References
- Norakma, M.; Zaibunnisa, A., and Razarinah, W. W. The Changes of Phenolics Profiles, Amino Acids and Volatile Compounds of Fermented Seaweed Extracts Obtained Through Microbial Fermentation. Mater. Today: Proc 2021, 48, 815.
- Krzyzanowska, J.; Czubacka, A., and Oleszek, W. Dietary Phytochemicals and Human Health. Bio-Farms Nutraceuticals. 2010, 698, 74–98.
- Cotas, J.; Leandro, A.; Monteiro, P.; Pacheco, D.; Figueirinha, A.; Gonçalves, A. M. M.; Da Silva, G. J.; Pereira, L. Seaweed Phenolics: From Extraction to Applications. Mar. Drugs. 2020, 18 (8), 384. DOI: 10.3390/md18080384.
- Tabassum, M. R.; Xia, A.; Murphy, J. D., Seasonal Variation of Chemical Composition and Biomethane Production from the Brown Seaweed Ascophyllum Nodosum. Bioresour. Technol. 2016, 216, 219. DOI: 10.1016/j.biortech.2016.05.071.
- Abdala-Díaz, R. T.; Cabello-Pasini, A.; Márquez-Garrido, E.; López Figueroa, F. Intra-Thallus Variation of Phenolic Compounds, Antioxidant Activity, and Phenolsulphatase Activity in Cystoseira Tamariscifolia (Phaeophyceae) from Southern Spain. Cienc. Marinas. 2014, 40 (1), 01. DOI: 10.7773/cm.v40i1.2350.
- Wojtunik-Kulesza, K.; Oniszczuk, A.; Oniszczuk, T.; Combrzyński, M.; Nowakowska, D.; Matwijczuk, A. Influence of in vitro Digestion on Composition, Bioaccessibility and Antioxidant Activity of Food Polyphenols—a Non-Systematic Review. Nutrients. 2020, 12 (5), 1401. DOI: 10.3390/nu12051401.
- Thakur, N.; Raigond, P.; Singh, Y.; Mishra, T.; Singh, B.; Lal, M. K.; Dutt, S., Recent Updates on Bioaccessibility of Phytonutrients. Trends Food Sci. Technol. 2020, 97, 366. DOI: 10.1016/j.tifs.2020.01.019.
- Rein, M. J.; Renouf, M.; Cruz‐hernandez, C.; Actis‐goretta, L.; Thakkar, S. K.; da Silva Pinto, M. Bioavailability of Bioactive Food Compounds: A Challenging Journey to Bioefficacy. Br. J Clin. Pharmacol. 2013, 75 (3), 588. DOI: 10.1111/j.1365-2125.2012.04425.x.
- Hussain, M. B.; Hassan, S.; Waheed, M.; Javed, A.; Farooq, M. A., and Tahir, A. Bioavailability and Metabolic Pathway of Phenolic Compounds. In Plant Physiological Aspects of Phenolic Compounds; Soto-Hernández, M., García-Mateos, R., Palma-Tenango, M., Eds.; London, UK: IntechOpen, 2019; pp 1–18.
- Santos, S. A.; Félix, R.; Pais, A.; Rocha, S. M.; Silvestre, A. J. The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies. Biomolecules. 2019, 9 (12), 847. DOI: 10.3390/biom9120847.
- Rao, S.; Schwarz, L. J.; Santhakumar, A. B.; Chinkwo, K. A.; Blanchard, C. L. Cereal Phenolic Contents as Affected by Variety and Environment. Cereal Chem. 2018, 95 (5), 589. DOI: 10.1002/cche.10085.
- Stengel, D. B.; Connan, S.; Popper, Z. A., Algal Chemodiversity and Bioactivity: Sources of Natural Variability and Implications for Commercial Application. Biotechnol. Adv. 2011, 29, 483.
- CID 359. https://pubchem.ncbi.nlm.nih.gov/compound/359#section=2D-Structure
- Rengasamy, K. R.; Aderogba, M. A.; Amoo, S. O.; Stirk, W. A.; Van Staden, J. Potential Antiradical and Alpha-Glucosidase Inhibitors from Ecklonia Maxima (Osbeck) Papenfuss. Food Chem. 2013, 141 (2), 1412. DOI: 10.1016/j.foodchem.2013.04.019.
- CID 14309078. https://pubchem.ncbi.nlm.nih.gov/compound/14309078#section=2D-Structure
- Kannan, R. R.; Aderogba, M. A.; Ndhlala, A. R.; Stirk, W. A.; Van Staden, J. Acetylcholinesterase Inhibitory Activity of Phlorotannins Isolated from the Brown Alga, Ecklonia Maxima (Osbeck) Papenfuss. Food Res. Int. 2013, 54 (1), 1250. DOI: 10.1016/j.foodres.2012.11.017.
- CID 145937. https://pubchem.ncbi.nlm.nih.gov/compound/145937#section=2D-Structure
- Kang, J.-I.; Kim, S.-C.; Kim, M.-K.; Boo, H.-J.; Jeon, Y.-J.; Koh, Y.-S.; Yoo, E.-S.; Kang, S.-M.; Kang, H.-K. Effect of Dieckol, a Component of Ecklonia Cava, on the Promotion of Hair Growth. Int. J. Mol. Sci. 2012, 13 (5), 6407. DOI: 10.3390/ijms13056407.
- Rengasamy, K. R.; Kulkarni, M. G.; Stirk, W. A.; Van Staden, J. Eckol-A New Plant Growth Stimulant from the Brown Seaweed Ecklonia Maxima. J Appl. Phycol. 2015, 27 (1), 581. DOI: 10.1007/s10811-014-0337-z.
