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Original Articles

Soybean Isoflavones: Effects of Processing and Health Benefits

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Pages 51-75 | Published online: 16 Aug 2006

References

  • Adlercreutz , H. , Hamalainen , E. , Gorbach , S. and Goldin , B. 1992a . Dietary phytoestrogens and the menopause in Japan . Lancet , 339 : 1233 (letter)[PUBMED] [INFOTRIEVE]
  • Akiyama , T. , Ishida , J. , Nakagawa , S. , Ogawara , H. , Watanabe , S. , Itoh , N. , Shibuya , M. and Fukami , Y. 1987 . Genistein a specific inhibitor of tyrosine protein kinases . J. Biol. Chem. , 262 : 5592 – 5595 . [PUBMED] [INFOTRIEVE]
  • Anderson , J. J. , Ambrose , W. W. and Garner , S. C. 1995b . Orally dosed genistein from soy and prevention of cancerous bone loss in two ovariectomized rat models . J. Nutr. , 125 : 799S (abs)
  • Anderson , J. J. B. , Thomsen , K. and Christiansen , C. 1987 . “ High protein meals, insular hormones and urinary calcium excretion in human subjects ” . In Osteoporosis Edited by: Christiansen , C. , Johansen , J. S. and Riis , B. J. 240 – 245 . Viborg, , Denmark : Nrrhaven A/S .
  • Anderson , J. W. , Johnstone , B. M. and Cook-Newell , M. L. 1995a . Meta-analysis of the effects of soy protein intake on serum lipids . N. Engl. J. Med. , 333 : 276 – 282 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Anthony , M. S. , Burke , G. L. , Hughes , C. L. Jr. and Clarkson , T.B. 1995 . Does soy improve coronary heart disease (CHD) risk? . Circulation , 91 : 925 – 929 .
  • Anthony , M. S. , Clarkson , T. B. , Hughes , C. L. Jr. , Morgan , T. M. and Burke , G. L. 1996 . Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys . J. Nutr. , 126 : 43 – 50 . [PUBMED] [INFOTRIEVE]
  • Badger , T. M. , Ronis , M. J. J. , Kakkak , R. , Rowlands , J. C. and Korourian , S. 2002 . The health consequences of early soy consumption . J. Nutr. , 132 : 559S – 565S . [PUBMED] [INFOTRIEVE]
  • Baird , D. D. , Umbach , D. M. , Lansdell , L. , Hughes , C. L. , Setchell , K. D. R. , Weinberg , C. R. , Haney , A. F. , Wilcox , A. J. and McLachlan , J. A. 1995 . Dietary intervention study to assess estrogenicity to dietary soy among postmenopausal women . J. Clin. Endocrinol. Metab. , 80 : 1685 – 1690 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Barnes , S. and Kim , H. 1998 . Soy isoflavones, estrogens and growth factor signaling . The Soy Connection Newsletter , 6 : 2 [CSA]
  • Barnes , S. , Kirk , M. and Coward , L. 1994 . Isoflavones and their conjugates in soy foods: extraction conditions and analysis by HPLC-mass spectrometry . J. Agric. Food Chem. , 42 : 2466 – 2474 .
  • Barz , W. and Welle , R. 1992 . “ Biosynthesis and metabolism of isoflavones and pterocarpan phytoalexins in chickpea, soybean and phytopathogenic fungi ” . In Recent Advances in Phytochemistry: Phenolic Metabolism in Plants Edited by: Stafford , H. A. and Ibrahim , R. K. Vol. 26 , 139 – 164 . New York, NY : Plenum Press .
  • Bennets , H. W. , Underwood , E. J. and Shier , F. L. 1946 . A specific breeding problem of sheep on subterranean clover pasture in Western Australia . Aust. J. Agric. Res. , 22 : 131 – 138 .
  • Bickoff , E. M. , Livingston , A. L. , Hendrickson , A. P. and Booth , A. N. 1962 . Relative potency of several estrogen-like compounds found in forages . J. Agric. Food Chem. , 10 : 410 – 413 .
