Acetaminophen Hepatotoxicity: The First 35 Years

REFERENCES

• Rumack B.H., Matthew H. Acetaminophen Poisoning and Toxicity. Pediatrics 1975; 55: 871–876
   PubMed Web of Science ®Google Scholar
• Rumack B. Memoriam: Henry Matthew, MD 1914–1997. J. Toxicol. Clin. Toxicol. 1997; 35: v–vi
   Google Scholar
• Prescott L.F., Roscoe P., Wright N., Brown S.S. Plasma-Paracetamol Half-Life and Hepatic Necrosis in Patients with Paracetamol Overdosage. Lancet 1971; 1: 519–522
   PubMed Web of Science ®Google Scholar
• Rawlins M.D., Henderson D.B., Hijab A.R. Pharmacokinetics of Paracetamol (Acetaminophen) After Intravenous and Oral Administration. Eur. J. Clin. Pharmacol. 1977; 11: 283–286
   PubMed Web of Science ®Google Scholar
• Mitchell J.R., Jollow D.J., Potter W.Z., Gillette J.R., Brodie B.B. Acetaminophen-Induced Hepatic Necrosis. IV. Protective Role of Glutathione. J. Pharmacol. Exp. Ther. 1973; 187: 211–217
   PubMed Web of Science ®Google Scholar
• Piperno E., Berssenbruegge D.A. Reversal of Experimental Paracetamol Toxicosis with N-Acetylcysteine. Lancet 1976; 2: 738–739
   PubMed Web of Science ®Google Scholar
• Rumack B.H., Peterson R.C., Koch G.G., Amara I.A. Acetaminophen Overdose. 662 Cases with Evaluation of Oral Acetylcysteine Treatment. Arch. Int. Med. 1981; 141: 380–385
   PubMed Web of Science ®Google Scholar
• Gazzard B.G., Murray-Lyon I.M., Davis M., Thompson R.P.H., Williams R., Goulding R. Treatment of Paracetamol Poisoning. Lancet 1974; 1: 864–865, Letter
   Web of Science ®Google Scholar
• Prescott L.F., Matthew H. Cysteamine for Paracetamol Overdosage. Lancet 1974; 1: 998, Letter
   Google Scholar
• Koch-Weser J. Drug Therapy. Acetaminophen. N. Engl. J. Med. 1976; 295: 1297–1300
   PubMed Web of Science ®Google Scholar
• Prescott L.F., Park J., Proudfoot A.T. Cysteamine for Paracetamol Poisoning. Lancet 1976; 1: 357, Letter
   PubMed Web of Science ®Google Scholar
• Stewart M.J., Adriaenssens P.I., Jarvie D.R., Prescott L.F. Inappropriate Methods for the Emergency Determination of Plasma Paracetamol. Ann. Clin. Biochem. 1979; 16: 89–95
   PubMed Web of Science ®Google Scholar
• Blair D., Rumack B.H. Acetaminophen in Serum and Plasma Estimated by High-Pressure Liquid Chromatography: A Micro-Scale Method. Clin. Chem. 1977; 23: 743–745
   PubMed Web of Science ®Google Scholar
• Smilkstein M.J., Knapp G.L., Kulig K.W., Rumack B.H. Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose. Analysis of the National Multicenter Study (1976–1985). N. Engl. J. Med. 1988; 319: 1557–1562, see comments
   PubMed Web of Science ®Google Scholar
• Harrison P.M., Keays R., Bray G.P., Alexander G.J., Williams R. Improved Outcome of Paracetamol-Induced Fulminant Hepatic Failure by Late Administration of Acetylcysteine. Lancet 1990; 335: 1572–1573, see comments