- CID 3008868. https://pubchem.ncbi.nlm.nih.gov/compound/3008868#section=2D-Structure
- Lee, S.-H.; Han, J.-S.; Heo, S.-J.; Hwang, J.-Y.; Jeon, Y.-J. Protective Effects of Dieckol Isolated from Ecklonia Cava Against High Glucose-Induced Oxidative Stress in Human Umbilical Vein Endothelial Cells. Toxicol. In Vitro. 2010, 24 (2), 375. DOI: 10.1016/j.tiv.2009.11.002.
- CID 10480940. https://pubchem.ncbi.nlm.nih.gov/compound/10480940#section=2D-Structure
- Sanjeewa, K. K. A.; Kim, E.-A.; Son, K.-T.; Jeon, Y.-J., Bioactive Properties and Potentials Cosmeceutical Applications of Phlorotannins Isolated from Brown Seaweeds: A Review. J. Photochem. Photobiol. B: Biol. 2016, 162, 100. DOI: 10.1016/j.jphotobiol.2016.06.027.
- Nwosu, F.; Morris, J.; Lund, V. A.; Stewart, D.; Ross, H. A.; McDougall, G. J. Anti-Proliferative and Potential Anti-Diabetic Effects of Phenolic-Rich Extracts from Edible Marine Algae. Food Chem. 2011, 126 (3), 1006. DOI: 10.1016/j.foodchem.2010.11.111.
- CID 5320532. https://pubchem.ncbi.nlm.nih.gov/compound/5320532#section=2D-Structure
- Wei, R.; Lee, M.-S.; Lee, B.; Oh, C.-W.; Choi, C.-G.; Kim, H.-R. Isolation and Identification of Anti-Inflammatory Compounds from Ethyl Acetate Fraction of Ecklonia Stolonifera and Their Anti-Inflammatory Action. J. Appl. Phycol. 2016, 28 (6), 3535. DOI: 10.1007/s10811-016-0847-y.
- CID 3008867. https://pubchem.ncbi.nlm.nih.gov/compound/3008867#section=2D-Structure
- Yang, Y.-I.; Jung, S.-H.; Lee, K.-T.; Choi, J.-H. 8,8′-Bieckol, Isolated from Edible Brown Algae, Exerts Its Anti-Inflammatory Effects Through Inhibition of NF-κB Signaling and ROS Production in LPS-Stimulated Macrophages. Int. Immunopharmacol. 2014, 23 (2), 460. DOI: 10.1016/j.intimp.2014.09.019.
- CID 10429214. https://pubchem.ncbi.nlm.nih.gov/compound/10429214#section=2D-Structure
- Ryu, B.; Ahn, B.-N.; Kang, K.-H.; Kim, Y.-S.; Li, Y.-X.; Kong, C.-S.; Kim, S.-K.; Kim, D. G., Dioxinodehydroeckol Protects Human Keratinocyte Cells from UVB-Induced Apoptosis Modulated by Related Genes Bax/bcl-2 and Caspase Pathway. J. Photochem. Photobiol. B: Biol. 2015, 153, 352. DOI: 10.1016/j.jphotobiol.2015.10.018.
- CID 16075395. https://pubchem.ncbi.nlm.nih.gov/compound/16075395#section=2D-Structure
- Ding, Y.; Wang, L.; Im, S.; Hwang, O.; Kim, H.-S.; Kang, M.-C.; Lee, S.-H. Anti-Obesity Effect of Diphlorethohydroxycarmalol Isolated from Brown Alga Ishige Okamurae in High-Fat Diet-Induced Obese Mice. Mar. Drugs. 2019, 17 (11), 637. DOI: 10.3390/md17110637.
- CID 130976. https://pubchem.ncbi.nlm.nih.gov/compound/130976#section=2D-Structure
- Eom, S.-H.; Moon, S.-Y.; Lee, D.-S.; Kim, H.-J.; Park, K.; Lee, E.-W.; Kim, T. H.; Chung, Y.-H.; Lee, M.-S.; Kim, Y.-M. In vitro Antiviral Activity of Dieckol and Phlorofucofuroeckol-A Isolated from Edible Brown Alga Eisenia Bicyclis Against Murine Norovirus. Algae. 2015, 30 (3), 241. DOI: 10.4490/algae.2015.30.3.241.
- Vázquez-Rodríguez, B.; Gutiérrez-Uribe, J. A.; Antunes-Ricardo, M.; Santos-Zea, L., and Cruz-Suárez, L. E. Ultrasound-Assisted Extraction of Phlorotannins and Polysaccharides from Silvetia Compressa (Phaeophyceae). J. Appl. Phycol. 2020, 32, 1441.
- CID 15984097. https://pubchem.ncbi.nlm.nih.gov/compound/15984097#section=2D-Structure
- Lee, M.-S.; Shin, T.; Utsuki, T.; Choi, J.-S.; Byun, D.-S.; Kim, H.-R. Isolation and Identification of Phlorotannins from Ecklonia Stolonifera with Antioxidant and Hepatoprotective Properties in Tacrine-Treated HepG2 Cells. J. Agric. Food Chem. 2012, 60 (21), 5340. DOI: 10.1021/jf300157w.
- CID 23427055. https://pubchem.ncbi.nlm.nih.gov/compound/23427055#section=2D-Structure
- Yoon, M.; Cho, S. Triphlorethol A, a Dietary Polyphenol from Seaweed, Decreases Sleep Latency and Increases Non-Rapid Eye Movement Sleep in Mice. Mar. Drugs. 2018, 16 (5), 139. DOI: 10.3390/md16050139.
