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Review

Biological Functions and Utilization of Different Part of the Papaya: A Review

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References

  • Sharma, A.; Bachheti, A.; Sharma, P.; Bachheti, R. K.; Husen, A. Phytochemistry, Pharmacological Activities, Nanoparticle Fabrication, Commercial Products and Waste Utilization of Carica Papaya L.: A Comprehensive Review. Curr. Res. Biotechnol. 2020, 2, 145–160. DOI: 10.1016/j.crbiot.2020.11.001.
  • Khaw, K. Y.; Parat, M. O.; Shaw, P. N.; Nguyen, T. T. T.; Pandey, S.; Thurecht, K. J.; Falconer, J. R. Factorial Design-Assisted Supercritical Carbon-Dioxide Extraction of Cytotoxic Active Principles from Carica Papaya Leaf Juice. Sci. Rep. 2019, 9(1), 1–12. DOI: 10.1038/s41598-018-37171-9.
  • Nguyen, T. T.; Parat, M. O.; Shaw, P. N.; Hewavitharana, A. K.; Hodson, M. P. Traditional Aboriginal Preparation Alters the Chemical Profile of Carica Papaya Leaves and Impacts on Cytotoxicity Towards Human Squamous Cell Carcinoma. PLoS One. 2016, 11(2), 1–15. DOI: 10.1371/journal.pone.0147956.
  • Kelebek, H.; Selli, S.; Gubbuk, H.; Gunes, E. Comparative Evaluation of Volatiles, Phenolics, Sugars, Organic Acids and Antioxidant Properties of Sel-42 and Tainung Papaya Varieties. Food Chem. 2015, 173, 912–919‬. DOI: 10.1016/j.foodchem.2014.10.116.
  • Jin, B. R.; Ju, J. Y.; Nugroho, A.; Lee, M.; An, H. J. Carica Papaya Leaf Extract Inhibits Prostatitis-Associated Prostatic Hyperplasia via the TRAF6/TAK1/MEK/NF-κB Pathway. Biomed. Pharmacother. 2021, 135, 111197. DOI: 10.1016/j.biopha.2020.111197.
  • Nafiu, A. B.; Alli-Oluwafuyi, A. M.; Haleemat, A.; Olalekan, I. S.; Rahman, M. T. Papaya (Carica Papaya L.; Pawpaw). In Nonvitamin and Nonmineral Nutritional Supplement; Academic Press: 2019; pp. 335–359. doi:10.1016/b978-0-12-812491-8.00048-5
  • Shaban, N. Z.; El-Kot, S. M.; Awad, O. M.; Hafez, A. M.; Fouad, G. M. The Antioxidant and Anti-Inflammatory Effects of Carica Papaya Linn. Seeds Extract on Ccl4-Induced Liver Injury in Male Rats. BMC Complementary Med. Ther. 2021, 21(1), 1–15. DOI: 10.1186/s12906-021-03479-9.
  • Hamim, I.; Borth, W. B.; Marquez, J.; Green, J. C.; Melzer, M. J.; Hu, J. S. Transgene-Mediated Resistance to Papaya Ringspot virus: Challenges and Solutions. Phytoparasitica. 2018, 46(1), 1–18. DOI: 10.1007/s12600-017-0636-4.
  • Zou, Y.; Zhang, L.; Rao, S.; Zhu, X.; Ye, L.; Chen, W.; Li, X. The Relationship Between the Expression of Ethylene-Related Genes and Papaya Fruit Ripening Disorder Caused by Chilling Injury. PLoS One. 2014, 9(12), e116002. DOI: 10.1371/journal.pone.0116002.
  • Mendy, T. K.; Misran, A.; Mahmud, T. M. M.; Ismail, S. I. Antifungal Properties of Aloe Vera Through In Vitro and In Vivo Screening Against Postharvest Pathogens of Papaya Fruit. Sci. Hortic. 2019, 257, 108767. DOI: 10.1016/j.scienta.2019.108767.
  • Soib, H. H.; Ismail, H. F.; Husin, F.; Abu Bakar, M. H.; Yaakob, H.; Sarmidi, M. R. Bioassay-Guided Different Extraction Techniques of Carica Papaya (Linn.) Leaves on in vitro Wound-Healing Activities. Molecules. 2020, 25(3), 517. DOI: 10.3390/molecules25030517.
  • Anjum, V.; Arora, P.; Ansari, S. H.; Najmi, A. K.; Ahmad, S. Antithrombocytopenic and Immunomodulatory Potential of Metabolically Characterized Aqueous Extract of Carica Papaya Leaves. Pharm. Biol. 2017, 55(1), 2043–2056. DOI: 10.1080/13880209.2017.1346690.
  • Nugroho, A.; Heryani, H.; Choi, J. S.; Park, H. J. Identification and Quantification of Flavonoids in Carica Papaya Leaf and Peroxynitrite-Scavenging Activity. Asian Pac. J. Trop. Biomed. 2017, 7(3), 208–213. DOI: 10.1016/j.apjtb.2016.12.009.
  • Hamed, A. N. E.; Abouelela, M. E.; El Zowalaty, A. E.; Badr, M. M.; Abdelkader, M. S. A. Chemical Constituents from Carica Papaya Linn. Leaves as Potential Cytotoxic, EGFR Wt and Aromatase (CYP19A) Inhibitors; a Study Supported by Molecular Docking. RSC Adv. 2022, 12(15), 9154–9162. DOI: 10.1039/d1ra07000b.
  • Khor, B. K. K.; Chear, N. J. Y.; Azizi, J.; Khaw, K. Y. Chemical Composition, Antioxidant and Cytoprotective Potentials of Carica Papaya Leaf Extracts: A Comparison of Supercritical Fluid and Conventional Extraction Methods. Molecules. 2021, 26(5), 1489. DOI: 10.3390/molecules26051489.
