A Critical Review on the Gluten-Induced Enteropathy/Celiac Disease: Gluten-Targeted Dietary and Non-Dietary Therapeutic Approaches

References

• Dowd, B.; Walker-Smith, J. S. G. Samuel Gee, Aretaeus, and the Coeliac Affection. Br. Med. J. 1974, 2(5909), 45. DOI: 10.1136/bmj.2.5909.45.
   PubMedGoogle Scholar
• Yan, D.; Holt, P. R. W. D. Willem Dicke. Brilliant Clinical Observer and Translational Investigator. Discoverer of the Toxic Cause of Celiac Disease. Clinical and Translational Science. 2009, 2(6), 446–448. DOI: 10.1111/j.1752-8062.2009.00167.x.
   PubMed Web of Science ®Google Scholar
• Weijers, H.; Lindquist, B.; Anderson, C.; Rey, J.; Shmerling, D.; Visakorpi, J.; Hadorn, B.; Grüttner, R. Diagnostic Criteria in Coeliac Disease. Acta. Paediatr. Scand. 1970, 59, 461–463.
   Web of Science ®Google Scholar
• Ludvigsson, J. F.; Leffler, D. A.; Bai, J. C.; Biagi, F.; Fasano, A.; Green, P. H.; Hadjivassiliou, M.; Kaukinen, K.; Kelly, C. P.; Leonard, J. N., et al. The Oslo Definitions for Coeliac Disease and Related Terms. Gut. 2013, 62(1), 43–52. DOI: 10.1136/gutjnl-2011-301346.
   PubMed Web of Science ®Google Scholar
• Van Heel, D. A.; Franke, L.; Hunt, K. A.; Gwilliam, R.; Zhernakova, A.; Inouye, M.; Wapenaar, M. C.; Barnardo, M. C.; Bethel, G.; Holmes, G. K., et al. A Genome-Wide Association Study for Celiac Disease Identifies Risk Variants in the Region Harboring IL2 and IL21. Nat. Genet. 2007, 39(7), 827–829. DOI: 10.1038/ng2058.
   PubMed Web of Science ®Google Scholar
• Lundin, K. E. Non-Celiac Gluten Sensitivity-Why Worry? BMC Med. 2014, 12(1), 1–3. DOI: 10.1186/1741-7015-12-86.
   Google Scholar
• Dale, H. F.; Biesiekierski, J. R.; Lied, G. A. Non-Coeliac Gluten Sensitivity and the Spectrum of Gluten-Related Disorders: An Updated Overview. Nutr. res. rev. 2019, 32(1), 28–37. DOI: 10.1017/S095442241800015X.
   PubMed Web of Science ®Google Scholar
• Shewry, P. R.; Tatham, A. S. The Prolamin Storage Proteins of Cereal Seeds: Structure and Evolution. Biochem. J. 1990, 267(1), 1. DOI: 10.1042/bj2670001.
   PubMed Web of Science ®Google Scholar
• Wieser, H. Comparative Investigations of Gluten Proteins from Different Wheat Species I. Qualitative and Quantitative Composition of Gluten Protein Types. Eur. Food Res. Technol. 2000, 211(4), 262–268. DOI: 10.1007/s002170000165.
   Web of Science ®Google Scholar
• Leišová-Svobodová, L.; Sovová, T.; Dvořáček, V. Analysis of Oat Seed Transcriptome with Regards to Proteins Involved in Celiac Disease. Sci. Rep. 2022, 12(1), 1–11. DOI: 10.1038/s41598-022-12711-6.
   PubMedGoogle Scholar
• Pronin, D.; Börner, A.; Scherf, K. A. Old and Modern Wheat (Triticum Aestivum L.) Cultivars and Their Potential to Elicit Celiac Disease. Food Chem. 2021, 339, 127952. DOI: 10.1016/j.foodchem.2020.127952.
   PubMed Web of Science ®Google Scholar
• Brandtzaeg, P. The Changing Immunological Paradigm in Coeliac Disease. Immunol. Lett. 2006, 105(2), 127–139. DOI: 10.1016/j.imlet.2006.03.004.
   PubMed Web of Science ®Google Scholar
• Maiuri, L.; Ciacci, C.; Ricciardelli, I.; Vacca, L.; Raia, V.; Auricchio, S.; Picard, J.; Osman, M.; Quaratino, S.; Londei, M. Association Between Innate Response to Gliadin and Activation of Pathogenic T Cells in Coeliac Disease. Lancet. 2003, 362(9377), 30–37. DOI: 10.1016/S0140-6736(03)13803-2.
   PubMed Web of Science ®Google Scholar
• Maiuri, L.; Ciacci, C.; Auricchio, S.; Brown, V.; Quaratino, S.; Londei, M. Interleukin 15 Mediates Epithelial Changes in Celiac Disease. Gastroenterol. 2000, 119(4), 996–1006. DOI: 10.1053/gast.2000.18149.
   PubMed Web of Science ®Google Scholar
• Tollefsen, S. HLA-DQ2 and -DQ8 Signatures of Gluten T Cell Epitopes in Celiac Disease. J. Clin. Invest. 2006, 116(8), 2226–2236. DOI: 10.1172/JCI27620.
   PubMed Web of Science ®Google Scholar
• Bernardo, D. Human Intestinal Dendritic Cells as Controllers of Mucosal Immunity. Revista Española de Enfermedades Digestivas. 2013, 105(5), 279–290. DOI: 10.4321/S1130-01082013000500006.
   PubMed Web of Science ®Google Scholar
• Del Pozzo, G.; Farina, F.; Picascia, S.; Laezza, M.; Vitale, S.; Gianfrani, C. HLA Class II Genes in Precision-Based Care of Childhood Diseases: What We Can Learn from Celiac Disease. Pediatr. Res. 2021, 89(2), 307–312. DOI: 10.1038/s41390-020-01217-4.
   PubMed Web of Science ®Google Scholar
• Molberg, Ø.; Kett, K.; Scott, H.; Thorsby, E.; Sollid, L.; Lundin, K. Gliadin Specific, HLA Dq2‐restricted T Cells are Commonly Found in Small Intestinal Biopsies from Coeliac Disease Patients, but Not from Controls. Scandinavian Journal of Immunology. 1997, 46(1), 103–109. DOI: 10.1046/j.1365-3083.1997.d01-93.x-i2.
   Web of Science ®Google Scholar
• Bodd, M.; Kim, C. Y.; Lundin, K. E.; Sollid, L. M. T-Cell Response to Gluten in Patients with HLA-DQ2. 2 Reveals Requirement of Peptide-MHC Stability in Celiac Disease. Gastroenterol. 2012, 142(3), 552–561. DOI: 10.1053/j.gastro.2011.11.021.
   PubMed Web of Science ®Google Scholar
• Camarca, A.; Anderson, R. P.; Mamone, G.; Fierro, O.; Facchiano, A.; Costantini, S.; Zanzi, D.; Sidney, J.; Auricchio, S.; Sette, A., et al. Intestinal T Cell Responses to Gluten Peptides are Largely Heterogeneous: Implications for a Peptide-Based Therapy in Celiac Disease. J. Immunol. 2009, 182(7), 4158–4166. DOI: 10.4049/jimmunol.0803181.
   PubMed Web of Science ®Google Scholar
• Vader, W.; Kooy, Y.; Van Veelen, P.; De Ru, A.; Harris, D.; Benckhuijsen, W.; Peña, S.; Mearin, L.; Drijfhout, J. W.; Koning, F. The Gluten Response in Children with Celiac Disease is Directed Toward Multiple Gliadin and Glutenin Peptides. Gastroenterol. 2002, 122(7), 1729–1737. DOI: 10.1053/gast.2002.33606.
   PubMed Web of Science ®Google Scholar
• Stepniak, D.; Vader, L. W.; Kooy, Y.; van Veelen, P. A.; Moustakas, A.; Papandreou, N. A.; Eliopoulos, E.; Drijfhout, J. W.; Papadopoulos, G. K.; Koning, F. T-Cell Recognition of HLA-DQ2-Bound Gluten Peptides Can Be Influenced by an N-Terminal Proline at P-1. Immunogenetics. 2005, 57(1–2), 8–15. DOI: 10.1007/s00251-005-0780-8.
   PubMed Web of Science ®Google Scholar
• van de Wal, Y.; Kooy, Y. M.; van Veelen, P.; Vader, W.; August, S. A.; Drijfhout, J. W.; Peña, S. A.; Koning, F. Glutenin is Involved in the Gluten‐driven Mucosal T Cell Response. Eur. J. Immunol. 1999, 29(10), 3133–3139. DOI: 10.1002/(SICI)1521-4141(199910)29:10<3133:AID-IMMU3133>3.0.CO;2-G.
   PubMed Web of Science ®Google Scholar
• Kooy-Winkelaar, Y.; van Lummel, M.; Moustakas, A. K.; Schweizer, J.; Mearin, M. L.; Mulder, C. J.; Roep, B. O.; Drijfhout, J. W.; Papadopoulos, G. K.; van Bergen, J., et al. Gluten-Specific T Cells Cross-React Between HLA-DQ8 and the HLA-DQ2α/DQ8β Transdimer. J. Immunol. 2011, 187(10), 5123–5129. DOI: 10.4049/jimmunol.1101179.
   PubMed Web of Science ®Google Scholar
• Vader, L. W.; Stepniak, D. T.; Bunnik, E. M.; Kooy, Y. M.; De Haan, W.; Drijfhout, J. W.; Van Veelen, P. A.; Koning, F. Characterization of Cereal Toxicity for Celiac Disease Patients Based on Protein Homology in Grains 1 1The Authors Thank Drs. R. R. P. de Vries and R. Offringa for Critical Reading of the Manuscript, A. de Ru for Mass Spectrometric Analysis, and W. Benckhuijsen for Peptide Synthesis. Gastroenterol. 2003, 125(4), 1105–1113. DOI: 10.1016/S0016-5085(03)01204-6.
   PubMed Web of Science ®Google Scholar
• Arentz-Hansen, H.; Fleckenstein, B.; Molberg, Ø.; Scott, H.; Koning, F.; Jung, G.; Roepstorff, P.; Lundin, K. E. A.; Sollid, L. M.; Londei, M., et al. The Molecular Basis for Oat Intolerance in Patients with Celiac Disease. PLoS Med. 2004, 1, e1. DOI: 10.1371/journal.pmed.0010001.
