Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis

References

• Adamson DC, Wildemann B, et al (1996). Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 274: 1917–1921.
   PubMed Web of Science ®Google Scholar
• Brenneman DE, Westbrook GL, et al (1988). Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide. Nature 335: 639–642.
   PubMed Web of Science ®Google Scholar
• Cheng-Mayer C, Levy JA (1988). Distinct biological and serological properties of human immunodeficiency viruses from the brain. Ann Neurol 23: S58–S61.
   Web of Science ®Google Scholar
• Cherner M, Masliah E, et al (2002). Neurocognitive dys-function predicts postmortem findings of HIV encephalitis. Neurology 59: 1563–1567.
   PubMed Web of Science ®Google Scholar
• Cinque P, Vago L, et al (1998). Cerebrospinal fluid HIV-1 RNA levels: correlation with HIV encephalitis. Aids 12: 389–394.
   PubMed Web of Science ®Google Scholar
• Collman R, Balliet JW, et al (1992). An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain on human immunodeficiency virus type 1. J Virol 66: 7517–7521.
   PubMed Web of Science ®Google Scholar
• Everall IP, Heaton RK, et al (1999). Cortical synaptic density is reduced in mild to moderate human immunodeficiency virus neurocognitive disorder. HNRC Group. HIV Neurobehavioral Research Center. Brain Pathol 9: 209–217.
   PubMed Web of Science ®Google Scholar
• Fellay J, Marzolini C, et al (2002). Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Lancet 359: 30–36.
   PubMed Web of Science ®Google Scholar
• Gabuzda D, He J, et al (1998). Chemokine receptors in HIV-1 infection of the central nervous system. Semin Immunol 10: 203–213.
   Google Scholar
• Gartner S, Markovits P, et al (1986). The role of mononu-clear phagocytes in HTLV-III LAV infection. Science 233: 214–218.
   Google Scholar
• Gelbard HA, Nottet HS, et al (1994). Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. J Virol 68: 4628–4635.
   PubMed Web of Science ®Google Scholar
• Gendelman HE, Orenstein JM, et al (1988). Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med 167: 1428–1441.
   PubMed Web of Science ®Google Scholar
• Genis P, Jett M, et al (1992). Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J Exp Med 176: 1703–1718.
   PubMed Web of Science ®Google Scholar
• Ghorpade A, Nukuna A, et al (1998a). Human immunodeficiency virus neurotropism: an analysis of viral replication and cytopathicity for divergent strains in monocytes and microglia. J Virol 72: 3340–3350.
   Google Scholar
• Ghorpade A, Xia MQ, et al (1998b). Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia. J Virol 72: 3351–3361.
   Google Scholar
• Glass JD, Fedor H, et al (1995). Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 38: 755–762.
   PubMed Web of Science ®Google Scholar
• Gonzalez E, Rovin BH, et al (2002). HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. Proc Natl Acad Sci U S A 99: 13795–13800.
   PubMed Web of Science ®Google Scholar
• Gorry PR, Taylor J, et al (2002). Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate. J Virol 76: 6277–6292.
   PubMed Web of Science ®Google Scholar
• Heinzinger N, Baca-Regen L, et al (1995). Efficient synthesis of viral nucleic acids following monocyte infection by HIV-1. Virology 206: 731–735.
   Google Scholar
• Jellinger KA, Setinek U, et al (2000). Neuropathology and general autopsy findings in AIDS during the last 15 years. Acta Neuropathol (Berl) 100: 213–220.
   PubMed Web of Science ®Google Scholar
• Johnson RT (1995). The pathogenesis of HIV infections of the brain. Curr Top Microbiol Immunol 202: 3–10.
   Google Scholar
• Koenig S, Gendelman HE, et al (1986). Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233: 1089–1093.
   PubMed Web of Science ®Google Scholar
• Koyanagi Y, Miles S, et al (1987). Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science 236: 819–822.