  • Wang, X.; Hu, C.; Ai, Q.; Chen, Y.; Wang, Z.; Ou, S. Isolation and Identification Carpaine in Carica Papaya L. Leaf by HPLC-UV Method. Int. J. Food Prop. 2015, 18(7), 1505–1512. DOI: 10.1080/10942912.2014.900785.
  • Balavijayalakshmi, J.; Ramalakshmi, V. Carica Papaya Peel Mediated Synthesis of Silver Nanoparticles and Its Antibacterial Activity Against Human Pathogens. J. Appl. Res. Technol. 2017, 15(5), 413–422. DOI: 10.1016/j.jart.2017.03.010.
  • Lydia, E.; Riyazudin, M.; John, S.; Thiyagarajan, S. Investigation on the Phytochemicals Present in the Fruit Peel of Carica Papaya and Evaluation of Its Antioxidant Properties. Int. J. Health Allied Sci. 2016, 5(4), 247. DOI: 10.4103/2278-344x.194127.
  • Insanu, M.; Nayaka, N. M. D. M. W.; Solihin, L.; Wirasutisna, K. R.; Pramastya, H.; Fidrianny, I. Antioxidant Activities and Phytochemicals of Polar, Semi-Polar, and Nonpolar Extracts of Used and Unused Parts of Carica Papaya Fruit. Biocatal. Agric. Biotechnol. 2022, 39, 102270. DOI: 10.1016/j.bcab.2021.102270.
  • Nieto Calvache, J.; Cueto, M.; Farroni, A.; de Escalada Pla, M.; Gerschenson, L. N. Antioxidant Characterization of New Dietary Fiber Concentrates from Papaya Pulp and Peel (Carica Papaya L.). J. Funct. Foods. 2016, 27, 319–328. DOI: 10.1016/J.jff.2016.09.012.
  • Chan-León, A.; Estrella-Maldonado, H.; Dubé, P.; Fuentes-Ortíz, G.; Moo-Huchin, V. M.; Can-Cauich, C. A.; Sauri-Duch, E.; Desjardins, Y.; Santamaría, J. M. Determination of Total Phenolic Contents and Antioxidant Activities of Fruits from Wild and Creole Carica Papaya Genotypes in Comparison to Commercial Papaya Cultivars. J. Food Meas. Charact. 2021, 15(6), 5669–5682. DOI: 10.1007/s11694-021-01121-3.
  • Sani, M. S. A.; Bakar, J.; Azid, A.; Iqbal, M. J. Chemometrics-Based Evaluation on the Effect of Sonication, Contact Time and Solid-To-Solvent Ratio on Total Phenolics and Flavonoids, Free Fatty Acids and Antibacterial Potency of Carica Papaya Seed Against S. Enteritidis, B. Cereus. Food Chem. Adv. 2022, 1, 100033. DOI: 10.1016/J.focha.2022.100033.
  • Sani, M. S. A.; Bakar, J.; Rahman, R. A.; Abas, F. Effects of Coated Capillary Column, Derivatization, and Temperature Programming on the Identification of Carica Papaya Seed Extract Composition Using GC/MS Analysis. J. Anal. Test. 2020, 4(1), 23–34. DOI: 10.1007/s41664-020-00118-z.
  • Macêdo, J. F. D. S.; Ribeiro, L. S.; Bruno, R. D. L. A.; Alves, E. U.; de Andrade, A. P.; Lopes, K. P.; da Costa, F. B.; Zanuncio, J. C.; Ribeiro, W. S. Green Leaves and Seeds Alcoholic Extract Controls Sporobulus Indicus Germination in Laboratory Conditions. Sci. Rep. 2020, 10(1), 1–6. DOI: 10.1038/s41598-020-58321-y.
  • Kadiri, O.; Akanbi, C. T.; Olawoye, B. T.; Gbadamosi, S. O. Characterization and Antioxidant Evaluation of Phenolic Compounds Extracted from the Protein Concentrate and Protein Isolate Produced from Pawpaw (Carica Papaya Linn.) Seeds. Int. J. Food Prop. 2017, 20(11), 2423–2436. DOI: 10.1080/10942912.2016.1230874.
  • Singh, P. G.; B, M.; Shailasreesekhar, S.; Ts, G.; Basalingappa, K. M.; Bv, D. S. In Vitro Antioxidant, Anti-Inflammatory and Anti-Microbial Activity of Carica Papaya Seeds. Global J. Med. Res. 2020, 20(2), 19–38. DOI: 10.34257/gjmrbvol20is2pg19.
  • Kyei-Barffour, I.; Kwarkoh, R. K. B.; Acheampong, D. O.; Brah, A. S.; Akwetey, S. A.; Aboagye, B. Alkaloidal Extract from Carica Papaya Seeds Ameliorates Ccl4-Induced Hepatocellular Carcinoma in Rats. Heliyon. 2021, 7(8), e07849. DOI: 10.1016/j.heliyon.2021.E07849.
  • Chandrasekaran, R.; Seetharaman, P.; Krishnan, M.; Gnanasekar, S.; Sivaperumal, S. Carica Papaya (Papaya) Latex: A New Paradigm to Combat Against Dengue and Filariasis Vectors Aedes Aegypti and Culex Quinquefasciatus. (Diptera: Culicidae). (Diptera: Culicidae). 3 Biotech. 2018, 8(2), 83. DOI: 10.1007/s13205-018-1105-6.
