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Original

Phase II Trial Of Pegylated-liposomal Doxorubicin (Doxil™) In Sarcoma*

ORIGINAL ARTICLE

Pages 167-176 | Published online: 25 Mar 2003

References

  • Gabizon A.A., Barenholz Y., Bialer M. Prolongation of the circulation time of doxorubicin encapsulated in liposomes containing a polyethylene glycol-derivatized phospholipid: pharmacokinetic studies in rodents and dogs. Pharm. Res. 1993; 10(5)703–708
  • Gabizon A., Catane R., Uziely B., et al. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res. 1994; 54(4)987–992
  • Northfelt D.W., Martin F.J., Working P., et al. Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol: pharmacokinetics, tumor localization, and safety in patients with AIDS-related Kaposi's sarcoma. J. Clin. Pharmacol. 1996; 36(1)55–63
  • Skubitz K.M., Hamdan H., Thompson R.C. A phase I study of ambulatory continuous infusion chemotherapy with cyclophosphamide, doxorubicin, and dacarbazine (ciCAD) for soft tissue sarcomas. J. Infus. Chemother. 1992; 2: 97–105
  • Zalupski M., Metch B., Balcerzak S., et al. Phase III comparison of doxorubicin and dacarbazine given by bolus versus infusion in patients with soft-tissue sarcomas: a Southwest Oncology Group study. J. Natl Cancer Inst. 1991; 83(13)926–932
  • Huang S.K., Mayhew E., Gilani S., Lasic D.D., Martin F.J., Papahadjopoulos D. Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma. Cancer Res. 1992; 52(24)6774–6781
  • Vaage J., Barbera Guillem, E., Abra R., Huang A., Working P. Tissue distribution and therapeutic effect of intravenous free or encapsulated liposomal doxorubicin on human prostate carcinoma xenografts. Cancer 1994; 73(5)1478–1484
  • Northfelt D.W., Dezube B.J., Thommes J.A., et al. Efficacy of pegylated-liposomal doxorubicin in the treatment of AIDS-related Kaposi's sarcoma after failure of standard chemotherapy. J. Clin. Oncol. 1997; 15(2)653–659
  • Madhavan S., Northfelt D.W. Lack of vesicant injury following extravasation of liposomal doxorubicin [letter]. J. Natl. Cancer Inst. 1995; 87(20)1556–1557
  • Northfelt D.W. Stealth liposomal doxorubicin (SLD) delivers more doxorubicin (DOX) to AIDS-related Kaposi's sarcoma (AIDS-KS) lesions than to normal skin. Proc. Am. Soc. Clin. Oncol. 1994; 13: 51, (abstract)
  • Symon Z., Peyser A., Tzemach D., et al. Selective delivery of doxorubicin to patients with breast carcinoma metastases by stealth liposomes. Cancer 1999; 86(1)72–78
  • Uziely B., Jeffers S., Isacson R., et al. Liposomal doxorubicin: antitumor activity and unique toxicities during two complementary phase I studies. J. Clin. Oncol. 1995; 13(7)1777–1785
  • Skubitz K.M., Hamdan H., Thompson R.C., Jr. Ambulatory continuous infusion ifosfamide with oral etoposide in advanced sarcomas. Cancer 1993; 72(10)2963–2969
  • Antman K., Crowley J., Balcerzak S.P., et al. An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas. J. Clin. Oncol. 1993; 11(7)1276–1285
  • Antman K., Crowley J., Balcerzak S.P., et al. A Southwest Oncology Group and Cancer and Leukemia Group B phase II study of doxorubicin, dacarbazine, ifosfamide, and mesna in adults with advanced osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. Cancer 1998; 82(7)1288–1295
  • Legha S.S., Benjamin R.S., Mackay B., et al. Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion. Ann. Intern. Med. 1982; 96(2)133–139
  • Lokich J., Bothe A., Zipoli T., et al. Constant infusion schedule for adriamycin: a phase I–II clinical trial of a 30-day schedule by ambulatory pump delivery system. J. Clin. Oncol. 1983; 1(1)24–28
  • O'Bryan R.M., Baker L.H., Gottlieb J.E. Dose response evaluation of adriamycin in human neoplasia. Cancer 1977; 39(5)1940–1948
  • Borden E.C., Amato D.A., Rosenbaum C., et al. Randomized comparison of three adriamycin regimens for metastatic soft tissue sarcomas. J Clin. Oncol. 1987; 5(6)840–850
  • O'Bryan R.M., Luce J.K., Talley R.W., Gottlieb J.A., Baker L.H., Bonadonna G. Phase II evaluation of adriamycin in human neoplasia. Cancer 1973; 32(1)1–8
  • Gottlieb J.A., Benjamin R.S., Baker L.H., et al. Role of DTIC (NSC-45388) in the chemotherapy of sarcomas. Cancer Treat. Rep. 1976; 60(2)199–203
