Influence of the Storage Orientation on the Aerodynamic Particle Size of a Suspension Metered Dose Inhaler Containing Propellant HFA-227

References

• Dolovich M. Characterization of medical aerosols: physical and clinical requirements for new inhalers. Aerosol Science and Technology 1995; 22: 392–399
   Web of Science ®Google Scholar
• Elvecrog J. Metered dose inhalers in a CFC-free future. Pharmaceutical Technology Europe 1997; 9(1)52–55
   Google Scholar
• Keller M. Innovations and perspectives of metered dose inhalers in pulmonary drug delivery. International Journal of Pharmaceutics 1999; 186: 81–90
   PubMed Web of Science ®Google Scholar
• Dunbar C.A., Watkins A.P., Miller J.F. Characterization of the pMDI spray using numerical methods. Proceedings of ICLASS. August, 18–221997, 876–883
   Google Scholar
• Dunbar C.A. Atomization mechanisms of the pressurized metered dose inhaler. Particulate Science and Technology 1998; 15(3–4)253–271
   Web of Science ®Google Scholar
• Polli G.P., Grim W.M., Bacher F.A., Yunker M.H. Influence of formulation on aerosol particle size. Journal of Pharmaceutical Sciences 1969; 58(4)484–486
   PubMed Web of Science ®Google Scholar
• Moren F. Drug Deposition of pressurized inhalation aerosols I. influence of actuator tube design. International Journal of Pharmaceutics 1978; 1: 205–212
   Web of Science ®Google Scholar
• Kim C.S., Trujillo D., Sackner M.A. Size aspects of metered dose inhalers. American Review of Respiratory Disease 1985; 132(1)137–142
   PubMed Web of Science ®Google Scholar
• Clark A.R. The physics of aerosol formation by MDIs—limitations of the current approach. Journal of Biopharmaceutical Sciences 1992; 3(1/ 2)69–76
   Google Scholar
• Brambilla G., Ganderton D., Garzia R., Lewis D., Meakin B., Ventura P. Modulation of aerosol clouds produced by pressurized inhalation aerosols. International Journal of Pharmaceutics 1999; 186(1)53–61
   PubMed Web of Science ®Google Scholar
• Dolovich M.B., Ruffin R.E., Roberts R., Newhouse M.T. Optimal delivery of aerosols from metered dose inhalers. Chest 80 (suppl.) 1981; 911–915
   Google Scholar
• Meyer K.C., Auerbach W.R. Drug delivery to the lung. Polymeric Site-Specific Pharmacotherapy, A.J. Domb. John Wiley and Sons, New York 1994; 347–367
   Google Scholar
• Pritchard J.N. The influence of lung deposition on clinical response. Journal of Medicine 2001; 14(1)S19–S26
   Google Scholar
• Leach C.L., Davidson P.J., Boudreau R.J. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. European Respiratory Journal 1998; 12: 1346–1353
   PubMed Web of Science ®Google Scholar
• Matthys H. Chlorofluorocarbon-free aerosol therapy in patients with pulmonary airflow obstruction. Respiration 1996; 63(3)321–324
   PubMedGoogle Scholar
• Byron P.R., Miller N.C., Blondino F.E., Visich J.E., Ward G.H. Some aspects of alternative propellant solvency. Respiratory Drug Delivery IV 1994; 239–242
   Google Scholar
• Vervaet C., Byron P.R. Drug-surfactant-propellant interactions in HFA-formulations. International Journal of Pharmaceutics 1999; 186: 13–30
   PubMed Web of Science ®Google Scholar
• Cummings R.H. Pressurized metered dose inhalers: chlorofluorocarbon to hydrofluoroalkane transition-valve performance. Journal of Allergy and Clinical Immunology 1999; S230–S235
   Google Scholar
• McDonald K.J., Martin G.P. Transition to CFC-free metered dose inhalers—into the new millennium. International Journal of Pharmaceutics 2000; 201: 89–107
   PubMed Web of Science ®Google Scholar
• Milosovich S. Particle size determination via cascade impaction. Pharmaceutical Technology 1992; 16: 82–86
   Google Scholar
• Johnsen M.A. Properties of aerosol particles. Spray Technology and Marketing 1992; 2(8)46–55
   Google Scholar
• United States Pharmacopeia 25. 1969–1980, General Chapter 601 (2001)
   Google Scholar
• Sequeira J., Berry J., Sharpe S., Naini V., Hart J. A comparison of metered dose inhaler particle size distribution by andersen cascade impaction using two types of entry ports. Respiratory Drug Delivery VIII 2002; 2: 573–576
   Google Scholar
• Ranucci J. Dynamic plume-particle size analysis using laser diffraction. Pharmaceutical Technology 1992; 16: 108–114
   Google Scholar
• Witt W., Rothele S. Laser diffraction—unlimited?. Part. Syst. Charact 1996; 13: 280–286
   Web of Science ®Google Scholar
• Le Brun P.P.H., de Boer A.H., Gjaltema D., Hagedoorn P., Heijerman H.G.M., Frijlink H.W. Inhalation of tobramycin in cystic fibrosis. International Journal of Pharmaceutics 1999; 189(2)205–214
   PubMed Web of Science ®Google Scholar
• Sethi S.K., Norwood D.L., Haywood P.A., Prime D. Impact of extractable testing on MDI development programs. Journal of Biopharmaceutical Sciences 1992; 3(1/2)063–068
   Google Scholar
• Howlett D. Pharmaceutical aerosol valves—an overview. Spray Technology and Marketing 1994; 18–22
   Google Scholar
• Hickey A.J., Dalby R.N., Byron P.R. Effects of surfactants on aerosol powders in suspension. Implications for airborne particle size. International Journal of Pharmaceutics 1988; 42(1–3)267–270
   Web of Science ®Google Scholar
• Ranucci J.A., Cooper D., Sethachutkul K. Effect of actuator design on metered dose inhaler plume particle size. Pharmaceutical Technology 1992; 16: 84–92
   Google Scholar
• Dalby R.N., Byron P.R. Comparison of output particle size distributions from pressurized aerosols formulated as solutions or suspensions. Pharmaceutical Research 1988; 5(1)36–39
   PubMed Web of Science ®Google Scholar
• Evans R.M., Farr S.J., Armstrong N.A., Chatham S.M. Formulation and in vitro evaluation of pressurized inhalation aerosols containing isotropic systems of lecithin and water. Pharmaceutical Research 1991; 8(5)629–635
   PubMed Web of Science ®Google Scholar
• Tzou T.Z. Aerodynamic particle size of metered dose inhalers determined by the quartz crystal microbalance and the andersen cascade impactor. International Journal of Pharmaceutics 1999; 186: 71–79
   PubMed Web of Science ®Google Scholar