  • Samrot, A. V.; Saigeetha, S.; Mun, C. Y.; Abirami, S.; Purohit, K.; Cypriyana, P. J. J.; Dhas, T. S.; Inbathamizh, L.; Kumar, S. S. Utilization of Carica Papaya Latex on Coating of Spions for Dye Removal and Drug Delivery. Sci. Rep. 2021, 11(1), 1–13. DOI: 10.1038/s41598-021-03328-2.
  • Mansur, F. A. F.; Luoga, W.; Behnke, J. M.; Buttle, D. J.; Duce, I. R.; Garnett, M. C. Developing Novel Anthelmintics: The Stability of Cysteine Proteinase Activity in a Supernatant Extract of Papaya Latex. Heliyon. 2021, 7(10), e08125. DOI: 10.1016/j.heliyon.2021.e08125.
  • Yap, J. Y.; Hii, C. L.; Ong, S. P.; Lim, K. H.; Abas, F.; Pin, K. Y. Quantification of Carpaine and Antioxidant Properties of Extracts from Carica Papaya Plant Leaves and Stalks. J. Bioresources Bioprod. 2021, 6(4), 350–358. DOI: 10.1016/j.jobab2021.03.002.
  • Asghar, N.; Naqvi, S. A. R.; Hussain, Z.; Rasool, N.; Khan, Z. A.; Shahzad, S. A.; Sherazi, T. A.; Janjua, M. R. S. A.; Nagra, S. A.; Zia-Ul-Haq, M., et al. Compositional Difference in Antioxidant and Antibacterial Activity of All Parts of the Carica Papaya Using Different Solvents. Chem. Cent. J. 2016, 10(1). DOI: 10.1186/j13065-016-0149-0.
  • Sofi, F. R.; Raju, C. V.; Lakshmisha, I. P.; Singh, R. R. Antioxidant and Antimicrobial Properties of Grape and Papaya Seed Extracts and Their Application on the Preservation of Indian Mackerel (Rastrelliger kanagurta) During Ice Storage. J. Food Sci. Technol. 2016, 53(1), 104–117. DOI: 10.1007/s13197-015-1983-0.
  • Maran, M.; Gangadharan, S.; Emerson, I. A. Molecular Dynamics Study of Quercetin Families and Its Derivative Compounds from Carica Papaya Leaf as Breast Cancer Inhibitors. Chem. Phys. Lett. 2022, 793, 139470. DOI: 10.1016/j.cplett.2022.139470.
  • Tayal, N.; Srivastava, P.; Srivastava, N. Anti Angiogenic Activity of Carica Papaya Leaf Extract. J. Pure Appl. Microbiol. 2019, 13(1), 567–571. DOI: 10.22207/jpam.13.1.64.
  • Anilkumar, A.; Bhanu, A. In Vitro Anticancer Activity of “Methanolic Extract of Papaya Blackseeds” (MPB) in Hep G2 Cell Lines and Its Effect in the Regulation of Bcl-2, Caspase-3 and P53 Gene Expression. Adv. Cancer Biol- Metastasis. 2022, 4, 100025. DOI: 10.1016/j.adcanc.2021.100025.
  • Seo, S. A.; Ngo, H. T. T.; Hwang, E.; Park, B.; Yi, T. H. Protective Effects of Carica Papaya Leaf Against Skin Photodamage by Blocking Production of Matrix Metalloproteinases and Collagen Degradation in UVB-Irradiated Normal Human Dermal Fibroblasts. S. Afr. J. Bot. 2020, 131, 398–405. DOI: 10.1016/j.sajb.2020.03.019.
  • Inam, A.; Shahzad, M.; Shabbir, A.; Shahid, H.; Shahid, K.; Javeed, A. Carica Papaya Ameliorates Allergic Asthma via Down Regulation of IL-4, IL-5, Eotaxin, TNF-α, NF-ĸB, and iNos Levels. Phytomedicine. 2017, 32, 1–7. DOI: 10.1016/j.phymed.2017.04.009.
  • Kharaeva, Z. F.; Zhanimova, L. R.; Mustafaev, M. S.; De Luca, C.; Mayer, W.; Chung Sheun Thai, J.; Tiew Siok Tuan, R.; Korkina, L. G. Effects of Standardised Fermented Papaya Gel on Clinical Symptoms, Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic Periodontitis: An Open Randomised Clinical Study. Mediators Inflammation. 2016, 2016, 1–12. DOI: 10.1155/2016/9379840.
  • Wattanapitayakul, S. K.; Kunchana, K.; Jarisarapurin, W.; Chularojmontri, L. Screening of Potential Tropical Fruits in Protecting Endothelial Dysfunction In Vitro. Food Nutr. Res. 2021, 65, 7807. DOI: 10.29219/fnr.v65.7807.
  • Nafiu, A. B.; Rahman, M. T. Selenium Added Unripe Carica Papayapulp Extracts Enhance Wound Repair Through TGF-β1 and VEGF-A Signalling Pathway. BMC Complementary Altern. Med. 2015, 15(1), 1–10. DOI: 10.1186/s12906-015-0900-4.
  • Das, A.; Dickerson, R.; Ghatak, P. D.; Gordillo, G. M.; Chaffee, S.; Saha, A.; Khanna, S.; Roy, S. May Dietary Supplementation Augment Respiratory Burst in Wound-Site Inflammatory Cells? Antioxid. Redox Signaling. 2018, 28(5), 401–405. DOI: 10.1089/ars.2017.7304.
  • Oboh, G.; Olabiyi, A. A.; Akinyemi, A. J.; Ademiluyi, A. O. Inhibition of Key Enzymes Linked to Type 2 Diabetes and Sodium Nitroprusside-Induced Lipid Peroxidation in Rat Pancreas by Water-Extractable Phytochemicals from Unripe Pawpaw Fruit (Carica papaya). J. Basic. Clin. Physiol. Pharmacol. 2014, 25(1), 21–34. DOI: 10.1515/jbcpp-2013-0002.