   PubMed Web of Science ®Google Scholar
• Hardy, M. Y.; Tye-Din, J. A.; Stewart, J. A.; Schmitz, F.; Dudek, N. L.; Hanchapola, I.; Purcell, A. W.; Anderson, R. P. Ingestion of Oats and Barley in Patients with Celiac Disease Mobilizes Cross-Reactive T Cells Activated by Avenin Peptides and Immuno-Dominant Hordein Peptides. J. Autoimmun. 2015, 56, 56–65. DOI: 10.1016/j.jaut.2014.10.003.
   PubMed Web of Science ®Google Scholar
• Sjöström, H.; Lundin, K.; Molberg, O.; Körner, R.; McAdam, S.; Anthonsen, D.; Quarsten, H.; Noren, O.; Roepstorff, P.; Thorsby, E., et al. Identification of a Gliadin T-Cell Epitope in Coeliac Disease: General Importance of Gliadin Deamidation for Intestinal T-Cell Recognition. Scandinavian Journal of Immunology. 1998, 48(2), 111–115. DOI: 10.1046/j.1365-3083.1998.00397.x.
   PubMed Web of Science ®Google Scholar
• Qiao, S. -W.; Bergseng, E.; Molberg, Ø.; Jung, G.; Fleckenstein, B.; Sollid, L. M. Refining the Rules of Gliadin T Cell Epitope Binding to the Disease-Associated DQ2 Molecule in Celiac Disease: Importance of Proline Spacing and Glutamine Deamidation. J. Immunol. 2005, 175(1), 254–261. DOI: 10.4049/jimmunol.175.1.254.
   PubMed Web of Science ®Google Scholar
• Arentz–Hansen, H.; Mcadam, S. N.; Molberg, Ø.; Fleckenstein, B.; Lundin, K. E.; Jørgensen, T. J.; Jung, G.; Roepstorff, P.; Sollid, L. M. Celiac Lesion T Cells Recognize Epitopes That Cluster in Regions of Gliadins Rich in Proline Residues. Gastroenterol. 2002, 123(3), 803–809. DOI: 10.1053/gast.2002.35381.
   PubMed Web of Science ®Google Scholar
• Qiao, S. -W.; Sollid, L. M. Two Novel HLA-DQ2. 5-Restricted Gluten T Cell Epitopes in the DQ2. 5-Glia-γ4 Epitope Family. Immunogenetics. 2019, 71(10), 665–667. DOI: 10.1007/s00251-019-01138-5.
   PubMed Web of Science ®Google Scholar
• Tye-Din, J. A.; Stewart, J. A.; Dromey, J. A.; Beissbarth, T.; van Heel, D. A.; Tatham, A.; Henderson, K.; Mannering, S. I.; Gianfrani, C.; Jewell, D. P., et al. Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease. Science Translational Medicine. 2010, 2(41), 41ra51-41ra51. DOI: 10.1126/scitranslmed.3001012.
   PubMed Web of Science ®Google Scholar
• Dørum, S.; Bodd, M.; Fallang, L. -E.; Bergseng, E.; Christophersen, A.; Johannesen, M. K.; Qiao, S. -W.; Stamnaes, J.; De Souza, G. A.; Sollid, L. M. HLA-DQ Molecules as Affinity Matrix for Identification of Gluten T Cell Epitopes. J. Immunol. 2014, 193(9), 4497–4506. DOI: 10.4049/jimmunol.1301466.
   PubMed Web of Science ®Google Scholar
• Van De Wal, Y.; Kooy, Y. M.; Van Veelen, P. A.; Peña, S. A.; Mearin, L. M.; Molberg, Ø.; Lundin, K. E.; Sollid, L. M.; Mutis, T.; Benckhuijsen, W. E. Small Intestinal T Cells of Celiac Disease Patients Recognize a Natural Pepsin Fragment of Gliadin. Proceedings of the National Academy of Sciences, USA 1998, 95, 10050–10054 doi:10.1073/pnas.95.17.10050.
   Google Scholar
• Arentz-Hansen, H.; Körner, R.; Molberg, Ø.; Quarsten, H.; Vader, W.; Kooy, Y. M.; Lundin, K. E.; Koning, F.; Roepstorff, P.; Sollid, L. M., et al. The Intestinal T Cell Response to α-Gliadin in Adult Celiac Disease is Focused on a Single Deamidated Glutamine Targeted by Tissue Transglutaminase. J. Exp. Med. 2000, 191(4), 603–612. DOI: 10.1084/jem.191.4.603.
   PubMed Web of Science ®Google Scholar
• Sollid, L. M.; Tye-Din, J. A.; Qiao, S. -W.; Anderson, R. P.; Gianfrani, C.; Koning, F. Update 2020: Nomenclature and Listing of Celiac Disease–Relevant Gluten Epitopes Recognized by CD4+ T Cells. Immunogenetics. 2020, 72(1–2), 85–88. DOI: 10.1007/s00251-019-01141-w.
   PubMed Web of Science ®Google Scholar
• Ménard, S.; Lebreton, C.; Schumann, M.; Matysiak-Budnik, T.; Dugave, C.; Bouhnik, Y.; Malamut, G.; Cellier, C.; Allez, M.; Crenn, P., et al. Paracellular versus Transcellular Intestinal Permeability to Gliadin Peptides in Active Celiac Disease. Am. J. Pathol. 2012, 180(2), 608–615. DOI: 10.1016/j.ajpath.2011.10.019.
   PubMed Web of Science ®Google Scholar
• Manavalan, J. S.; Hernandez, L.; Shah, J. G.; Konikkara, J.; Naiyer, A. J.; Lee, A. R.; Ciaccio, E.; Minaya, M. T.; Green, P. H.; Bhagat, G. Serum Cytokine Elevations in Celiac Disease: Association with Disease Presentation. Hum. Immunol. 2010, 71(1), 50–57. DOI: 10.1016/j.humimm.2009.09.351.
   PubMed Web of Science ®Google Scholar
• Caruso, R.; Marafini, I.; Sedda, S.; Del Vecchio Blanco, G.; Giuffrida, P.; MacDonald, T. T.; Corazza, G. R.; Pallone, F.; Di Sabatino, A.; Monteleone, G. Analysis of the Cytokine Profile in the Duodenal Mucosa of Refractory Coeliac Disease Patients. Clinical Sci. 2014, 126(6), 451–458. DOI: 10.1042/CS20130478.
   Web of Science ®Google Scholar
• Van Leeuwen, M.; Lindenbergh-Kortleve, D.; Raatgeep, H.; De Ruiter, L.; De Krijger, R.; Groeneweg, M.; Escher, J.; Samsom, J. Increased Production of Interleukin-21, but Not Interleukin-17A, in the Small Intestine Characterizes Pediatric Celiac Disease. Mucosal Immunol. 2013, 6(6), 1202–1213. DOI: 10.1038/mi.2013.19.
   PubMed Web of Science ®Google Scholar
• Sarra, M.; Cupi, M.; Monteleone, I.; Franzè, E.; Ronchetti, G.; Di Sabatino, A.; Gentileschi, P.; Franceschilli, L.; Sileri, P.; Sica, G., et al. IL-15 Positively Regulates IL-21 Production in Celiac Disease Mucosa. Mucosal Immunol. 2013, 6(2), 244–255. DOI: 10.1038/mi.2012.65.
   PubMed Web of Science ®Google Scholar
• Mention, J. -J.; Ahmed, M. B.; Bègue, B.; Barbe, U.; Verkarre, V.; Asnafi, V.; Colombel, J. -F.; Cugnenc, P. -H.; Ruemmele, F. M.; Mcintyre, E., et al. Interleukin 15: A Key to Disrupted Intraepithelial Lymphocyte Homeostasis and Lymphomagenesis in Celiac Disease. Gastroenterol. 2003, 125(3), 730–745. DOI: 10.1016/S0016-5085(03)01047-3.
   PubMed Web of Science ®Google Scholar
• Malamut, G.; El Machhour, R.; Montcuquet, N.; Martin-Lannerée, S.; Dusanter-Fourt, I.; Verkarre, V.; Mention, J. -J.; Rahmi, G.; Kiyono, H.; Butz, E. A., et al. IL-15 Triggers an Antiapoptotic Pathway in Human Intraepithelial Lymphocytes That is a Potential New Target in Celiac Disease–Associated Inflammation and Lymphomagenesis. J. Clin. Invest. 2010, 120(6), 2131–2143. DOI: 10.1172/JCI41344.
   PubMed Web of Science ®Google Scholar
• King, A.; Moodie, S.; Fraser, J.; Curtis, D.; Reid, E.; Dearlove, A.; Ellis, H.; Ciclitira, P. CTLA-4/CD28 Gene Region is Associated with Genetic Susceptibility to Coeliac Disease in UK Families. J. Med. Genet. 2002, 39(1), 51–54. DOI: 10.1136/jmg.39.1.51.
   PubMed Web of Science ®Google Scholar
• Kumar, J.; Kumar, M.; Pandey, R.; Chauhan, N. S. Physiopathology and Management of Gluten‐induced Celiac Disease. J. Food Sci. 2017, 82(2), 270–277. DOI: 10.1111/1750-3841.13612.
   PubMed Web of Science ®Google Scholar
• Lundin, K. E.; Qiao, S. -W.; Snir, O.; Sollid, L. M. Coeliac Disease–From Genetic and Immunological Studies to Clinical Applications. Scand. J. Gastroenterol. 2015, 50(6), 708–717. DOI: 10.3109/00365521.2015.1030766.
   PubMed Web of Science ®Google Scholar
• Castillo, N. E.; Theethira, T. G.; Leffler, D. A. The Present and the Future in the Diagnosis and Management of Celiac Disease. Gastroenterology Report. 2015, 3(1), 3–11. DOI: 10.1093/gastro/gou065.
   PubMed Web of Science ®Google Scholar
• Lundin, K. E.; Sollid, L. M. Advances in Coeliac Disease. Curr. Opin. Gastroenterol. 2014, 30(2), 154–162. DOI: 10.1097/MOG.0000000000000041.
   PubMed Web of Science ®Google Scholar
• Mazumdar, K.; Alvarez, X.; Borda, J. T.; Dufour, J.; Martin, E.; Bethune, M. T.; Khosla, C.; Sestak, K.; Bereswill, S.; Bereswill, S. Visualization of Transepithelial Passage of the Immunogenic 33-Residue Peptide from α-2 Gliadin in Gluten-Sensitive Macaques. PLoS One. 2010, 5(4), e10228. DOI: 10.1371/journal.pone.0010228.
   PubMed Web of Science ®Google Scholar
• Rubio-Tapia, A.; Hill, I. D.; Kelly, C. P.; Calderwood, A. H.; Murray, J. A. ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease. Official Journal of the American College of Gastroenterology| ACG. 2013, 108(5), 656–676. DOI: 10.1038/ajg.2013.79.