   PubMed Web of Science ®Google Scholar
• Keays R., Harrison P.M., Wendon J.A., Forbes A., Gove C., Alexander G.J., Williams R. Intravenous Acetylcysteine in Paracetamol Induced Fulminant Hepatic Failure: A Prospective Controlled Trial. Br. Med. J. 1991; 303: 1026–1029
   PubMed Web of Science ®Google Scholar
• Mitchell J.R., Jollow D.J., Potter W.Z., Davis D.C., Gillette J.R., Brodie B.B. Acetaminophen-Induced Hepatic Necrosis. I. Role of Drug Metabolism. J. Pharmacol. Exp. Ther. 1973; 187: 185–194
   PubMed Web of Science ®Google Scholar
• Jollow D.J., Mitchell J.R., Potter W.Z., Davis D.C., Gillette J.R., Brodie B.B. Acetaminophen-Induced Hepatic Necrosis. II. Role of Covalent Binding In Vivo. J. Pharmacol. Exp. Ther. 1973; 187: 195–202
   PubMed Web of Science ®Google Scholar
• Potter W.Z., Davis D.C., Mitchell J.R., Jollow D.J., Gillette J.R., Brodie B.B. Acetaminophen-Induced Hepatic Necrosis. 3. Cytochrome P450-Mediated Covalent Binding In Vitro. J. Pharmacol. Exp. Ther. 1973; 187: 203–210
   PubMed Web of Science ®Google Scholar
• Potter W.Z., Thorgeirsson S.S., Jollow D.J., Mitchell J.R. Acetaminophen-Induced Hepatic Necrosis. V. Correlation of Hepatic Necrosis, Covalent Binding and Glutathione Depletion in Hamsters. Pharmacology 1974; 12: 129–143
   PubMed Web of Science ®Google Scholar
• Rumack B.H., Peterson R.G. Acetaminophen Overdose: Incidence, Diagnosis, and Management in 416 Patients. Pediatrics 1978; 62: 898–903
   PubMed Web of Science ®Google Scholar
• Woo O.F., Mueller P.D., Olson K.R., Anderson I.B., Kim S.Y. Shorter Duration of Oral N-Acetylcysteine Therapy for Acute Acetaminophen Overdose. Ann. Emerg. Med. 2000; 35: 363–368
   PubMed Web of Science ®Google Scholar
• Nelson S.D. Molecular Mechanisms of the Hepatotoxicity Caused by Acetaminophen. Semin. Liver Dis. 1990; 10: 267–278
   PubMed Web of Science ®Google Scholar
• Brent J.A., Rumack B.H. Role of Free Radicals in Toxic Hepatic Injury. I. Free Radical Biochemistry. J. Toxicol. Clin. Toxicol. 1993; 31: 139–171
   PubMed Web of Science ®Google Scholar
• Brent J.A., Rumack B.H. Role of Free Radicals in Toxic Hepatic Injury. J. Toxicol. Clin. Toxicol. 1993; 31: 173–196
   PubMed Web of Science ®Google Scholar
• Thomson J.S., Prescott L.F. Liver Damage and Impaired Glucose Tolerance After Paracetamol Overdosage. Br. Med. J. 1966; 5512: 506–507
   Google Scholar
• Davidson D.G., Eastham W.N. Acute Liver Necrosis Following Overdose of Paracetamol. Br. Med. J. 1966; 5512: 497–499
   Web of Science ®Google Scholar
• , Liver Necrosis from Paracetamol. Br. Med. J. 1966, 5512, 485–486.