  • Abubakar, M.; Onyike, E.; Ibrahim, M. A. In vitro and in vivo Studies on the Alpha-Glucosidase Inhibitory Effects of the Leaf Extract of Carica Papaya Linn. Comp. Clin. Pathol. 2019, 28(4), 1061–1067. DOI: 10.1007/s00580-019-02928-9.
  • Miranda-Osorio, P. H.; Castell-Rodríguez, A. E.; Vargas-Mancilla, J.; Tovilla-Zárate, C. A.; Ble-Castillo, J. L.; Aguilar-Domínguez, D. E.; Juárez-Rojop, I. E.; Díaz-Zagoya, J. C. Protective Action of Carica Papaya on β-Cells in Streptozotocin-Induced Diabetic Rats. Int. J. Environ. Res. Public Health. 2016, 13(5), 446. DOI: 10.3390/ijerph13050446.
  • Airaodion, A. I.; Ogbuagu, E. O.; Ekenjoku, J. A.; Ogbuagu, U.; Okoroukwu, V. N. Antidiabetic Effect of Ethanolic Extract of Carica Papaya Leaves in Alloxan-Induced Diabetic Rats. Am. J Biomed. Sci. Res. 2019, 5(3), 227–234. DOI: 10.34297/ajbsr.2019.05.000917.
  • Agada, R.; Usman, W. A.; Shehu, S.; Thagariki, D. In vitro and in vivo Inhibitory Effects of Carica Papaya Seed on α-Amylase and α-Glucosidase Enzymes. Heliyon. 2020, 6(3), e03618. DOI: 10.1016/j.heliyon.2020.e03618.
  • Dwivedi, M. K.; Sonter, S.; Mishra, S.; Patel, D. K.; Singh, P. K. Antioxidant, Antibacterial Activity, and Phytochemical Characterization of Carica Papaya Flowers. Beni-Suef Univ. J. Basic Appl. Sci. 2020, 9(1). DOI: 10.1186/s43088-020-00048-w.
  • Callixte, C.; Baptiste, N. J.; Arwati, H. Phytochemical Screening and Antimicrobial Activities of Methanolic and Aqueous Leaf Extracts of Carica Papaya Grown in Rwanda. Mol. Cell. Biomed. Sci. 2020, 4(1), 39. DOI: 10.21705/mcbs.v4i1.74.
  • Onaebi, C.; Onyeke, C.; Osibe, D.; Ugwuja, F.; Okoro, A.; Onyegirim, P. Antimicrobial Activity of Ocimum Gratissimum L. And Carica Papaya L. Against Postharvest Pathogens of Avocado Pear (Persea Americana Mill.). J. Plant Pathol. 2020, 102(2), 319–325. DOI: 10.1007/s42161-019-00420-5.
  • Prasetya, A. T.; Mursiti, S.; Maryan, S.; Jati, N. K. Isolation and Identification of Active Compounds from Papaya Plants and Activities as Antimicrobial. IOP Conf. Ser. Mater. Sci. Eng. 2018, 349(1), 012007. DOI: 10.1088/1757-899x/349/1/012007.
  • Ghosh, S.; Saha, M.; Bandyopadhyay, P. K.; Jana, M. Extraction, Isolation and Characterization of Bioactive Compounds from Chloroform Extract of Carica Papaya Seed and It’s in vivo Antibacterial Potentiality in Channa Punctatus Against Klebsiella PKBSG14. Microb. Pathogenesis. 2017, 111, 508–518. DOI: 10.1016/j.micpath.2017.08.033.
  • Teng, W. C.; Chan, W.; Suwanarusk, R.; Ong, A.; Ho, H. K.; Russell, B.; Rénia, L.; Koh, H. L. In vitro Antimalarial Evaluations and Cytotoxicity Investigations of Carica Papaya Leaves and Carpaine. Nat. Prod. Communicat. 2019, 14(1), 33–36. DOI: 10.1177/1934578x1901400110.
  • Julianti, T.; De Mieri, M.; Zimmermann, S.; Ebrahimi, S. N.; Kaiser, M.; Neuburger, M.; Raith, M.; Brun, R.; Hamburger, M. HPLC-Based Activity Profiling for Antiplasmodial Compounds in the Traditional Indonesian Medicinal Plant Carica Papaya L. J. Ethnopharmacol. 2014, 155(1), 426–434. DOI: 10.1016/j.jep.2014.05.050.
  • Zeleke, G.; Kebebe, D.; Mulisa, E.; Gashe, F. In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica Papaya Linn (Caricaceae) Against Plasmodium Berghei in Mice. J. Parasitol. Res. 2017, 2017, 1–9. DOI: 10.1155/2017/3121050.
  • Sharma, N.; Mishra, K. P.; Chanda, S.; Bhardwaj, V.; Tanwar, H.; Ganju, L.; Kumar, B.; Singh, S. B. Evaluation of Anti-Dengue Activity of Carica Papaya Aqueous Leaf Extract and Its Role in Platelet Augmentation. Arch. Virol. 2019, 164(4), 1095–1110. DOI: 10.1007/s00705-019-04179-z.
  • Park, J.; Kim, J.; Jang, Y. S. Current Status and Perspectives on Vaccine Development Against Dengue Virus Infection. J. Microbiol. 2022, 60(3), 247–254. DOI: 10.1007/s12275-022-1625-y.
  • Norahmad, N. A.; Mohd Abd Razak, M. R.; Mohmad Misnan, N.; Md Jelas, N. H.; Sastu, U. R.; Muhammad, A.; Ho, T. C. D.; Jusoh, B.; Zolkifli, N. A.; Thayan, R., et al. Effect of Freeze-Dried Carica Papaya Leaf Juice on Inflammatory Cytokines Production During Dengue Virus Infection in AG129 Mice. BMC Complementary Altern. Med. 2019, 19(1), 1–10. DOI: 10.1186/s12906-019-2438-3.