  • Blair , H. C. , Jordan , S. E. , Peterson , T. G. and Barnes , S. 1996 . Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats . J. Cellular Biochem. , 61 : 629 – 637 .
  • Brandi , M. L. 1993 . New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs . Am. J. Med. , 95 : 69S – 74S . [PUBMED] [INFOTRIEVE] [CROSSREF]
  • Brenner , B. M. , Meyer , T. W. and Hostetter , T. H. 1982 . Dietary protein intake and the progressive nature of kidney disease . N. Engl. J. Med. , 307 : 652 – 657 . [PUBMED] [INFOTRIEVE]
  • Breslau , N. A. , Brinkley , L. , Hill , K. D. and Pak , C. Y. C. 1988 . Relationship of animal protein-rich diet to kidney stone formation and calcium metabolism . J. Clin. Endocrinol. Metabol. , 66 : 140 – 145 . [CSA]
  • Brzezinski , A. , Adlercreutz , H. , Shaoul , R. , Rosler , A. , Shmueli , A. , Tanos , V. and Schenker , J. G. 1997 . Short-term effects of phytoestrogen-rich diet on postmenopausal women . Menopause , 4 : 89 – 94 .
  • Burke , G. L. The potential use of a dietary soy supplement as a post-menopausal hormone replacement therapy . In: The Abstracts of the 2nd International Symposium on the Role of Soy in Preventing and Treating Chronic Disease . Sept 15–18 , Brussel, Belgium. pp. 40
  • Cassidy , A. , Bingham , S. and Setchell , K. D. R. 1994 . Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women: implications for the prevention of breast cancer . Am. J. Clin. Nutr. , 60 : 333 – 340 . [PUBMED] [INFOTRIEVE] [CSA]
  • Cassidy , A. , Bingham , S. and Setchell , K. D. R. 1994 . Biological effects of isoflavones in young women—importance of the chemical composition of soy products . Br. J. Nutr. , 74 : 587 – 594 . [CSA]
  • Col , N. , Eckman , M. H. , Karas , R. H. , Pauker , S.G. , Goldberg , R. J. , Ross , E. M. , Orr , R. K. and Wong , J. B. 1997 . Patient-specific decisions about hormone replacement therapy in postmenopausal women . J. Am. Med. Assoc. , 277 : 1140 – 1147 . [CROSSREF]
  • Coward , L. , Smith , M. , Kirk , M. and Barnes , S. 1998 . Chemical modification of isoflavones in soy foods during cooking and processing . Am J. Clin. Nutr. , 68 ( suppl ) : 1486S – 1491S . [PUBMED] [INFOTRIEVE] [CSA]
  • Crouse , J. R. , Terry , J. G. , Morgan , T. M. , McGill , B. L. , Davis , D. H. , King , T. , Ellis , J. E. and Burke , G. L. 1998 . Soy protein containing isoflavones reduces plasma concentrations of lipids and lipoproteins . Circulation , 97 : 816 (abs)
  • Cruz , M. L A. , Wong , W. W. , Mimouni , F. , Hachey , D. L. , Setchell , K. D. R. , Klein , P. D. and Tsang , R. C. 1994 . Effects of infant nutrition on cholesterol synthesis rates . Pediatr. Res. , 35 : 135 – 140 . [PUBMED] [INFOTRIEVE] [CSA]
  • D'amico , G. , Gentile , M. , Manna , G. , Fellin , G. , Ceceeri , R. , Cofano , F. , Petrini , C. , Lavarda , F. , Perolini , S. and Porrini , M. 1993 . Effects of vegetarian soy diet on hyperlipidaemia in nephritic syndrome . Lancet , 339 : 1131 – 1133 .
