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Original Articles

Mapping the Active Site of the Bacterial Enzyme LpxC Using Novel Carbohydrate‐Based Hydroxamic Acid InhibitorsFootnote*

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Pages 583-609 | Received 24 Feb 2005, Accepted 05 May 2005, Published online: 16 Aug 2006

References

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  • The crystal structure of A. aeolicus LpxC and the solution structure A. aeolicus LpxC binding with 1 were recently solved, both of which showed that there is a hydrophobic passage/tunnel, capturing the long acyl chain of either substrate or inhibitor. See refs 9 and 10

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