  • Agada, R.; Thagriki, D.; Esther Lydia, D.; Khusro, A.; Alkahtani, J.; Al Shaqha, M. M.; Alwahibi, M. S.; Soliman Elshikh, M. Antioxidant and Anti-Diabetic Activities of Bioactive Fractions of Carica Papaya Seeds Extract. J. King Saud Univ. Sci. 2021, 33(2), 101342. DOI: 10.1016/j.jksus.2021.101342.
  • Garcia-Oliveira, P.; Otero, P.; Pereira, A. G.; Chamorro, F.; Carpena, M.; Echave, J.; Fraga-Corral, M.; Simal-Gandara, J.; Prieto, M. A. Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment. Pharmaceuticals. 2021, 14(2), 157. DOI: 10.3390/ph14020157.
  • Stoner, G. D. Food-Based Approach to Cancer Prevention. Food Front. 2020, 1(1), 6–8. DOI: 10.1002/fft2.3.
  • Otsuki, N.; Dang, N. H.; Kumagai, E.; Kondo, A.; Iwata, S.; Morimoto, C. Aqueous Extract of Carica Papaya Leaves Exhibits Anti-Tumor Activity and Immunomodulatory Effects. J. Ethnopharmacol. 2010, 127(3), 760–767. DOI: 10.1016/j.jep.2009.11.024.
  • Calis, H.; Sengul, S.; Guler, Y.; Karabulut, Z. Non-Healing Wounds: Can It Take Different Diagnosis? Int. Wound J. 2020, 17(2), 443–448. DOI: 10.1111/iwj.13292.
  • Umeno, A.; Horie, M.; Murotomi, K.; Nakajima, Y.; Yoshida, Y. Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones. Molecules. 2016, 21(6), 708. DOI: 10.3390/molecules21060708.
  • Pinto, L. A.; Cordeiro, K. W.; Carrasco, V.; Carollo, C. A.; Cardoso, C. A. L.; Argadoña, E. J. S.; Freitas, K. D. C. Antiulcerogenic Activity of Carica Papaya Seed in Rats. Naunyn-Schmiedeberg’s Arch. Pharmacol. 2015, 388(3), 305–317. DOI: 10.1007/s00210-014-1069-y.
  • Oloyede, H. O. B.; Adaja, M. C.; Ajiboye, T. O.; Salawu, M. O. Anti-Ulcerogenic Activity of Aqueous Extract of Carica Papaya Seed on Indomethacin-Induced Peptic Ulcer in Male Albino Rats. J. Integr. Med. 2015, 13(2), 105–114. DOI: 10.1016/s2095-4964(15)60160-1.
  • Ghaffarilaleh, V.; Fisher, D.; Henkel, R. Carica Papaya Seed Extract Slows Human Sperm. J. Ethnopharmacol. 2019, 241, 111972. DOI: 10.1016/j.jep.2019.111972.
  • Nwaehujor, C. O.; Ode, J. O.; Ekwere, M. R.; Udegbunam, R. I. Anti-Fertility Effects of Fractions from Carica Papaya (Pawpaw) Linn. Methanol Root Extract in Male Wistar Rats. Arabian J. Chem. 2019, 12(7), 1563–1568. DOI: 10.1016/J.arabjc.2014.10.018.
  • Lohiya, N. K.; Manivannan, B.; Goyal, S.; Ansari, A. S. Sperm Motility Inhibitory Effect of the Benzene Chromatographic Fraction of the Chloroform Extract of the Seeds of Carica Papaya in Langur Monkey, Presbytis Entellus Entellus. Asian J. Andrology. 2008, 10(2), 298–306. DOI: 10.1111/j.1745-7262.2008.00331.x.
  • Uddin, T. M.; Chakraborty, A. J.; Khusro, A.; Zidan, B. R. M.; Mitra, S.; Emran, T. B.; Dhama, K.; Ripon, M. K. H.; Gajdács, M.; Sahibzada, M. U. K., et al. Antibiotic Resistance in Microbes: History, Mechanisms, Therapeutic Strategies and Future Prospects. J. Infect. Public Health. 2021, 14(12), 1750–1766. DOI: 10.1016/j.jiph.2021.10.020.
  • Suleman, S.; Beyene Tufa, T.; Kebebe, D.; Belew, S.; Mekonnen, Y.; Gashe, F.; Mussa, S.; Wynendaele, E.; Duchateau, L.; De Spiegeleer, B. Treatment of Malaria and Related Symptoms Using Traditional Herbal Medicine in Ethiopia. J. Ethnopharmacol. 2018, 213, 262–279. DOI: 10.1016/j.jep.2017.10.034.
  • Keramagi, A. R.; Skariyachan, S. Prediction of Binding Potential of Natural Leads Against the Prioritized Drug Targets of Chikungunya and Dengue Viruses by Computational Screening. 3 Biotech. 2018, 8(6), 1–14. DOI: 10.1007/s13205-018-1303-2.
  • Mandal, A.; Biswas, D.; Hazra, B. Natural Products from Plants with Prospective Anti-HIV Activity and Relevant Mechanisms of Action. In Studies in Natural Products Chemistry, 1st, 2020; Vol. 66, pp. 225–271. Elsevier Inc. 10.1016/b978-0-12-817907-9.00009-x.
  • Kehinde, I.; Ramharack, P.; Nlooto, M.; Gordon, M. The Pharmacokinetic Properties of HIV-1 Protease Inhibitors: A Computational Perspective on Herbal Phytochemicals. Heliyon. 2019, 5(10), e02565. DOI: 10.1016/j.heliyon.2019.e02565.