- CID 45103527. https://pubchem.ncbi.nlm.nih.gov/compound/45103527#section=2D-Structure
- Parys, S.; Kehraus, S.; Krick, A.; Glombitza, K.-W.; Carmeli, S.; Klimo, K.; Gerhäuser, C.; König, G. M. In vitro Chemopreventive Potential of Fucophlorethols from the Brown Alga Fucus Vesiculosus L. By Anti-Oxidant Activity and Inhibition of Selected Cytochrome P450 Enzymes. Phytochemistry. 2010, 71 (2–3), 221. DOI: 10.1016/j.phytochem.2009.10.020.
- Kawamura-Konishi, Y.; Watanabe, N.; Saito, M.; Nakajima, N.; Sakaki, T.; Katayama, T.; Enomoto, T. Isolation of a New Phlorotannin, a Potent Inhibitor of Carbohydrate-Hydrolyzing Enzymes, from the Brown Alga Sargassum Patens. J. Agric. Food Chem. 2012, 60 (22), 5565. DOI: 10.1021/jf300165j.
- CID 45103528. https://pubchem.ncbi.nlm.nih.gov/compound/45103528#section=2D-Structure
- CID 46238950. https://pubchem.ncbi.nlm.nih.gov/compound/46238950#section=2D-Structure
- CID 71655821. https://pubchem.ncbi.nlm.nih.gov/compound/71655821#section=2D-Structure
- Lee, S.-H.; Ko, S.-C.; Kang, M.-C.; Lee, D. H.; Jeon, Y.-J., Octaphlorethol A, a Marine Algae Product, Exhibits Antidiabetic Effects in Type 2 Diabetic Mice by Activating AMP-Activated Protein Kinase and Upregulating the Expression of Glucose Transporter 4. Food Chem. Toxicol. 2016, 91, 58. DOI: 10.1016/j.fct.2016.02.022.
- CID 7244. https://pubchem.ncbi.nlm.nih.gov/compound/7244#section=2D-Structure
- Chung, H. Y.; Ma, W. C. J.; Ang, P. O.; Kim, J.-S.; Chen, F. Seasonal Variations of Bromophenols in Brown Algae (Padina Arborescens , Sargassum Siliquastrum , and Lobophora Variegata) Collected in Hong Kong. J. Agric. Food Chem. 2003, 51 (9), 2619. DOI: 10.1021/jf026082n.
- CID 7808. https://pubchem.ncbi.nlm.nih.gov/compound/7808#section=2D-Structure
- CID 11847. https://pubchem.ncbi.nlm.nih.gov/compound/11847#section=2D-Structure
- CID 85405. https://pubchem.ncbi.nlm.nih.gov/compound/85405#section=2D-Structure
- Ko, S.-C.; Ding, Y.; Kim, J.; Ye, B.-R.; Kim, E.-A.; Jung, W.-K.; Heo, S.-J.; Lee, S.-H. Bromophenol (5-Bromo-3,4-Dihydroxybenzaldehyde) Isolated from Red Alga Polysiphonia Morrowii Inhibits Adipogenesis by Regulating Expression of Adipogenic Transcription Factors and AMP-Activated Protein Kinase Activation in 3T3-L1 Adipocytes. Phytother. Res. 2019, 33 (3), 737. DOI: 10.1002/ptr.6266.
- CID 1483. https://pubchem.ncbi.nlm.nih.gov/compound/1483#section=2D-Structure
- Kim, K. Y.; Nam, K. A.; Kurihara, H.; Kim, S. M. Potent α-Glucosidase Inhibitors Purified from the Red Alga Grateloupia Elliptica. Phytochemistry. 2008, 69 (16), 2820. DOI: 10.1016/j.phytochem.2008.09.007.
- CID 12005. https://pubchem.ncbi.nlm.nih.gov/compound/12005#section=2D-Structure
- CID 370. https://pubchem.ncbi.nlm.nih.gov/compound/370#section=2D-Structure
- Rajauria, G., Optimization and Validation of Reverse Phase HPLC Method for Qualitative and Quantitative Assessment of Polyphenols in Seaweed. J. Pharm. Biomed. Anal. 2018, 148, 230. DOI: 10.1016/j.jpba.2017.10.002.
- CID 1794427. https://pubchem.ncbi.nlm.nih.gov/compound/1794427#section=2D-Structure
- CID 689043. https://pubchem.ncbi.nlm.nih.gov/compound/689043#section=2D-Structure
- CID 445858. https://pubchem.ncbi.nlm.nih.gov/compound/445858#section=2D-Structure
- CID 5281672. https://pubchem.ncbi.nlm.nih.gov/compound/5281672#section=2D-Structure
- Yoshie-Stark, Y.; Hsieh, Y.-P.; Suzuki, T., Distribution of Flavonoids and Related Compounds from Seaweeds in Japan. J. Tokyo Univ. Fish. 2003, 89, 1.
- CID 5280343. https://pubchem.ncbi.nlm.nih.gov/compound/5280343#section=2D-Structure
- CID 5281792. https://pubchem.ncbi.nlm.nih.gov/compound/5281792#section=2D-Structure
- Agregan, R.; Munekata, P. E.; Franco, D.; Dominguez, R.; Carballo, J.; Lorenzo, J. M., Phenolic Compounds from Three Brown Seaweed Species Using LC-DAD–ESI-MS/MS. Food Res. Int. 2017, 99, 979. DOI: 10.1016/j.foodres.2017.03.043.
- CID 6508. https://pubchem.ncbi.nlm.nih.gov/compound/6508#section=2D-Structure
- CID 243. https://pubchem.ncbi.nlm.nih.gov/compound/243#section=2D-Structure
- Farvin, K. S.; Jacobsen, C., Phenolic Compounds and Antioxidant Activities of Selected Species of Seaweeds from Danish Coast. Food Chem. 2013, 138, 1670.
