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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 32, 2003 - Issue 1-2
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Original

Disregulated Expression of the Th2 Cytokine Gene in Patients with Intraoral Squamous Cell Carcinoma

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Pages 17-30 | Published online: 17 Mar 2003

References

  • Banat G. A., Christ O., Cochlovius B., Pralle H. B., Zoller M. Tumour‐induced suppression of immune response and its correction. Cancer Immunol. Immunother. 2001; 49: 573–586
  • Barth R. J., Jr., Camp B. J., Martuscello T., Dain B. J., Memoli V. J. The cytokine microenvironment of human colon carcinoma lymphocyte expression of tumor necrosis factor‐γ and interleukin‐4 predicts improved survival. Cancer 1996; 78: 1168–1177
  • Chen L., Linsley P. S., Hellstrom K. E. Costimulation of T‐cells for tumour immunity. Immunol. Today 1993; 14: 483–486
  • Coffman R. L., Varkila K., Scott P., Chatelain R. Role of cytokines in the differentiation of CD4+ T‐cell sub‐sets in vivo. Immunol. Rev. 1991; 123: 189–197
  • Das S. N., Khanna N. N., Khanna S. Delayed hypersensitivity in patients with carcinoma of the oral cavity. Ann. Acad. Med. Singap. 1983; 12: 416–419
  • Das S. N., Khanna N. N., Khanna S. An observation of in vivo and in vitro parameters of cellular immune competence in oral cancer and their correlation with tumour load and prognosis. Cancer Investig. 1986; 4: 207–218
  • Del Prete G. F., De Carli M., Ricci M., Romagnani S. Helper activity for immunoglobulin synthesis of T helper type I (Th1) and Th2 human T‐cell clones: the help of Th1 clones is limited by their cytotoxic capacity. J. Exp. Med. 1991; 174: 809–813
  • Ehlers S., Smith K. A. Differentiation of T‐cell lymphokine gene expression: the in vitro acquisition of T‐cell memory. J. Exp. Med. 1991; 173: 25–36
  • Gajewski T. F., Finch F. W. Antiproliferative effects of IFN‐γ in immune regulation I. IFN‐γ inhibits the proliferation of Th2 but not Th1 murine helper T‐lymphocyte clones. J. Immunol. 1988; 140: 4245–4252
  • Gajewski T. F., Lancki D. W., Stack R., Fitch F. W. Anergy of the Th0 helper T‐lymphocytes induces downregulation of Th1 characteristics and a transition to a Th‐2 like phenotype. J. Exp. Med. 1993; 179: 481–486
  • Goto S., Sato M., Kaneko R., Itoh M., Sato S., Takeuchi S. Analysis of Th1 and Th2 cytokine production by peripheral blood mononuclear cells as a parameter of immunological dysfunction in advanced cancer patients. Cancer Immunol. Immunother. 1999; 48: 435–442
  • Gratas C., Tohma Y., Barnas C., Taniere P., Hainaut P., Ohgaki H. Upregulation of Fas (APO‐1/CD95) ligand and downregulation of Fas expression in human oesophageal cancer. Cancer Res. 1998; 58: 2057–2062
  • Hahne M., Rimoldi D., Schroter M., Romero P., Schreier M., French L. E. Melanoma cell expression of Fas (Apo‐1/CD95) ligand; implications for tumour immune escape. Science 1996; 274: 1363–1366
  • Halak B. K., Maguire H. C., Lattime E. C. Tumour induced interleukin 10 inhibits type I immune responses directed at a tumour antigen as well as a non tumour antigen present at the tumour site. Cancer Res. 1999; 59: 911–917
  • Heinzel F. P., Sadick M. D., Holaday B. J., Coffman R., Locksley R. M. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T‐cell subsets. J. Exp. Med. 1989; 169: 59–72
  • Hsieh C. S., Heimberger A. B., Gold J. S., O'Garra A., Murphy K. Differential regulation of T‐helper phenotype development by IL‐4 and IL‐10 in an αβ–transgenic system. Proc. Natl. Acad. Sci. U. S. A. 1992; 89: 6065–6069
  • Jung T., Lack G., Schauer U., Uberuck W., Renz H., Gelfand E. W., Rieger C. H. Allergens, IgE1 mediators inflammatory mechanisms. Decreased frequency of interferon‐γ and interleukin‐2 producing cells in patients with atopic diseases measured at the single cell level. J. Allergy Clin. Immunol. 1995; 96: 515–527
  • Kelso A., Groves P., Troutt A. B., Francis K. Evidence for the stochastic acquisition of cytokine profile by CD4+ T‐cells activated in a T‐helper type 2‐like response in vivo. Eur. J. Immunol. 1995; 25: 1168–1175
  • Khanna N. N., Das S. N., Khanna S. Serum immunoglobulins in squamous cell carcinoma of the oral cavity. J. Surg. Oncol. 1982; 20: 46–48
  • Knerer B., Hulla W., Martinek H., Formanek M., Temmel A., Kornfehl J. IL‐1 and TNF‐α but not IL‐2 expression is found in squamous cell carcinomas of the head and neck by RT‐PCR. Acta Oto‐laryngol. 1996; 116: 132–136
