361
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Neurocognitive Dysfunction and Regional Cerebral Blood Flow in Medically Naïve Patients With Obsessive-Compulsive Disorder

, , , , &

REFERENCES

  • Abbruzzese , M. , Ferri , S. and Scarone , S. 1995 . Wisconsin Card Sorting Test performance in obsessive-compulsive disorder: No evidence for involvement of dorsolateral prefrontal cortex . Psychiatry Research , 58 ( 1 ) : 37 – 43 .
  • Abramovitch , A. , Dar , R. , Hermesh , H. and Schweiger , A. 2012 . Comparative neuropsychology of adult obsessive-compulsive disorder and attention deficit/hyperactivity disorder: Implications for a novel executive overload model of OCD . Journal of Neuropsychology , 6 ( 2 ) : 161 – 191 .
  • Andres , S. , Lazaro , L. , Salamero , M. , Boget , T. , Penades , R. and Castro-Fornieles , J. 2008 . Changes in cognitive dysfunction in children and adolescents with obsessive-compulsive disorder after treatment . Journal of Psychiatric Research , 42 ( 6 ) : 507 – 514 .
  • Ashburner , J. 2009 . Computational anatomy with the SPM software . Magnetic Resonance Imaging , 27 ( 8 ) : 1163 – 1174 .
  • Busatto , G. F. , Zamignani , D. R. , Buchpiguel , C. A. , Garrido , G. E. , Glabus , M. F. , Rocha , E. T. … and Miguel , E. C. 2000 . A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive-compulsive disorder using single photon emission computed tomography (SPECT) . Psychiatry Research , 99 ( 1 ) : 15 – 27 .
  • Cath , D. C. , Spinhoven , P. , Landman , A. D. and van Kempen , G. M. 2001 . Psychopathology and personality characteristics in relation to blood serotonin in Tourette's syndrome and obsessive-compulsive disorder . Journal of Psychopharmacology , 15 ( 2 ) : 111 – 119 .
  • Cavedini , P. , Zorzi , C. , Baraldi , C. , Patrini , S. , Salomoni , G. , Bellodi , L. … and Perna , G. 2012 . The somatic marker affecting decisional processes in obsessive-compulsive disorder . Cognitive Neuropsychiatry , 17 ( 2 ) : 177 – 190 .
  • Cavedini , P. , Zorzi , C. , Piccinni , M. , Cavallini , M. C. and Bellodi , L. 2010 . Executive dysfunctions in obsessive-compulsive patients and unaffected relatives: Searching for a new intermediate phenotype . Biological Psychiatry , 67 ( 12 ) : 1178 – 1184 .
  • Chamberlain , S. R. , Menzies , L. , Hampshire , A. , Suckling , J. , Fineberg , N. A. , del Campo , N. … and Sahakian , B. J. 2008 . Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives . Science , 321 ( 5887 ) : 421 – 422 .
  • Cocchi , L. , Harrison , B. J. , Pujol , J. , Harding , I. H. , Fornito , A. , Pantelis , C. and Yucel , M. 2012 . Functional alterations of large-scale brain networks related to cognitive control in obsessive-compulsive disorder . Human Brain Mapping , 33 ( 5 ) : 1089 – 1106 .
  • Cummings , J. L. 1995 . Anatomic and behavioral aspects of frontal-subcortical circuits . Annals of the New York Academy of Sciences , 769 : 1 – 13 .
  • de Geus , F. , Denys , D. A. , Sitskoorn , M. M. and Westenberg , H. G. 2007 . Attention and cognition in patients with obsessive-compulsive disorder . Psychiatry and Clinical Neurosciences , 61 ( 1 ) : 45 – 53 .
  • den Braber , A. , Ent , D. , Blokland , G. A. , van Grootheest , D. S. , Cath , D. C. , Veltman , D. J. … and Boomsma , D. I. 2008 . An fMRI study in monozygotic twins discordant for obsessive-compulsive symptoms . Biological Psychology , 79 ( 1 ) : 91 – 102 .
  • Devous , M. D. Sr. , Trivedi , M. H. and Rush , A. J. 2001 . Regional cerebral blood flow response to oral amphetamine challenge in healthy volunteers . Journal of Nuclear Medicine , 42 ( 4 ) : 535 – 542 .
  • Guehl , D. , Benazzouz , A. , Aouizerate , B. , Cuny , E. , Rotge , J. Y. , Rougier , A. … and Burbaud , P. 2008 . Neuronal correlates of obsessions in the caudate nucleus . Biological Psychiatry , 63 ( 6 ) : 557 – 562 .