- CID 8468. https://pubchem.ncbi.nlm.nih.gov/compound/8468#section=2D-Structure
- CID 10742. https://pubchem.ncbi.nlm.nih.gov/compound/10742#section=2D-Structure
- CID 72. https://pubchem.ncbi.nlm.nih.gov/compound/72#section=2D-Structure
- CID 338. https://pubchem.ncbi.nlm.nih.gov/compound/338#section=2D-Structure
- CID 3469. https://pubchem.ncbi.nlm.nih.gov/compound/3469#section=2D-Structure
- CID 9064. https://pubchem.ncbi.nlm.nih.gov/compound/9064#section=2D-Structure
- Rodríguez-Bernaldo De Quirós, A.; Lage-Yusty, M. A.; López-Hernández, J. Determination of Phenolic Compounds in Macroalgae for Human Consumption. Food Chem. 2010, 121 (2), 634. DOI: 10.1016/j.foodchem.2009.12.078.
- CID 107905. https://pubchem.ncbi.nlm.nih.gov/compound/107905#section=2D-Structure
- CID 65064. https://pubchem.ncbi.nlm.nih.gov/compound/65064#section=2D-Structure
- CID 10621.
- CID 5281670. https://pubchem.ncbi.nlm.nih.gov/compound/5281670#section=2D-Structure
- CID 9211. https://pubchem.ncbi.nlm.nih.gov/compound/9211#section=2D-Structure
- Reddy, P.; Urban, S. Meroditerpenoids from the Southern Australian Marine Brown Alga Sargassum Fallax. Phytochemistry. 2009, 70 (2), 250. DOI: 10.1016/j.phytochem.2008.12.007.
- CID 21592366. https://pubchem.ncbi.nlm.nih.gov/compound/21592366#section=2D-Structure
- Wang, C.; Jiang, D.; Sun, Y.; Gu, Y.; Ming, Y.; Zheng, J.; Yu, C.; Chen, X.; Qi, H. Synergistic Effects of UVA Irradiation and Phlorotannin Extracts of Laminaria Japonica on Properties of Grass Carp Myofibrillar Protein Gel. J. Sci. Food Agric. 2021, 101 (7), 2659. DOI: 10.1002/jsfa.10890.
- Imbs, T.; Zvyagintseva, T. Phlorotannins are Polyphenolic Metabolites of Brown Algae. Russian J. Mar. Biol. 2018, 44 (4), 263. DOI: 10.1134/S106307401804003X.
- Steevensz, A. J.; MacKinnon, S. L.; Hankinson, R.; Craft, C.; Connan, S.; Stengel, D. B.; Melanson, J. E. Profiling Phlorotannins in Brown Macroalgae by Liquid Chromatography–high Resolution Mass Spectrometry. Phytochem. Anal. 2012, 23 (5), 547. DOI: 10.1002/pca.2354.
- Shannon, E.; Conlon, M.; Hayes, M. Seaweed Components as Potential Modulators of the Gut Microbiota. Mar. Drugs. 2021, 19 (7), 358. DOI: 10.3390/md19070358.
- Connan, S.; Goulard, F.; Stiger, V.; Deslandes, E., and Ar Gall, E. Interspecific and Temporal Variation in Phlorotannin Levels in an Assemblage of Brown Algae. 2004, 47 (5), 410–416.
- Dong, H.; Dong, S.; Erik Hansen, P.; Stagos, D.; Lin, X.; Liu, M. Progress of Bromophenols in Marine Algae from 2011 to 2020: Structure, Bioactivities, and Applications. Mar. Drugs. 2020, 18 (8), 411. DOI: 10.3390/md18080411.
- Liu, M.; Hansen, P. E.; Lin, X. Bromophenols in Marine Algae and Their Bioactivities. Mar. Drugs. 2011, 9 (7), 1273. DOI: 10.3390/md9071273.
- Liwa, A.; Barton, E.; Cole, W., and Nwokocha, C. Bioactive Plant Molecules, Sources and Mechanism of Action in the Treatment of Cardiovascular Disease. In Pharmacognosy; Badal, S., Delgoda, R., Eds.; Elsevier, 2017; pp 315.
- Luna-Guevara, M. L.; Luna-Guevara, J. J.; Hernández-Carranza, P.; Ruíz-Espinosa, H., and Ochoa-Velasco, C. E. Phenolic Compounds: A Good Choice Against Chronic Degenerative Diseases. In Studies in Natural Products Chemistry , Elsevier, 2018; Vol. 59, pp 79–108.
- D’-Archivio, M.; Filesi, C.; Varì, R.; Scazzocchio, B.; Masella, R. Bioavailability of the Polyphenols: Status and Controversies. Int. J. Mol. Sci. 2010, 11 (4), 1321. DOI: 10.3390/ijms11041321.
- Arfaoui, L. Dietary Plant Polyphenols: Effects of Food Processing on Their Content and Bioavailability. Molecules. 2021, 26 (10), 2959. DOI: 10.3390/molecules26102959.
- Shahidi, F.; Peng, H., Bioaccessibility and Bioavailability of Phenolic Compounds. J. Food Bioactives. 2018, 4, 11. DOI: 10.31665/JFB.2018.4162.
- Vladimir-Knežević, S.; Blažeković, B.; Štefan, M. B., and Babac, M. Plant Polyphenols as Antioxidants Influencing the Human Health. In Phytochemicals as Nutraceuticals-Global Approaches to Their Role in Nutrition and Health, IntechOpen, 2012; pp 156–170.
- Cardona, F.; Andrés-Lacueva, C.; Tulipani, S.; Tinahones, F. J.; Queipo-Ortuño, M. I. Benefits of Polyphenols on Gut Microbiota and Implications in Human Health. J. Nutr. Biochem. 2013, 24 (8), 1415. DOI: 10.1016/j.jnutbio.2013.05.001.