   Google Scholar
• Thummel K.E., Lee C.A., Kunze K.L., Nelson S.D., Slattery J.T. Oxidation of Acetaminophen to N-Acetyl-p-Aminobenzoquinone Imine by Human CYP3A4. Biochem. Pharmacol. 1993; 45: 1563–1569
   PubMed Web of Science ®Google Scholar
• Prescott L.F. Paracetamol, Alcohol and the Liver. Br. J. Clin. Pharmacol. 2000; 49: 291–301
   PubMed Web of Science ®Google Scholar
• Manyike P.T., Kharasch E.D., Kalhorn T.F., Slattery J.T. Contribution of CYP2E1 and CYP3A to Acetaminophen Reactive Metabolite Formation. Clin. Pharmacol. Ther. 2000; 67: 275–282
   PubMed Web of Science ®Google Scholar
• Umeno M., McBride O.W., Yang C.S., Gelboin H.V., Gonzalez F.J. Human Ethanol-Inducible P450IIE1: Complete Gene Sequence, Promoter Characterization, Chromosome Mapping, and cDNA-Directed Expression. Biochemistry 1988; 27: 9006–9013
   PubMed Web of Science ®Google Scholar
• Umeno M., Song B.J., Kozak C., Gelboin H.V., Gonzalez F.J. The Rat P450IIE1 Gene: Complete Intron and Exon Sequence, Chromosome Mapping, and Correlation of Developmental Expression with Specific 5′ Cytosine Demethylation. J. Biol. Chem. 1988; 263: 4956–4962
   PubMed Web of Science ®Google Scholar
• Tsutsumi M., Takada A., Wang J.S. Genetic Polymorphisms of Cytochrome P4502E1 Related to the Development of Alcoholic Liver Disease. Gastroenterology 1994; 107: 1430–1435
   PubMed Web of Science ®Google Scholar
• Ueshima Y., Tsutsumi M., Takase S., Matsuda Y., Kawahara H. Acetaminophen Metabolism in Patients with Different Cytochrome P-4502E1 Genotypes. Alcohol Clin. Exp. Res. 1996; 20: 25A–28A
   PubMed Web of Science ®Google Scholar
• Laskin D.L. Sinusoidal Lining Cells and Hepatotoxicity. Toxicol. Pathol. 1996; 24: 112–118
   PubMed Web of Science ®Google Scholar
• Waksman J.C., Fantuzzi G., Bogdan G.M., Dart R.C., Dinarello C. Interleukin-18 (IL18) Is Involved in Acetaminophen (APAP) Induced Hepatic Injury in a FAS/FAS Ligand Independent Mechanism. J. Toxicol. Clin. Toxicol. 2001; 39: 495–496
   Google Scholar
• Waksman J.C., Fantuzzi G., Bogdan G.M., Dart R.C., Dinarello C. Decreased Serum Interleukin-6 (IL-6) Following Acute Acetaminophen (APAP) Overdose Is Associated with Hepatic Injury. J. Toxicol. Clin. Toxicol. 2001; 39: 486
   Google Scholar
• Ekstrom G., von Bahr C., Ingelman-Sundberg M. Human Liver Microsomal Cytochrome P-450IIE1. Immunological Evaluation of Its Contribution to Microsomal Ethanol Oxidation, Carbon Tetrachloride Reduction and NADPH Oxidase Activity. Biochem. Pharmacol. 1989; 38: 689–693
   PubMed Web of Science ®Google Scholar
• Ronis M.J., Huang J., Crouch J., Mercado C., Irby D., Valentine C.R., Lumpkin C.K., Ingelman-Sundberg M., Badger T.M. Cytochrome P450 CYP 2E1 Induction During Chronic Alcohol Exposure Occurs by a Two-Step Mechanism Associated with Blood Alcohol Concentrations in Rats. J. Pharmacol. Exp. Ther. 1993; 264: 944–950
   PubMed Web of Science ®Google Scholar
• Lucas D., Berthou F., Dreano Y., Lozac'h P., Volant A., Menez J.F. Comparison of Levels of Cytochromes P-450, CYP1A2, CYP2E1, and Their Related Monooxygenase Activities in Human Surgical Liver Samples. Alcohol Clin. Exp. Res. 1993; 17: 900–905
   PubMed Web of Science ®Google Scholar