  • Bielack S.S., Erttmann R., Wrinkler K., Landbeck G. Doxorubicin: effect of different schedules on toxicity and anti-tumor efficacy. Eur. J. Cancer Clin. Oncol. 1989; 25(5)873–882
  • Blair S.C., Zalupski M.M., Baker L.H. Ifosfamide and etoposide in the treatment of advanced soft tissue sarcomas. Am. J. Clin. Oncol. 1994; 17(6)480–484
  • Kane M.J. Chemotherapy of advanced soft tissue and osteosarcomas. Semin. Oncol. 1989; 16(4)297–304
  • Samuels B.L., Vogelzang N.J., Ruane M., Simon M.A. Continuous venous infusion of doxorubicin in advanced sarcomas. Cancer Treat. Rep. 1987; 71(10)971–972
  • Schoenfeld D.A., Rosenbaum C., Horton J., Wolter J.M., Falkson G., DeConti R.C. A comparison of adriamycin versus vincristine and adriamycin, and cyclophosphamide versus vincristine, actinomycin-D, and cyclophosphamide for advanced sarcoma. Cancer 1982; 50(12)2757–2762
  • Patel S.R., Vadhan-Raj S., Burgess M.A., et al. Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas. Am. J. Clin. Oncol. 1998; 21(3)317–321
  • Le Cesne A., Judson I., Crowther D., et al. Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colony-stimulating factor in advanced soft tissue sarcomas: A trial of the European Organization for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group. J. Clin. Oncol. 2000; 18(14)2676–2684
  • Leyvraz S., Bacchi M., Cerny T., et al. Phase I multicenter study of combined high-dose ifosfamide and doxorubicin in the treatment of advanced sarcomas. Swiss Group for Clinical Research (SAKK) [see comments]. Ann. Oncol. 1998; 9(8)877–884
  • Santoro A., Tursz T., Mouridsen H., et al. Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group [see comments]. J. Clin. Oncol. 1995; 13(7)1537–1545
  • Dirix L.Y., Van Oosterom A.T. The role of ifosfamide in the treatment of sarcomas. Semin. Oncol. 1989; 116(1 Suppl. 3)39–45
  • Bramwell V.H., Mouridsen H.T., Santoro A., et al. Cyclophosphamide versus ifosfamide: final report of a randomized phase II trial in adult soft tissue sarcomas. Eur. J. Cancer Clin. Oncol. 1987; 23(3)311–321
  • Bramwell V., Quirt I., Warr D., et al. Combination chemotherapy with doxorubicin, dacarbazine, and ifosfamide in advanced adult soft tissue sarcoma. Canadian Sarcoma Group—National Cancer Institute of Canada Clinical Trials Group. J. Natl. Cancer Inst. 1989; 81(19)1496–1499
  • Loehrer P.J., Sr., Sledge G.W., Jr., Nicaise C., et al. Ifosfamide plus doxorubicin in metastatic adult sarcomas: a multi-institutional phase II trial. J. Clin. Oncol. 1989; 7(11)1655–1659
  • Mansi J.L., Fisher C., Wiltshaw E., MacMillan S., King M., Stuart-Harris R. A phase I–II study of ifosfamide in combination with adriamycin in the treatment of adult soft tissue sarcoma. Eur. J. Cancer Clin. Oncol. 1988; 24(9)1439–1443
  • Yap B.S., Baker L.H., Sinkovics J.G., et al. Cyclophosphamide, vincristine, adriamycin, and DTIC (CYVADIC) combination chemotherapy for the treatment of advanced sarcomas. Cancer Treat. Rep. 1980; 64(1)93–98
  • Judson I., Radford J.A., Harris M., et al. Randomised phase II trial of pegylated liposomal doxorubicin (DOXIL/CAELYX) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma: a study by the EORTC Soft Tissue and Bone Sarcoma Group. Eur. J. Cancer 2001; 37(7)870–877
  • Toma S., Tucci A., Villani G., Carteni G., Spadini N., Palumbo R. Liposomal doxorubicin (Caelyx) in advanced pretreated soft tissue sarcomas: a phase II study of the Italian Sarcoma Group (ISG). Anticancer Res. 2000; 20(1B)485–491
  • Garcia A.A., Kempf R.A., Rogers M., Muggia F.M. A phase II study of Doxil (liposomal doxorubicin): lack of activity in poor prognosis soft tissue sarcomas. Ann. Oncol. 1998; 9(10)1131–1133
  • Chidiac T., Budd G.T., Pelley R., et al. Phase II trial of liposomal doxorubicin (Doxil) in advanced soft tissue sarcomas [In Process Citation]. Invest. New Drugs 2000; 18(3)253–259
  • Skubitz K.M., Skubitz A.P. Mechanism of transient dyspnea induced by pegylated-liposomal doxorubicin (Doxil). Anticancer Drugs 1998; 9(1)45

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