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Research Article

PARTICIPATION OF CONTRASTING CHANGES IN IL-10 AND IL-12 production-dates printpubdate="05/03/02" IN THE REDUCTION OF TH1-PREDOMINANCE BY HACHIMI-JIO-GAN IN AUTOIMMUNE MRL/MP-lpr/lpr MICE

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Pages 17-29 | Published online: 20 May 2002

References

  • Andrew B.S., Eisenberg R.A., Theofilopoulos A.N., Izui S., Wilson C.B., McConahey P.J., Murphy E.D., Roths J.B., Dixon F.J. Spontaneous Murine Lupus-like Syndromes. Clinical and Immunopathological Manifestations in Several Strains. J. Exp. Med. 1978; 148: 1198–1215
  • Watanabe-Fukunaga R., Brannan C.I., Copeland N.G., Jenkins N.A., Nagata S. Lymphoproliferation Disorder in Mice Explained by Defects in Fas Antigen that Mediates Apoptosis. Nature (Lond.) 1992; 356: 314–317
  • Radvanyi L.G., Raju K., Spaner D., Mills G.B., Miller R.G. Interleukin-2 Reverses the Defect in Activation-Induced Apoptosis in T Cells from Auto-immune lpr Mice. Cellular Immunol. 1998; 183: 1–12
  • Koh D.R., Ho A., Rahemtulla A., Fund-Leung W., Griesser H., Mak T. Murine Lupus in MRL/lpr Mice Lacking CD4 or CD8 T Cell. Eur. J. Immunol. 1995; 25: 2558–2562
  • Takahashi S., Fossati L., Iwamoto M., Merino R., Motta R., Kobayakawa T., Izui S. Imbalance Towards Th1 Predominance is Associated with Acceleration of Lupus-like Autoimmune Syndrome in MRL Mice. J. Clin. Invest. 1996; 97: 1597–1604
  • Hsieh C.S., Macatonia S.E., Tripp C.S., Wolf S.F., O'garra A., Murphy K.M. Development of Th1 CD4+ Cells Through IL-12 Produced by Listeria-Induced Macrophage. Science 1993; 260: 547–549
  • Macatonia S.E., Hosken N.A., Litton M., Vieira P., Hsieh C.S., Cuplpepper J.A., Wysocka M., Trinchieri K.M., O'Garra A. Dendritic Cells Produce IL-12 and Direct the Development of Th1 Cells from Naïve CD4+ T Cells. J. Immunol. 1995; 154: 5071–5079
  • Stern A.S., Podlaski F.J., Hulmes J.D., Pan Y.E., Quinn P.M., Wokitzky A.G., Familletti P.C., Stremlo T., Truitt R., Chizzonite R., Gately M.K. Purification to Homogeneity and Partial Characterization of Cytotoxic Lymphocyte Maturation Factor from Human B-Lymphoblastoid Cells. Proc. Natl. Acad. Sci. U.S.A. 1990; 87: 6808–6812
  • Seder R.A., Gazzinelli R., Sher A., Paul W.E. Interleukin 12 Acts Directly CD4+ T Cells to Enhance Priming for Interferon g production-dates printpubdate="05/03/02" and Diminishes Interluekin 4 Inhibition of such Priming. Proc. Natl. Acad. Sci. U.S.A. 1993; 90: 10,188–10,192
  • Schwarting A., Tesch G., Kinoshita K., Maron R., Weiner H.L., Kelly R.V. IL-12 Drives IFN-γ-Dependent Autoimmune Kidney Disease in MRL-Faslpr mice. J. Immunol. 1999; 163: 6884–6891
  • Okamura H., Tsutsui H., Komatsu T., Yutsudo M., Hakura A., Tanimoto T., Torigoe K., Okura T., Nukada Y., Hattori K., Kurimoto M. Cloning of New Cytokine that Induces IFN-γ production-dates printpubdate="05/03/02" by T Cells. Nature 1995; 378: 88–91
  • Ushio S., Namba K., Hattori K., Nukada Y., Akita K., Tanabe K., Micallef M., Fujii M., Torigoe K., Tanimoto T., Fukuda S., Ikeda M., Okamura H., Kurimoto M. Cloning of cDNA for Human IFN-γ Inducing Factor, Expression in Escherichia coli, and Studies on the Biological Activities of the Protein. J. Immunol. 1996; 156: 4274–4279
  • Inagawa H., Suzuki T., Kawakita T. Effect of Ba-Wei-Di-Huang-Wan (Japanese name, Hachimi-jio-gan) on Immunological Functional Disorders in Senescence Accelerated Mice (in Japanese). J. Trad. Med. 1998; 15: 189–193
