38
Views
6
CrossRef citations to date
0
Altmetric
Original

The Effect of Fenofibrate on the Levels of High Sensitivity C‐Reactive Protein in Dyslipidemic Obese Patients

, M.D. &
Pages 343-349 | Published online: 07 Jul 2009

References

  • Benzaquen L R, Yu H, Rifai N. High sensitivity C‐reactive protein: an emerging role in cardiovascular risk assessment. Crit Rev Clin Lab Sci 2002; 39: 459–497
  • Wellen K E, Hotamisligil G S. Obesity‐induced inflammatory changes in adipose tissue. J Clin Invest 2003; 112: 1785–1788
  • Blake G J, Ridker P M. Inflammatory bio‐markers and cardiovascular risk prediction. J Intern Med 2002; 252: 283–294
  • Ridker P M. Inflammation, atherosclerosis, and cardiovascular risk: an epidemiologic view. Blood Coagul Fibrinolysis 1999; 10: S9–S12
  • Ridker P M. High‐sensitivity C‐reactive protein and cardiovascular risk: rationale for screening and primary prevention. Am J Cardiol 2003; 92: 17K–22K
  • Futterman L G, Lemberg L. High sensitivity C‐reactive protein is the most effective prognostic measurement of acute coronary events. Am J Crit Care 2002; 11: 482–486
  • Rifai N, Ridker P M. High‐sensitivity C‐reactive protein: a novel and promising marker of coronary heart disease. Clin Chem 2001; 47: 403–411
  • Ridker P M, Buring J E, Cook N R, Rifai N. C‐reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8‐year follow‐up of 14719 initially healthy American women. Circulation 2003; 107: 391–397
  • Wang T D, Chen W J, Lin J W, Cheng C C, Chen M F, Lee Y T. Efficacy of fenofibrate and simvastatin on endothelial function and inflammatory markers in patients with combined hyperlipidemia: relations with baseline lipid profiles. Atherosclerosis 2003; 170: 315–323
  • Kuller L H, Tracy R P, Shaten J, Meilahn E N. Relation of C‐reactive protein and coronary heart disease in the MRFIT nested case‐control study. Multiple risk factor intervention trial. Am J Epidemiol 1996; 144: 537–547
  • Tracy R P, Lemaitre R N, Psaty B M, Ives D G, Evans R W, Cushman M, Meilahn E N, Kuller L H. Relationship of C‐reactive protein to risk of cardiovascular disease in the elderly. Results from the cardiovascular health study and the rural health promotion project. Arterioscler Thromb Vasc Biol 1997; 17: 1121–1127
  • Winegar D A, Brown P J, Wilkison W O, Lewis M C, Ott R J, Tong W O, Brown H R, Lehmann J M, Kliewer S A, Plunket K D, Way J M, Bodkin N L, Hansen B C. Effects of fenofibrate on lipid parameters in obese rhesus monkeys. J Lipid Res 2001; 42: 1543–1551
  • Gavish D, Leibovitz E, Shapira I, Rubinstein A. Bezafibrate and simvastatin combination therapy for diabetic dyslipidaemia: efficacy and safety. J Intern Med 2000; 247: 563–569
  • Evans M, Anderson R A, Graham J, Ellis G R, Morris K, Davies S, Jackson S K, Lewis M J, Frenneaux M P, Rees A. Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus. Circulation 2000; 18(101)1773–1779
  • Watts G F, Dimmitt S B. Fibrates, dyslipoproteinaemia and cardiovascular disease. Curr Opin Lipidol 1999; 10: 561–574
  • Rizos E, Kostoula A, Elisaf M, Mikhailidis D P. Effect of ciprofibrate on C‐reactive protein and fibrinogen levels. Angiology 2002; 53: 273–277
  • Baron R B. Lipid abnormalities. Current Medical Diagnosis and Treatment40th ed., L M Tiernay, S J McPce, M A Papadakus. McGraw‐Hill, Lange Medical Books, New York 2001; 1208–1221
  • Ferrannini E, Haffner S M, Mitchell B D, Stem M P. Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia 1991; 34: 416–422
  • Vidal H. Obesity and inflammation: the adipocytokines. Ann Endocrinol (Paris) 2003; 64: S40–S44
  • Ridker P M, Glynn R J, Hennekens C H. C‐reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation 1998; 97: 2007–2011
  • Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart J C. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998; 98: 2088–2093
  • Elisaf M. Effects of fibrates on serum metabolic parameters. Curr Med Res Opin 2002; 18: 269–276
  • Zhao S P, Ye H J, Zhou H N, Nie S, Li Q Z. Gemfibrozil reduces release of tumor necrosis factor‐alpha in peripheral blood mononuclear cells from healthy subjects and patients with coronary heart disease. Clin Chim Acta 2003; 332: 61–67
  • Chen Y E, Fu M, Zhang J, Zhu X, Lin Y, Akinbami M A, Song Q. Peroxisome proliferator‐activated receptors and the cardiovascular system. Vitam Horm 2003; 66: 157–188
  • Staels B, Koenig W, Habib A, Merval R, Lebret M, Torra I P, Delerive P, Fadel A, Chinetti G, Fruchart J C, Najib J, Maclouf J, Tedgui A. Activation of human aortic smooth‐muscle cells is inhibited by PPARalpha but not by PPAR gamma activators. Nature 1998; 393: 790–793
  • Lee H J, Choi S S, Park M K, An Y J, Seo S Y, Kim M C, Hong S H, Hwang T H, Kang D Y, Garber A J, Kim D K. Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats. Biochem Biophys Res Commun 2002; 296: 293–299
  • Idzior‐Walus B, Sieradzki J, Rostworowski W, Zdzienicka A, Kawalec E, Wojcik J, Zarnecki A, Blane G. Effects of comicronised fenofibrate on lipid and insulin sensitivity in patients with polymetabolic syndrome X. Eur J Clin Invest 2000; 30: 871–878

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.