Repeated courses of antenatal corticosteroids: Is it justified?

References

• Kipikasa J, Bolognese RJ. Obstetric Management of Prematurity. In: Martin RJ (ed.): Neonatal-perinatal Medicine. St. Louis: Mosby, 1997; 264–84.
   Google Scholar
• Royal College of Obstetricians and Gynaecologists. Antenatal corticosteroids to prevent respiratory distress syndrome. RCOG Guideline No: 7. London: UK, 1996.
   Google Scholar
• National Institute of Health. Antenatal corticosteroids revisited: repeat courses. NIH Consensus Statement. 2000; 17: 1–18.
   Google Scholar
• American College of Obstetricians and Gynecologists. Committee opinion: antenatal corticosteroid therapy for fetal maturation. Obstet Gynecol 2002; 99: 871–3.
   Google Scholar
• Ballard PL, Ballard RA. Scientific basis and therapeutic regimens for use of antenatal glucocorticoids. Am J Obstet Gynecol 1995; 173: 254–62.
   Google Scholar
• Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 1972; 50: 515–25.
   Google Scholar
• Crowley P. Prophylactic corticosteroids for preterm birth (Cochrane review). Update Software 2000, Issue 2: Oxford: The Cochrane Library.
   Google Scholar
• National Institutes of Health. Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes. JAMA 1995; 273: 413–8.
   Google Scholar
• Spencer C, Neales K. Antenatal corticosteroids to prevent neonatal respiratory distress syndrome. We do not know whether repeated doses are better than a single dose. BMJ 2000; 320: 325–6.
   Google Scholar
• Smith GN, Kingdom JC, Penning DH, Matthews SG. Antenatal corticosteroids: is more better? Lancet 2000; 355: 251–2.
   Google Scholar
• Crowley PA. Antenatal corticosteroid therapy: a metaanalysis of the randomized trials 1972–94. Am J Obstet Gynecol 1995; 173: 322–35.
   Google Scholar
• Brocklehurst P, Gates S, McKenzie-McHarg K, Alfirevic Z, Chamberlain G. Are we prescribing multiple courses of antenatal corticosteroids? A survey of practice in the UK. Br J Obstet Gynaecol 1999; 106: 977–9.
   Google Scholar
• Quinlivan JA, Evans SF, Dunlop SA, Beazley LD, Newnham JP. Use of corticosteroids by Australian obstetricians – a survey of clinical practice. Aust N Z J Obstet Gynaecol 1998; 38: 1–7.
   Google Scholar
• Guinn DA, Atkinson MW, Sullivan L, Lee M, MacGregor S, Parilla BV et al. Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: a randomized controlled trial. Jama 2001; 286: 1581–7.
   Google Scholar
• Banks BA, Cnaan A, Morgan MA et al. Multiple courses of antenatal corticosteroids and outcome of premature neonates. North American ThyrotropinReleasing Hormone Study Group. Am J Obstet Gynecol 1999; 181: 709–17.
   Google Scholar
• French NP, Hagan R, Evans SF, Godfrey M, Newnham JP. Repeated antenatal corticosteroids: size at birth and subsequent development. Am J Obstet Gynecol 1999; 180: 114–21.
   Google Scholar
• Pratt L, Waschbusch L, Ladd W, Gangnon R, Hendricks SK. Multiple vs. single betamethasone therapy. Neonatal and maternal effects. J Reprod Med 1999; 44: 257–64.
   Google Scholar
• Abbasi S, Hirsch D, Davis J et al. Effect of single versus multiple courses of antenatal corticosteroids on maternal and neonatal outcome. Am J Obstet Gynecol 2000; 182:1243–9.
   Google Scholar
• Elimian A, Verma U, Visintainer P, Tejani N. Effectiveness of multidose antenatal steroids. Obstet Gynecol 2000; 95: 34–6.
   Google Scholar
• Smith LM, Qureshi N, Chao CR. Effects of single and multiple courses of antenatal glucocorticoids in preterm newborns less than 30 weeks’ gestation. J Matern Fetal Med 2000; 9: 131–5.
   Google Scholar
• Vermillion ST, Soper DE, Newman RB. Neonatal sepsis and death after multiple courses of antenatal betamethasone therapy. Am J Obstet Gynecol 2000; 183: 810–4.
