References
- Schlievert, P. M. Role of superantigens in human disease. J. Infect. Dis. 1993, 167, 997–1002. [PUBMED], [INFOTRIEVE]
- Stevens, D. L. The toxic shock syndromes. Infect. Dis. Clin. North Am. 1996, 10, 727–746. [PUBMED], [INFOTRIEVE], [CSA]
- O'Reilly, M.; Newcomb, D.E.; Remick, D. Endotoxin, sepsis, and the primrose path. Shock 1999, 12, 411–420. [PUBMED], [INFOTRIEVE]
- Ulevitch, R. J. Regulation of receptor-dependent activation of the innate immune response. J. Infect. Dis. 2003, 187, 351–355. [CROSSREF]
- Calandra, T.; Baumgartner, J.D.; Grau, G.E.; Wu, M.M.; Lambert, P.H.; Schellekens, J.; Verhoef, J.; Glauser, M.P.; and the Swiss-Dutch J5 Immunoglobulin Study Group Prognostic values of tumor necrosis factor/cachectin, interferon-alpha, and interferon-gamma in the serum of patients with septic shock. J. Infect. Dis. 1990, 161, 982–987. [PUBMED], [INFOTRIEVE]
- Kotzin, B. L.; Leung, D.Y.M.; Kappler, J.; Marrack, P.A. Superantigens and their potential role in human disease. Adv. Immunol. 1993, 54, 99–166. [PUBMED], [INFOTRIEVE]
- McCormick, J. K.; Yarwood, J.M.; Schlievert, P.M. Toxic shock syndrome and bacterial superantigens: an update. Annu. Rev. Microbiol. 2001, 55, 77–104. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Choi, Y.; Kotzin, B.; Hernon, L.; Callahan, J.; Marrack, P.; Kappler, J. Interaction of Staphylococcus aureus toxin “superantigens” with human T cells. Proc. Natl. Acad. Sci. U. S. A. 1989, 86, 8941–8945. [PUBMED], [INFOTRIEVE], [CSA]
- Scholl, P.; Diez, A.; Mourad, W.; Parsonnet, J.; Geha, R.S.; Chatila, T. Toxic shock syndrome toxin-1 binds to major histocompatibility complex class II molecules. Proc. Natl. Acad. Sci. U. S. A. 1989, 86, 4210–4214. [PUBMED], [INFOTRIEVE], [CSA]
- Baker, M. D.; Acharya, K.A. Superantigens: structure, function, and diversity. In Superantigen Protocols; Krakauer, T., Ed.; Humana Press: Totowa, NJ, 2003; 1–31.
- Jupin, C.; Anderson, S.; Damais, C.; Alouf, J.E.; Parant, M. Toxic shock syndrome toxin 1 as an inducer of human tumor necrosis factors and gamma interferon. J. Exp. Med. 1988, 167, 752–761. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Cameron, S. B.; Nawijn, M.C.; Kum, W.W.; Savelkoul, H.F.; Chow, A.W. Regulation of helper T cell responses to staphylococcal superantigens. Eur. Cytokine Netw. 2001, 12, 210–222. [PUBMED], [INFOTRIEVE], [CSA]
- Miethke, T.; Wahl, C.; Heeg, K.; Echtenacher, B.; Krammer, P.H.; Wagner, H. T cell-mediated lethal shock triggered in mice by the superantigen SEB: critical role of TNF. J. Exp. Med. 1992, 175, 91–98. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Krakauer, T.; Vilcek, J.; Oppenheim, J. J. Proinflammatory cytokines: TNF and IL-1 families, chemokines, TGFβ and others. In Fundamental Immunology, 4th Ed.; Paul, W., Ed.; Raven Press: Philadelphia, 1998; 619–783.