   PubMed Web of Science ®Google Scholar
• Chen, Z. E.; Lee, H. E.; Wu, T. -T. Histologic Evaluation in the Diagnosis and Management of Celiac Disease: Practical Challenges, Current Best Practice Recommendations and Beyond. Human Pathology. 2022, 132, 20–30. DOI: 10.1016/j.humpath.2022.07.017.
   PubMed Web of Science ®Google Scholar
• Villanacci, V.; Vanoli, A.; Leoncini, G.; Arpa, G.; Salviato, T.; Bonetti, L. R.; Baronchelli, C.; Saragoni, L.; Parente, P. Celiac Disease: Histology-Differential Diagnosis-Complications. A Practical Approach. Pathologica. 2020, 112(3), 186. DOI: 10.32074/1591-951X-157.
   PubMed Web of Science ®Google Scholar
• McCarty, T. R.; O’Brien, C. R.; Gremida, A.; Ling, C.; Rustagi, T. Efficacy of Duodenal Bulb Biopsy for Diagnosis of Celiac Disease: A Systematic Review and Meta-Analysis. Endoscopy International Open. 2018, 6(11), E1369–1378. DOI: 10.1055/a-0732-5060.
   PubMedGoogle Scholar
• Lundin, K. E.; Brottveit, M.; Skodje, G. Noncoeliac gluten sensitivity. In Coeliac Disease and Gluten-Related Disorders, Schieptti, A., Sanders, D. Eds.; United States: Academic Press, 2021; Vol. 2022, pp 177–195 DOI:10.1016/C2019-0-03606-0.
   Google Scholar
• Marsh, M. N. Gluten, Major Histocompatibility Complex, and the Small Intestine: A Molecular and Immunobiologic Approach to the Spectrum of Gluten Sensitivity (‘Celiac sprue’). Gastroenterol. 1992, 102(1), 330–354. DOI: 10.1016/0016-5085(92)91819-P.
   PubMed Web of Science ®Google Scholar
• Molina-Infante, J.; Carroccio, A. Suspected Nonceliac Gluten Sensitivity Confirmed in Few Patients After Gluten Challenge in Double-Blind, Placebo-Controlled Trials. Clinical Gastroenterology and Hepatology. 2017, 15(3), 339–348. DOI: 10.1016/j.cgh.2016.08.007.
   PubMed Web of Science ®Google Scholar
• Thompson, T. Gluten Contamination of Commercial Oat Products in the United States. New Engl. J. Med. 2004, 351(19), 2021–2022. DOI: 10.1056/NEJM200411043511924.
   PubMed Web of Science ®Google Scholar
• Deora, V.; Aylward, N.; Sokoro, A.; El-Matary, W. Serum Vitamins and Minerals at Diagnosis and Follow-Up in Children with Celiac Disease. J. Pediatr. Gastroenterol. Nutr. 2017, 65(2), 185–189. DOI: 10.1097/MPG.0000000000001475.
   PubMed Web of Science ®Google Scholar
• ALWITRY, A. Vitamin a Deficiency in Coeliac Disease. The British Journal of Ophthalmology. 2000, 84(9), 1075. DOI: 10.1136/bjo.84.9.1075e.
   Web of Science ®Google Scholar
• Abdalla, A.; Saifullah, S. M.; Osman, M.; Baniya, R.; Sidahmed, S.; LaChance, J.; Bachuwa, G. Prevalence of Occult Celiac Disease in Females with Iron Deficiency in the United States: An NHANES Analysis. Journal of Community Hospital Internal Medicine Perspectives. 2017, 7(6), 347–350. DOI: 10.1080/20009666.2017.1396169.
   PubMed Web of Science ®Google Scholar
• Beniwal, N.; Ameta, G.; Chahar, C. K. Celiac Disease in Children with Severe Acute Malnutrition (SAM): A Hospital Based Study. Indian J. Pediatr. 2017, 84(5), 339–343. DOI: 10.1007/s12098-017-2300-x.
   PubMed Web of Science ®Google Scholar
• Rajpoot, P.; Makharia, G. K. Problems and Challenges to Adaptation of Gluten Free Diet by Indian Patients with Celiac Disease. Nutrients. 2013, 5(12), 4869–4879. DOI: 10.3390/nu5124869.
   PubMed Web of Science ®Google Scholar
• Hmida, N. B.; Ahmed, M. B.; Moussa, A.; Rejeb, M. B.; Said, Y.; Kourda, N.; Meresse, B.; Abdeladhim, M.; Louzir, H.; Cerf-Bensussan, N. Impaired Control of Effector T Cells by Regulatory T Cells: A Clue to Loss of Oral Tolerance and Autoimmunity in Celiac Disease? Official Journal of the American College of Gastroenterology| ACG. 2012, 107(4), 604–611. DOI: 10.1038/ajg.2011.397.
   PubMed Web of Science ®Google Scholar
• Veeraraghavan, G.; Leffler, D. A.; Kaswala, D. H.; Mukherjee, R. Celiac Disease 2015 Update: New Therapies. Expert Review of Gastroenterology & Hepatology. 2015, 9(7), 913–927. DOI: 10.1586/17474124.2015.1033399.
   Google Scholar
• Xia, J.; Siegel, M.; Bergseng, E.; Sollid, L. M.; Khosla, C. Inhibition of HLA-DQ2-Mediated Antigen Presentation by Analogues of a High Affinity 33-Residue Peptide from α2-Gliadin. J. Am Chem. Soc. 2006, 128(6), 1859–1867. DOI: 10.1021/ja056423o.
   PubMed Web of Science ®Google Scholar
• Xia, J.; Bergseng, E.; Fleckenstein, B.; Siegel, M.; Kim, C. -Y.; Khosla, C.; Sollid, L. M. Cyclic and Dimeric Gluten Peptide Analogues Inhibiting DQ2-Mediated Antigen Presentation in Celiac Disease. Bioorganic & Medicinal Chemistry. 2007, 15(20), 6565–6573. DOI: 10.1016/j.bmc.2007.07.001.
   PubMed Web of Science ®Google Scholar
• Jüse, U.; van de Wal, Y.; Koning, F.; Sollid, L. M.; Fleckenstein, B. Design of New High-Affinity Peptide Ligands for Human Leukocyte Antigen-DQ2 Using a Positional Scanning Peptide Library. Hum. Immunol. 2010, 71(5), 475–481. DOI: 10.1016/j.humimm.2010.01.021.
   PubMed Web of Science ®Google Scholar
• Siegel, M.; Bethune, M. T.; Gass, J.; Ehren, J.; Xia, J.; Johannsen, A.; Stuge, T. B.; Gray, G. M.; Lee, P. P.; Khosla, C. Rational Design of Combination Enzyme Therapy for Celiac Sprue. Chemistry & Biology. 2006, 13(6), 649–658. DOI: 10.1016/j.chembiol.2006.04.009.
   PubMed Web of Science ®Google Scholar
• Siegel, M.; Khosla, C. Transglutaminase 2 Inhibitors and Their Therapeutic Role in Disease States. Pharmacology & Therapeutics. 2007, 115(2), 232–245. DOI: 10.1016/j.pharmthera.2007.05.003.
   PubMed Web of Science ®Google Scholar
• Stoven, S.; Murray, J. A.; Marietta, E. Celiac Disease: Advances in Treatment via Gluten Modification. Clinical Gastroenterology and Hepatology. Clinical Gastroenterology and Hepatology. 2012, 10(8), 859–862. DOI: 10.1016/j.cgh.2012.06.005.
   PubMedGoogle Scholar
• Sollid, L. M.; Jabri, B. Celiac Disease and Transglutaminase 2: A Model for Posttranslational Modification of Antigens and HLA Association in the Pathogenesis of Autoimmune Disorders. Curr Opin Immunol. 2011, 23(6), 732–738. DOI: 10.1016/j.coi.2011.08.006.
   PubMed Web of Science ®Google Scholar
• Carroccio, A.; Di Prima, L.; Noto, D.; Fayer, F.; Ambrosiano, G.; Villanacci, V.; Lammers, K.; Lafiandra, D.; De Ambrogio, E.; Di Fede, G. Searching for Wheat Plants with Low Toxicity in Celiac Disease: Between Direct Toxicity and Immunologic Activation. Digestive Liver Dis. 2011, 43(1), 34–39. DOI: 10.1016/j.dld.2010.05.005.
   Web of Science ®Google Scholar
• Makharia, G. K. Current and Emerging Therapy for Celiac Disease. Frontiers in Medicine. 2014, 1, 6. DOI: 10.3389/fmed.2014.00006.
   PubMedGoogle Scholar
• Gil-Humanes, J.; Pistón, F.; Giménez, M. J.; Martín, A.; Barro, F.; Alvarez, M. L.; Alvarez, M. L. The Introgression of RNAi Silencing of γ-Gliadins into Commercial Lines of Bread Wheat Changes the Mixing and Technological Properties of the Dough. PLoS One. 2012, 7(9), 2012. DOI: 10.1371/journal.pone.0045937.
   Web of Science ®Google Scholar
• Spaenij–Dekking, L.; Kooy–Winkelaar, Y.; van Veelen, P.; Drijfhout, J. W.; Jonker, H.; van Soest, L.; Smulders, M. J.; Bosch, D.; Gilissen, L. J.; Koning, F. Natural Variation in Toxicity of Wheat: Potential for Selection of Nontoxic Varieties for Celiac Disease Patients. Gastroenterol. 2005, 129(3), 797–806. DOI: 10.1053/j.gastro.2005.06.017.
   PubMed Web of Science ®Google Scholar
• van den Broeck, H.; Hongbing, C.; Lacaze, X.; Dusautoir, J. -C.; Gilissen, L.; Smulders, M.; van der Meer, I. In Search of Tetraploid Wheat Accessions Reduced in Celiac Disease-Related Gluten Epitopes. Mol BioSyst. 2010, 6(11), 2206–2213. DOI: 10.1039/c0mb00046a.
   PubMedGoogle Scholar
• Stepniak, D.; Wiesner, M.; de Ru, A. H.; Moustakas, A. K.; Drijfhout, J. W.; Papadopoulos, G. K.; van Veelen, P. A.; Koning, F. Large-Scale Characterization of Natural Ligands Explains the Unique Gluten-Binding Properties of HLA-DQ2. J. Immunol. 2008, 180(5), 3268–3278. DOI: 10.4049/jimmunol.180.5.3268.
   PubMed Web of Science ®Google Scholar
• Brzozowski, B. Immunoreactivity of Wheat Proteins Modified by Hydrolysis and Polymerisation. Eur. Food Res. Technol. 2016, 242(7), 1025–1040. DOI: 10.1007/s00217-015-2608-6.