  • Kumar, J.; Ramlal, A.; Mallick, D.; Mishra, V. An Overview of Some Biopesticides and Their Importance in Plant Protection for Commercial Acceptance. Plants. 2021, 10(6), 1185. DOI: 10.3390/plants10061185.
  • Hayatie, L.; Biworo, A.; Suhartono, E. Aqueous Extracts of Seed and Peel of Carica Papaya Against Aedes Aegypti. J. Med. Bioeng. 2015, 4(5), 417–421. DOI: 10.12720/jomb.4.5.417-421.
  • Rahayu, R.; Darmis, A.; Jannatan, R. Potency of Papaya Leaf (Carica Papaya L.) as Toxicant and Repellent Against German Cockroach (Blattella Germanica L.). Pak. J. Biological Sci. 2020, 23(2), 126–131. DOI: 10.3923/pjbs.2020.126.131.
  • Wijanarko, A.; Nur, D. F.; Sahlan, M.; Afnan, N. T.; Utami, T. S.; Hermansyah, H. Production of a Biopesticide Based on a Cysteine Protease Enzyme from Latex and Papaya (Carica papata) for Spodoptera Litura in Red Chili Peppers (Capsicum annuum). Int. J. Technol. 2017, 8(8), 1455–1461. DOI: 10.14716/ijtech.v8i8.788.
  • Joshi, A. A.; Chilkawar, P. M.; Jadhav, B. A. Studies on Physico-Chemical Properties of Noni Fruit (Morinda citrifolia) and Preparation of Noni Beverages. Int. J. Food Sci. Nutr. Diet. 2012, 1(1), 3–8. DOI: 10.19070/2326-3350-120002.
  • Joymak, W.; Ngamukote, S.; Chantarasinlapin, P.; Adisakwattana, S. Unripe Papaya By-Product: From Food Wastes to Functional Ingredients in Pancakes. Foods. 2021, 10(3), 615. DOI: 10.3390/foods10030615.
  • Sharifudin, S. A.; Ho, W. Y.; Yeap, S. K.; Abdullah, R.; Koh, S. P. Fermentation and Characterisation of Potential Kombucha Cultures on Papaya-Based Substrates. Lwt. 2021, 151, 112060. DOI: 10.1016/j.lwt.2021.112060.
  • Mada, T.; Duraisamy, R.; Abera, A.; Guesh, F. Effect of Mixed Banana and Papaya Peel Pectin on Chemical Compositions and Storage Stability of Ethiopian Traditional Yoghurt (Ergo). Int. Dairy J. 2022, 131, 105396. DOI: 10.1016/j.idairyj.2022.105396.
  • Ávila, S.; Kugo, M.; Silveira Hornung, P.; Apea-Bah, F. B.; Songok, E. M.; Beta, T. Carica Papaya Seed Enhances Phytochemicals and Functional Properties in Cornmeal Porridges. Food Chem. 2020, 323, 126808. DOI: 10.1016/j.foodchem.2020.126808.
  • Lee, W. J.; Lee, M. H.; Su, N. W. Characteristics of Papaya Seed Oils Obtained by Extrusion-Expelling Processes. J. Sci. Food Agric. 2011, 91(13), 2348–2354. DOI: 10.1002/jsfa.4466.
  • Tulamandi, S.; Rangarajan, V.; Rizvi, S. S. H.; Singhal, R. S.; Chattopadhyay, S. K.; Saha, N. C. A Biodegradable and Edible Packaging Film Based on Papaya Puree, Gelatin, and Defatted Soy Protein. Food Pack. Shelf Life. 2016, 10, 60–71. DOI: 10.1016/j.fpsl.2016.10.007.
  • Rodríguez, G. M.; Sibaja, J. C.; Espitia, P. J. P.; Otoni, C. G. Antioxidant Active Packaging Based on Papaya Edible Films Incorporated with Moringa Oleifera and Ascorbic Acid for Food Preservation. Food Hydrocolloids. 2020, 103, 105630. DOI: 10.1016/J.foodhyd.2019.105630.
  • Ma, Y.; Zhao, Y.; Xie, J.; Sameen, D. E.; Ahmed, S.; Dai, J.; Qin, W.; Li, S.; Liu, Y. Optimization, Characterization and Evaluation of Papaya Polysaccharide-Corn Starch Film for Fresh Cut Apples. Int. J. Biol. Macromol. 2021, 166, 1057–1071. DOI: 10.1016/j.ijbiomac.2020.10.261.
  • Sahoo, M.; Vishwakarma, S.; Panigrahi, C.; Kumar, J. Nanotechnology: Current Applications and Future Scope in Food. Food Front. 2021, 2(1), 3–22. DOI: 10.1002/fft2.58.
  • Banala, R. R.; Nagati, V. B.; Karnati, P. R. Green Synthesis and Characterization of Carica Papaya Leaf Extract Coated Silver Nanoparticles Through X-Ray Diffraction, Electron Microscopy and Evaluation of Bactericidal Properties. Saudi J. Biol. Sci. 2015, 22(5), 637–644. DOI: 10.1016/j.sjbs.2015.01.007.
  • Devanesan, S.; Jayamala, M.; AlSalhi, M. S.; Umamaheshwari, S.; Ranjitsingh, A. J. A. Antimicrobial and Anticancer Properties of Carica Papaya Leaves Derived di-Methyl Flubendazole Mediated Silver Nanoparticles. J. Infect. Public Health. 2021, 14(5), 577–587. DOI: 10.1016/j.jiph.2021.02.004.
