Toxicity of Hexamethylenediamine (HMDA)

References

• Bethell, D. R., Pegg, A. E. (1979). Effects of diamines on ornithine decarboxylase activity in control and virally transformed mouse fibroblasts. Biochem. J. 180:87–94. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Bidleman, T. F. (1988). Atmospheric processes wet and dry deposition of organic compounds are controlled by their vapor-particle partitioning. Environ. Sci. Technol. 22:361–367. [CSA]
   Web of Science ®Google Scholar
• Budavari, S. (2001). The Merck Index. 13th Ed. Whitehouse Station, NJ: Merck and Co. 4713.
   Google Scholar
• Ceressa, C. (1948). The blood picture of certain workers in the nylon industry. Med. Lav. 39:162–165.
   Google Scholar
• Ceresa, C., de Blasiis, M. (1950). Poisoning with hexamethylenediamine. Med. Lav. 41:78–85. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Chapman, S. K., Glant, S. K. (1980). Antiproliferative effects of inhibitors of polyamine synthesis in tumors of neural origin. J. Pharm. Sci. 69:733–735. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Craig, D. K., McNeill, D., Hejtmancik, M., Persing, R. L., Peters, A., Athey, P., Fisher, G. L. (1986). Final Report on the Repeated Dose Inhalation Study of 1,6-Hexanediamine Dihydrochloride (CAS No. 124-09-4) in Fisher 344 Rats. Battelle, Columbus, OH: National Toxicology Program.
   Google Scholar
• Craig, D. K., McNeill, D., Hejtmancik, M., Persing, R. L., Peters, A., Athey, P., Fisher, G. L. (1986). Final Report on the Repeated Dose Inhalation Study of 1,6-Hexanediamine Dihydrochloride (CAS No. 124-09-4) in B6C3F1 Mice. Battelle, Columbus, OH: National Toxicology Program.
   Google Scholar
• Dashiell, O. L., Kennedy, G. L. Jr. (1984). The effects of fasting on the acute oral toxicity of nine chemicals in the rat. J. Appl. Toxicol. 4:320–325. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• David, R. M., d'A. Heck, H. (1983). Localization of 1,6-(14C)diaminohexane (HMDA) in the prostate and the effects of HMDA on early gestation in Fischer-344 rats. Toxicol. Lett. 17:49–55. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Dieke, S. H., Allen, G. S., Richter, C. P. (1947). The acute toxicity of thioureas and related compounds to wild and domestic norway rats. J. Pharmacol. Exp. Ther. 90:260–270.
   PubMed Web of Science ®Google Scholar
• DuPont Company. (1937). The Toxicity and Potential Dangers of Some Aliphatic Diamines. Haskell Laboratory, unpublished report.
   Google Scholar
• DuPont Company. (1947). Hexamethylene Diamine and Hexamethylene Diisocyanate. Haskell Laboratory, unpublished report.
   Google Scholar
• DuPont Company. (1948). Acute Toxicity Tests With Diisobutyl Hexamethylene Diamine, Monoisobutyl Hexamethylene Diamine, and Hexamethylene Diamine. Haskell Laboratory, unpublished report.
   Google Scholar
• DuPont Company. (1962). Preliminary Report on the Toxicity of PACM. Haskell Laboratory, unpublished report.
   Google Scholar
• DuPont Company. (1969). Skin Primary Irritation Test. Haskell Laboratory, unpublished report.
   Google Scholar
• DuPont Company. (1972). Skin Irritation Test on Rabbits. Haskell Laboratory, unpublished report.
   Google Scholar
• DuPont Company. (1975). In Vitro Microbial Mutagenicity Studies of 1,6-Hexanediamine. Haskell Laboratory, unpublished report.
   Google Scholar
• DuPont Company. (1985a). Static Acute 96-Hour LC50 of 1,6-Hexanediamine to the Fathead Minnow, Pimephales Promelas. Haskell Laboratory, unpublished report.
   Google Scholar
• DuPont Company. (1985b). Acute Toxicity Test in Daphnia Magna. Haskell Laboratory, unpublished report.
   Google Scholar
• DuPont Company. (1992). Mutagenicity Testing of H-19,320 in an Abbreviated (1 Trial) Salmonella Typhimurium Plate Incorporation Assay. Haskell Laboratory, unpublished report.
   Google Scholar
• Duverneuil, G., Buisson, G. (1952). Dermatitis from hexamethylenediamine. Arch. Mal. Prof. Med. Trav. Secur. Soc. 13:389–390.
   PubMedGoogle Scholar
• Engibaryan, L. A., Frangulyan, R. A. (1983). Allergic diseases in workers in contact with some chemical substances. Zh. Eksp. Klin. Med. 23:596–599.
   Google Scholar
• Gage, J. C. (1970). Subacute inhalation toxicity of 109 industrial chemicals. Br. J. Ind. Med. 27:1–18. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Gallo, G., Ghiringhelli, L. (1958). Occupational exposure to hexamethylenediamine. Med. Lav. 49:683–689. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Hecht, G., Gloxhuber, Ch. (1962). Effects of intraperitoneal injections (of insoluble substances) in rats. Arch. Int. Pharmacodyn. 140:655–668.