- Ed Nignpense, B.; Francis, N.; Blanchard, C.; Santhakumar, A. B. Bioaccessibility and Bioactivity of Cereal Polyphenols: A Review. Foods. 2021, 10 (7), 1595. DOI: 10.3390/foods10071595.
- Ginsburg, I.; Koren, E.; Shalish, M.; Kanner, J.; Kohen, R. Saliva Increases the Availability of Lipophilic Polyphenols as Antioxidants and Enhances Their Retention in the Oral Cavity. Arch. Oral. Biol. 2012, 57 (10), 1327. DOI: 10.1016/j.archoralbio.2012.04.019.
- Lodhia, P.; Yaegaki, K.; Khakbaznejad, A.; Imai, T.; Sato, T.; Tanaka, T.; Murata, T.; Kamoda, T., Effect of Green Tea on Volatile Sulfur Compounds in Mouth Air. J. Nutr. Sci. Vitaminol. 2008, 54, 89.
- Alminger, M.; Aura, A. M.; Bohn, T.; Dufour, C.; El, S.; Gomes, A.; Karakaya, S.; Martínez‐cuesta, M. C.; Mcdougall, G. J.; Requena, T. In vitro Models for Studying Secondary Plant Metabolite Digestion and Bioaccessibility. Compr. Rev. Food Sci. Food Saf. 2014, 13 (4), 413. DOI: 10.1111/1541-4337.12081.
- Velderrain-Rodríguez, G.; Palafox-Carlos, H.; Wall-Medrano, A.; Ayala-Zavala, J.; Chen, C. O.; Robles-Sánchez, M.; Astiazaran-García, H.; Alvarez-Parrilla, E.; González-Aguilar, G. Phenolic Compounds: Their Journey After Intake. Food Funct. 2014, 5 (2), 189. DOI: 10.1039/C3FO60361J.
- Frontela, C.; Ros, G.; Martínez, C.; Sánchez-Siles, L. M.; Canali, R.; Virgili, F. Stability of Pycnogenol® as an Ingredient in Fruit Juices Subjected to in vitro Gastrointestinal Digestion. J. Sci. Food Agric. 2011, 91 (2), 286. DOI: 10.1002/jsfa.4183.
- Bermudezsoto, M.; Tomasbarberan, F.; Garciaconesa, M. Stability of Polyphenols in Chokeberry (Aronia Melanocarpa) Subjected to in vitro Gastric and Pancreatic Digestion. Food Chem. 2007, 102 (3), 865. DOI: 10.1016/j.foodchem.2006.06.025.
- Marín, L.; Miguélez, E. M.; Villar, C. J.; Lombó, F., Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties. BioMed Res. Int. 2015, 2015, 1. DOI: 10.1155/2015/905215.
- Bang, S.-H.; Hyun, Y.-J.; Shim, J.; Hong, S.-W.; Kim, D.-H. Metabolism of Rutin and Poncirin by Human Intestinal Microbiota and Cloning of Their Metabolizing α-L-Rhamnosidase from Bifidobacterium Dentium. J. Microbiol. Biotechnol. 2015, 25 (1), 18. DOI: 10.4014/jmb.1404.04060.
- Erk, T.; Hauser, J.; Williamson, G.; Renouf, M.; Steiling, H.; Dionisi, F.; Richling, E. Structure–and Dose–absorption Relationships of Coffee Polyphenols. BioFactors. 2014, 40 (1), 103. DOI: 10.1002/biof.1101.
- Walton, M. C.; McGhie, T. K.; Reynolds, G. W.; Hendriks, W. H. The Flavonol Quercetin-3-Glucoside Inhibits Cyanidin-3-Glucoside Absorption in vitro. J. Agric. Food Chem. 2006, 54 (13), 4913. DOI: 10.1021/jf0607922.
- Piazzon, A.; Vrhovsek, U.; Masuero, D.; Mattivi, F.; Mandoj, F.; Nardini, M. Antioxidant Activity of Phenolic Acids and Their Metabolites: Synthesis and Antioxidant Properties of the Sulfate Derivatives of Ferulic and Caffeic Acids and of the Acyl Glucuronide of Ferulic Acid. J. Agric. Food Chem. 2012, 60 (50), 12312. DOI: 10.1021/jf304076z.
- Gardner, C. D.; Oelrich, B.; Liu, J. P.; Feldman, D.; Franke, A. A.; Brooks, J. D. Prostatic Soy Isoflavone Concentrations Exceed Serum Levels After Dietary Supplementation. Prostate. 2009, 69 (7), 719. DOI: 10.1002/pros.20922.
- Del Rio, D.; Borges, G.; Crozier, A. Berry Flavonoids and Phenolics: Bioavailability and Evidence of Protective Effects. Br. J. Nutr. 2010, 104 (S3), S67. DOI: 10.1017/S0007114510003958.
- Hidalgo, M.; Oruna-Concha, M. J.; Kolida, S.; Walton, G. E.; Kallithraka, S.; Spencer, J. P.; de Pascual-Teresa, S., de Pascual-Teresa, S. Metabolism of Anthocyanins by Human Gut Microflora and Their Influence on Gut Bacterial Growth. J. Agric. Food Chem. 2012, 60 (15), 3882. DOI: 10.1021/jf3002153.
- Viskupičová, J.; Ondrejovič, M., and Šturdík, E. Bioavailability and Metabolism of Flavonoids. J. Food Nutr. Res. 2008, 47, 151–162.
- Mosele, J. I.; Macià, A.; Motilva, M.-J. Metabolic and Microbial Modulation of the Large Intestine Ecosystem by Non-Absorbed Diet Phenolic Compounds: A Review. Molecules. 2015, 20 (9), 17429. DOI: 10.3390/molecules200917429.