  • Hansen , E. S. , Hasselbalch , S. , Law , I. and Bolwig , T. G. 2002 . The caudate nucleus in obsessive-compulsive disorder. Reduced metabolism following treatment with paroxetine: A PET study . The International Journal of Neuropsychopharmacology , 5 ( 1 ) : 1 – 10 .
  • Harrison , B. J. , Pujol , J. , Cardoner , N. , Deus , J. , Alonso , P. , Lopez-Sola , M. … and Soriano-Mas , C. 2013 . Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder . Biological Psychiatry , 73 ( 4 ) : 321 – 328 .
  • Horwath , E. and Weissman , M. M. 2000 . The epidemiology and cross-national presentation of obsessive-compulsive disorder . The Psychiatric Clinics of North America , 23 ( 3 ) : 493 – 507 .
  • Hou , J. , Wu , W. , Lin , Y. , Wang , J. , Zhou , D. , Guo , J. … and Li , H. 2012 . Localization of cerebral functional deficits in patients with obsessive-compulsive disorder: A resting-state fMRI study . Journal of Affective Disorders , 138 ( 3 ) : 313 – 321 .
  • Kim , M. S. , Park , S. J. , Shin , M. S. and Kwon , J. S. 2002 . Neuropsychological profile in patients with obsessive-compulsive disorder over a period of 4-month treatment . Journal of Psychiatric Research , 36 ( 4 ) : 257 – 265 .
  • Kuelz , A. K. , Hohagen , F. and Voderholzer , U. 2004 . Neuropsychological performance in obsessive-compulsive disorder: A critical review . Biological Psychology , 65 ( 3 ) : 185 – 236 .
  • Kwon , J. S. , Shin , Y. W. , Kim , C. W. , Kim , Y. I. , Youn , T. , Han , M. H. … and Kim , J. J. 2003 . Similarity and disparity of obsessive-compulsive disorder and schizophrenia in MR volumetric abnormalities of the hippocampus-amygdala complex . Journal of Neurology, Neurosurgery, and Psychiatry , 74 ( 7 ) : 962 – 964 .
  • Lacerda , A. L. , Dalgalarrondo , P. , Caetano , D. , Haas , G. L. , Camargo , E. E. and Keshavan , M. S. 2003 . Neuropsychological performance and regional cerebral blood flow in obsessive-compulsive disorder . Progress in Neuro-Psychopharmacology & Biological Psychiatry , 27 ( 4 ) : 657 – 665 .
  • Mancebo , M. C. , Greenberg , B. , Grant , J. E. , Pinto , A. , Eisen , J. L. , Dyck , I. and Rasmussen , S. A. 2008 . Correlates of occupational disability in a clinical sample of obsessive-compulsive disorder . Comprehensive Psychiatry , 49 ( 1 ) : 43 – 50 .
  • Martinot , J. L. , Allilaire , J. F. , Mazoyer , B. M. , Hantouche , E. , Huret , J. D. , Legaut-Demare , F. … and Syrota , A. 1990 . Obsessive-compulsive disorder: A clinical, neuropsychological and positron emission tomography study . Acta Psychiatrica Scandinavica , 82 ( 3 ) : 233 – 242 .
  • Melcher , T. , Falkai , P. and Gruber , O. 2008 . Functional brain abnormalities in psychiatric disorders: Neural mechanisms to detect and resolve cognitive conflict and interference . Brain Research Reviews , 59 ( 1 ) : 96 – 124 .
  • Mellet , E. , Tzourio , N. , Crivello , F. , Joliot , M. , Denis , M. and Mazoyer , B. 1996 . Functional anatomy of spatial mental imagery generated from verbal instructions . The Journal of Neuroscience , 16 ( 20 ) : 6504 – 6512 .
  • Menzies , L. , Achard , S. , Chamberlain , S. R. , Fineberg , N. , Chen , C. H. , del Campo , N. … and Bullmore , E. 2007 . Neurocognitive endophenotypes of obsessive-compulsive disorder . Brain, 130( , : 3223 – 3236 . Pt 12)
  • Menzies , L. , Chamberlain , S. R. , Laird , A. R. , Thelen , S. M. , Sahakian , B. J. and Bullmore , E. T. 2008 . Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited . Neuroscience and Biobehavioral Reviews , 32 ( 3 ) : 525 – 549 .
  • Middleton , F. A. and Strick , P. L. 2000 . Basal ganglia and cerebellar loops: Motor and cognitive circuits. Brain research . Brain Research Reviews , 31 ( 2–3 ) : 236 – 250 .
  • Milad , M. R. and Rauch , S. L. 2012 . Obsessive-compulsive disorder: Beyond segregated cortico-striatal pathways . Trends in Cognitive Sciences , 16 ( 1 ) : 43 – 51 .