  • Furuya Y., Kawakita T., Tajima S. Effect of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) on Insulin Resistance in Non-Insulin Dependent Diabetes Mellitus Model Mice (Japanese). J. Trad. Med. 1999; 16: 1123–128
  • Furuya Y., Kawakita T., Nomoto K. Immunomodulating Effect of a Traditional Japanese Medicine, Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan), on Th1 Predominance in Autoimmune MRL/MP-lpr/lpr Mice. Int. Immunopharmac. 2001; 1(3)551–559
  • Koch F., Stanzl U., Jennewein P., Janke K., Heufler C., Kampgen E., Romani N., Schuler G. High Level IL-12 production-dates printpubdate="05/03/02" by Murine Dendritic Cells, Upregulation via MHC Class II and CD40 Molecules and Downregulation by IL-4 and IL-10. J. Exp. Med. 1996; 184: 741–746
  • Shibata Y., Foster L.A., Kurimoto M., Okamura H., Nakamura R.M. Immunoregulatory Roles of IL-10 in Innate Immunity, IL-10 Inhibits Macrophage production-dates printpubdate="05/03/02" of IFN-γ-Inducing Factors but Enhances NK Cell production-dates printpubdate="05/03/02" of IFN-γ. J. Immunol. 1998; 161: 4283–4288
  • Malefyt R.W., Haanen J., Spits H., Roncarolo M.G., Velde A.T., Figdor C., Johnson K., Kastelein R., Yssel H., Vries J.E. Interleukin 10 (IL-10) and Viral IL-10 Strongly Reduce Antigen-Specific Human T Cell Proliferation by Diminishing the Antigen-Presenting Capacity of Monocytes via Downregulation of Class II Major Histocompatibility Complex Expression. J. Exp. Med. 1991; 174: 915–924
  • Fiorentino D.F., Zlotnik A., Mosmann T.R., Howard M., O'garra A. IL-10 Inhibits Cytokine production-dates printpubdate="05/03/02" by Activated Macrophages. J. Immunol. 1991; 147: 3815–3822
  • Bogdan C., Vodovotz Y., Nathan C. Macrophage Deactivation by Interleukin-10. J. Exp. Med. 1991; 174: 1549–1555
  • Thierfelder W.E., van Deursen J.M., Yamamoto K., Tripp R.A., Sarawar S.R., Carson R.T., Sangster M.Y., Vignali D.A., Doherty P.C., Grosveld G.C., Ihle J.N. Requirement for STAT4 in Interleukin-12-Mediated Responses of Natural Killer and T Cells. Nature 1996; 382: 1171–174
  • Kaplan M.H., Schindler U., Smiley S.T., Grusby M.J. STAT6 is Required for Mediateing Responses to IL-4 and for Development of Th2 Cells. Immunity 1996; 4: 313–319
  • Presky D.H., Yang H., Minetti L.J., Chua A.O., Navabi N., Wu C-Y., Gately M.K., Gubler U. A Functional Interleukin 12 Receptor Complex in Composed of Two β-Type Cytokine Receptor Subunits. Proc. Natl. Acad. Sci. U.S.A. 1996; 93: 14,002–14,007
  • Szabo S.J., Dighe A.S., Gubler U., Murphy K.M. Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 cells. J. Exp. Med. 1997; 185: 817–824
  • Thibodeauzx D.K., Hunter S.E., Waldburge K.E., Bliss J.L., Trepicchio W.L., Sypek J.P., Joannopoulos K.D., Goldman S.J., Leonard J.P. Autocrine Regulation of IL-12 Receptor Expression is Independent of Secondary IFN-γ Secretion and not Restricted to T and NK cells. J. Immunol. 1999; 163: 5257–5264
  • Yoshimoto T., Takeda K., Tanaka T., Ohkusu K., Kashiwamura S., Okamura H., Akira S., Nakanishi K. IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells, Synergism with IL-18 for IFN-γ production-dates printpubdate="05/03/02". J. Immunol. 1998; 161: 3400–3407
  • Marshall J.D., Aste-Amezaga M., Chehimi S.S., Murphy M., Olsen H., Trincheri G. Regulation of Human IL-18 mRNA Expression. Clin. Immunol. 1999; 90: 15–21
  • Ding L., Linsley P.S., Huang L.Y., Germain R.N., Shevach E.M. IL-10 Inhibits Macrophage Costimulatory Activity by Selectively Inhibiting the Up-Regulation of B7 Expression. J. Immunol. 1993; 151: 1224–1234

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