  • Dalais , F. S. , Rice , G. E. , Bell , R. J. , Murkies , A. L. , Medley , G. , Stauss , B. J. G. and Wahlquist , M. L. Dietary soy supplementation increases vaginal cytology maturation index and bone mineral content in postmenopausal women . In: The Abstracts of the 2nd International Symposium on the Role of Soy in Preventing and Treating Chronic Disease . Sept 15–18 , Brussels, Belgium. pp. 44
  • Duncan , A. M. , Merz-Demlow , B. E. , Xu , X. , Phipps , W. R. and Kurzer , M. S. 2000 . Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer . Cancer Epidemiol. Biomakers Prev. , 9 : 581 – 586 .
  • Ebel , J. and Grisebach , H. 1988 . Defense strategies of soybean against the fungus Phytophthora megasperma f.sp. Glycinea: a molecular analysis . Trends Biochem. Sci. , 13 : 23 – 27 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Eldridge , A. and Kwolek , W . 1983 . Soybean isoflavones: effect of environment and variety on composition . J. Agric. Food Chem. , 31 : 394 – 396 . [PUBMED] [INFOTRIEVE]
  • Evans , B. A. J. , Griffiths , K. and Morton , M. S. 1995 . Inhibition of 5α-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids . J. Endocrinol. , 147 : 295 – 302 . [PUBMED] [INFOTRIEVE]
  • Farmakalidis , E. and Murphy , P. A. 1985 . Isolation of 6″-O-acetylgenistein and 6:-O-acetyldaidzein from toasted defatted soy flakes . J. Agric. Food Chem. , 33 : 385 – 389 .
  • Food and Drug Administration (FDA). 1999 . Food labeling: health claims, soy protein and coronary heart disease . Fed. Regist. , 57 : 699 – 733 .
  • Geller , J. , Sionitt , L. , Partido , C. , Espanol , M. , Barnes , S. and Hoffman , R. M. High Inhibitory Effect of the Isoflavones, Genistein, on the Growth of Human Benign Prostate Hypotrophy Tissue In Histoculture . In: Proceedings of the 10th International Endocrinology Conference . June 12–15 , San Francisco. pp. 156
  • Green , J. and Kleenman , C. R. 1991 . Role of bone in regulation of systemic acid–base balance . Kidney Int. , : 9 – 13 .
  • Harding , C. , Mortan , M. , Gould , V. , McMichael-Phillips , D. , Howell , A. and Bundredd , N. J. Dietary soy supplementation in oestrogenic in menopausal women . In: The Abstracts of the 2nd International Symposium on the Role of Soy in Preventing and Treating Chronic Disease . Sept 15–18 , Brussels, Belgium. pp. 46
  • Ho , S. C. 1996 . Body measurements, bone mass and fractures—does the East differ from the West? Clin . Orthop. Relat. Res. , 323 : 75 – 80 . [CROSSREF]
  • Hodges , R. E. , Krehl , W. A. , Stone , D. B. and Lopez , A. 1967 . Dietary carbohydrates and low cholesterol diets: effects on serum lipids of man . Am. J. Clin. Nutr. , 20 : 198 – 203 . [PUBMED] [INFOTRIEVE]
  • Huggert , A. C. , Pridmore , S. , Malnoe , A. , Haschke , F. and Offord , E. A. 1997 . Phytoestrogens in soy-based infant formula . Lancet , 350 : 815 – 816 .
  • Jordan , V. C. 1997 . Tamoxifen: the herald of a new era of preventative therapeutics . J. Natl. Cancer Inst. , 89 : 747 – 749 . [PUBMED] [INFOTRIEVE] [CROSSREF]
  • Jordan , V. C. 1990 . The only true antioestrogen is no oestrogen . Mol. Cell. Endocrinol. , 74 : C91 – C96 . [PUBMED] [INFOTRIEVE] [CROSSREF]
  • Kim , H. , Peterson , T. G. and Barnes , S. 1998 . Mechanisms of action of the isoflavone genestein: emerging role of its effects through transforming growth factor beta signaling pathways . Am. J. Clin. Nutr. , 68 : 1418S – 1425S . [PUBMED] [INFOTRIEVE] [CSA]
  • Korzenik , J. R. , Burge , C. , White , R. , Barnes , S. and Topazian , M. 1995 . A pilot trial of soybean powder in the treatment of gastrointestinal hemorrhage and epistaxis in hereditary hemorrhagic telangectasia . J. Nutr. , 804 : 3S – 10S .