- Gaya, P.; Arqués, J. L.; Medina, M.; Álvarez, I.; Landete, J. M. A New HPLC-PAD/HPLC-ESI-MS Method for the Analysis of Phytoestrogens Produced by Bacterial Metabolism. Food Anal. Methods. 2016, 9 (2), 537. DOI: 10.1007/s12161-015-0226-3.
- Bode, L. M.; Bunzel, D.; Huch, M.; Cho, G.-S.; Ruhland, D.; Bunzel, M.; Bub, A.; Franz, C. M.; Kulling, S. E. In vivo and in vitro Metabolism of Trans-Resveratrol by Human Gut Microbiota. Am. J. Clin. Nutr. 2013, 97 (2), 295. DOI: 10.3945/ajcn.112.049379.
- Del Rio, D.; Costa, L. G.; Lean, M. E. J.; Crozier, A. Polyphenols and Health: What Compounds are Involved? Nutr. Metab. Cardiovasc. Dis. 2010, 20 (1), 1. DOI: 10.1016/j.numecd.2009.05.015.
- Fernández-García, E.; Carvajal-Lérida, I.; Pérez-Gálvez, A. In vitro Bioaccessibility Assessment as a Prediction Tool of Nutritional Efficiency. Nutr. Res. 2009, 29 (11), 751. DOI: 10.1016/j.nutres.2009.09.016.
- Dima, C.; Assadpour, E.; Dima, S.; Jafari, S. M. Bioavailability and Bioaccessibility of Food Bioactive Compounds; Overview and Assessment by in vitro Methods. Compr. Rev. Food Sci. Food Saf. 2020, 19 (6), 2862. DOI: 10.1111/1541-4337.12623.
- Buniowska, M.; Capella, J.; Barba, F.; Esteve, M., and Frigola, A. Analytical Methods forDetermining Bioavailability and Bioaccessibility of Bioactive Compounds from Fruits and Vegetables: Areview. Compr. Rev. Food Sci. Food Saf. 2014, 13, 155–171.
- Porrini, M.; Riso, P. Factors Influencing the Bioavailability of Antioxidants in Foods: A Critical Appraisal. Nutr. Metab. Cardiovasc. Dis. 2008, 18 (10), 647. DOI: 10.1016/j.numecd.2008.08.004.
- Corona, G.; Ji, Y.; Anegboonlap, P.; Hotchkiss, S.; Gill, C.; Yaqoob, P.; Spencer, J. P.; Rowland, I. Gastrointestinal Modifications and Bioavailability of Brown Seaweed Phlorotannins and Effects on Inflammatory Markers. Br. J. Nutr. 2016, 115 (7), 1240. DOI: 10.1017/S0007114516000210.
- Catarino, M. D.; Marçal, C.; Bonifácio-Lopes, T.; Campos, D.; Mateus, N.; Silva, A. M. S.; Pintado, M. M.; Cardoso, S. M. Impact of Phlorotannin Extracts from Fucus Vesiculosus on Human Gut Microbiota. Mar. Drugs. 2021, 19 (7), 375. DOI: 10.3390/md19070375.
- Francisco, J.; Horta, A.; Pedrosa, R.; Afonso, C.; Cardoso, C.; Bandarra, N. M.; Gil, M. M. Bioaccessibility of Antioxidants and Fatty Acids from Fucus Spiralis. Foods. 2020, 9 (4), 440. DOI: 10.3390/foods9040440.
- Corona, G.; Coman, M. M.; Guo, Y.; Hotchkiss, S.; Gill, C.; Yaqoob, P.; Spencer, J. P. E.; Rowland, I. Effect of Simulated Gastrointestinal Digestion and Fermentation on Polyphenolic Content and Bioactivity of Brown Seaweed Phlorotannin-Rich Extracts. Mol. Nutr. Food Res. 2017, 61 (11), 1700223. DOI: 10.1002/mnfr.201700223.
- Baldrick, F. R.; McFadden, K.; Ibars, M.; Sung, C.; Moffatt, T.; Megarry, K.; Thomas, K.; Mitchell, P.; Wallace, J. M. W.; Pourshahidi, L. K., et al. Impact of a (Poly)phenol-Rich Extract from the Brown Algae Ascophyllum Nodosum on DNA Damage and Antioxidant Activity in an Overweight or Obese Population: A Randomized Controlled Trial. Am. J. Clin. Nutr. 2018, 108 (4), 688. DOI: 10.1093/ajcn/nqy147.
- Nova, P.; Pimenta-Martins, A.; Laranjeira Silva, J.; Silva, A. M.; Gomes, A. M.; Freitas, A. C. Health Benefits and Bioavailability of Marine Resources Components That Contribute to Health – What’s New? Crit. Rev. Food Sci. Nutr. 2020, 60 (21), 3680. DOI: 10.1080/10408398.2019.1704681.
- Baldrick, F. R.; McFadden, K.; Ibars, M.; Sung, C.; Moffatt, T.; Megarry, K.; Thomas, K.; Mitchell, P.; Wallace, J. M.; Pourshahidi, L. K. Impact of a (Poly) Phenol-Rich Extract from the Brown Algae Ascophyllum Nodosum on DNA Damage and Antioxidant Activity in an Overweight or Obese Population: A Randomized Controlled Trial. Am. J. Clin. Nutr. 2018, 108 (4), 688. DOI: 10.1093/ajcn/nqy147.
- García, Y.; Díaz-Castro, J. Advantages and Disadvantages of the Animal Models V. In vitro Studies in Iron Metabolism: A Review. Animal. 2013, 7 (10), 1651. DOI: 10.1017/S1751731113001134.