   Web of Science ®Google Scholar
• Wolf, C.; Siegel, J. B.; Tinberg, C.; Camarca, A.; Gianfrani, C.; Paski, S.; Guan, R.; Montelione, G.; Baker, D.; Pultz, I. S. Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions. J Am Chem Soc. 2015, 137(40), 13106–13113. DOI: 10.1021/jacs.5b08325.
   PubMed Web of Science ®Google Scholar
• Rey, M.; Yang, M.; Lee, L.; Zhang, Y.; Sheff, J. G.; Sensen, C. W.; Mrazek, H.; Halada, P.; Man, P.; McCarville, J. L., et al. Addressing Proteolytic Efficiency in Enzymatic Degradation Therapy for Celiac Disease. Sci Rep. 2016, 6(1), 1–13. DOI: 10.1038/srep30980.
   PubMedGoogle Scholar
• Tack, G. J.; Van de Water, J. M.; Bruins, M. J.; Kooy-Winkelaar, E. M.; van Bergen, J.; Bonnet, P.; Vreugdenhil, A. C.; Korponay-Szabo, I.; Edens, L.; von Blomberg, B. M. E. Consumption of Gluten with Gluten-Degrading Enzyme by Celiac Patients: A Pilot-Study. World J. Gastroenterol. 2013, 19(35), 5837. DOI: 10.3748/wjg.v19.i35.5837.
   PubMed Web of Science ®Google Scholar
• Wieser, H. Chemistry of Gluten Proteins. Food Microbiol. 2007, 24(2), 115–119. DOI: 10.1016/j.fm.2006.07.004.
   PubMed Web of Science ®Google Scholar
• Stepniak, D.; Spaenij-Dekking, L.; Mitea, C.; Moester, M.; de Ru, A.; Baak-Pablo, R.; van Veelen, P.; Edens, L.; Koning, F. Highly Efficient Gluten Degradation with a Newly Identified Prolyl Endoprotease: Implications for Celiac Disease. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2006, 291(4), G621–629. DOI: 10.1152/ajpgi.00034.2006.
   PubMed Web of Science ®Google Scholar
• Gass, J.; Bethune, M. T.; Siegel, M.; Spencer, A.; Khosla, C. Combination Enzyme Therapy for Gastric Digestion of Dietary Gluten in Patients with Celiac Sprue. Gastroenterol. 2007, 133(2), 472–480. DOI: 10.1053/j.gastro.2007.05.028.
   PubMed Web of Science ®Google Scholar
• Catassi, C.; Fabiani, E.; Iacono, G.; D’Agate, C.; Francavilla, R.; Biagi, F.; Volta, U.; Accomando, S.; Picarelli, A.; De Vitis, I., et al. A Prospective, Double-Blind, Placebo-Controlled Trial to Establish a Safe Gluten Threshold for Patients with Celiac Disease. Am. J. Clin. Nutr. 2007, 85(1), 160–166. DOI: 10.1093/ajcn/85.1.160.
   PubMed Web of Science ®Google Scholar
• Lähdeaho, M. -L.; Kaukinen, K.; Laurila, K.; Vuotikka, P.; Koivurova, O. -P.; Kärjä-Lahdensuu, T.; Marcantonio, A.; Adelman, D. C.; Mäki, M. Glutenase ALV003 Attenuates Gluten-Induced Mucosal Injury in Patients with Celiac Disease. Gastroenterol. 2014, 146(7), 1649–1658. DOI: 10.1053/j.gastro.2014.02.031.
   PubMed Web of Science ®Google Scholar
• Heredia-Sandoval, N. G.; Islas-Rubio, A. R.; Cabrera-Chávez, F.; de la Barca, A. M. C. Transamidation of Gluten Proteins During the Bread-Making Process of Wheat Flour to Produce Breads with Less Immunoreactive Gluten. Food & Function. 2014, 5(8), 1813–1818. DOI: 10.1039/C4FO00118D.
   PubMed Web of Science ®Google Scholar
• Di Sabatino, A.; Vanoli, A.; Giuffrida, P.; Luinetti, O.; Solcia, E.; Corazza, G. R. The Function of Tissue Transglutaminase in Celiac Disease. Autoimmunity Rev. 2012, 11(10), 746–753. DOI: 10.1016/j.autrev.2012.01.007.
   PubMed Web of Science ®Google Scholar
• Mazzarella, G.; Salvati, V. M.; Iaquinto, G.; Stefanile, R.; Capobianco, F.; Luongo, D.; Bergamo, P.; Maurano, F.; Giardullo, N.; Malamisura, B., et al. Reintroduction of Gluten Following Flour Transamidation in Adult Celiac Patients: A Randomized, Controlled Clinical Study. Clinic. Develop. Immunol. 2012, 2012, 1–10. DOI: 10.1155/2012/329150.
   Google Scholar
• Ribeiro, M.; Nunes, F. M.; Guedes, S.; Domingues, P.; Silva, A. M.; Carrillo, J. M.; Rodriguez-Quijano, M.; Branlard, G.; Igrejas, G. Efficient Chemo-Enzymatic Gluten Detoxification: Reducing Toxic Epitopes for Celiac Patients Improving Functional Properties. Sci Rep. 2015, 5(1), 1–17. DOI: 10.1038/srep18041.
   Google Scholar
• McCarville, J. L.; Nisemblat, Y.; Galipeau, H. J.; Jury, J.; Tabakman, R.; Cohen, A.; Naftali, E.; Neiman, B.; Halbfinger, E.; Murray, J. A., et al. BL-7010 Demonstrates Specific Binding to Gliadin and Reduces Gluten-Associated Pathology in a Chronic Mouse Model of Gliadin Sensitivity. PLoS One. 2014, 9(11), e109972. DOI: 10.1371/journal.pone.0109972.
   PubMed Web of Science ®Google Scholar
• Pinier, M.; Verdu, E. F.; Nasser–Eddine, M.; David, C. S.; Vézina, A.; Rivard, N.; Leroux, J. C. Polymeric Binders Suppress Gliadin-Induced Toxicity in the Intestinal Epithelium. Gastroenterol. 2009, 136(1), 288–298. DOI: 10.1053/j.gastro.2008.09.016.
   PubMed Web of Science ®Google Scholar
• Galipeau, H. J.; Verdu, E. F. The Double-Edged Sword of Gut Bacteria in Celiac Disease and Implications for Therapeutic Potential. Mucosal Immunol. 2022, 15(2), 235–243. DOI: 10.1038/s41385-021-00479-3.
   PubMed Web of Science ®Google Scholar
• Wong, S. H.; Yu, J. Gut Microbiota in Colorectal Cancer: Mechanisms of Action and Clinical Applications. Nature Reviews Gastroenterology & Hepatology. 2019, 16(11), 690–704. DOI: 10.1038/s41575-019-0209-8.
   PubMed Web of Science ®Google Scholar
• Sabahi, S.; Abbasi, A.; Mortazavi, S. A. Characterization of Cinnamon Essential Oil and Its Application in Malva Sylvestris Seed Mucilage Edible Coating to the Enhancement of the Microbiological, Physicochemical and Sensory Properties of Lamb Meat During Storage. J. Appl. Microbiol. 2022, 133(2), 2022. DOI: 10.1111/jam.15578.
   Web of Science ®Google Scholar
• Orlando, A.; Linsalata, M.; Bianco, G.; Notarnicola, M.; D’Attoma, B.; Scavo, M. P.; Tafaro, A.; Russo, F. Lactobacillus Rhamnosus GG Protects the Epithelial Barrier of Wistar Rats from the Pepsin-Trypsin-Digested Gliadin (PTG)-Induced Enteropathy. Nutrients. 2018, 10(11), 1698. DOI: 10.3390/nu10111698.
   PubMed Web of Science ®Google Scholar
• Laparra, J. M.; Olivares, M.; Gallina, O.; Sanz, Y.; Leulier, F.; Leulier, F. Bifidobacterium longum CECT 7347 Modulates Immune Responses in a Gliadin-Induced Enteropathy Animal Model. PLoS One. 2012, 7(2), e30744. DOI: 10.1371/journal.pone.0030744.
   PubMed Web of Science ®Google Scholar
• Lindfors, K.; Blomqvist, T.; Juuti-Uusitalo, K.; Stenman, S.; Venäläinen, J.; Mäki, M.; Kaukinen, K. Live Probiotic Bifidobacterium Lactis Bacteria Inhibit the Toxic Effects Induced by Wheat Gliadin in Epithelial Cell Culture. Clinical & Experimental Immunology. 2008, 152(3), 552–558. DOI: 10.1111/j.1365-2249.2008.03635.x.
   PubMed Web of Science ®Google Scholar
• Mickowska, B.; Romanová, K.; Urminská, D. Reduction of Immunoreactivity of Rye and Wheat Prolamins by Lactobacilli and Flavourzyme Proteolysis During Sourdough Fermentation–A Way to Obtain Low-Gluten Bread. Journal of Food & Nutrition Research. 2019, 58, 153–166.
   Web of Science ®Google Scholar
• Bradauskiene, V.; Vaiciulyte-Funk, L.; Mazoniene, E.; Cernauskas, D. Fermentation with Lactobacillus Strains for Elimination of Gluten in Wheat (Triticum Aestivum) By-Products. In Proceedings of the Baltic Conference on Food Science and Technology: conference proceedings. LLU, 2019.
   Google Scholar
• Sarno, M.; Lania, G.; Cuomo, M.; Nigro, F.; Passannanti, F.; Budelli, A.; Fasano, F.; Troncone, R.; Auricchio, S.; Barone, M. V., et al. Lactobacillus Paracasei CBA L74 Interferes with Gliadin Peptides Entrance in Caco-2 Cells. Int. J. Food Sci. Nutr. 2014, 65(8), 953–959. DOI: 10.3109/09637486.2014.940283.
   PubMed Web of Science ®Google Scholar
• D’Arienzo, R.; Maurano, F.; Lavermicocca, P.; Ricca, E.; Rossi, M. Modulation of the Immune Response by Probiotic Strains in a Mouse Model of Gluten Sensitivity. Cytokine. 2009, 48(3), 254–259. DOI: 10.1016/j.cyto.2009.08.003.
   PubMed Web of Science ®Google Scholar
• D’arienzo, R.; Stefanile, R.; Maurano, F.; Mazzarella, G.; Ricca, E.; Troncone, R.; Auricchio, S.; Rossi, M. Immunomodulatory Effects of Lactobacillus Casei Administration in a Mouse Model of Gliadin‐sensitive Enteropathy. Scandinavian Journal of Immunology. 2011, 74(4), 335–341. DOI: 10.1111/j.1365-3083.2011.02582.x.