  • Lucey D. R., Clerici M., Shearer G. M. Type I and type II cytokine disregulation in human infections, neoplastic and inflammatory diseases. Clin. Microbiol. Rev. 1996; 9: 532–562
  • Macatonia S. E., Hsieh C. S., Murphy K., O'Garra A. Dendritic cells and macrophages are required for Th1 development of CD4+ T‐cells from αβ‐TCR transgenic mice: IL‐12 substitution for macrophages to stimulate IFN‐γ production in IFN‐γ dependent. Int. Immunol. 1993; 5: 1119–1128
  • Maggi E., Parronchi P., Manetti R., Simonelli C., Piccinni M. P., Rugiu F. S., et al. Reciprocal regulatory effects of IFN‐γ and IL‐4 on the in vitro development of human Th1 and Th2 clones. J. Immunol. 1992; 148: 2142–2147
  • Meyaard L., Hovenkamp E., Keet I. P.M., Hooibrink B., Jong I. H., Otto S. A., Meidema F. Single cell analysis of IL‐4 and IFN‐γ production by T‐cells from HIV‐infected individuals. J. Immunol. 1996; 157: 2712–2718
  • Misra N., Murtaza A., Walker B., Shankar Narayan N. P., Misra R. S., Ramesh V., et al. Cytokine profile of circulating T‐cells of leprosy patients reflect both indiscriminate and polarized T‐helper subsets: T‐helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae. Immunology 1995; 86: 97–103
  • Mosmann T. R., Chervinski H., Bond M. W., Geidlin M. A., Coffman R. L. Two types of murine helper T‐cell clone. I. Definition according to profile of lymphokine activities and secreted proteins. J. Immunol. 1986; 136: 2348–2357
  • Mosmann T. R., Schumacher J. H., Street N. F., Budd R., O'Gara A., Fong T. A. Diversity of cytokine synthesis and function of mouse CD4+ T‐cells. Immunol. Rev. 1991; 123: 209–229
  • Mullis K. B., Faloona F. A. Specific synthesis of DNA in vitro via a polymerase catalyzed chain reaction. Methods Enzymol. 1987; 155: 335–350
  • O'Gara A., Murphy K. Role of cytokines in determining T‐lymphocyte functions. Curr. Opin. Immunol. 1994; 6: 458–466
  • Pellegrini P., Barghella A. M., Del Beato T., Cicia S., Adorono D., Casciani C. U. Disregulation in Th1 and Th2 subsets of CD4+ T‐cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression. Cancer Immunol. Immunother. 1996; 42: 1–8
  • Powrie F., Coffman R. Interleukin‐4 and Interleukin‐10 synergize to inhibit cell mediated immunity in vivo. Eur. J. Immunol. 1993; 23: 2223–2229
  • Rabinowich H., Suminami Y., Reichert T. E., Crowley‐Nowick P., Bell M., Edwards R. Expression of cytokine genes or proteins and signalling molecules in lymphocytes associated with human ovarian carcinoma. Int. J. Cancer. 1996; 68: 276–284
  • Rosenberg S. A. Immunotherapy and gene therapy of cancer. Cancer Res. 1991; 51: 5074s–5079s
  • Roussel E., Cingras M. C., Grimm E. A., Bruner J. M., Moser R. P. Predominance of intratumoral immune response in fresh tumour‐infiltrating lymphocytes from human gliomas. Clin. Exp. Immunol. 1996; 105: 344–352
  • Seder R. A., Paul W. E. Acquisition of lymphokine producing phenotype by CD4+ T‐cells. Annu. Rev. Immunol. 1994; 12: 635–673
  • Tamada K., Harada M., Abe K., Li T., Nomoto K. Immunosuppressive activity of cloned natural killer (NK 1.1+) T‐cell established from murine tumour infiltrating lymphocytes. J. Immunol. 1997; 158: 4846–4854
  • Tinhofer I., Marschitz I., Kos M., Henn T., Egle E., Villunger A., Greil R. Differential sensitivity of CD4+ and CD8+ T‐lymphocytes to the killing efficacy of Fas (Apo1/CD95) ligand+ tumour cells in B chronic lymphocytic leukemia. Blood 1998; 91: 4273–4284
  • Walker B. R., Butler R., Colston M. J. Role of Th1 lymphocytes in the development of protective immunity against Mycobacterium leprae. Analysis of lymphocyte function by polymerase chain reaction detection of cytokine messenger RNA. J. Immunol. 1992; 148: 1885–1889
  • Wang M. B., Lichtensteim A., Mickel R. A. Hierarchical immunosuppression of regional lymphnodes in patients with head and neck squamous cell carcinoma. Otolaryngol. Head Neck Surg. 1991; 105: 517–527
  • Wang Q., Redovan C., Tubbs R., Olencki T., Klein E., Kudoh S. Selective cytokine gene expression in renal cell carcinoma tumour cells and tumour infittrating lymphocytes. Int. J. Cancer. 1995; 61: 780–785
  • Woods K. V., El‐Naggar A., Clayman G. L., Grimm E. A. Variable expression of cytokines in human head and neck squamous cell carcinoma cell lines and consistent expression in surgical specimens. Cancer Res. 1998; 58: 3132–3141
  • Zaks T. Z., Chappell D. B., Rosenberg S. A., Restifo N. P. CD95‐mediated suicide of tumour‐reactive T‐cells following activation by specific tumour selective rescue by caspase inhibition. J. Immunol. 1999; 162: 3273–3279

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