   Google Scholar
• McEvoy C, Bowling S, Williamson K, Collins J, Tolaymat L, Maher J. Timing of antenatal corticosteroids and neonatal pulmonary mechanics. Am J Obstet Gynecol 2000; 183: 895–9.
   Google Scholar
• Jazayeri A, Gavrila D, Sincich T. Repeated antenatal corticosteroid treatments. Do they reduce neonatal morbidity? J Reprod Med 2001; 46: 788–90.
   Google Scholar
• Vermillion ST, Bland ML, Soper DE. Effectiveness of a rescue dose of antenatal betamethasone after an initial single course. Am J Obstet Gynecol 2001; 185: 1086–9.
   Google Scholar
• Banks BA, Macones G, Cnaan A, Merrill JD, Ballard PL, Ballard RA. Multiple courses of antenatal corticosteroids are associated with early severe lung disease in preterm neonates. J Perinatol 2002; 22: 101–7.
   Google Scholar
• Wijnberger LD, Mostert JM, van Dam KI, Mol BW, Brouwers H, Visser GH. Comparison of single and repeated antenatal corticosteroid therapy to prevent neonatal death and morbidity in the preterm infant. Early Hum Dev 2002; 67: 29–36.
   Google Scholar
• Stewart JD, Sienko AE, Gonzalez CL, Christensen HD, Rayburn WF. Placebo-controlled comparison between a single dose and a multidose of betamethasone in accelerating lung maturation of mice offspring. Am J Obstet Gynecol 1998; 179: 1241–7.
   Google Scholar
• Jenkins TM, Wapner RJ, Thom EA, Das AF, Spong CY. Are weekly courses of antenatal steroids beneficial or dangerous? JAMA 2002; 287: 187–8. [Discussion 189–90]
   Google Scholar
• Murphy KE, Hannah M, Brocklehurst P. Are weekly courses of antenatal steroids beneficial or dangerous? JAMA 2002; 287: 188. [Discussion 189–90]
   Google Scholar
• MacArthur BA, Howie RN, Dezoete JA, Elkins J. School progress and cognitive development of 6-year-old children whose mothers were treated antenatally with betamethasone. Pediatrics 1982; 70: 99–105.
   Google Scholar
• Collaborative Group on Antenatal Steroid Therapy. Effects of antenatal dexamethasone administration in the infant: long-term follow-up. J Pediatr 1984; 104: 259–67.
   Google Scholar
• Smolders-de Haas H, Neuvel J, Schmand B, Treffers PE, Koppe JG, Hoeks J. Physical development and medical history of children who were treated antenatally with corticosteroids to prevent respiratory distress syndrome: a 10-to 12-year follow-up. Pediatrics 1990; 86: 65–70.
   Google Scholar
• Dessens AB, Haas HS, Koppe JG. Twenty-year followup of antenatal corticosteroid treatment. Pediatrics 2000; 105: E77.
   Google Scholar
• Newnham JP, Moss TJ, Nitsos I, Sloboda DM. Antenatal corticosteroids: the good, the bad and the unknown. Curr Opin Obstet Gynecol 2002; 14: 607–12.
   Google Scholar
• McKenna DS, Wittber GM, Nagaraja HN, Samuels P. The effects of repeat doses of antenatal corticosteroids on maternal adrenal function. Am J Obstet Gynecol 2000; 183: 669–73.
   Google Scholar
• Helal KJ, Gordon MC, Lightner CR, Barth WH Jr. Adrenal suppression induced by betamethasone in women at risk for premature delivery. Obstet Gynecol 2000; 96: 287–90.
   Google Scholar
• Rotmensch S, Vishne TH, Celentano C, Dan M, Ben-Rafael Z. Maternal infectious morbidity following multiple courses of betamethasone. J Infect 1999; 39: 49–54.
   Google Scholar
• Thorp JA, Jones AM, Hunt C, Clark R. The effect of multidose antenatal betamethasone on maternal and infant outcomes. Am J Obstet Gynecol 2001; 184: 196–202.
   Google Scholar
• Ikegami M, Jobe AH, Newnham J, Polk DH, Willet KE, Sly P. Repetitive prenatal glucocorticoids improve lung function and decrease growth in preterm lambs. Am J Respir Crit Care Med 1997; 156: 178–84.