   PubMed Web of Science ®Google Scholar
• De Angelis, M.; Coda, R.; Silano, M.; Minervini, F.; Rizzello, C. G.; Di Cagno, R.; Vicentini, O.; De Vincenzi, M.; Gobbetti, M. Fermentation by Selected Sourdough Lactic Acid Bacteria to Decrease Coeliac Intolerance to Rye Flour. J. Cereal Sci. 2006, 43(3), 301–314. DOI: 10.1016/j.jcs.2005.12.008.
   Web of Science ®Google Scholar
• Rizzello, C. G.; De Angelis, M.; Di Cagno, R.; Camarca, A.; Silano, M.; Losito, I.; De Vincenzi, M.; De Bari, M. D.; Palmisano, F.; Maurano, F., et al. Highly Efficient Gluten Degradation by Lactobacilli and Fungal Proteases During Food Processing: New Perspectives for Celiac Disease. Appl. Environ. Microbiol. 2007, 73(14), 4499–4507. DOI: 10.1128/AEM.00260-07.
   PubMed Web of Science ®Google Scholar
• De Angelis, M.; Rizzello, C. G.; Fasano, A.; Clemente, M. G.; De Simone, C.; Silano, M.; De Vincenzi, M.; Losito, I.; Gobbetti, M. VSL# 3 Probiotic Preparation Has the Capacity to Hydrolyze Gliadin Polypeptides Responsible for Celiac Sprue Probiotics and Gluten Intolerance. Biochim. Biophys. Acta-Mol. Basis Dis. 2006, 1762(1), 80–93. DOI: 10.1016/j.bbadis.2005.09.008.
   PubMed Web of Science ®Google Scholar
• Abbasi, A.; Aghebati-Maleki, A.; Yousefi, M.; Aghebati-Maleki, L. Probiotic Intervention as a Potential Therapeutic for Managing Gestational Disorders and Improving Pregnancy Outcomes. Journal of Reproductive Immunology. 2021, 143, 103244. DOI: 10.1016/j.jri.2020.103244.
   PubMed Web of Science ®Google Scholar
• Ashraf, R.; Shah, N. P. Immune System Stimulation by Probiotic Microorganisms. Critical Reviews in Food Science and Nutrition. 2014, 54(7), 938–956. DOI: 10.1080/10408398.2011.619671.
   Google Scholar
• Sabahi, S.; Mortazavi, S. A.; Nassiri, M.; Ghazvini, K.; Shahidi, F.; Abbasi, A.; et al. Production of Functional Ice Cream Fortified by Immunoglobulin Y Against Escherichia coli O157: H7 and Helicobacter Pylori. Biointerface Research in Applied Chemistry. 2022, 13(2), 188–198. doi:10.33263/BRIAC132.188.
   Web of Science ®Google Scholar
• Haza, A.; Zabala, A.; Arranz, N.; Morales, P. Protective Effect of a Lactobacillus Salivarius Strain of Human Origin. Food Sci. Technol. Int. 2005, 11(4), 251–259. DOI: 10.1177/1082013205056402.
   Web of Science ®Google Scholar
• Orlando, A.; Linsalata, M.; Notarnicola, M.; Tutino, V.; Russo, F. Lactobacillus GG Restoration of the Gliadin Induced Epithelial Barrier Disruption: The Role of Cellular Polyamines. BMC Microbiol. 2014, 14(1), 1–12. DOI: 10.1186/1471-2180-14-19.
   Google Scholar
• Oscarsson, E.; Håkansson, Å.; Andrén Aronsson, C.; Molin, G.; Agardh, D. Effects of Probiotic Bacteria Lactobacillaceae on the Gut Microbiota in Children with Celiac Disease Autoimmunity: A Placebo-Controlled and Randomized Clinical Trial. Front. Nutrit. 2021, 8, 354. DOI: 10.3389/fnut.2021.680771.
   Web of Science ®Google Scholar
• Di Cagno, R.; De Angelis, M.; Lavermicocca, P.; De Vincenzi, M.; Giovannini, C.; Faccia, M.; Gobbetti, M. Proteolysis by Sourdough Lactic Acid Bacteria: Effects on Wheat Flour Protein Fractions and Gliadin Peptides Involved in Human Cereal Intolerance. Appl. Environ. Microbiol. 2002, 68(2), 623–633. DOI: 10.1128/AEM.68.2.623-633.2002.
   PubMed Web of Science ®Google Scholar
• Di Cagno, R.; De Angelis, M.; Auricchio, S.; Greco, L.; Clarke, C.; De Vincenzi, M.; Giovannini, C.; D’Archivio, M.; Landolfo, F.; Parrilli, G., et al. Sourdough Bread Made from Wheat and Nontoxic Flours and Started with Selected Lactobacilli is Tolerated in Celiac Sprue Patients. Appl. Environ. Microbiol. 2004, 70(2), 1088–1096. DOI: 10.1128/AEM.70.2.1088-1096.2004.
   PubMed Web of Science ®Google Scholar
• Ciccocioppo, R.; Finamore, A.; Ara, C.; Di Sabatino, A.; Mengheri, E.; Corazza, G. R. Altered Expression, Localization, and Phosphorylation of Epithelial Junctional Proteins in Celiac Disease. Am. J. Clin. Pathol. 2006, 125(4), 502–511. DOI: 10.1309/DTYRA91G8R0KTM8M.
   PubMed Web of Science ®Google Scholar
• Olivares, M.; Laparra, M.; Sanz, Y. Oral Administration of Bifidobacterium longum CECT 7347 Modulates Jejunal Proteome in an in vivo Gliadin-Induced Enteropathy Animal Model. J Proteomics. 2012, 77, 310–320. DOI: 10.1016/j.jprot.2012.09.005.
   PubMed Web of Science ®Google Scholar
• Ozma, M. A.; Abbasi, A.; Ahangarzadeh Rezaee, M.; Hosseini, H.; Hosseinzadeh, N.; Sabahi, S.; Noori, S. M. A.; Sepordeh, S.; Khodadadi, E.; Lahouty, M., et al. A Critical Review on the Nutritional and Medicinal Profiles of Garlic’s (Allium Sativum L.) Bioactive Compounds. Food Rev. Int. 2022, 1–38. DOI: 10.1080/87559129.2022.2100417.
   Google Scholar
• Karimi, N.; Jabbari, V.; Nazemi, A.; Ganbarov, K.; Karimi, N.; Tanomand, A.; Karimi, S.; Abbasi, A.; Yousefi, B.; Khodadadi, E., et al. Thymol, Cardamom and Lactobacillus Plantarum Nanoparticles as a Functional Candy with High Protection Against Streptococcus Mutans and Tooth Decay. Microb. Pathogenesis. 2020, 148, 104481. DOI: 10.1016/j.micpath.2020.104481.
   PubMed Web of Science ®Google Scholar
• Abbasi, A.; Saadat, T. R.; Saadat, Y. R. Microbial exopolysaccharides–β-Glucans–as Promising Postbiotic Candidates in Vaccine Adjuvants. Int J Biol Macromol. 2022, 223, 346–361. DOI: 10.1016/j.ijbiomac.2022.11.003.
   PubMed Web of Science ®Google Scholar
• Sarteshnizi, R. A.; Hosseini, H.; Khosroshahi, N. K.; Shahraz, F.; Khaneghah, A. M.; Kamran, M.; Komeili, R.; Chiavaro, E. Effect of Resistant Starch and β-Glucan Combination on Oxidative Stability, Frying Performance, Microbial Count and Shelf Life of Prebiotic Sausage During Refrigerated Storage. Food Technol. Biotechnol. 2017, 55(4), 475. DOI: 10.17113/ftb.55.04.17.5479.
   PubMed Web of Science ®Google Scholar
• Sarteshnizi, R. A.; Hosseini, H.; Bondarianzadeh, D.; Colmenero, F. J.; Khaksar, R. Optimization of Prebiotic Sausage Formulation: Effect of Using β-Glucan and Resistant Starch by D-Optimal Mixture Design Approach. LWT Food Sci. Technol. 2015, 62(1), 704–710. DOI: 10.1016/j.lwt.2014.05.014.
   Web of Science ®Google Scholar
• Haghshenas, M.; Hosseini, H.; Nayebzadeh, K.; Khanghah, A. M.; Kakesh, B. S.; Fonood, R. K. Production of Prebiotic Functional Shrimp Nuggets Using ß-Glucan and Reduction of Oil Absorption by Carboxymethyl Cellulose: Impacts on Sensory and Physical Properties. J Aquacul Res Dev. 2014, 5(04), 245–248. DOI: 10.4172/2155-9546.1000245.
   Google Scholar
• Hurtado-Romero, A.; Del Toro-Barbosa, M.; Garcia-Amezquita, L. E.; García-Cayuela, T. Innovative Technologies for the Production of Food Ingredients with Prebiotic Potential: Modifications, Applications, and Validation Methods. Trends in Food Science & Technology. 2020, 104, 117–131. DOI: 10.1016/j.tifs.2020.08.007.
   Web of Science ®Google Scholar
• Marasco, G.; Cirota, G. G.; Rossini, B.; Lungaro, L.; Di Biase, A. R.; Colecchia, A.; Volta, U.; De Giorgio, R.; Festi, D.; Caio, G. Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients. Nutrients. 2020, 12(9), 2674. DOI: 10.3390/nu12092674.
   PubMed Web of Science ®Google Scholar
• Drabińska, N.; Jarocka-Cyrta, E.; Markiewicz, L. H.; Krupa-Kozak, U. The Effect of Oligofructose-Enriched Inulin on Faecal Bacterial Counts and Microbiota-Associated Characteristics in Celiac Disease Children Following a Gluten-Free Diet: Results of a Randomized, Placebo-Controlled Trial. Nutrients. 2018, 10(2), 201. DOI: 10.3390/nu10020201.
   PubMed Web of Science ®Google Scholar
• Drabińska, N.; Jarocka-Cyrta, E.; Ratcliffe, N. M.; Krupa-Kozak, U. The Profile of Urinary Headspace Volatile Organic Compounds After 12-Week Intake of Oligofructose-Enriched Inulin by Children and Adolescents with Celiac Disease on a Gluten-Free Diet: Results of a Pilot, Randomized, Placebo-Controlled Clinical Trial. Molecules. 2019, 24(7), 1341. DOI: 10.3390/molecules24071341.
   PubMed Web of Science ®Google Scholar
• Smecuol, E.; Hwang, H. J.; Sugai, E.; Corso, L.; Chernavsky, A. C.; Bellavite, F. P.; González, A.; Vodánovich, F.; Moreno, M. L.; Vázquez, H., et al. Exploratory, Randomized, Double-Blind, Placebo-Controlled Study on the Effects of Bifidobacterium Infantis Natren Life Start Strain Super Strain in Active Celiac Disease. J. Clin. Gastroenterol. 2013, 47(2), 139–147. DOI: 10.1097/MCG.0b013e31827759ac.