• Girre C., Lucas D., Hispard E., Menez C., Dally S., Menez J.F. Assessment of Cytochrome P4502E1 Induction in Alcoholic Patients by Chlorzoxazone Pharmacokinetics. Biochem. Pharmacol. 1994; 47: 1503–1508
   PubMed Web of Science ®Google Scholar
• Dupont I., Lucas D., Clot P., Menez C., Albano E. Cytochrome P4502E1 Inducibility and Hydroxyethyl Radical Formation Among Alcoholics. J. Hepatol. 1998; 28: 564–571
   PubMed Web of Science ®Google Scholar
• Tsutsumi M., Lasker J.M., Shimizu M., Rosman A.S., Lieber C.S. The Intralobular Distribution of Ethanol-Inducible P450IIE1 in Rat and Human Liver. Hepatology 1989; 10: 437–446
   PubMed Web of Science ®Google Scholar
• Terelius Y., Lindros K.O., Albana E., Inglelman-Sundberg M. Isoenzyme-Specificity of Cytochrome P450-Mediated Hepatotoxicity. Frontiers in Biotransformation, K. Ruckpaul, H. Rein. Akademie-Verlag, Berlin 1992; 182–197, Chap. 8
   Google Scholar
• Burk R.F., Patel K., Lane J.M. Reduced Glutathione Protection Against Rat Liver Microsomal Injury by Carbon Tetrachloride Dependence on O2. Biochem. J. 1983; 215: 441–445
   PubMed Web of Science ®Google Scholar
• Burk R.F., Lane J.M., Patel K. Relationship of Oxygen and Glutathione in Protection Against Carbon Tetrachloride-Induced Hepatic Microsomal Lipid Peroxidation and Covalent Binding in the Rat. Rationale for the Use of Hyperbaric Oxygen to Treat Carbon Tetrachloride Ingestion. J. Clin. Investig. 1984; 74: 1996–2001
   PubMed Web of Science ®Google Scholar
• Garner R.C., McLean A.E. Increased Susceptibility to Carbon Tetrachloride Poisoning in the Rat After Pretreatment with Oral Phenobarbitone. Biochem. Pharmacol. 1969; 18: 645–650
   PubMed Web of Science ®Google Scholar
• Song B.J., Veech R.L., Park S.S., Gelboin H.V., Gonzalez F.J. Induction of Rat Hepatic N-Nitrosodimethylamine Demethylase by Acetone Is Due to Protein Stabilization. J. Biol. Chem. 1989; 264: 3568–3572
   PubMed Web of Science ®Google Scholar
• Eliasson E., Johansson I., Ingelman-Sundberg M. Ligand-Dependent Maintenance of Ethanol-Inducible Cytochrome P-450 in Primary Rat Hepatocyte Cell Cultures. Biochem. Biophys. Res. Commun. 1988; 150: 436–443
   PubMed Web of Science ®Google Scholar
• Winters D.K., Cederbaum A.I. Time Course Characterization of the Induction of Cytochrome P450 2E1 by Pyrazole and 4-Methylpyrazole. Biochim. Biophys. Acta 1992; 1117: 15–24
   PubMed Web of Science ®Google Scholar
• Wu D., Cederbaum A.I. Combined Effects of Streptozotocin-Induced Diabetes Plus 4-Methylpyrazole Treatment on Rat Liver Cytochrome P4502E1. Arch. Biochem. Biophys. 1993; 302: 175–182
   PubMed Web of Science ®Google Scholar
• Johansson I., Eliasson E., Ingelman-Sundberg M. Hormone Controlled Phosphorylation and Degradation of CYP2B1 and CYP2E1 in Isolated Rat Hepatocytes. Biochem. Biophys. Res. Commun. 1991; 174: 37–42
   PubMed Web of Science ®Google Scholar
• Miller M.S., Warner S.P., Jorquera R., Castonguay A., Schuller H.M. Expression of the Cytochrome P4502E and 2B Gene Families in the Lungs and Livers of Nonpregnant, Pregnant, and Fetal Hamsters. Biochem. Pharmacol. 1992; 44: 797–803
   PubMed Web of Science ®Google Scholar
• Chien J.Y., Thummel K.E., Slattery J.T. Pharmacokinetic Consequences of Induction of CYP2E1 by Ligand Stabilization. Drug Metab. Dispos. 1997; 25: 1165–1175
   PubMed Web of Science ®Google Scholar