  • Bere, A. W.; Mulati, O.; Kimotho, J.; Ng’Ong’a, F. Carica Papaya Leaf Extract Silver Synthesized Nanoparticles Inhibit Dengue Type 2 Viral Replication in vitro. Pharmaceuticals. 2021, 14(8), 718. DOI: 10.3390/ph14080718.
  • Kaur, H.; Kaur, S.; Singh, J.; Rawat, M.; Kumar, S. Expanding Horizon: Green Synthesis of TiO 2 Nanoparticles Using Carica Papaya Leaves for Photocatalysis Application. Mater. Res. Express. 2019, 6(9), 095034. DOI: 10.1088/2053-1591/ab2ec5.
  • Dulta, K.; Koşarsoy Ağçeli, G.; Chauhan, P.; Jasrotia, R.; Chauhan, P. K. Ecofriendly Synthesis of Zinc Oxide Nanoparticles by Carica Papaya Leaf Extract and Their Applications. J. Cluster Sci. 2022, 33(2), 603–617. DOI: 10.1007/s10876-020-01962-w.
  • Kokila, T.; Ramesh, P. S.; Geetha, D. Biosynthesis of AgNps Using Carica Papaya Peel Extract and Evaluation of Its Antioxidant and Antimicrobial Activities. Ecotoxicol. Environ. Saf. 2016, 134, 467–473. DOI: 10.1016/J.ecoenv.2016.03.021.
  • Phang, Y. K.; Aminuzzaman, M.; Akhtaruzzaman, M.; Muhammad, G.; Ogawa, S.; Watanabe, A.; Tey, L. H. Green Synthesis and Characterization of CuO Nanoparticles Derived from Papaya Peel Extract for the Photocatalytic Degradation of Palm Oil Mill Effluent (POME). Sustainability. 2021, 13(2), 1–15. DOI: 10.3390/su13020796.
  • Mohammad, I. Gold Nanoparticle: An Efficient Carrier for MCP I of Carica Papaya Seeds Extract as an Innovative Male Contraceptive in Albino Rats. J. Drug Delivery Sci. Technol. 2019, 52, 942–956. DOI: 10.1016/j.jddst.2019.06.010.
  • Subbaiah Munagapati, V.; Wen, H. Y.; Gollakota, A. R. K.; Wen, J. C.; Shu, C. M.; Andrew Lin, K. Y.; Tian, Z.; Wen, J. H.; Mallikarjuna Reddy, G.; Zyryanov, G. V. Magnetic Fe3o4 Nanoparticles Loaded Papaya (Carica Papaya L.) Seed Powder as an Effective and Recyclable Adsorbent Material for the Separation of Anionic Azo Dye (Congo Red) from Liquid Phase: Evaluation of Adsorption Properties. J. Mol. Liq. 2022, 345, 118255. DOI: 10.1016/j.molliq.2021.118255.
  • Chandrasekaran, R.; Gnanasekar, S.; Seetharaman, P.; Keppanan, R.; Arockiaswamy, W.; Sivaperumal, S. Formulation of Carica Papaya Latex-Functionalized Silver Nanoparticles for Its Improved Antibacterial and Anticancer Applications. J. Mol. Liq. 2016, 219, 232–238. DOI: 10.1016/j.molliq.2016.03.038.
  • Anadozie, S. O.; Adewale, O. B.; Fadaka, A. O.; Alofabi, O. B.; Roux, S. Synthesis of Gold Nanoparticles Using Extract of Carica Papaya Fruit: Evaluation of Its Antioxidant Properties and Effect on Colorectal and Breast Cancer Cells Scholastica. Bioresour. Technol. Rep. 2019, 100310. DOI: 10.1016/j.bcab.2022.102348.
  • Bhattacharjee, S.; Bardhan, M.; Ghosh, S.; Banerjee, A.; Pal, K.; Guha, A.; Mondal, D.; Basu, R.; Das, S.; Sinha, S. K. An in-Vivo Interpretation for Validating the Ameliorative Efficacy of Green Synthesized MnO2 Nano-Conjugate Using Carica Papaya (Papaya) Leaf Extract Against Acute Hepatic Damage. J. Drug Delivery Sci. Technol. 2021, 66, 102774. DOI: 10.1016/j.jddst.2021.102774.
  • Priya, R. Preparation and Evaluation of Herbal Anti –acne Face Pack. World J Pharm. Res. 2017, 6(6), 1000–1010. DOI: 10.20959/wjpr20176-8551.
  • Setiadi, P.; Anindia, F. Manufacture of Solid Soap Based on Crude Papain Enzyme and Antioxidant from Papaya. IOP Conf. Ser. Earth Environ. Sci. 2018, 105(1). DOI: 10.1088/1755-1315/105/1/012048.
  • Pathak, P. D.; Mandavgane, S. A.; Kulkarni, B. D. Waste to Wealth: A Case Study of Papaya Peel. Waste Biomass Valorization. 2019, 10(6), 1755–1766. DOI: 10.1007/s12649-017-0181-X/FIGURES/2.
  • Abbaszadeh, S.; Wan Alwi, S. R.; Webb, C.; Ghasemi, N.; Muhamad, I. I. Treatment of Lead-Contaminated Water Using Activated Carbon Adsorbent from Locally Available Papaya Peel Biowaste. J. Cleaner Prod. 2016, 118, 210–222. DOI: 10.1016/J.jclepro.2016.01.054.
  • Dahunsi, S. O.; Oranusi, S.; Efeovbokhan, V. E. Cleaner Energy for Cleaner Production: Modeling and Optimization of Biogas Generation from Carica Papayas (Pawpaw) Fruit Peels. J. Cleaner Prod. 2017, 156, 19–29. DOI: 10.1016/j.jclepro.2017.04.042.