  • Moers-Hornikx , V. M. , Sesia , T. , Basar , K. , Lim , L. W. , Hoogland , G. , Steinbusch , H. W. … and Vles , J. S. 2009 . Cerebellar nuclei are involved in impulsive behaviour . Behavioural Brain Research , 203 ( 2 ) : 256 – 263 .
  • Nabeyama , M. , Nakagawa , A. , Yoshiura , T. , Nakao , T. , Nakatani , E. , Togao , O. … and Kanba , S. 2008 . Functional MRI study of brain activation alterations in patients with obsessive-compulsive disorder after symptom improvement . Psychiatry Research , 163 ( 3 ) : 236 – 247 .
  • Okasha , A. , Rafaat , M. , Mahallawy , N. , El Nahas , G. , El Dawla , A. S. , Sayed , M. and El Kholi , S. 2000 . Cognitive dysfunction in obsessive-compulsive disorder . Acta Psychiatrica Scandinavica , 101 ( 4 ) : 281 – 285 .
  • Olley , A. , Malhi , G. and Sachdev , P. 2007 . Memory and executive functioning in obsessive-compulsive disorder: A selective review . Journal of Affective Disorders , 104 ( 1–3 ) : 15 – 23 .
  • Purcell , R. , Maruff , P. , Kyrios , M. and Pantelis , C. 1998 . Cognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal function . Biological Psychiatry , 43 ( 5 ) : 348 – 357 .
  • Rauch , S. L. , Wedig , M. M. , Wright , C. I. , Martis , B. , McMullin , K. G. , Shin , L. M. … and Wilhelm , S. 2007 . Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder . Biological Psychiatry , 61 ( 3 ) : 330 – 336 .
  • Reinsel , R. A. , Veselis , R. A. , Dnistrian , A. M. , Feshchenko , V. A. , Beattie , B. J. and Duff , M. R. 2000 . Midazolam decreases cerebral blood flow in the left prefrontal cortex in a dose-dependent fashion . The International Journal of Neuropsychopharmacology , 3 ( 2 ) : 117 – 127 .
  • Roh , K. S. , Shin , M. S. , Kim , M. S. , Ha , T. H. , Shin , Y. W. , Lee , K. J. and Kwon , J. S. 2005 . Persistent cognitive dysfunction in patients with obsessive-compulsive disorder: A naturalistic study . Psychiatry and Clinical Neurosciences , 59 ( 5 ) : 539 – 545 .
  • Sanematsu , H. , Nakao , T. , Yoshiura , T. , Nabeyama , M. , Togao , O. , Tomita , M. … and Kanba , S. 2009 . Predictors of treatment response to fluvoxamine in obsessive-compulsive disorder: An fMRI study . Journal of Psychiatric Research , 44 ( 4 ) : 193 – 200 .
  • Savage , C. R. , Deckersbach , T. , Wilhelm , S. , Rauch , S. L. , Baer , L. , Reid , T. and Jenike , M. A. 2000 . Strategic processing and episodic memory impairment in obsessive compulsive disorder . Neuropsychology , 14 ( 1 ) : 141 – 151 .
  • Saxena , S. , Bota , R. G. and Brody , A. L. 2001 . Brain-behavior relationships in obsessive-compulsive disorder . Seminars in Clinical Neuropsychiatry , 6 ( 2 ) : 82 – 101 .
  • Simpson , H. B. , Rosen , W. , Huppert , J. D. , Lin , S. H. , Foa , E. B. and Liebowitz , M. R. 2006 . Are there reliable neuropsychological deficits in obsessive-compulsive disorder? . Journal of Psychiatric Research , 40 ( 3 ) : 247 – 257 .
  • Stern , E. R. , Fitzgerald , K. D. , Welsh , R. C. , Abelson , J. L. and Taylor , S. F. 2012 . Resting-state functional connectivity between fronto-parietal and default mode networks in obsessive-compulsive disorder . PLOS ONE , 7 ( 5 ) : e36356 – 9 .
  • Ursu , S. and Carter , C. S. 2009 . An initial investigation of the orbitofrontal cortex hyperactivity in obsessive-compulsive disorder: Exaggerated representations of anticipated aversive events? . Neuropsychologia , 47 ( 10 ) : 2145 – 2148 .
  • Vakil , E. 2012 . Neuropsychological assessment: Principles, rationale, and challenges . Journal of Clinical and Experimental Neuropsychology , 34 ( 2 ) : 135 – 150 .
  • Viswanath , B. , Janardhan Reddy , Y. C. , Kumar , K. J. , Kandavel , T. and Chandrashekar , C. R. 2009 . Cognitive endophenotypes in OCD: A study of unaffected siblings of probands with familial OCD . Progress in Neuro-Psychopharmacology & Biological Psychiatry , 33 ( 4 ) : 610 – 615 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.