   PubMed Web of Science ®Google Scholar
• Olivares, M.; Castillejo, G.; Varea, V.; Sanz, Y. Double-Blind, Randomised, Placebo-Controlled Intervention Trial to Evaluate the Effects of Bifidobacterium longum CECT 7347 in Children with Newly Diagnosed Coeliac Disease. Br. J. Nutr. 2014, 112(1), 30–40. DOI: 10.1017/S0007114514000609.
   PubMed Web of Science ®Google Scholar
• Klemenak, M.; Dolinšek, J.; Langerholc, T.; Di Gioia, D.; Mičetić-Turk, D. Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease. Digestive Diseases and Sciences. 2015, 60(11), 3386–3392. DOI: 10.1007/s10620-015-3769-7.
   PubMed Web of Science ®Google Scholar
• Quagliariello, A.; Aloisio, I.; Bozzi Cionci, N.; Luiselli, D.; D’Auria, G.; Martinez-Priego, L.; Pérez-Villarroya, D.; Langerholc, T.; Primec, M.; Mičetić-Turk, D., et al. Effect of Bifidobacterium breve on the Intestinal Microbiota of Coeliac Children on a Gluten Free Diet: A Pilot Study. Nutrients. 2016, 8(10), 660. DOI: 10.3390/nu8100660.
   PubMed Web of Science ®Google Scholar
• Håkansson, Å.; Andrén Aronsson, C.; Brundin, C.; Oscarsson, E.; Molin, G.; Agardh, D. Effects of Lactobacillus Plantarum and Lactobacillus Paracasei on the Peripheral Immune Response in Children with Celiac Disease Autoimmunity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2019, 11(8), 1925. DOI: 10.3390/nu11081925.
   PubMed Web of Science ®Google Scholar
• Francavilla, R.; Piccolo, M.; Francavilla, A.; Polimeno, L.; Semeraro, F.; Cristofori, F.; Castellaneta, S.; Barone, M.; Indrio, F.; Gobbetti, M., et al. Clinical and Microbiological Effect of a Multispecies Probiotic Supplementation in Celiac Patients with Persistent IBS-Type Symptoms: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. J. Clin. Gastroenterol. 2019, 53(3), e117. DOI: 10.1097/MCG.0000000000001023.
   PubMed Web of Science ®Google Scholar
• Smecuol, E.; Constante, M.; Temprano, M.; Costa, A.; Moreno, M.; Pinto-Sanchez, M.; Vázquez, H.; Stefanolo, J.; Gonzalez, A.; D’Adamo, C., et al. Effect of Bifidobacterium Infantis NLS Super Strain in Symptomatic Coeliac Disease Patients on Long-Term Gluten-Free Diet–An Exploratory Study. Beneficial Microbes. 2020, 11(6), 527–534. DOI: 10.3920/BM2020.0016.
   PubMed Web of Science ®Google Scholar
• Ali, B.; Khan, A. R. Efficacy of Probiotics in Management of Celiac Disease. Cureus. 2022, 14. DOI: 10.7759/cureus.22031.
   Web of Science ®Google Scholar
• Demiroren, K. Can a Synbiotic Supplementation Contribute to Decreasing Anti-Tissue Transglutaminase Levels in Children with Potential Celiac Disease? Pediatric Gastroenterology, Hepatology & Nutrition. 2020, 23(4), 397. DOI: 10.5223/pghn.2020.23.4.397.
   PubMed Web of Science ®Google Scholar
• Feruś, K.; Drabińska, N.; Krupa-Kozak, U.; Jarocka-Cyrta, E. A Randomized, Placebo-Controlled, Pilot Clinical Trial to Evaluate the Effect of Supplementation with Prebiotic Synergy 1 on Iron Homeostasis in Children and Adolescents with Celiac Disease Treated with a Gluten-Free Diet. Nutrients. 2018, 10(11), 1818. DOI: 10.3390/nu10111818.
   PubMed Web of Science ®Google Scholar
• Roncoroni, L.; Bascuñán, K. A.; Doneda, L.; Scricciolo, A.; Lombardo, V.; Branchi, F.; Ferretti, F.; Dell’osso, B.; Montanari, V.; Bardella, M. T., et al. A Low FODMAP Gluten-Free Diet Improves Functional Gastrointestinal Disorders and Overall Mental Health of Celiac Disease Patients: A Randomized Controlled Trial. Nutrients. 2018, 10(8), 1023. DOI: 10.3390/nu10081023.
   PubMed Web of Science ®Google Scholar
• Homayouni Rad, A.; Aghebati Maleki, L.; Samadi Kafil, H.; Abbasi, A. Postbiotics: A Novel Strategy in Food Allergy Treatment. Crit. Rev. Food Sci. Nutr. 2021, 61(3), 492–499. DOI: 10.1080/10408398.2020.1738333.
   PubMed Web of Science ®Google Scholar
• Li, H.; Song, W.; Liu, T.; Xu, S.; Zhang, S.; Zhang, Y.; Liu, D.; Li, H.; Yu, J. Developing Novel Synbiotic Yoghurt with Lacticaseibacillus paracasei and Lactitol: Investigation of the Microbiology, Textural and Rheological Properties. Int. Dairy J. 2022, 135, 105475. DOI: 10.1016/j.idairyj.2022.105475.
   Web of Science ®Google Scholar
• Furrie, E.; Macfarlane, S.; Kennedy, A.; Cummings, J.; Walsh, S.; O’neil, D.; Macfarlane, G. Synbiotic Therapy (Bifidobacterium longum/Synergy 1) Initiates Resolution of Inflammation in Patients with Active Ulcerative Colitis: A Randomised Controlled Pilot Trial. Gut. 2005, 54(2), 242–249. DOI: 10.1136/gut.2004.044834.
   PubMed Web of Science ®Google Scholar
• Adebola, O. O.; Corcoran, O.; Morgan, W. A. Synbiotics: The Impact of Potential Prebiotics Inulin, Lactulose and Lactobionic Acid on the Survival and Growth of Lactobacilli Probiotics. J. Funct. Foods. 2014, 10, 75–84. DOI: 10.1016/j.jff.2014.05.010.
   Web of Science ®Google Scholar
• Abbasi, A.; Rad, A. H.; Maleki, L. A.; Kafil, H. S.; Baghbanzadeh, A. Antigenotoxicity and Cytotoxic Potentials of Cell-Free Supernatants Derived from Saccharomyces cerevisiae Var. Boulardii on HT-29 Human Colon Cancer Cell Lines. Probiotics Antimicrob. Proteins. 2023, 2023, 1–13. DOI: 10.1007/s12602-022-10039-1.
   Google Scholar
• Sabahi, S.; Homayouni Rad, A.; Aghebati-Maleki, L.; Sangtarash, N.; Ozma, M. A.; Karimi, A.; Hosseini, H.; Abbasi, A. Postbiotics as the New Frontier in Food and Pharmaceutical Research. Crit. Rev. Food Sci. Nutr. 2022, 2022, 1–28. DOI: 10.1080/10408398.2022.2056727.
   Google Scholar
• Conte, M.; Porpora, M.; Nigro, F.; Nigro, R.; Budelli, A. L.; Barone, M. V.; Nanayakkara, M. Pro-Pre and Postbiotic in Celiac Disease. Appl. Sci. 2021, 11(17), 8185. DOI: 10.3390/app11178185.
   Google Scholar
• Martorell, P.; Alvarez, B.; Llopis, S.; Navarro, V.; Ortiz, P.; Gonzalez, N.; Balaguer, F.; Rojas, A.; Chenoll, E.; Ramón, D., et al. Heat-Treated Bifidobacterium longum CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties. Antioxidants. 2021, 10(4), 536. DOI: 10.3390/antiox10040536.
   Web of Science ®Google Scholar
• Gao, J.; Li, Y.; Wan, Y.; Hu, T.; Liu, L.; Yang, S.; Gong, Z.; Zeng, Q.; Wei, Y.; Yang, W., et al. A Novel Postbiotic from Lactobacillus Rhamnosus GG with a Beneficial Effect on Intestinal Barrier Function. Front. Microbiol. 2019, 10, 477. DOI: 10.3389/fmicb.2019.00477.
   PubMed Web of Science ®Google Scholar
• Cao, Z.; Sugimura, N.; Burgermeister, E.; Ebert, M. P.; Zuo, T.; Lan, P. The Gut Virome: A New Microbiome Component in Health and Disease. EBioMedicine. 2022, 81, 104113. DOI: 10.1016/j.ebiom.2022.104113.
   PubMed Web of Science ®Google Scholar
• Mills, S.; Shanahan, F.; Stanton, C.; Hill, C.; Coffey, A.; Ross, R. P. Movers and Shakers: Influence of Bacteriophages in Shaping the Mammalian Gut Microbiota. Gut Microbes. 2013, 4(1), 4–16. DOI: 10.4161/gmic.22371.
   PubMed Web of Science ®Google Scholar
• Vitetta, L.; Vitetta, G.; Hall, S. Immunological Tolerance and Function: Associations Between Intestinal Bacteria, Probiotics, Prebiotics, and Phages. Front. Immunol. 2018, 9, 2240. DOI: 10.3389/fimmu.2018.02240.
   PubMed Web of Science ®Google Scholar
• El Mouzan, M.; Assiri, A.; Al Sarkhy, A.; Alasmi, M.; Saeed, A.; Al-Hussaini, A.; AlSaleem, B.; Al Mofarreh, M.; Lim, E.; Lim, E. Viral Dysbiosis in Children with New-Onset Celiac Disease. PLoS One. 2022, 17(1), e0262108. DOI: 10.1371/journal.pone.0262108.
   PubMed Web of Science ®Google Scholar
• Garmaeva, S.; Gulyaeva, A.; Sinha, T.; Shkoporov, A. N.; Clooney, A. G.; Stockdale, S. R.; Spreckels, J. E.; Sutton, T. D.; Draper, L. A.; Dutilh, B. E., et al. Stability of the Human Gut Virome and Effect of Gluten-Free Diet. Cell Rep. 2021, 35(7), 109132. DOI: 10.1016/j.celrep.2021.109132.
   PubMed Web of Science ®Google Scholar
• Febvre, H. P.; Rao, S.; Gindin, M.; Goodwin, N. D.; Finer, E.; Vivanco, J. S.; Lu, S.; Manter, D. K.; Wallace, T. C.; Weir, T. L. PHAGE Study: Effects of Supplemental Bacteriophage Intake on Inflammation and Gut Microbiota in Healthy Adults. Nutrients. 2019, 11(3), 666. DOI: 10.3390/nu11030666.