  • Asokan, M. A.; Senthur Prabu, S.; Kamesh, S.; Khan, W. Performance, Combustion and Emission Characteristics of Diesel Engine Fuelled with Papaya and Watermelon Seed Oil Bio-Diesel/diesel Blends. Energy. 2018, 145, 238–245. DOI: 10.1016/j.energy.2017.12.140.
  • Lobato-Gómez, M.; Hewitt, S.; Capell, T.; Christou, P.; Dhingra, A.; Girón-Calva, P. S. Transgenic and Genome-Edited Fruits: Background, Constraints, Benefits, and Commercial Opportunities. Hortic. Res. 2021, 8(1). DOI: 10.1038/s41438-021-00601-3.
  • Cabrera Mederos, D.; Giolitti, F.; Torres, C.; Portal, O. Distribution and Phylodynamics of Papaya Ringspot Virus on Carica Papaya in Cuba. Plant Pathol. 2019, 68(2), 239–250. DOI: 10.1111/ppa.12942.
  • Jia, R.; Zhao, H.; Huang, J.; Kong, H.; Zhang, Y.; Guo, J.; Huang, Q.; Guo, Y.; Wei, Q.; Zuo, J., et al. Use of Rnai Technology to Develop a PRSV-Resistant Transgenic Papaya. Sci. Rep. 2017, 7(1), 1–9. DOI: 10.1038/s41598-017-13049-0.
  • Vadlamudi, T.; Patil, B. L.; Kaldis, A.; Sai Gopal, D. V. R.; Mishra, R.; Berbati, M.; Voloudakis, A. DsRna-Mediated Protection Against Two Isolates of Papaya Ringspot Virus Through Topical Application of dsRna in Papaya. J. Virol. Methods. 2020, 275, 113750. DOI: 10.1016/j.jviromet.2019.113750.
  • Shen, W.; Tuo, D.; Yan, P.; Yang, Y.; Li, X.; Zhou, P. Reverse Transcription Loop-Mediated Isothermal Amplification Assay for Rapid Detection of Papaya Ringspot Virus. J. Virol. Methods. 2014, 204, 93–100. DOI: 10.1016/j.jviromet.2014.04.012.
  • An, N.; Lv, J.; Zhang, A.; Xiao, C.; Zhang, R.; Chen, P. Gene Expression Profiling of Papaya (Carica Papaya L.) Immune Response Induced by CTS-N After Inoculating PLDMV. Gene. 2020, 755, 144845. DOI: 10.1016/j.gene.2020.144845.
  • Terao, D.; de Lima Nechet, K.; Shiraishi Frighetto, R. T.; Cerqueira Sasaki, F. F. Ozonated Water Combined with Heat Treatment to Control the Stem-End Rot of Papaya. Sci. Hortic. 2019, 257, 108722. DOI: 10.1016/j.scienta.2019.108722.
  • Hanif, A.; Ahmad, S.; Jaskani, M. J.; Ahmad, R. Papaya Treatment with Putrescine Maintained the Overall Quality and Promoted the Antioxidative Enzyme Activities of the Stored Fruit. Sci. Hortic. 2020, 268, 109367. DOI: 10.1016/J.SCIENTA.2020.109367.
  • Albertini, S.; Lai Reyes, A. E.; Trigo, J. M.; Sarriés, G. A.; Spoto, M. H. F. Effects of Chemical Treatments on Fresh-Cut Papaya. Food Chem. 2016, 190, 1182–1189. DOI: 10.1016/j.foodchem.2015.06.038.
  • Vieira, A. C. F.; de Matos Fonseca, J.; Menezes, N. M. C.; Monteiro, A. R.; Valencia, G. A. Active Coatings Based on Hydroxypropyl Methylcellulose and Silver Nanoparticles to Extend the Papaya (Carica Papaya L.) Shelf Life. Int. J. Biol. Macromol. 2020, 164, 489–498. DOI: 10.1016/j.ijbiomac.2020.07.130.
  • Parven, A.; Sarker, M. R.; Megharaj, M.; Meftaul, I. Prolonging the Shelf Life of Papaya (Carica Papaya L.) Using Aloe Vera Gel at Ambient Temperature. Sci. Hortic. 2020, 265, 109228. DOI: 10.1016/j.scienta.2020.109228.
  • Maringgal, B.; Hashim, N.; Amin Tawakkal, I. S. M.; Muda Mohamed, M. T.; Hazwan Hamzah, M.; Ali, M. M.; Abd Razak, M. F. H. Kinetics of Quality Changes in Papayas (Carica Papaya L.) Coated with Malaysian Stingless Bee Honey. Sci. Hortic. 2020, 267, 109321. DOI: 10.1016/j.scienta.2020.109321.
  • Gomes, A. C. A.; da Costa Lima, M.; de Oliveira, K. Á. R.; dos Santos Lima, M.; Magnani, M.; Câmara, M. P. S.; de Souza, E. L. Coatings with Chitosan and Phenolic-Rich Extract from Acerola (Malpighia Emarginata D.C.) or Jabuticaba (Plinia Jaboticaba (Vell.) Berg) Processing By-Product to Control Rot Caused by Lasiodiplodia Spp. In Papaya (Carica Papaya L.) Fr. Int. J. Food Microbiol. 2020, 331, 108694. DOI: 10.1016/j.ijfoodmicro.2020.108694.
  • Ahenkorah, C. K.; Zaitoon, A.; Apalangya, V. A.; Afrane, G.; Lim, L. T. Moisture-Activated Release of Hexanal from Imidazolidine Precursor Encapsulated in Ethylcellulose/poly(ethylene Oxide) Nonwoven for Shelf-Life Extension of Papaya. Food Pack. Shelf Life. 2020, 25, 100532. DOI: 10.1016/j.fpsl.2020.100532.

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