cysteine and Its Activity to Destabilize Alzheimer’s β-amyloid Fibrils in Vitro. Neurosci. Lett. 2007, 429(2–3), 75–80. DOI: 10.1016/j.neulet.2007.09.042.
  • Kim, M. H.; Kim, M. J.; Lee, J. H.; Han, J. I.; Kim, J. H.; Sok, D.-E.; Kim, M. R. Hepatoprotective Effect of Aged Black Garlic on Chronic Alcohol-induced Liver Injury in Rats. J. Med. Food. 2011, 14(7–8), 732–738. DOI: 10.1089/jmf.2010.1454.

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