   PubMed Web of Science ®Google Scholar
• Lerner, A.; Ramesh, A.; Matthias, T. The Revival of the Battle Between David and Goliath in the Enteric Viruses and Microbiota Struggle: Potential Implication for Celiac Disease. Microorganisms. 2019, 7(6), 173. DOI: 10.3390/microorganisms7060173.
   PubMed Web of Science ®Google Scholar
• Wagh, S. K.; Lammers, K. M.; Padul, M. V.; Rodriguez-Herrera, A.; Dodero, V. I. Celiac Disease and Possible Dietary Interventions: From Enzymes and Probiotics to Postbiotics and Viruses. Int. J. Mol. Sci. 2022, 23(19), 11748. DOI: 10.3390/ijms231911748.
   PubMed Web of Science ®Google Scholar
• Héder, M. From NASA to EU: The Evolution of the TRL Scale in Public Sector Innovation. The Innovation Journal. 2017, 22, 1–23.
   Google Scholar
• Keijzer, C.; Zee, R. V. D.; Eden, W. V.; Broere, F. Treg Inducing Adjuvants for Therapeutic Vaccination Against Chronic Inflammatory Diseases. Front. Immunol. 2013, 4, 245. DOI: 10.3389/fimmu.2013.00245.
   PubMed Web of Science ®Google Scholar
• Ghaffari, S.; Abbasi, A.; Somi, M. H.; Moaddab, S. Y.; Nikniaz, L.; Kafil, H. S.; Ebrahimzadeh Leylabadlo, H. Akkermansia Muciniphila: From Its Critical Role in Human Health to Strategies for Promoting Its Abundance in Human Gut Microbiome. Crit. Rev. Food Sci. Nutr. 2022, 1–21. DOI: 10.1080/10408398.2022.2045894.
   Google Scholar
• Baunwall, S. M. D.; Lee, M. M.; Eriksen, M. K.; Mullish, B. H.; Marchesi, J. R.; Dahlerup, J. F.; Hvas, C. L. Faecal Microbiota Transplantation for Recurrent Clostridioides Difficile Infection: An Updated Systematic Review and Meta-Analysis. EClinicalMedicine. 2020, 29, 100642. DOI: 10.1016/j.eclinm.2020.100642.
   PubMedGoogle Scholar
• Littmann, E. R.; Lee, J. -J.; Denny, J. E.; Alam, Z.; Maslanka, J. R.; Zarin, I.; Matsuda, R.; Carter, R. A.; Susac, B.; Saffern, M. S., et al. Host Immunity Modulates the Efficacy of Microbiota Transplantation for Treatment of Clostridioides Difficile Infection. Nat Commun. 2021, 12(1), 1–15. DOI: 10.1038/s41467-020-20793-x.
   PubMed Web of Science ®Google Scholar
• Akobeng, A. K.; Singh, P.; Kumar, M.; Al Khodor, S. Role of the Gut Microbiota in the Pathogenesis of Coeliac Disease and Potential Therapeutic Implications. Eur. J. Nutr. 2020, 59(8), 3369–3390. DOI: 10.1007/s00394-020-02324-y.
   PubMed Web of Science ®Google Scholar
• Malamut, G.; Cellier, C. Refractory Celiac Disease. Gastroenterology Clinics of North America. 2019, 48(1), 137–144. DOI: 10.1016/j.gtc.2018.09.010.
   PubMed Web of Science ®Google Scholar
• van Beurden, Y. H.; van Gils, T.; van Gils, N. A.; Kassam, Z.; Mulder, C. J.; Aparicio-Pagés, N. Serendipity in Refractory Celiac Disease: Full Recovery of Duodenal Villi and Clinical Symptoms After Fecal Microbiota Transfer. Journal of Gastrointestinal & Liver Diseases. 2016, 25(3), 385–388. DOI: 10.15403/jgld.2014.1121.253.cel.
   PubMed Web of Science ®Google Scholar
• Choi, K.; Siegel, M.; Piper, J. L.; Yuan, L.; Cho, E.; Strnad, P.; Omary, B.; Rich, K. M.; Khosla, C. Chemistry and Biology of Dihydroisoxazole Derivatives: Selective Inhibitors of Human Transglutaminase 2. Chemistry & Biology. 2005, 12(4), 469–475. DOI: 10.1016/j.chembiol.2005.02.007.
   PubMed Web of Science ®Google Scholar
• Büchold, C.; Hils, M.; Gerlach, U.; Weber, J.; Pelzer, C.; Heil, A.; Aeschlimann, D.; Pasternack, R. Features of ZED1227: The First-In-Class Tissue Transglutaminase Inhibitor Undergoing Clinical Evaluation for the Treatment of Celiac Disease. Cells. 2022, 11(10), 1667. DOI: 10.3390/cells11101667.
   PubMed Web of Science ®Google Scholar
• Jabri, B. Transglutaminase 2 Inhibition for Prevention of Mucosal Damage in Celiac Disease. New Engl. J. Med. 2021, 385(1), 76. DOI: 10.1056/NEJMe2107502.
   PubMed Web of Science ®Google Scholar
• Verdu, E. F.; Schuppan, D. Co-Factors, Microbes, and Immunogenetics in Celiac Disease to Guide Novel Approaches for Diagnosis and Treatment. Gastroenterol. 2021, 161(5), 1395–1411. e1394. DOI: 10.1053/j.gastro.2021.08.016.
   PubMed Web of Science ®Google Scholar
• Paterson, B.; Lammers, K.; Arrieta, M.; Fasano, A.; Meddings, J. The Safety, Tolerance, Pharmacokinetic and Pharmacodynamic Effects of Single Doses of AT‐1001 in Coeliac Disease Subjects: A Proof of Concept Study. Alimentary Pharmacology & Therapeutics. 2007, 26(5), 757–766. DOI: 10.1111/j.1365-2036.2007.03413.x.
   PubMed Web of Science ®Google Scholar
• Leffler, D. A.; Kelly, C. P.; Abdallah, H.; Colatrella, A.; Harris, L.; Leon, F.; Arterburn, L.; Paterson, B.; Lan, Z.; Murray, J. A Randomized, Double-Blind Study of Larazotide Acetate to Prevent the Activation of Celiac Disease During Gluten Challenge. Official Journal of the American College of Gastroenterology| ACG. 2012, 107(10), 1554–1562. DOI: 10.1038/ajg.2012.211.
   PubMed Web of Science ®Google Scholar
• Leffler, D. A.; Kelly, C. P.; Green, P. H.; Fedorak, R. N.; DiMarino, A.; Perrow, W.; Rasmussen, H.; Wang, C.; Bercik, P.; Bachir, N. M., et al. Larazotide Acetate for Persistent Symptoms of Celiac Disease Despite a Gluten-Free Diet: A Randomized Controlled Trial. Gastroenterol. 2015, 148(7), 1311–1319. e1316. DOI: 10.1053/j.gastro.2015.02.008.
   PubMed Web of Science ®Google Scholar
• Kelly, C.; Green, P.; Murray, J.; Dimarino, A.; Colatrella, A.; Leffler, D.; Alexander, T.; Arsenescu, R.; Leon, F.; Jiang, J., et al. Larazotide Acetate in Patients with Coeliac Disease Undergoing a Gluten Challenge: A Randomised Placebo‐controlled Study. Alimentary Pharmacology & Therapeutics. 2013, 37(2), 252–262. DOI: 10.1111/apt.12147.
   PubMed Web of Science ®Google Scholar
• Bach, J. -F. The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases. New Engl. J. Med. 2002, 347(12), 911–920. DOI: 10.1056/NEJMra020100.
   PubMed Web of Science ®Google Scholar
• Daveson, A. J.; Jones, D. M.; Gaze, S.; McSorley, H.; Clouston, A.; Pascoe, A.; Cooke, S.; Speare, R.; Macdonald, G. A.; Anderson, R., et al. Effect of Hookworm Infection on Wheat Challenge in Celiac Disease–A Randomised Double-Blinded Placebo Controlled Trial. PLoS One. 2011, 6(3), e17366. DOI: 10.1371/journal.pone.0017366.
   PubMed Web of Science ®Google Scholar
• Croese, J.; Giacomin, P.; Navarro, S.; Clouston, A.; McCann, L.; Dougall, A.; Ferreira, I.; Susianto, A.; O’Rourke, P.; Howlett, M., et al. Experimental Hookworm Infection and Gluten Microchallenge Promote Tolerance in Celiac Disease. J. Allergy Clin. Immunol. 2015, 135(2), 508–516. e505. DOI: 10.1016/j.jaci.2014.07.022.
   PubMed Web of Science ®Google Scholar
• Theron, M.; Bentley, D.; Nagel, S.; Manchester, M.; Gerg, M.; Schindler, T.; Silva, A.; Ecabert, B.; Teixeira, P.; Perret, C., et al. Pharmacodynamic Monitoring of RO5459072, a Small Molecule Inhibitor of Cathepsin S. Front. Immunol. 2017, 8, 806. DOI: 10.3389/fimmu.2017.00806.
   PubMed Web of Science ®Google Scholar
• Goel, G.; King, T.; Daveson, A. J.; Andrews, J. M.; Krishnarajah, J.; Krause, R.; Brown, G. J.; Fogel, R.; Barish, C. F.; Epstein, R., et al. Epitope-Specific Immunotherapy Targeting CD4-Positive T Cells in Coeliac Disease: Two Randomised, Double-Blind, Placebo-Controlled Phase 1 Studies. The Lancet Gastroenterology & Hepatology. 2017, 2(7), 479–493. DOI: 10.1016/S2468-1253(17)30110-3.
   PubMed Web of Science ®Google Scholar
• Yokoyama, S.; Perera, P. -Y.; Waldmann, T. A.; Hiroi, T.; Perera, L. P. Tofacitinib, a Janus Kinase Inhibitor Demonstrates Efficacy in an IL-15 Transgenic Mouse Model That Recapitulates Pathologic Manifestations of Celiac Disease. Journal of Clinical Immunology. 2013, 33(3), 586–594. DOI: 10.1007/s10875-012-9849-y.
   PubMed Web of Science ®Google Scholar
• Mei, H. E.; Frölich, D.; Giesecke, C.; Loddenkemper, C.; Reiter, K.; Schmidt, S.; Feist, E.; Daridon, C.; Tony, H. -P.; Radbruch, A., et al. Steady-State Generation of Mucosal IgA+ Plasmablasts is Not Abrogated by B-Cell Depletion Therapy with Rituximab. Blood, the Journal of the American Society of Hematology. 2010, 116(24), 5181–5190. DOI: 10.1182/blood-2010-01-266536.
