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Journal of Toxicology: Clinical Toxicology Volume 39, 2001 - Issue 2
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Research Article

Cardiovascular Effects of Buccal Exposure to Dermal Nicotine Patches in the Dog: A Comparative Evaluation

Eugene H. Herman Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland, U.S.A.
,
Dr. Eugene Herman Division of Applied Pharmacology Research, Office of Testing and Research, Center for Drug Evaluation and Research, 8301 Muirkirk Road, Laurel, MD, 20708, U.S.A.
,
James A. Vick Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland, U.S.A.
,
John M. Strong Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland, U.S.A.
,
Robert J. Parker Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland, U.S.A.
,
Harry M. Geyer III Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland, U.S.A.
,
E. Douglas Kramer Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland, U.S.A.
,
Karen M. Higgins Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland, U.S.A.
&
Frank D. Sistare Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland, U.S.A.
 show all
Pages 135-142 | Published online: 30 Apr 2001

REFERENCES

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  • Jacob P., Benowitz N. L., Copeland J. R., Risner M. E., Cone E. J. Improved Gas Chromatographic Method for the Determination of Nicotine and Cotinine in Biologic Fluids. J. Chromatog 1981; 222: 61–70
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  • Joseph A. M., Norma S. M., Lerry L. H. The Safety of Transdermal Nicotine as an Aid to Smoking Cessation in Patients with Cardiac Disease. N. Engl. J. Med. 1996; 335: 1792–1798
  • Greenland S., Satterford M. H., Lanes S. F. Meta-Analysis to Assess the Incidence of Adverse Effects Associated with Transdermal Nicotine Patch. Drug Safety 1998; 18(4)297–308
  • Montello N., Brackett C. C., Sobol T. Use of Transdermal Nicotine Systems in a Possible Suicide Attempt. J.Am. Board Fam. Pract 1994; 7: 417–420
  • Sanchez P., Ducasse J. L., Lapeyre-Mestre M., Martinet O., Rouge P., Jorda M. F., Cathala B. Nicotine Poisoning as a Cause of Cardiac Arrest. J. Toxicol. Clin.Toxicol 1996; 34: 475–475
  • Kochak G. M., Sun J. X., Choi R. L., Piraino A. J. Pharmacokinetic Disposition of Multiple-Dose Transdermal Nicotine in Healthy Adult Smokers. Pharm. Res. 1992; 9: 1451–1455

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