   Google Scholar
• Hejtmancik, M., Placke, M., Mezza, L., Peters, A., Taylor, S. (1985a). Final Report on the Two-Week Dosed Water Repeated Study of 1,6-Hexanediamine (CAS No. 124-09-4) in Fisher 344 Rats. Battelle, Columbus, OH: National Toxicology Program.
   Google Scholar
• Hejtmancik, M., Placke, M., Mezza, L., Peters, A., Taylor, S. (1985b). Final Report on the Two-Week Dosed Water Study of 1,6-Hexanediamine (CAS No. 124-09-4) in B6C3F1 Mice. Battelle, Columbus, OH: National Toxicology Program.
   Google Scholar
• Hejtmancik, M., Persing, R., Prentice, B., Peters, A. C. (1988a). Final Report on the Prechronic Inhalation Studies of 1,-Hexanediamine Dihydrochloride (CAS No. 6055-52-3) in Fisher 344 Rats. Battelle, Columbus, OH: National Toxicology Program.
   Google Scholar
• Hejtmancik, M., Persing, R., Craig, D. K., Athey, P. M., Peters, A. C. (1988b). Final Report on the Prechronic Inhalation Studies of 1,-Hexanediamine Dihydrochloride (CAS No. 6055-52-3) in B6C3F1 Mice. Battelle, Columbus, OH: National Toxicology Program.
   Google Scholar
• Izmerov, N. F. (1982). Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure. Centre of International Projects: Moscow, 74 ( RTECS).
   Google Scholar
• Johannsen, F. R., Levinskas, G. J. (1987a). Toxicological profile of orally administered 1,6-hexane diamine in the rat. J. Appl. Toxicol. 7:259–263. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Johannsen, F. R., Levinskas, G. J., Ben-Dyke, R., Hogan, G. K. (1987b). Subchronic inhalation toxicity of hexamethylenediamine in rats. Fundam. Appl. Toxicol. 9:504–511. [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMedGoogle Scholar
• Kallio, A., Poesoe, H., Guha, S. K., Jaenne, J. (1977). Polyamines and their biosynthetic enzymes in Ehrlich ascites-carcinoma cells. modification of tumor polyamine pattern by diamines. Biochem. J. 166:89–94. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Kennedy, G. L. Jr., Ferenz, R. L., Burgess, B. A. (1986). Estimation of acute oral toxicity in rats by determination of the approximate lethal dose rather than the LD50. J. Appl. Toxicol. 6:145–148. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Kim, M. N., Jang, J. C., Lee, I. M., Lee, H. S., Yoon, J. S. (2002). Toxicity and biodegradation of diamines. J. Environ. Sci. Health 37:53–64. [CSA]
   PubMed Web of Science ®Google Scholar
• Kulakov, A. E. (1964). Effect of small concentrations of hexamethylenediamine on the human organism. Gig. Sanit. 29:8–13. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Kulakov, A. E. (1965). Effect of chronic inhalation of small quantities of hexamethylenediamine on animals. Gig. Sanit. 30:15–20. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Li, S., Fan, M., Huang, L., Zhu, X., Liu, Y., Wang, M. (1984). Effects of diamines and their derivatives on activity of ornithine decarboxylase in mouse sarcoma 180 in vivo. Zhongguo Yixue Kexueyuan Xuebao 6:405–409. [PUBMED], [INFOTRIEVE]
   Google Scholar
• Luebke, R. W., Copeland, C. B., Irsula, O., Riddle, M. M., Rogers, R. R., Lau, C., Smialowicz, R. J. (1989). Suppression of lymphocyte proliferation by hexamethylene diamine. Toxicology 56:301–313. [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Maitre, A., Berode, M., Perdrix, A., Stoklov, M., Mallion, J. M., Savolainen, H. (1996). Urinary hexane diamine as an indicator of occupational exposure to hexamethylene. Int. Arch. Occup. Environ. Health 69:65–68. [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Manen, C. A., Hood, R. D., Farina, J. (1983). Ornithine decarboxylase inhibitors and fetal growth retardation in mice. Teratology 28:237–242. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Martynova, A. P. (1957). Problems of hygiene in the production of caprolactam and polyamide fibers. Gig. Tr. Prof. Zabol. 1:23–29.
   Google Scholar
• Meylan, W. M., Howard, P. H. (1991). Bond contribution method for estimating Henry's law constants. Environ. Toxicol. Chem. 10:1283–1293. [CSA]
   Web of Science ®Google Scholar
• Meylan, W. M., Howard, P. H. (1993). Computer estimation of the atmospheric gas-phase reaction rate of organic compounds with hydroxyl radicals and ozone. Chemosphere 26:2293–2299. [CROSSREF]
   Web of Science ®Google Scholar
• Meylan, W. M., Howard, P. H. (1995). Atom/fragment contribution method for estimating octanol–water partition coefficients. J. Pharm. Sci. 84:83–92. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Monsanto Chemical Co. (nd), Cited in WEEL Documentation.
   Google Scholar
• Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., Zeiger, E. (1983). Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ. Mutagen. 8(7):1–119.