   Google Scholar
• Leffler, D. A.; Dennis, M.; Hyett, B.; Kelly, E.; Schuppan, D.; Kelly, C. P. Etiologies and Predictors of Diagnosis in Nonresponsive Celiac Disease. Clinical Gastroenterology and Hepatology. 2007, 5(4), 445–450. DOI: 10.1016/j.cgh.2006.12.006.
   PubMed Web of Science ®Google Scholar
• Hujoel, I. A.; Murray, J. A. Refractory Celiac Disease. Current Gastroenterol. Reports. 2020, 22(4), 1–8. DOI: 10.1007/s11894-020-0756-8.
   PubMedGoogle Scholar
• Roshan, B.; Leffler, D. A.; Jamma, S.; Dennis, M.; Sheth, S.; Falchuk, K.; Najarian, R.; Goldsmith, J.; Tariq, S.; Schuppan, D. The Incidence and Clinical Spectrum of Refractory Celiac Disease in a North American Referral Center. Official Journal of the American College of Gastroenterology| ACG. 2011, 106(5), 923–928. DOI: 10.1038/ajg.2011.104.
   PubMed Web of Science ®Google Scholar
• Green, P. H.; Paski, S.; Ko, C. W.; Rubio-Tapia, A. AGA Clinical Practice Update on Management of Refractory Celiac Disease: Expert Review. Gastroenterol. 2022, 163(5), 2022. DOI: 10.1053/j.gastro.2022.07.086.
   Web of Science ®Google Scholar
• Burkhardt, J.; Chapa‐rodriguez, A.; Bahna, S. Gluten Sensitivities and the Allergist: Threshing the Grain from the Husks. Allergy. 2018, 73(7), 1359–1368. DOI: 10.1111/all.13354.
   PubMed Web of Science ®Google Scholar
• Pillon, R.; Ziberna, F.; Badina, L.; Ventura, A.; Longo, G.; Quaglia, S.; De Leo, L.; Vatta, S.; Martelossi, S.; Patano, G., et al. Prevalence of Celiac Disease in Patients with Severe Food Allergy. Allergy. 2015, 70(10), 1346–1349. DOI: 10.1111/all.12692.
   PubMed Web of Science ®Google Scholar
• Hommeida, S.; Alsawas, M.; Murad, M. H.; Katzka, D. A.; Grothe, R. M.; Absah, I. The Association Between Celiac Disease and Eosinophilic Esophagitis: Mayo Experience and Meta-Analysis of the Literature. J. Pediatr. Gastroenterol. Nutr. 2017, 65(1), 58–63. DOI: 10.1097/MPG.0000000000001499.
   PubMed Web of Science ®Google Scholar
• Jensen, E. T.; Eluri, S.; Lebwohl, B.; Genta, R. M.; Dellon, E. S. Increased Risk of Esophageal Eosinophilia and Eosinophilic Esophagitis in Patients with Active Celiac Disease on Biopsy. Clinical Gastroenterology and Hepatology. 2015, 13(8), 1426–1431. DOI: 10.1016/j.cgh.2015.02.018.
   PubMed Web of Science ®Google Scholar
• Johnson, J.; Boynton, K.; Peterson, K. Co-Occurrence of Eosinophilic Esophagitis and Potential/Probable Celiac Disease in an Adult Cohort: A Possible Association with Implications for Clinical Practice. Diseases of the Esophagus. 2016, 29(8), 977–982. DOI: 10.1111/dote.12419.
   PubMed Web of Science ®Google Scholar
• Ari, A.; Morgenstern, S.; Chodick, G.; Matar, M.; Silbermintz, A.; Assa, A.; Mozer-Glassberg, Y.; Rinawi, F.; Nachmias-Friedler, V.; Shamir, R., et al. Oesophageal Eosinophilia in Children with Coeliac Disease. Arch. Dis. Childhood. 2017, 102(9), 825–829. DOI: 10.1136/archdischild-2016-311944.
   PubMed Web of Science ®Google Scholar
• Denham, J. M.; Hill, I. D. Celiac Disease and Autoimmunity: Review and Controversies. Current Allergy and Asthma Reports. 2013, 13(4), 347–353. DOI: 10.1007/s11882-013-0352-1.
   Google Scholar
• Ress, K.; Annus, T.; Putnik, U.; Luts, K.; Uibo, R.; Uibo, O. Celiac Disease in Children with Atopic Dermatitis. Pediatric Dermatology. 2014, 31(4), 483–488. DOI: 10.1111/pde.12372.
   PubMed Web of Science ®Google Scholar
• Enroth, S.; Dahlbom, I.; Hansson, T.; Johansson, Å.; Gyllensten, U. Prevalence and Sensitization of Atopic Allergy and Coeliac Disease in the Northern Sweden Population Health Study. International Journal of Circumpolar Health. 2013, 72(1), 21403. DOI: 10.3402/ijch.v72i0.21403.
   Google Scholar
• Ciacci, C.; Cavallaro, R.; Iovino, P.; Sabbatini, F.; Palumbo, A.; Amoruso, D.; Tortora, R.; Mazzacca, G. Allergy Prevalence in Adult Celiac Disease. J. Allergy Clin. Immunol. 2004, 113(6), 1199–1203. DOI: 10.1016/j.jaci.2004.03.012.
   PubMed Web of Science ®Google Scholar
• Assa, A.; Frenkel‐nir, Y.; Tzur, D.; Katz, L. H.; Shamir, R. Large Population Study Shows That Adolescents with Celiac Disease Have an Increased Risk of Multiple Autoimmune and Nonautoimmune Comorbidities. Acta Paediatrica. 2017, 106(6), 967–972. DOI: 10.1111/apa.13808.
   PubMed Web of Science ®Google Scholar
• Ludvigsson, J. F.; Hemminki, K.; Wahlström, J.; Almqvist, C. Celiac Disease Confers a 1.6-Fold Increased Risk of Asthma: A Nationwide Population-Based Cohort Study. J. Allergy Clin. Immunol. 2011, 127(4), 1071–1073. e1074. DOI: 10.1016/j.jaci.2010.12.1076.
   PubMedGoogle Scholar
• Smedby, K.; Åkerman, M.; Hildebrand, H.; Glimelius, B.; Ekbom, A.; Askling, J. Malignant Lymphomas in Coeliac Disease: Evidence of Increased Risks for Lymphoma Types Other Than Enteropathy-Type T Cell Lymphoma. Gut. 2005, 54(1), 54–59. DOI: 10.1136/gut.2003.032094.
   PubMed Web of Science ®Google Scholar
• Ilus, T.; Kaukinen, K.; Virta, L. J.; Pukkala, E.; Collin, P. Incidence of Malignancies in Diagnosed Celiac Patients: A Population-Based Estimate. Official Journal of the American College of Gastroenterology| ACG. 2014, 109(9), 1471–1477. DOI: 10.1038/ajg.2014.194.
   PubMed Web of Science ®Google Scholar
• Lebwohl, B.; Granath, F.; Ekbom, A.; Smedby, K. E.; Murray, J. A.; Neugut, A. I.; Green, P. H.; Ludvigsson, J. F. Mucosal Healing and Risk for Lymphoproliferative Malignancy in Celiac Disease: A Population-Based Cohort Study. Ann. Internal Med. 2013, 159(3), 169–175. DOI: 10.7326/0003-4819-159-3-201308060-00006.
   PubMed Web of Science ®Google Scholar
• Dhalwani, N. N.; West, J.; Sultan, A. A.; Ban, L.; Tata, L. J. Women with Celiac Disease Present with Fertility Problems No More Often Than Women in the General Population. Gastroenterol. 2014, 147(6), 1267–1274. e1261. DOI: 10.1053/j.gastro.2014.08.025.
   PubMed Web of Science ®Google Scholar
• Zugna, D.; Richiardi, L.; Akre, O.; Stephansson, O.; Ludvigsson, J. F. A Nationwide Population-Based Study to Determine Whether Coeliac Disease is Associated with Infertility. Gut. 2010, 59(11), 1471–1475. DOI: 10.1136/gut.2010.219030.
   PubMed Web of Science ®Google Scholar
• Tata, L.; Card, T.; Logan, R.; Hubbard, R.; Smith, C.; West, J. Fertility and Pregnancy-Related Events in Women with Celiac Disease: A Population-Based Cohort Study. Gastroenterol. 2005, 128(4), 849–855. DOI: 10.1053/j.gastro.2005.02.017.
   PubMed Web of Science ®Google Scholar
• Zanini, B.; Lanzarotto, F.; Mora, A.; Bertolazzi, S.; Turini, D.; Cesana, B.; Donato, F.; Ricci, C.; Lonati, F.; Vassallo, F., et al. Five Year Time Course of Celiac Disease Serology During Gluten Free Diet: Results of a Community Based “CD-Watch” Program. Digestive Liver Dis. 2010, 42(12), 865–870. DOI: 10.1016/j.dld.2010.05.009.
   Web of Science ®Google Scholar
• Rubio-Tapia, A.; Rahim, M. W.; See, J. A.; Lahr, B. D.; Wu, T. -T.; Murray, J. A. Mucosal Recovery and Mortality in Adults with Celiac Disease After Treatment with a Gluten-Free Diet. Official Journal of the American College of Gastroenterology| ACG. 2010, 105(6), 1412–1420. DOI: 10.1038/ajg.2010.10.
   PubMed Web of Science ®Google Scholar
• Wahab, P. J.; Meijer, J. W.; Mulder, C. J. Histologic Follow-Up of People with Celiac Disease on a Gluten-Free Diet: Slow and Incomplete Recovery. Am. J. Clin. Pathol. 2002, 118(3), 459–463. DOI: 10.1309/EVXT-851X-WHLC-RLX9.
   PubMed Web of Science ®Google Scholar
• Kalayci, A. G.; Kansu, A.; Girgin, N.; Kucuk, O.; Aras, G. Bone Mineral Density and Importance of a Gluten-Free Diet in Patients with Celiac Disease in Childhood. Pediatrics. 2001, 108(5), e89-e89. DOI: 10.1542/peds.108.5.e89.
   PubMed Web of Science ®Google Scholar
• Kemppainen, T.; Heikkinen, M.; Ristikankare, M.; Kosma, V.; Julkunen, R. Nutrient Intakes During Diets Including Unkilned and Large Amounts of Oats in Celiac Disease. Eur. J. Clin. Nutr. 2010, 64(1), 62–67. DOI: 10.1038/ejcn.2009.113.
   PubMed Web of Science ®Google Scholar