718
Views
263
CrossRef citations to date
0
Altmetric
Research Article

Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE),†,

, , , , , & show all
Pages 255-271 | Published online: 04 Mar 2002

REFERENCES

  • Nebert D.W., Gonzalez F.J. P450 Genes: Structure, Evolution, and Regulation. Annu. Rev. Biochem. 1987; 56: 945–993
  • Nelson D.R., Kamataki T., Waxman D.J., Guengerich F.P., Estabrook R.W., Feyereisen R., Gonzalez F.J., Coon M.J., Gunsalus I.C., Gotoh O. The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature. DNA Cell Biol. 1993; 12(1)1–51
  • Jaiswal A.K. Jun and Fos Regulation of NAD(P)H:quinone Oxidoreductase Gene Expression. Pharmacogenetics 1994; 4(1)1–10
  • Guenthner T. Conjugation Reactions in Drug Metabolism, G. Mulder. Taylor & Francis, London 1990; 365–404
  • Rushmore T., Pickett C.B., Lu A.Y.H. Regulation of Expression of Rat Liver Glutathione Transferases: Xenobiotic and Antioxidant Induction of the Ya Subunit Gene. Springer, Berlin 1994
  • Vatsis K.P., Weber W.W., Bell D.A., Dupret J.M., Evans D.A., Grant D.M., Hein D.W., Lin H.J., Meyer U.A., Relling M.V., , et al. Nomenclature for N-acetyltransferases. Pharmacogenetics 1995; 5: 1–17
  • Weinshilboum R.M., Otterness D.M., Aksoy I.A., Wood T.C., Her C., Raftogianis R.B. Sulfation and Sulfotransferases 1: Sulfotransferase Molecular Biology: cDNAs and Genes. FASEB J. 1997; 11(1)3–14
  • Mackenzie P.I., Owens I.S., Burchell B., Bock K.W., Bairoch A., Belanger A., Fournel-Gigleux S., Green M., Hum D.W., Iyanagi T., Lancet D., Louisot P., Magdalou J., Chowdhury J.R., Ritter J.K., Schachter H., Tephly T.R., Tipton K.F., Nebert D.W. The U.D.P. Glycosyltransferase Gene Superfamily: Recommended Nomenclature Update Based on Evolutionary Divergence. Pharmacogenetics 1997; 7(4)255–269
  • Tukey R.H., Strassburg C.P. Human UDP-Glucuronosyltransferases: Metabolism, Expression, and Disease. Annu. Rev. Pharmacol. Toxicol. 2000; 40(14)581–616
  • Mulder G., Coughtrie M.W.H., Burchell B. GJM Conjugation Reactions in Drug Metabolism. Taylor & Francis, London 1990; 51–106
  • Glatt H. Sulfation and Sulfotransferases 4: Bioactivation of Mutagens via Sulfation. FASEB J. 1997; 11(5)314–321
  • Bolton J.L., Trush M.A., Penning T.M., Dryhurst G., Monks T.J. Role of Quinones in Toxicology. Chem. Res. Toxicol. 2000; 13(3)135–160
  • Sueyoshi T., Kawamoto T., Zelko I., Honkakoski P., Negishi M. The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene. J. Biol. Chem. 1999; 274(10)6043–6046
  • Honkakoski P., Zelko I., Sueyoshi T., Negishi M. The Nuclear Orphan Receptor CAR-retinoid X Receptor Heterodimer Activates the Phenobarbital-responsive Enhancer Module of the CYP2B Gene. Mol. Cell. Biol. 1998; 18(10)5652–5658
  • Wei P., Zhang J., Egan-Hafley M., Liang S., Moore D.D. The Nuclear Receptor CAR Mediates Specific Xenobiotic Induction of Drug Metabolism. Nature 2000; 407(6806)920–923
  • Kliewer S.A., Moore J.T., Wade L., Staudinger J.L., Watson M.A., Jones S.A., McKee D.D., Oliver B.B., Willson T.M., Zetterstrom R.H., Perlmann T., Lehmann J.M. An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway. Cell 1998; 92(1)73–82
  • Kliewer S.A., Lehmann J.M., Willson T.M. Orphan Nuclear Receptors: Shifting Endocrinology into Reverse. Science 1999; 284(5415)757–760
  • Waxman D.J. P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR. Arch. Biochem. Biophys. 1999; 369(1)11–23
  • Moore J.T., Kliewer S.A. Use of the Nuclear Receptor PXR to Predict Drug Interactions. Toxicology 2000; 153(1–3)1–10