• Kharasch E.D., Thummel K.E., Mhyre J., Lillibridge J.H. Single-Dose Disulfiram Inhibition of Chlorzoxazone Metabolism: A Clinical Probe for P450 2E1. Clin. Pharmacol. Ther. 1993; 53: 643–650
   PubMed Web of Science ®Google Scholar
• Eliasson E., Johansson I., Ingelman-Sundberg M. Substrate-, Hormone- and cAMP Regulated Cytochrome P450 Degradation. Proc. Natl Acad. Sci. USA 1990; 87: 3225
   PubMed Web of Science ®Google Scholar
• Lieber C.S., DeCarli L.M. Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase After Ethanol Feeding. Science 1968; 162: 917–918
   PubMed Web of Science ®Google Scholar
• Rubin E., Hutterer F., Lieber C.S. Ethanol Increases Hepatic Smooth Endoplasmic Reticulum and Drug-Metabolizing Enzymes. Science 1968; 159: 1469–1470
   PubMed Web of Science ®Google Scholar
• Takahashi H., Johansson I., French S.W., Ingelman-Sundberg M. Effects of Dietary Fat Composition on Activities of the Microsomal Ethanol Oxidizing System and Ethanol-Inducible Cytochrome P450 (CYP2E1) in the Liver of Rats Chronically Fed Ethanol. Pharmacol. Toxicol. 1992; 70: 347–351
   PubMedGoogle Scholar
• Cheng P.Y., Morgan E.T. Hepatic Cytochrome P450 Regulation in Disease States. Curr. Drug Metab. 2001; 2: 165–183
   PubMed Web of Science ®Google Scholar
• Raucy J.L., Lasker J.M., Lieber C.S., Black M. Acetaminophen Activation by Human Liver Cytochromes P450IIE1 and P450IA2. Arch. Biochem. Biophys. 1989; 271: 270–283
   PubMed Web of Science ®Google Scholar
• Brady J.F., Xiao F., Wang M.H., Li Y., Ning S.M., Gapac J.M., Yang C.S. Effects of Disulfiram on Hepatic P450IIE1, Other Microsomal Enzymes, and Hepatotoxicity in Rats. Toxicol. Appl. Pharmacol. 1991; 108: 366–373
   PubMed Web of Science ®Google Scholar
• Kharasch E.D., Hankins D.C., Baxter P.J., Thummel K.E. Single-Dose Disulfiram Does Not Inhibit CYP2A6 Activity. Clin. Pharmacol. Ther. 1998; 64: 39–45
   PubMed Web of Science ®Google Scholar
• Sarich T., Kalhorn T., Magee S., al Sayegh F., Adams S., Slattery J., Goldstein J., Nelson S., Wright J. The Effect of Omeprazole Pretreatment on Acetaminophen Metabolism in Rapid and Slow Metabolizers of S-Mephenytoin. Clin. Pharmacol. Ther. 1997; 62: 21–28
   PubMed Web of Science ®Google Scholar
• Lee S.S., Buters J.T., Pineau T., Fernandez-Salguero P., Gonzalez F.J. Role of CYP2E1 in the Hepatotoxicity of Acetaminophen. J. Biol. Chem. 1996; 271: 12063–12067
   PubMed Web of Science ®Google Scholar
• Zaher H., Buters J.T., Ward J.M., Bruno M.K., Lucas A.M., Stern S.T., Cohen S.D., Gonzalez F.J. Protection Against Acetaminophen Toxicity in CYP1A2 and CYP2E1 Double-Null Mice. Toxicol. Appl. Pharmacol. 1998; 152: 193–199
   PubMed Web of Science ®Google Scholar
• Wright N., Prescott L.F. Potentiation by Previous Drug Therapy of Hepatotoxicity Following Paracetamol Overdosage. Scott. Med. J. 1973; 18: 56–58
   PubMed Web of Science ®Google Scholar
• Perucca E., Richens A. Paracetamol Disposition in Normal Subjects and in Patients Treated with Antiepileptic Drugs. Br. J. Clin. Pharmacol. 1979; 7: 201–206
   PubMed Web of Science ®Google Scholar
• Prescott L.F., Critchley J.A., Balali-Mood M., Pentland B. Effects of Microsomal Enzyme Induction on Paracetamol Metabolism in Man. Br. J. Clin. Pharmacol. 1981; 12: 149–153