   Google Scholar
• Pratt L, Magness RR, Phernetton T, Hendricks SK, Abbott DH, Bird IM. Repeated use of betamethasone in rabbits: effects of treatment variation on adrenal suppression, pulmonary maturation, and pregnancy outcome. Am J Obstet Gynecol 1999; 180: 995–1005.
   Google Scholar
• Jobe AH, Wada N, Berry LM, Ikegami M, Ervin MG. Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep. Am J Obstet Gynecol 1998; 178: 880–5.
   Google Scholar
• Matthews SG. Antenatal glucocorticoids and programming of the developing CNS. Pediatr Res 2000; 47: 291–300.
   Google Scholar
• Uno H, Eisele S, Sakai A et al. Neurotoxicity of glucocorticoids in the primate brain. Horm Behav 1994; 28: 336–48.
   Google Scholar
• Levitt NS, Lindsay RS, Holmes MC, Seckl JR. Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology 1996; 64: 412–8.
   Google Scholar
• Dunlop SA, Archer MA, Quinlivan JA, Beazley LD, Newnham JP. Repeated prenatal corticosteroids delay myelination in the ovine central nervous system. J Matern Fetal Med 1997; 6: 309–13.
   Google Scholar
• Lam PM, Yuen PM, Lau TK, Leung TN. Relationship between birthweight and repeated courses of antenatal corticosteroids. Aust N Z J Obstet Gynaecol 2001; 41: 281–4.
   Google Scholar
• Shelton SD, Boggess KA, Murtha AP, Groff AO, Herbert WN. Repeated fetal betamethasone treatment and birth weight and head circumference. Obstet Gynecol 2001; 97: 301–4.
   Google Scholar
• Ng PC. The fetal and neonatal hypothalamicpituitary-adrenal axis. Arch Dis Child Fetal Neonatal Ed 2000; 82: F250–4.
   Google Scholar
• Clark PM. Programming of the hypothalamopituitary-adrenal axis and the fetal origins of adult disease hypothesis. Eur J Pediatr 1998; 157: S7–10.
   Google Scholar
• Ng PC, Blackburn ME, Brownlee KG, Buckler JM, Dear PR. Adrenal response in very low birthweight babies after dexamethasone treatment for bronchopulmonary dysplasia. Arch Dis Child 1989; 64: 1721–6.
   Google Scholar
• Ng PC, Wong GW, Lam CW et al. Pituitary-adrenal suppression and recovery in preterm very low birth weight infants after dexamethasone treatment for bronchopulmonary dysplasia. J Clin Endocrinol Metab 1997; 82: 2429–32.
   Google Scholar
• Ford LR, Willi SM, Hollis BW, Wright NM. Suppression and recovery of the neonatal hypothalamicpituitary-adrenal axis after prolonged dexamethasone therapy. J Pediatr 1997; 131: 722–6.
   Google Scholar
• Ballard PL, Gluckman PD, Liggins GC, Kaplan SL, Grumbach MM. Steroid and growth hormone levels in premature infants after prenatal betamethasone therapy to prevent respiratory distress syndrome. Pediatr Res 1980; 14: 122–7.
   Google Scholar
• Terrone DA, Smith LG Jr, Wolf EJ, Uzbay LA, Sun S, Miller RC. Neonatal effects and serum cortisol levels after multiple courses of maternal corticosteroids. Obstet Gynecol 1997; 90: 819–23.
   Google Scholar
• Ng PC, Lam CW, Lee CH et al. Reference ranges and factors affecting the human corticotropin-releasing hormone test in preterm, very low birth weight infants. J Clin Endocrinol Metab 2002; 87: 4621–8.
   Google Scholar
• French NP, Hagan R, Evan S, Godfrey M, Newnham JP. Repeated antenatal corticosteroids (CS): behaviour outcomes in a regional population of very preterm infants. Pediatr Res 1998; 43: 214A.
   Google Scholar
• Esplin E, Fausett MB, Smith S et al. Multiple courses of antenatal steroids are associated with a delay in long-term psychomotor development in children with birth weights ≤1500 grams. Am J Obstet Gynecol 2000; 182: S24.
   Google Scholar
• Wallace EM, Chapman J, Stenson B, Wright S. Antenatal corticosteroid prescribing. setting standards of care. Br J Obstet Gynaecol 1997; 104: 1262–6.
   Google Scholar