   PubMed Web of Science ®Google Scholar
• Letendre S, Rought S, et al (2002). Polymorphisms in the MDR-1 gene are associated with differences in indinavir concentrations in CSF. In: Viral and host genetic factors regulating HIV/CNS disease. Washington, DC: p. 49.
   Google Scholar
• Maschke M, Kastrup O, et al (2000). Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART). J Neurol Neurosurg Psychiatry 69: 376–380.
   PubMed Web of Science ®Google Scholar
• McArthur JC, McClernon DR, et al (1997). Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain. Ann Neurol 42: 689–698.
   PubMed Web of Science ®Google Scholar
• Navia B, Jordan B, et al (1986). The AIDS dementia complex: I. Clinical features. Ann Neurol 19: 517–524.
   PubMed Web of Science ®Google Scholar
• Neuenburg JK, Brodt HR, et al (2002). HIV-related neuropathology, 1985 to 1999: rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy. J Acquir Immune Defic Syndr 31: 171–177.
   PubMed Web of Science ®Google Scholar
• New DR, Ma M, et al (1997). Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures. J NeuroVirol 3: 168–173.
   PubMed Web of Science ®Google Scholar
• Nottet HS, Jett M, et al (1995). A regulatory role for astrocytes in HIV-1 encephalitis. An overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-alpha by activated HIV-1-infected monocytes is attenuated by primary human astrocytes. J Immunol 154: 3567–3581.
   PubMed Web of Science ®Google Scholar
• Persidsky Y, Buttini M, et al (1997). An analysis of HIV-1-associated inflammatory products in brain tissue of humans and SCID mice with HIV-1 encephalitis. J NeuroVirol 3: 401–416.
   PubMed Web of Science ®Google Scholar
• Persidsky Y, Ghorpade A, et al (1999). Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis. Am J Pathol 155: 1599–1611.
   PubMed Web of Science ®Google Scholar
• Persidsky Y, Limoges J, et al (1996). Human immunodeficiency virus encephalitis in SCID mice [see comments]. Am J Pathol 149: 1027–1053.
   Google Scholar
• Poluektova L, Moran T, et al (2001). The regulation of alpha chemokines during HIV-1 infection and leukocyte activation: relevance for HIV-1-associated dementia. J Neuroimmunol 120: 112–128.
   Google Scholar
• Power C, Gill MJ, et al (2002). Progress in clinical neuro-sciences: The neuropathogenesis of HIV infection: host-virus interaction and the impact of therapy. Can J Neurol Sci 29: 19–32.
   PubMed Web of Science ®Google Scholar
• Price R, Brew B, et al (1988). The brain and AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 239: 586–592.
   PubMed Web of Science ®Google Scholar
• Sacktor N, Lyles RH, et al (2001). HIV-associated neurologic disease incidence changes: multicenter AIDS Cohort Study, 1990–1998. Neurology 56: 257–260.
   PubMed Web of Science ®Google Scholar
• Sacktor N, McDermott MP, et al (2002). HIV-associated cognitive impairment before and after the advent of combination therapy. J NeuroVirol 8: 136–142.
   PubMed Web of Science ®Google Scholar
• Tyor WR, Power C, et al (1993). A model of human immunodeficiency virus encephalitis in SCID mice. Proc Natl Acad Sci U S A 90: 8658–8662.
   Google Scholar
• Wiley CA, Schrier RD, et al (1986). Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci U S A 83: 7089–7093.
   PubMed Web of Science ®Google Scholar
• Yoshimura T, Takeya M, et al (1991). Production and characterization of muse monoclonal antibodies against human monocyte chemoattractant protein-1. J Immunology 147: 2229–2233.
   Google Scholar
• Zink WE, Anderson E, et al (2002). Impaired spatial cognition and synaptic potentiation in a murine model of human immunodeficiency virus type 1 encephalitis. J Neurosci 22: 2096–2105.
   Google Scholar