- Corona, G.; Vauzour, D.; Amini, A., and Spencer, J. P. The Impact of Gastrointestinal Modifications, Blood-Brain Barrier Transport, and Intracellular Metabolism on Polyphenol Bioavailability: An Overview. Polyphenols Hum. Health Dis. 2014, 1, 591–604.
- Manach, C.; Scalbert, A.; Morand, C.; Rémésy, C.; Jiménez, L. Polyphenols: Food Sources and Bioavailability. Am. J. Clin. Nutr. 2004, 79 (5), 727. DOI: 10.1093/ajcn/79.5.727.
- Écile Cren-Olivé, C.; Teissier, E.; Duriez, P.; Rolando, C. Effect of Catechin O-Methylated Metabolites and Analogues on Human LDL Oxidation. Free Radical Biol. Med. 2003, 34 (7), 850. DOI: 10.1016/S0891-5849(02)01433-8.
- Carocho, M.; Ferreira, I. C., A Review on Antioxidants, Prooxidants and Related Controversy: Natural and Synthetic Compounds, Screening and Analysis Methodologies and Future Perspectives. Food Chem. Toxicol. 2013, 51, 15. DOI: 10.1016/j.fct.2012.09.021.
- Zhu, B. Catechol-O-Methyltransferase (COMT)-Mediated Methylation Metabolism of Endogenous Bioactive Catechols and Modulation by Endobiotics and Xenobiotics: Importance in Pathophysiology and Pathogenesis. Curr. drug metab. 2002, 3 (3), 321. DOI: 10.2174/1389200023337586.
- Marchetti, F.; De Santi, C.; Vietri, M.; Pietrabissa, A.; Spisni, R.; Mosca, F.; Pacifici, G. M. Differential Inhibition of Human Liver and Duodenum Sulphotransferase Activities by Quercetin, a Flavonoid Present in Vegetables, Fruit and Wine. Xenobiotica. 2001, 31 (12), 841. DOI: 10.1080/00498250110069159.
- Cardoso, C.; Afonso, C.; Lourenço, H.; Costa, S.; Nunes, M. L. Bioaccessibility Assessment Methodologies and Their Consequences for the Risk–benefit Evaluation of Food. Trends Food Sci. Technol. 2015, 41 (1), 5. DOI: 10.1016/j.tifs.2014.08.008.
- Chitindingu, K.; Benhura, M. A.; Muchuweti, M. In vitro Bioaccessibility Assessment of Phenolic Compounds from Selected Cereal Grains: A Prediction Tool of Nutritional Efficiency. LWT - Food Sci. Technol. 2015, 63 (1), 575. DOI: 10.1016/j.lwt.2015.02.026.
- Ninfali, P.; Mari, M.; Meli, M. A.; Roselli, C.; Antonini, E. In vitro Bioaccessibility of Avenanthramides in Cookies Made with Malted Oat Flours. Int. J. Food Sci. Technol. 2019, 54 (5), 1558. DOI: 10.1111/ijfs.14020.
- Fang, J. Bioavailability of Anthocyanins. Drug Metab. Rev. 2014, 46 (4), 508. DOI: 10.3109/03602532.2014.978080.
- Tarko, T.; Duda-Chodak, A. Influence of Food Matrix on the Bioaccessibility of Fruit Polyphenolic Compounds. J. Agric. Food Chem. 2020, 68 (5), 1315. DOI: 10.1021/acs.jafc.9b07680.
- Liu, F.; Ma, C.; Gao, Y.; McClements, D. J. Food-Grade Covalent Complexes and Their Application as Nutraceutical Delivery Systems: A Review. Compr. Rev. Food Sci. Food Saf. 2017, 16 (1), 76. DOI: 10.1111/1541-4337.12229.
- Sęczyk, Ł.; Świeca, M.; Kapusta, I.; Gawlik-Dziki, U. Protein–phenolic Interactions as a Factor Affecting the Physicochemical Properties of White Bean Proteins. Molecules. 2019, 24 (3), 408. DOI: 10.3390/molecules24030408.
- Quan, T. H.; Benjakul, S.; Sae-Leaw, T.; Balange, A. K.; Maqsood, S., Protein–polyphenol Conjugates: Antioxidant Property, Functionalities and Their Applications. Trends Food Sci. Technol. 2019, 91, 507. DOI: 10.1016/j.tifs.2019.07.049.
- Chanphai, P.; Tajmir-Riahi, H., Tea Polyphenols Bind Serum Albumins: A Potential Application for Polyphenol Delivery. Food Hydrocolloids. 2019, 89, 461. DOI: 10.1016/j.foodhyd.2018.11.008.
- Ozdal, T.; Capanoglu, E.; Altay, F. A Review on Protein–phenolic Interactions and Associated Changes. Food Res. Int. 2013, 51 (2), 954. DOI: 10.1016/j.foodres.2013.02.009.
- Le Bourvellec, C.; Renard, C. Interactions Between Polyphenols and Macromolecules: Quantification Methods and Mechanisms. Crit. Rev. Food Sci. Nutr. 2012, 52 (3), 213. DOI: 10.1080/10408398.2010.499808.
- Laurent, C.; Besançon, P.; Caporiccio, B. Flavonoids from a Grape Seed Extract Interact with Digestive Secretions and Intestinal Cells as Assessed in an in vitro Digestion/caco-2 Cell Culture Model. Food Chem. 2007, 100 (4), 1704. DOI: 10.1016/j.foodchem.2005.10.016.
- Alminger, M.; Aura, A. M.; Bohn, T.; Dufour, C.; El, S. N.; Gomes, A.; Karakaya, S.; Martínez-Cuesta, M. C.; McDougall, G. J.; Requena, T., et al. In vitro Models for Studying Secondary Plant Metabolite Digestion and Bioaccessibility. Compr. Rev. Food Sci. Food Saf. 2014, 13 (4), 413. DOI: 10.1111/1541-4337.12081.