  • Gu Y.Z., Hogenesch J.B., Bradfield C.A. The PAS Superfamily: Sensors of Environmental and Developmental Signals. Annu. Rev. Pharmacol. Toxicol. 2000; 40(1)519–561
  • Issemann I., Green S. Activation of a Member of the Steroid Hormone Receptor Superfamily by Peroxisome Proliferators. Nature 1990; 347(6294)645–650
  • Rao M.S., Reddy J.K. Peroxisome Proliferation and Hepatocarcinogenesis. Carcinogenesis 1987; 8(5)631–636
  • Wattenberg L.W. Inhibition of Carcinogenic Effects of Polycyclic Hydrocarbons by Benzyl Isothiocyanate and Related Compounds. J. Natl. Cancer Inst. 1977; 58(2)395–398
  • Prochaska H.J., Talalay P. Regulatory Mechanisms of Monofunctional and Bifunctional Anticarcinogenic Enzyme Inducers in Murine Liver. Cancer Res. 1988; 48(17)4776–4782
  • Friling R.S., Bensimon A., Tichauer Y., Daniel V. Xenobiotic-Inducible Expression of Murine Glutathione S-transferase Ya Subunit Gene Is Controlled by an Electrophile-Responsive Element. Proc. Natl. Acad. Sci. USA 1990; 87(16)6258–6262
  • Pinkus R., Weiner L.M., Daniel V. Role of Oxidants and Antioxidants in the Induction of AP-1, NF-kappaB, and Glutathione S-transferase Gene Expression. J. Biol. Chem. 1996; 271(23)13422–13429
  • Buetler T.M., Gallagher E.P., Wang C., Stahl D.L., Hayes J.D., Eaton D.L. Induction of Phase I and Phase II Drug-Metabolizing Enzyme mRNA, Protein, and Activity by BHA, Ethoxyquin, and Oltipraz. Toxicol. Appl. Pharmacol. 1995; 135(1)45–57
  • Fei P., Matwyshyn G.A., Rushmore T.H., Kong A.N.T. Transcription Regulation of Rat Glutathione S-transferase Ya Subunit Gene Expression by Chemopreventive Agents. Pharm. Res. 1996; 13(7)1043–1048
  • Munzel P.A., Schmohl S., Heel H., Kalberer K., Bock-Hennig B.S., Bock K.W. Induction of Human UDP Glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 Cells. Drug Metab. Dispos. 1999; 27(5)569–573
  • Okuda A., Imagawa M., Maeda Y., Sakai M., Muramatsu M. Structural and Functional Analysis of an Enhancer GPEI Having a Phorbol 12-O-tetradecanoate 13-acetate Responsive Element-like Sequence Found in the Rat Glutathione Transferase P Gene. J. Biol. Chem. 1989; 264(28)16919–16926
  • Rushmore T.H., Pickett C.B. Transcriptional Regulation of the Rat Glutathione S-transferase Ya Subunit Gene. Characterization of a Xenobiotic-responsive Element Controlling Inducible Expression by Phenolic Antioxidants. J. Biol. Chem. 1990; 265(24)14648–14653
  • Li Y., Jaiswal A.K. Regulation of Human NAD(P)H:quinone Oxidoreductase Gene. Role of AP1 Binding Site Contained Within Human Antioxidant Response Element. J. Biol. Chem. 1992; 267(21)15097–15104
  • Kataoka K., Noda M., Nishizawa M. Maf Nuclear Oncoprotein Recognizes Sequences Related to an AP-1 Site and Forms Heterodimers with Both Fos and Jun. Mol. Cell. Biol. 1994; 14(1)700–712
  • Igarashi K., Kataoka K., Itoh K., Hayashi N., Nishizawa M., Yamamoto M. Regulation of Transcription by Dimerization of Erythroid Factor NF-E2 p45 with Small Maf Proteins. Nature 1994; 367(6463)568–572
  • Talalay P. Mechanisms of Induction of Enzymes That Protect Against Chemical Carcinogenesis. Adv. Enzyme Regul. 1989; 28: 237–250
  • Venugopal R., Jaiswal A.K. Nrf1 and Nrf2 Positively and c-Fos and Fra1 Negatively Regulate the Human Antioxidant Response Element-mediated Expression of NAD(P)H:quinone Oxidoreductase1 Gene. Proc. Natl. Acad. Sci. USA 1996; 93(25)14960–14965
  • Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., Oyake T., Hayashi N., Satoh K., Hatayama I., Yamamoto M., Nabeshima Y. An Nrf2/Sall Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes Through Antioxidant Response Elements. Biochem. Biophys. Res. Commun. 1997; 236(2)313–322
  • Moinova H.R., Mulcahy R.T. Up-regulation of the Human Gamma-glutamylcysteine Synthetase Regulatory Subunit Gene Involves Binding of Nrf-2 to an Electrophile Responsive Element. Biochem. Biophys. Res. Commun. 1999; 261(3)661–668
  • Alam J., Stewart D., Touchard C., Boinapally S., Choi A.M., Cook J.L. Nrf2, A Cap 'n' Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene. J. Biol. Chem. 1999; 274(37)26071–26078
  • Wasserman W.W., Fahl W.E. Functional Antioxidant Responsive Elements. Proc. Natl. Acad. Sci. USA 1997; 94(10)5361–5366
  • Itoh K., Wakabayashi N., Katoh Y., Ishii T., Igarashi K., Engel J.D., Yamamoto M. Keap1 Represses Nuclear Activation of Antioxidant Responsive Elements by Nrf2 Through Binding to the Amino-terminal Neh2 Domain. Genes Dev. 1999; 13(1)76–86
  • Gonzalez F.A., Raden D.L., Davis R.J. Identification of Substrate Recognition Determinants for Human ERK1 and ERK2 Protein Kinases. J. Biol. Chem. 1991; 266(33)22159–22163
  • Alvarez E., Northwood I.C., Gonzalez F.A., Latour D.A., Seth A., Abate C., Curran T., Davis R.J. Pro-Leu-Ser/Thr-Pro is a Consensus Primary Sequence for Substrate Protein Phosphorylation. Characterization of the Phosphorylation of c- myc and c-jun Proteins by an Epidermal Growth Factor Receptor Threonine 669 Protein Kinase. J. Biol. Chem. 1991; 266(23)15277–15285
  • Marshall C.J. MAP Kinase Kinase Kinase, MAP Kinase Kinase and MAP Kinase. Curr. Opin. Genet. Dev. 1994; 4(1)82–89
  • Cobb M.H., Goldsmith E.J. How MAP Kinases Are Regulated. J. Biol. Chem. 1995; 270(25)14843–14846
  • Cano E., Mahadevan L.C. Parallel Signal Processing Among Mammalian MAPKs. Trends Biochem. Sci. 1995; 20(3)117–122
  • Kyriakis J.M., Avruch J. Protein Kinase Cascades Activated by Stress and Inflammatory Cytokines. Bioessays 1996; 18(7)567–577
  • Karin M. The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases. J. Biol. Chem. 1995; 270(28)16483–16486
  • Karin M. Mitogen-activated Protein Kinase Cascades as Regulators of Stress Responses. Ann. NY Acad. Sci. 1998; 851: 139–146
  • Benson A.M., Batzinger R.P., Ou S.Y., Bueding E., Cha Y.N., Talalay P. Elevation of Hepatic Glutathione S-transferase Activities and Protection Against Mutagenic Metabolites of Benzo(a)pyrene by Dietary Antioxidants. Cancer Res. 1978; 38(12)4486–4495
  • Lam L.K., Fladmoe A.V., Hochalter J.B., Wattenberg L.W. Short Time Interval Effects of Butylated Hydroxyanisole on the Metabolism of Benzo(a)pyrene. Cancer Res. 1980; 40(8 Pt 1)2824–2828
  • Sparnins V.L., Chuan J., Wattenberg L.W. Enhancement of Glutathione S-transferase Activity of the Esophagus by Phenols. Cancer Res. 1982; 42(4)1205–1207
  • Sparnins V.L., Venegas P.L., Wattenberg L.W. Glutathione S-Transferase Activity: Enhancement by Compounds Inhibiting Chemical Carcinogenesis and by Dietary Constituents. J. Natl Cancer Inst. 1982; 68(3)493–496
  • Yu R., Tan T.H., Kong A.T. Butylated Hydroxyanisole and its Metabolite tert-Butylhydroquinone Differentially Regulate Mitogen-activated Protein Kinases. The Role of Oxidative Stress in the Activation of Mitogen-activated Protein Kinases by Phenolic Antioxidants. J. Biol. Chem. 1997; 272(46)28962–28970
  • De Long M.J., Prochaska H.J., Talalay P. Tissue-specific Induction Patterns of Cancer-protective Enzymes in Mice by tert-butyl-4-hydroxyanisole and Related Substituted Phenols. Cancer Res. 1985; 45(2)546–551