  • Kosslak , R. M. , Joshi , R. S. , Bower , B. A. , Paaren , H. E. and Appelbaum , E. R. 1990 . Strain specific inhibition of nod gene induction in Bardyrhizobium japonicum by flavonoid compounds . Appl. Environ. Microbiol. , 56 : 1333 – 1341 . [CSA]
  • Kudou , S. , Fleury , Y. , Welti , D. , Magnolato , D. , Uchida , T. , Kitamura , K. and Okubo , K. 1991 . Malonyl isoflavone glycosides in soybean seeds (Glycine max Merrill) . Biol. Chem. , 55 : 2227 – 2233 .
  • Kuiper , G. G. J. M. , Nilsson , S. and Gustaffson , J.-A. 1998 . “ Characteristics and function of the novel estrogen receptor β ” . In Hormones and Signaling Edited by: O'Malley , B. W . Vol. 1 , 89 – 112 . New York, NY : Academic Press .
  • Kurowaska , E. M. , Jordan , J. , Spence , J. D. , Wetmore , S. , Piche , L. , Radzikowski , M. and Carroll , K. K. Role of the main components of whole soybean products, soy protein and soy oil in reducing hypercholesterolemia . In: The Abstracts of the 2nd International Symposium on the Role of Soy in Preventing and Treating Chronic Disease . Sept 15–18 , Brussels, Belgium. pp. 22
  • Kurzer , M. S. 2002 . Hormonal effects of soy in premenopausal women and men . J. Nutr. , 132 : 570S – 573S . [PUBMED] [INFOTRIEVE]
  • Lamartiniere , C. A. , Moore , J. B. , Brown , N. M. , Thomson , R. , Hardin , M. J. and Barnes , S. 1995 . Genistein suppresses mammary cancer in rats . Carcinogenesis , 16 : 2833 – 2840 . [PUBMED] [INFOTRIEVE]
  • Liggins , J. , Mulligan , A. , Runswick , S. and Bingam , S. A. 2002 . Daidzein and genestein contents of cereals . Euro. J. Clin. Nutr. , 56 : 961 – 966 . [CROSSREF] [CSA]
  • Lin , S. H. , Peng , H. C. and Chien , Y. W. 2002 . The contents and distribution of major isoflavones in commercial soy products . Nutr. Science J. (abstract) , 27 : 139 – 146 . [CSA]
  • Liu , K. 1997 . “ Chemistry and nutritional value of soybean components ” . In Soybeans: Chemistry Technology and Utilization Edited by: Liu , K. 83 – 93 . New York, NY : Chapman and Hall, International Thomson Pub .
  • Lock , M. 1994 . Menopause in cultural context . Expt. Gerontol. , 29 : 307 – 311 . [CROSSREF] [CSA]
  • Mahungu , S. M. , Diaz-Mercado , S. , Li , J. , Schwenk , M. , Singletary , K. and Faller , J. 1999 . Stability of isoflavones during extrusion processing of corn/soy mixture . J. Agric. Food Chem. , 47 : 279 – 284 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Matsamura , M. and Obata , A. 1993 . β-glucosidases from soybeans hydrolyze daidzein and genistein . J. Food Sci. , 58 : 144 – 147 .
  • Matsuda , S. , Narimoto , F. , Matsumoto , Y. , Ohba , R. , Teramoto , Y. , Ohta , N. and Ueda , S. 1994 . Solubilization of a novel isoflavone glycoside-hydrolyzing β-glucosidase from Lactobacillus casei Sub sp Rhamnosus . J. Ferment. Bioeng. , 77 : 439 – 442 . [CROSSREF] [CSA]
  • McAllister , K. A. , Grogg , K. M. , Johnson , D. W. , Gallione , C. J. , Baldwin , M. A. , Jackson , C. E. , Helmbold , E. A. , Markel , D. , McKinnon , W. C. and Murell , J. 1994 . Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary hemorrhagic telangiectasin, type 1 . Nature Genetics , 8 : 345 – 351 . [PUBMED] [INFOTRIEVE] [CROSSREF]
  • Messina , M. J. 1997 . “ Soy foods: their role in disease prevention ” . In Soybeans: Chemistry Technology and Utilization Edited by: Liu , K. 443 – 477 . ITP Florence, KY : Chapman and Hall .