- Tao, X.; Lipsky, P. E. The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F. Rheum. Dis. Clin. North Am. 2000, 26, 29–50. [PUBMED], [INFOTRIEVE], [CSA]
- Gu, W. Z.; Brandwein, S.R. Inhibition of type II collagen-induced arthritis in rats by triptolide. Int. J. Immunopharmacol. 1998, 20, 389–400. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Wang, J.; Xu, R.; Jin, R.; Chen, Z.; Fidler, J. M. Immunosuppressive activity ofthe Chinese medicinal plant Tripterygium wilfordii. I. Prolongation of rat cardiac and renal allograft survival by the PG27 extract and immunosuppressive synergy in combination therapy with cyclosporine. Transplantation 2000, 70, 447–455. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Yang, S. X.; Xie, S.S.; Gao, H.L.; Ma, D.L.; Long, Z.Z. Triptolide suppresses T-lymphocyte proliferation by inhibiting interleukin-2 receptor expression, but spares interleukin-2 production and mRNA expression. Int. J. Immunopharmacol. 1994, 16, 895–904. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Tao, X.; Cai, J. J.; Lipsky, P.E. The identity of immunosuppressive components of the ethyl acetate extract and chloroform methanol extract (T2) of Tripterygium wilfordii Hook F. J. Pharmacol. Exp. Ther. 1995, 272, 1305–1312. [PUBMED], [INFOTRIEVE], [CSA]
- Chen, B. J. Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. Leuk. Lymphoma 2001, 42, 253–265. [PUBMED], [INFOTRIEVE], [CSA]
- Qiu, D.; Kao, P. N. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook F. Drugs R&D 2003, 4, 1–18. [CSA]
- Tao, X.; Schulze-Koops, H.; Ma, L.; Cai, J.; Mao, Y.; Lipsky, P. E. Effects of Tripterygium wilfordii hook F extracts on induction of cyclooxygenase 2 activity and prostaglandin E2 production. Arthritis Rheum. 1998, 41, 130–138. [PUBMED], [INFOTRIEVE]
- Lin, N.; Sato, T.; Ito, A. Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts. Arthritis Rheum. 2001, 44, 2193–2200. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Hu, K. B.; Liu, Z.H.; Guo, X.H.; Liu, D.; Li, L.S. Triptolide inhibits vascular endothelial growth factor expression and production in endothelial cells. Acta Pharmacol. Sin. 2001, 22, 651–656. [PUBMED], [INFOTRIEVE], [CSA]
- Zhao, G.; Vaszar, L. T.; Qiu, D.; Shi, L.; Kao, P.N. Anti-inflammatory effects of triptolide in human bronchial epithelial cells. Am. J. Physiol., Lung Cell. Mol. Physiol. 2000, 279, L958–L966. [CSA]
- Hong, Y.; Zhou, W.; Li, K.; Sacks, S. H. Triptolide is a potent suppressant of C3, CD40 and B7h expression in activated human proximal tubular epithelial cells. Kidney Int. 2002, 62, 1291–1300. [PUBMED], [INFOTRIEVE]
- Zhou, H. F.; Niu, D.B.; Xue, B.; Li, F.Q.; Liu, X.Y.; He, Q.H.; Wang, X.H.; Wang, X.M. Triptolide inhibits TNF-alpha, IL-1 beta and NO production in primary microglial cultures. NeuroReport 2003, 14, 1091–1095. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Qiu, D.; Zhao, G.; Aoki, Y.; Shi, L.; Uyei, A.; Nazarian, S.; Ng, J. C.; Kao, P.N. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J. Biol. Chem. 1999, 274, 13443–13450. [PUBMED], [INFOTRIEVE], [CROSSREF]
- Chang, W. T.; Kang, J.J.; Lee, K.Y.; Wei, K.; Anderson, E.; Gotmare, S.; Ross, J.A.; Rosen, G.D. Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway. J. Biol. Chem. 2001, 276, 2221–2227. [PUBMED], [INFOTRIEVE]
- Choi, Y. J.; Kim, T.G.; Kim, Y.H.; Lee, S.H.; Kwon, Y.K.; Suh, S.I.; Park, J.W.; Kwon, T.K. Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells. Biochem. Pharmacol. 2003, 66, 273–280., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Du, Z. Y.; Li, X.Y.; Li, Y.C.; Wang, S.Y. Analysis of triptolide-regulated gene expression in Jurkat cells by complementary DNA microarray. Acta Pharmacol. Sin. 2003, 24, 864–872. [PUBMED], [INFOTRIEVE], [CSA]
- Krishna, G.; Liu, K.; Shigemitsu, H.; Gao, M.; Raffin, T. A.; Rosen, G.D. PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis. Am. J. Pathol. 2001, 158 (3), 997–1004. [PUBMED], [INFOTRIEVE]
- Krakauer, T. Inhibition of toxic shock syndrome toxin-induced cytokine production and T cell activation by interleukin 10, interleukin 4, and dexamethasone. J. Infect. Dis. 1994, 172, 988–992.
- Krakauer, T. Induction of CC chemokines in human peripheral blood mononuclear cells by staphylococcal exotoxins and its prevention by pentoxifylline. J. Leukoc. Biol. 1999, 66, 158–164. [PUBMED], [INFOTRIEVE], [CSA]
- Yang, S. X.; Gao, H.L.; Xie, S.S.; Zhang, W.R.; Long, Z.Z. Immunosuppression of triptolide and its effect on skin allograft survival. Int. J. Immunopharmacol. 1992, 14, 963–969. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Faul, J. L.; Nishimura, T.; Berry, G.J.; Benson, G.V.; Pearl, R.G.; Kao, P.N. Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats. Am. J. Respir. Crit. Care Med. 2000, 162, 2252–2258. [PUBMED], [INFOTRIEVE], [CSA]
- Huynh, P. N.; Hikim, A.P.; Wang, C.; Stefonovic, K.; Lue, Y.H.; Leung, A.; Atienza, V.; Baravarian, S.; Reutrakul, V.; Swerdloff, R.S. Long-term effects of triptolide on spermatogenesis, epididymal sperm function, and fertility in male rats. J. Androl. 2000, 21, 689–699. [PUBMED], [INFOTRIEVE], [CSA]