- Vitali Čepo, D.; Radić, K.; Turčić, P.; Anić, D.; Komar, B.; Šalov, M. Food (Matrix) Effects on Bioaccessibility and Intestinal Permeability of Major Olive Antioxidants. Foods. 2020, 9 (12), 1831. DOI: 10.3390/foods9121831.
- Mignet, N.; Seguin, J.; Chabot, G. G. Bioavailability of Polyphenol Liposomes: A Challenge Ahead. Pharmaceutics. 2013, 5 (4), 457. DOI: 10.3390/pharmaceutics5030457.
- Quirós-Sauceda, A.; Palafox-Carlos, H.; Sáyago-Ayerdi, S.; Ayala-Zavala, J.; Bello-Perez, L. A.; Alvarez-Parrilla, E.; De La Rosa, L.; González-Córdova, A.; González-Aguilar, G. Dietary Fiber and Phenolic Compounds as Functional Ingredients: Interaction and Possible Effect After Ingestion. Food Funct. 2014, 5 (6), 1063. DOI: 10.1039/C4FO00073K.
- Liu, D.; Martinez-Sanz, M.; Lopez-Sanchez, P.; Gilbert, E. P.; Gidley, M. J., Adsorption Behaviour of Polyphenols on Cellulose is Affected by Processing History. Food Hydrocolloids. 2017, 63, 496. DOI: 10.1016/j.foodhyd.2016.09.012.
- Quijada-Morín, N.; Hernandez-Hierro, J. M.; Rivas-Gonzalo, J. C.; Escribano-Bailon, M. T. Extractability of Low Molecular Mass Flavanols and Flavonols from Red Grape Skins. Relationship to Cell Wall Composition at Different Ripeness Stages. J. Agric. Food Chem. 2015, 63 (35), 7654. DOI: 10.1021/acs.jafc.5b00261.
- Jakobek, L.; Matić, P., Non-Covalent Dietary Fiber-Polyphenol Interactions and Their Influence on Polyphenol Bioaccessibility. Trends Food Sci. Technol. 2019, 83, 235. DOI: 10.1016/j.tifs.2018.11.024.
- Domínguez-Avila, J. A.; Wall-Medrano, A.; Velderrain-Rodríguez, G. R.; Chen, C.-Y.-O.; Salazar-López, N. J.; Robles-Sánchez, M.; González-Aguilar, G. A. Gastrointestinal Interactions, Absorption, Splanchnic Metabolism and Pharmacokinetics of Orally Ingested Phenolic Compounds. Food Func. 2017, 8 (1), 15. DOI: 10.1039/C6FO01475E.
- Hilary, S.; Tomás-Barberán, F. A.; Martinez-Blazquez, J. A.; Kizhakkayil, J.; Souka, U.; Al-Hammadi, S.; Habib, H.; Ibrahim, W.; Platat, C., Polyphenol Characterisation of Phoenix Dactylifera L.(date) Seeds Using HPLC-Mass Spectrometry and Its Bioaccessibility Using Simulated in-Vitro Digestion/caco-2 Culture Model. Food Chem. 2020, 311, 125969. DOI: 10.1016/j.foodchem.2019.125969.
- Saura-Calixto, F. Dietary Fiber as a Carrier of Dietary Antioxidants: An Essential Physiological Function. J. Agric. Food Chem. 2011, 59 (1), 43. DOI: 10.1021/jf1036596.
- Alqurashi, R. M.; Alarifi, S. N.; Walton, G. E.; Costabile, A. F.; Rowland, I. R.; Commane, D. M., In vitro Approaches to Assess the Effects of Açai (Euterpe Oleracea) Digestion on Polyphenol Availability and the Subsequent Impact on the Faecal Microbiota. Food Chem. 2017, 234, 190. DOI: 10.1016/j.foodchem.2017.04.164.
- Xu, X.; Li, W.; Lu, Z.; Beta, T.; Hydamaka, A. W. Phenolic Content, Composition, Antioxidant Activity, and Their Changes During Domestic Cooking of Potatoes. J. Agric. Food Chem. 2009, 57 (21), 10231. DOI: 10.1021/jf902532q.
- Makris, D. P.; Rossiter, J. T. Domestic Processing of Onion Bulbs (Allium Cepa) and Asparagus Spears (Asparagus Officinalis): Effect on Flavonol Content and Antioxidant Status. J. Agric. Food Chem. 2001, 49 (7), 3216. DOI: 10.1021/jf001497z.
- Bugianesi, R.; Salucci, M.; Leonardi, C.; Ferracane, R.; Catasta, G.; Azzini, E.; Maiani, G. Effect of Domestic Cooking on Human Bioavailability of Naringenin, Chlorogenic Acid, Lycopene and β-Carotene in Cherry Tomatoes. Eur. J. Nutr. 2004, 43 (6), 360. DOI: 10.1007/s00394-004-0483-1.
- Grosser, G.; Döring, B.; Ugele, B.; Geyer, J.; Kulling, S. E.; Soukup, S. T. Transport of the Soy Isoflavone Daidzein and Its Conjugative Metabolites by the Carriers SOAT, NTCP, OAT4, and OATP2B1. Arch. Toxicol. 2015, 89 (12), 2253. DOI: 10.1007/s00204-014-1379-3.
- González-Barrio, R.; Edwards, C. A.; Crozier, A. Colonic Catabolism of Ellagitannins, Ellagic Acid, and Raspberry Anthocyanins: In vivo and in vitro Studies. Drug Metab. Dispos. 2011, 39 (9), 1680. DOI: 10.1124/dmd.111.039651.