  • Messina , M. J. , Persky , V. , Setchell , K. D. R. and Barnes , S. 1994 . Soy intake and cancer risk. A review of the in vitro and in vivo data . Cancer , 21 : 113 – 131 .
  • Mitchell , J. H. , Cawood , E. , Kinniburgh , D. , Provan , A. , Collins , A., R. and Irvine , D. S. 2001 . Effects of a phytoestrogen food supplement on reproductive health of normal males . Clin. Sci. , 100 : 613 – 618 . [PUBMED] [INFOTRIEVE]
  • Morton , M. S. , Chan , P. S. F. , Cheng , C. , Blacklock , N. , MatosFerreira , A. , AbranchesMonteiro , N. , Correia , R. , Lloyd , S. and Griffiths , K. 1997 . Lignans and isoflavonoids in plasma and prosthetic fluids in men: samples from Portugal, Hong Kong and the UK . Prostrate. , 32 : 122 – 128 .
  • Murphy , C. T. , Kellie , S. and Westwick , J. 1993 . Tyrosine-kinase activity in rabbit's platelets stimulated with platelet-activating factor . Eur. J. Biochem. , 216 : 639 – 643 . [PUBMED] [INFOTRIEVE]
  • Murphy , P. A. , Song , T. , Buseman , G. and Barua , K. 1997 . Isoflavones in soy-based infant formulas . J. Agric. Food Chem. , 45 : 4635 – 4638 . [CROSSREF]
  • Murrill , W. B. , Brown , N. , Zhang , J.-X. , Manzolillo , P. A. , Barnes , S. and Lamartiniere , C. A. 1996 . Prepubertal genistein exposure suppresses mammary cancer enhances gland differentiation in rats . Carcinogenesis , 17 : 1451 – 1456 . [PUBMED] [INFOTRIEVE]
  • Nilausen , K. and Meinertz , H. Variation in the plasma lipoprotein response to the dietary soy protein in normolipidemic men . In: The Abstracts of the 2nd International Symposium on the Role of Soy in Preventing and Treating Chronic Disease . Sept 15–18 , Brussels, Belgium. pp. 47
  • Onoe , Y. , Miyaura , C. , Ohta , H. , Nozawa , S. and Suda , T. 1997 . Expression of estrogen receptor beta in rat bone . Endocrinology , 138 : 4509 – 4515 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Peterson , G. and Barnes , S. 1991 . Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance . Biochem. Biophys. Res. Comm. , 179 : 661 – 667 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Pienta , K. J. and Esper , P. S. 1993 . Risk factors for prostate cancer . Ann. Intern. Med. , 118 : 793 – 797 . [PUBMED] [INFOTRIEVE]
  • Potter , S. M. , Baum , J. , Surya , P. and Erdman , J. W. Jr. Effects of soy protein and isoflavones on plasma lipid profiles in postmenopausal women . In: The Abstracts of the 2nd International Symposium on the Role of Soy in Preventing and Treating Chronic Disease . Sept 15–18 , Brussels, Belgium. pp. 22
  • Potter , S. M. , Baum , J. A. , Teng , H. , Stillman , R. J. , Shay , N. F. and Erdman , J. W. 1998 . Soy proteins and isoflavones: their effects on blood lipids and bone density in postmenopausal women . Am. J. Clin. Nutr. , 68 : 1375S – 1379S . [PUBMED] [INFOTRIEVE] [CSA]
  • Powles , T. J. 1997 . Chemoprevention of breast cancer using tamoxifen . Endocrinol. Relat. Cancer , 4 : 255 – 260 . [CSA]
  • Pszczola , D. E. 2000 . Soy: why it's moving into the mainstream . Food Technol. , 54 : 76 – 86 .