   Google Scholar
• Murphey-Corb, M., Kong, H. L., Murray, M. L. (1983). Mutagenic activity from nitrosation of oligoamines. Environ. Mutagen. 5:101–109. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• National Defense Research Committee, (NDRC). (1942). Office of Scientific Research and Development, Progress Report NDCrc-132. RTECS.
   Google Scholar
• Oppenheimer, B. S., Oppenheimer, E. T., Danishefsky, I., Stout, A. P., Eirich, F. R. (1955). Further studies of polymers as carcinogenic agents in animals. Cancer Res. 15:333–340. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Osintseva, V. P., Kulakov, A. E., Bonashevskaia, T. I., Kolbasova, O. V. (1966). Morphological studies on the effect of hexamethylene diamine on albino rats. Gig. Sanit. 31:89–91. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Perrin, D. D. (1972). Dissociation Constants of Organic Bases in Aqueous Solution. In: IUPAC Chemical Series: Supplement. London: Buttersworth.
   Google Scholar
• Ponomareva, T. V., Merkushev, G. N. (1978). Effects of some nonradioactive and radioactive chemical compounds on the structure of the spleen. Arkh. Anat. Gistol. Embriol. 74:47–52. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Roi, A. A., Garbara, S. V. (1978). Study of the acute toxicity of hexamethylene diamine and products of microbic destruction. Gig. Sanit. 11:110.
   Google Scholar
• Sasaki, S. (1978). In: Hutzinger, O., Von Letyold, L. H., Zoeteman, B. C., eds. Aquatic Pollutants: Transformation and Biological Effects. Oxford: Pergamon Press, pp. 283–298.
   Google Scholar
• Schafer, E. W. Jr., Bowles, W. A. Jr., Hurlbut, J. (1983). The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Arch. Environ. Contam. Toxicol. 12:355–382. [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Scheier, A. (1965). Acute Bioiassay Studies. Academy of Natural Sciences of Philadelphia, Department of Limnology. ( Unpublished Report).
   Google Scholar
• Short, R. D., Johannsen, F. R., Schardein, J. L. (1991). A two-generation reproduction study in rats receiving diets containing hexamethylenediamine. Fundam. Appl. Toxicol. 16:490–494. [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMedGoogle Scholar
• Standard Oil Co. (nd). Cited under Section 8d of TSCA, Fiche No. 215309 and No. 206578.
   Google Scholar
• Strain, G. M., Flory, W., Tucker, T. A. (1984). Inhibition of synaptosomal uptake of amino acid transmitters by diamines. Neuropharmacology 23:971–975. [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   PubMed Web of Science ®Google Scholar
• Subramanyam, B., Callery, P. S., Geelhaar, L. A., Egorin, M. J. (1989). A cyclic imine intermediate in the in vitro metabolic conversion of 1,6-diaminohexane to 6-aminohexanoic acid and caprolactam. Xenobiotica 19:33–42., [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Swann, R. L., Laskowski, D. A., McCall, P. J., Vander Kuy, K., Dishburger, H. J. (1983). A rapid method for the estimation of the environmental parameters octanol/water partition coefficient, soil sorption constant, water to air ratio, and water solubility. Residue Rev. 85:23.
   Google Scholar
• Thomas, H. F., Hartman, P. E., Mudryi, M., Brown, D. L. (1979). Nitrous acid mutagenesis of duplex DNA as a three-component system. Mutat. Res. 61:129–151. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Tsyrkunov, L. P. (1966). Toxic effect of epoxy resins and their hardeners in vivo. Gig. Tr. Prof. Zabol. 10:52–54. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• U.S. Army Armament Research and Development Command (nd), Chemical Systems Laboratory, NIOSH Exchange Chemicals. NX#02313 (RTECS).
   Google Scholar
• Urano, K., Kato, Z. (1986). ZEvaluation of biodegradation ranks of priority organic compounds. J. Haz. Mat. 13:147–159. [CROSSREF], [CSA]
   Web of Science ®Google Scholar
• Vernot, E. H., MacEwen, J. D., Haun, C. C., Kinkead, E. R. (1977). Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions. Toxicol. Appl. Pharmacol. 42:417–423. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Von Oettingen, W. F. (1942). The toxicity and potential dangers of aliphatic and aromatic hydrocarbons. Yale J. Biol. Med. 15:167.
   PubMedGoogle Scholar
• Wilbury Laboratories. (1993). Acute Toxicity of H-19926 to the Freshwater Alga, Selenastrum Capriocornutum. ( unpublished report).
   Google Scholar
• Woodard Research Corporation. (1969). Hexamethylene-Diamine Evaluation of Acute LC50 for Bluegill Sunfish. ( unpublished report).
   Google Scholar
• Yaws, C. L. (1994). Handbook of Vapor Pressure. Vol. 2. Houston: C5 to C7 Compounds, Gulf Publishing Co.
   Google Scholar
• Zeller, H. (1957). Testing epidermal sensitizing substances in animal experiments. Arch. Exp. Pathol. Pharmakol. 232:239–240.
   PubMedGoogle Scholar