  • Rushmore T.H., Morton M.R., Pickett C.B. The Antioxidant Responsive Element. Activation by Oxidative Stress and Identification of the DNA Consensus Sequence Required for Functional Activity. J. Biol. Chem. 1991; 266(18)11632–11639
  • Yu R., Lei W., Mandlekar S., Weber M.J., Der C.J., Wu J., Kong A.T. Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals. J. Biol. Chem. 1999; 274(39)27545–27552
  • Yu R., Jiao J.J., Duh J.L., Gudehithlu K., Tan T.H., Kong A.N.T. Activation of Mitogen-activated Protein Kinases by Green Tea Polyphenols: Potential Signaling Pathways in the Regulation of Antioxidant-responsive Element-mediated Phase II Enzyme Gene Expression. Carcinogenesis 1997; 18(2)451–456
  • Chen C., Yu R., Owuor E.D., Kong A.N. Activation of Antioxidant-response Element (ARE), Mitogen-activated Protein Kinases (MAPKs) and Caspases by Major Green Tea Polyphenol Components During Cell Survival and Death. Arch. Pharm. Res. 2000; 23(6)605–612
  • Yu R., Mandlekar S., Lei W., Fahl W.E., Tan T.H., Kong A.T. p38 Mitogen-activated Protein Kinase Negatively Regulates the Induction of Phase II Drug-Metabolizing Enzymes That Detoxify Carcinogens. J. Biol. Chem. 2000; 275(4)2322–2327
  • Prestera T., Holtzclaw W.D., Zhang Y., Talalay P. Chemical and Molecular Regulation of Enzymes That Detoxify Carcinogens. Proc. Natl. Acad. Sci. USA 1993; 90(7)2965–2969
  • Guo Z., Smith T.J., Wang E., Sadrieh N., Ma Q., Thomas P.E., Yang C.S. Effects of Phenethyl Isothiocyanate, a Carcinogenesis Inhibitor, on Xenobiotic-metabolizing Enzymes and Nitrosamine Metabolism in Rats. Carcinogenesis 1992; 13(12)2205–2210
  • Yu R., Jiao J.J., Duh J.L., Tan T.H., Kong A.N.T. Phenethyl Isothiocyanate, a Natural Chemopreventive Agent, Activates c-Jun N-terminal Kinase 1. Cancer Res. 1996; 56(13)2954–2959
  • Patten E.J., DeLong M.J. Temporal Effects of the Detoxification Enzyme Inducer, Benzyl Isothiocyanate: Activation of c-Jun N-Terminal Kinase Prior to the Transcription Factors AP-1 and NFkappaB. Biochem. Biophys. Res. Commun. 1999; 257(1)149–155
  • Zhang Y., Talalay P., Cho C.G., Posner G.H. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Natl. Acad. Sci. USA 1992; 89(6)2399–2403
  • Zhang Y., Kolm R.H., Mannervik B., Talalay P. Reversible Conjugation of Isothiocyanates with Glutathione Catalyzed by Human Glutathione Transferases. Biochem. Biophys. Res. Commun. 1995; 206(2)748–755
  • Jiao D., Smith T.J., Yang C.S., Pittman B., Desai D., Amin S., Chung F.L. Chemopreventive Activity of Thiol Conjugates of Isothiocyanates for Lung Tumorigenesis. Carcinogenesis 1997; 18(11)2143–2147
  • Chan K., Kan Y.W. Nrf2 is Essential for Protection Against Acute Pulmonary Injury in Mice. Proc. Natl. Acad. Sci. USA 1999; 96(22)12731–12736
  • Moi P., Chan K., Asunis I., Cao A., Kan Y.W. Isolation of NF-E2-related Factor 2 (Nrf2), a NF-E2-like Basic Leucine Zipper Transcriptional Activator That Binds to the Tandem NF-E2/AP1 Repeat of the Beta-globin Locus Control Region. Proc. Natl. Acad. Sci. USA 1994; 91(21)9926–9930
  • Yu R., Chen C., Mo Y.Y., Hebbar V., Owuor E.D., Tan T.H., Kong A.N. Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism. J. Biol. Chem. 2000; 275(51)39907–39913
  • Wild A.C., Moinova H.R., Mulcahy R.T. Regulation of Gamma-glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2. J. Biol. Chem. 1999; 274(47)33627–33636

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.