  • Ruiz-Larrea , M. B. , Mohan , A. R. , Panganga , G. , Miller , N. J. , Bolwell , G. P. and RiceEvans , C. A. 1997 . Antioxidant activity of phytoestrogenic isoflavones . Free Radical Res. , 26 : 63 – 70 . [CSA]
  • Schleicher , R. , Zheng , M. , Zhang , M. and Lamartiniere , C. A. Genistein inhibition of prostate cancer cell growth and metastasis in vivo . In: The Abstracts of the 2nd International Symposium on the Role of Soy in Preventing and Treating Chronic Disease . Sept 15–18 , Brussels, Belgium. pp. 47
  • Setchell , K. D. R. 1998a . Absorption and metabolism of isoflavones . The Soy Connection Newsletter , 6 : 2 [CSA]
  • Setchell , K. D. R. 1998b . Phytoestrogens: biochemistry, physiology and implications for human health of soy isoflavones . Am. J. Clin. Nutr. , 68 : 1333S – 1346S . [PUBMED] [INFOTRIEVE] [CSA]
  • Setchell , K. D. R. , Brown , N. B. , Zimmer-Nechemias , L. , Brashear , W. T. , Wolf , B. , Kirsher , A. S. and Heubi , J. E. 2002 . Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability . Amer. J. Clin. Nutr. , 76 : 447 – 453 . [PUBMED] [INFOTRIEVE] [CSA]
  • Setchell , K. D. R. , Brown , N. M. and Lydeking-Olsen , E. 2002 . The clinical importance of the metabolite equol—a clue to the effectiveness of soy and its isoflavones . J. Nutr. , 132 : 3577 – 3584 . [PUBMED] [INFOTRIEVE]
  • Setchell , K. D. R. and Cassidy , A. 1999 . Dietary isoflavones: biological effects and relevance to human health . J. Nutr. , 129 : 758S – 767S . [PUBMED] [INFOTRIEVE]
  • Setchell , K. D. R. , Nechemias-Zimmer , L. , Cai , J. and Heubi , J. E. 1997 . Exposure of infants to phytoestrogens from soy-based infant formulas . Lancet , 350 : 23 – 27 . [PUBMED] [INFOTRIEVE] [CROSSREF]
  • Setchell , K. D. R. , Nechemias-Zimmer , L. , Cai , J. and Heubi , J. E. 1998 . The isoflavones content of infant formulas and the metabolic fate of these pyhtoestrogens in early life . Am. J. Clin. Nutr. , 68 : 1453S – 1461S . [PUBMED] [INFOTRIEVE] [CSA]
  • Sharpe , R. M. and Skakkebaek , N. E. 1993 . Are estrogens involved in falling sperm counts and disorders in the male reproductive tract? . Lancet , 341 : 1392 – 1395 . [PUBMED] [INFOTRIEVE] [CROSSREF]
  • Sherkat , F. , Nilsson , M. , Eng , J. and Hadjis , M. 2001 . Effects of processing on the isoflavones content of soy and soy-bovine milk products . Food Australia , 53 : 264 – 266 .