   PubMed Web of Science ®Google Scholar
• Miners J.O., Attwood J., Birkett D.J. Determinants of Acetaminophen Metabolism: Effect of Inducers and Inhibitors of Drug Metabolism on Acetaminophen's Metabolic Pathways. Clin. Pharmacol. Ther. 1984; 35: 480–486
   PubMed Web of Science ®Google Scholar
• Minton N.A., Henry J.A., Frankel R.J. Fatal Paracetamol Poisoning in an Epileptic. Hum. Toxicol. 1988; 7: 33–34
   PubMedGoogle Scholar
• Bray G.P., Harrison P.M., O'Grady J.G., Tredger J.M., Williams R. Long-Term Anticonvulsant Therapy Worsens Outcome in Paracetamol-Induced Fulminant Hepatic Failure. Hum. Exp. Toxicol. 1992; 11: 265–270, see comments
   PubMed Web of Science ®Google Scholar
• Makin A.J., Wendon J., Williams R. A 7-Year Experience of Severe Acetaminophen-Induced Hepatotoxicity (1987–1993). Gastroenterology 1995; 109: 1907–1916
   PubMed Web of Science ®Google Scholar
• Tomlinson B., Young R.P., Ng M.C., Anderson P.J., Kay R., Critchley J.A. Selective Liver Enzyme Induction by Carbamazepine and Phenytoin in Chinese Epileptics. Eur. J. Clin. Pharmacol. 1996; 50: 411–415
   PubMed Web of Science ®Google Scholar
• Clot P., Albano E., Eliasson E., Tabone M., Arico S., Israel Y., Moncada C., Ingelman-Sundberg M. Cytochrome P4502E1 Hydroxyethyl Radical Adducts as the Major Antigen in Autoantibody Formation Among Alcoholics. Gastroenterology 1996; 111: 206–216
   PubMed Web of Science ®Google Scholar
• Badger T.M., Ronis M.J., Ingelman-Sundberg M., Hakkak R. Pulsatile Blood Alcohol and CYP2E1 Induction During Chronic Alcohol Infusions in Rats. Alcohol 1993; 10: 453–457
   PubMed Web of Science ®Google Scholar
• Badger T.M., Huang J., Ronis M., Lumpkin C.K. Induction of Cytochrome P450 2E1 During Chronic Ethanol Exposure Occurs Via Transcription of the CYP 2E1 Gene When Blood Alcohol Concentrations Are High. Biochem. Biophys. Res. Commun. 1993; 190: 780–785
   PubMed Web of Science ®Google Scholar
• Takahashi T., Lasker J.M., Rosman A.S., Lieber C.S. Induction of Cytochrome P4502E1 in the Human Liver by Ethanol Is Caused by a Corresponding Increase in Encoding Messenger RNA. Hepatology 1993; 17: 236–245
   PubMed Web of Science ®Google Scholar
• , Slattery, J. T. Ethanol Effect on Glutathione Transporter as a Mechanism for Acetaminophen Hepatotoxicity in the Alcoholic. Personal communication, 2001.
   Google Scholar
• Dart R.C., Kuffner E.K., Rumack B.H. Treatment of Pain or Fever with Paracetamol (Acetaminophen) in the Alcoholic Patient: A Systematic Review. Am. J. Ther. 2000; 7: 123–134
   PubMedGoogle Scholar
• Seeff L.B., Cuccherini B.A., Zimmerman H.J., Adler E., Benjamin S.B. Acetaminophen Hepatotoxicity in Alcoholics. A Therapeutic Misadventure. Ann. Int. Med. 1986; 104: 399–404
   PubMed Web of Science ®Google Scholar
• Himmelstein D.U., Woolhandler S.J., Adler R.D. Elevated SGOT/SGPT Ratio in Alcoholic Patients with Acetaminophen Hepatotoxicity. Am. J. Gastroenterol. 1984; 79: 718–720
   PubMed Web of Science ®Google Scholar
• Zimmerman H.J., Maddrey W.C. Acetaminophen (Paracetamol) Hepatotoxicity with Regular Intake of Alcohol: Analysis of Instances of Therapeutic Misadventure. Hepatology 1995; 22((6))1898, [Published Erratum Appears in
   Web of Science ®Google Scholar