  • Shutt , D. , Weston , R. H. and Hogan , J. P. 1970 . Quantitative aspects of phytoestrogen metabolism in sheep fed on sudterranean clover (Trifolium subterranean cultivar clare) or red clover (Trifolium pretense) . Aust. J. Agric. Res. , 21 : 713 – 722 . [CROSSREF]
  • Slavin , J. L. 1996 . Phytoestrogens in breast milk—another advantage of breast-feeding? . Clin. Chem. , 42 : 841 – 842 . [PUBMED] [INFOTRIEVE] [CSA]
  • Stampfer , M. J. , Colditz , G. A. and Willet , W. C. 1991 . Postmenopausal estrogen therapy and cardiovascular disease . N. Engl. J. Med. , 325 : 756 – 762 . [PUBMED] [INFOTRIEVE]
  • Teusch , M. and Forkmann , G. 1987 . Malonyl-coenzyme A: Anthocynidin 3-glucoside malonyltransferase from flowers of Callistephus chinensis . Phytochemistry , 26 : 2181 – 2183 . [CROSSREF]
  • Tobais , J. H. , Cook , D. G. , Chambers , T. J. and Dalzell , N. 1994 . A comparison of bone mineral density between Caucasian, Asian and Afro-Caribbean women . Clin. Sci. (Lond). , 87 : 587 – 591 . [CSA]
  • Wachman , A. and Bernstein , D. S. 1968 . Diet and osteoporosis . Lancet May , 1 : 958 – 963 . [CROSSREF] [CSA]
  • Waggle , D. and Bryan , B. Recovery of Isoflavones from Soy Molasses . United States Patent 6,083,552 . (2000)
  • Wang , H. J. and Murphy , P. A. 1994b . Isoflavone composition of American and Japanese soybeans in Iowa: effects of variety, crop year and location . J. Agric. Food Chem. , 42 : 1674 – 1677 .
  • Wang , H. J. and Murphy , P. A. 1994 . Isoflavone content in commercial soybean foods . J. Agric. Food Chem. , : 1666 – 1673 .
  • Wang , H. J. and Murphy , P. A. 1996 . Mass balance study of isoflavones during soybean processing . J. Agric. Food Chem. , 44 : 2377 – 2383 . [CROSSREF]
  • Wang , J. and Sporns , P. 2000 . MALDI—TOF MS analysis of isoflavones in soy products . J. Agric. Food Chem. , 48 : 5887 – 5892 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Wilcox , G. , Wahlqvist , M. L. , Burger , H. G. and Medley , G. 1990 . Oestrogen effects of plant derived foods in postmenopausal women . Br. Med. J. , 301 : 905 – 906 .
  • Witztum , J. L. 1994 . The oxidation hypothesis of atherosclerosis . Lancet , 344 : 793 – 795 . [PUBMED] [INFOTRIEVE] [CROSSREF]
  • Woods , M. N. , Senie , R. and Kronenberg , F. Effects of dietary soy bar on menopausal symptoms . In: The Abstracts of the 2nd International Symposium on the Role of Soy in Preventing and Treating Chronic Disease . Sept 15–18 , Brussels, Belgium. pp. 41
  • Woods , R. J. 2000 . Searching for the determinants of intestinal calcium absorption . Am. J. Clin. Nutr. , 72 : 675 – 680 . [CSA]
  • Wu , A. H. , Ziegler , R. G. , Pike , M. C. , Nomura , A. M. Y. , West , D. W. , Kolonel , L. N. , Hornsross , P. L. , Rosenthel , J. F. and Hoover , R. N. 1996 . Menstral and reproductive factors and risk of breast cancer . Br. J. Cancer , 73 : 680 – 686 . [PUBMED] [INFOTRIEVE]
  • Xu , X. , Harris , K. S. , Wang , H.-J. , Murphy , P. A. and Hendrich , S. 1995 . Bioavailability of soybean isoflavones depends upon gut microflora in women . J. Nutr. , 125 : 2307 – 2315 . [PUBMED] [INFOTRIEVE]
  • Yoshida , K. , Tsukamoto , T. , Torii , H. , Doi , T. , Naeshiro , I. , Uemura , I. and Tanayama , S. 1985 . Metabolism of Ipriflavone (TC-80) in rats . Radioisotopes , 34 : 612 – 617 . [PUBMED] [INFOTRIEVE]
  • Zhou , Y. and Lee , A. S. 1998 . Mechanism for the suppression of the mammalian stress response by genestein, an anticancer phytoestrogen from soy . J. Natl. Cancer Inst. , 90 : 381 – 388 . [PUBMED] [INFOTRIEVE] [CROSSREF]
  • Zumoff , B. 1993 . Biological and endocrinological insights into the possible breast cancer risk from postmenopausal estrogen replacement therapy . Steroids , 58 : 196 – 204 . [PUBMED] [INFOTRIEVE] [CROSSREF]

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