• Schiodt F.V., Rochling F.A., Casey D.L., Lee W.M. Acetaminophen Toxicity in an Urban County Hospital. N. Engl. J. Med. 1997; 337: 1112–1117, see comments
   PubMed Web of Science ®Google Scholar
• Walker A.M. Acetaminophen Toxicity in an Urban County Hospital. N. Engl. J. Med. 1998; 338: 543–545, letter; comment
   PubMedGoogle Scholar
• Smilkstein M.J., Rumack B.H. Chronic Ethanol Use and Acute Acetaminophen Overdose Toxicity. J. Toxicol. Clin. Toxicol. 1998; 36: 476
   Google Scholar
• Whitcomb D.C., Block G.D. Association of Acetaminophen Hepatotoxicity with Fasting and Ethanol Use. J. Am. Med. Assoc. 1994; 272: 1845–1850, see comments
   PubMed Web of Science ®Google Scholar
• Schenker S., Speeg K.V., Jr., Perez A., Finch J. The Effects of Food Restriction in Man on Hepatic Metabolism of Acetaminophen. Clin. Nutr. 2001; 20: 145–150
   PubMed Web of Science ®Google Scholar
• Chien J.Y., Thummel K.E., Slattery J.T., Ro H., Nelson S.D., Lown K.E., Watkins P.B. Ethanol Increases Risk of Acetaminophen Hepatotoxicity in Healthy Adults. Hepatology 1998; 28: 380A
   Google Scholar
• Thummel K.E., Slattery J.T., Ro H., Chien J.Y., Nelson S.D., Lown K.E., Watkins P.B. Ethanol and Production of the Hepatotoxic Metabolite of Acetaminophen in Healthy Adults. Clin. Pharmacol. Ther. 2000; 67: 591–599
   PubMed Web of Science ®Google Scholar
• Kuffner E.K., Dart R.C., Bogdan G.M., Mlakar P., Casper E., Darton L. Evaluation of Hepatotoxicity in Alcoholic Patients from Therapeutic Dosing of Acetaminophen. J. Toxicol. Clin. Toxicol. 1999; 37: 641
   Google Scholar
• Kuffner E.K., Dart R.C., Bogdan G.M., Hill R.E., Casper E., Darton L. Effect of Maximal Daily Doses of Acetaminophen on the Liver of Alcoholic Patients. Arch. Int. Med. 2001; 161: 2247–2252
   PubMed Web of Science ®Google Scholar
• Slattery J.T., Nelson S.D., Thummel K.E. The Complex Interaction Between Ethanol and Acetaminophen. Clin. Pharmacol. Ther. 1996; 60: 241–246
   PubMed Web of Science ®Google Scholar
• Rumack B.H., Holtzman J., Chase H.P. Hepatic Drug Metabolism and Protein Malnutrition. J. Pharmacol. Exp. Ther. 1973; 186: 441–446
   PubMed Web of Science ®Google Scholar
• Schoene B., Fleischmann R.A., Remmer H., von Oldershausen H.F. Determination of Drug Metabolizing Enzymes in Needle Biopsies of Human Liver. Eur. J. Clin. Pharmacol. 1972; 4: 65–73
   PubMed Web of Science ®Google Scholar
• Gabrielle L., Leterrier F., Molinie C., Essioux H., Cristau P., Laverdant C. Determination of Human Liver Cytochrome P450 by a Micromethod Using the Electron Paramagnetic Resonance. Study of 141 Liver Biopsies. Gastroenterol. Clin. Biol. 1977; 1: 775–782
   PubMed Web of Science ®Google Scholar
• Poulsen H.E., Ranek L., Andreasen P.B. The Hepatic Glutathione Content in Liver Diseases. Scand. J. Clin. Lab. Investig. 1981; 41: 573–576
   PubMed Web of Science ®Google Scholar
• Siegers C.P., Bossen K.H., Younes M., Mahlke R., Oltmanns D. Glutathione and Glutathione-S-Transferases in the Normal and Diseased Human Liver. Pharmacol. Res. Commun. 1982; 14: 61–72
   PubMedGoogle Scholar
• Newman T.J., Bargman G.J. Acetaminophen Hepatotoxicity and Malnutrition. Am. J. Gastroenterol. 1979; 72: 647–650
   PubMed Web of Science ®Google Scholar
• Rumack B.H. Acetaminophen Overdose. Am. J. Med. 1983; 75: 104–112
   PubMed Web of Science ®Google Scholar