2,238
Views
67
CrossRef citations to date
0
Altmetric
Original Articles

Preparative Isolation of Cannabinoids from Cannabis sativa by Centrifugal Partition Chromatography

, , , , &
Pages 2421-2439 | Received 01 Apr 2004, Accepted 20 Apr 2004, Published online: 11 Jun 2009

References

  • Turner , C. E. , Elsohly , M. A. and Boeren , E. G. 1980 . Constituents of Cannabis sativa L. XVII. A review of the natural constituents . J. Nat. Prod. , 43 ( 2 ) : 169 – 234 .
  • Williamson , E. M. and Evans , F. J. 2000 . Cannabinoids in clinical practice . Drugs , 60 ( 6 ) : 1303 – 1314 .
  • Taura , F. , Morimoto , S. and Shoyama , Y. 1995 . Cannabinerolic acid, a cannabinoid from Cannabis sativa. . Phytochemistry , 39 ( 2 ) : 457 – 458 .
  • Grotenhermen , F. 2002 . “ Effects of cannabis and cannabinoids ” . In Cannabis and Cannabinoids Edited by: Grotenhermen , F. and Russo , E. 55 – 67 . New York : Haworth Press .
  • Shoyama , Y. , Yagi , M. , Nishioka , I. and Yamauchi , T. 1975 . Biosynthesis of cannabinoid acids . Phytochemistry , 14 : 2189
  • Tampier , L. , Linetzky , R. , Mardones , J. and Gormaz , E. 1973 . Effect of cannabinols from marihuana on smooth muscle . Arch. Biol. Med. Exp. , 9 : 16
  • Mechoulam , R. , Gaoni , Y. and Hashish IV . 1965 . The isolation and structure of cannabinolic, cannabidiolic and cannabigerolic acids . Tetrahedron , 21 : 1223 – 1229 .
  • Yamauchi , T. , Shomaya , Y. , Aramaki , H. , Azuma , T. and Nishioka , I. 1967 . Tetrahydrocannabinolic acid, a genuine substance of tetrahydrocannabinol . Chem. Pharm. Bull. , 15 : 1075 – 1076 .
  • Mechoulam , R. and Ben‐Zvi , Z. 1969 . Carboxylation of resorcinols with magnesium carbonate. Synthesis of cannabinoid acids . Chem. Commun. , 7 : 343 – 344 .
  • Gaoni , Y. and Mechoulam , R. 1971 . The isolation and structure of delta‐1‐tetrahydrocannabinol and other neutral cannabinoids from hashish . J. Am. Chem. Soc. , 93 ( 1 ) : 217 – 224 .
  • Lehmann , T. and Brenneisen , R. 1992 . A new chromatographic method for the isolation of (−)‐Δ9‐(trans)tetrahydrocannabinolic acid A . Phytochem. Anal. , 3 : 88 – 90 .
  • Murayama , W. , Kobayashi , T. , Kosuge , Y. , Yano , H. , Nunogaki , Y. and Nunogaki , K. 1982 . A new centrifugal counter‐current chromatograph and its application . J. Chromatogr. , 239 : 643
  • Foucault , A. P. 1994 . Centrifugal Partition Chromatography New York : Marcel Dekker, Inc. .
  • Korte , F. , Haag , M. and Claussen , U. 1965 . Tetrahydrocannabinolcarboxylic acid, a component of hashish . Angew. Chem. Int. Ed. Eng. , 4 : 872
  • Stahl , E. 1967 . Duennschichtchromatographie, ein Laboratoriumshandbuch 236 Berlin : Springer Verlag .
  • Corrigan , D. and Lynch , J. J. 1980 . An investigation of potential staining reagents for the glandular trichomes of Cannabis sativa . Planta Med. , : 163 – 169 .
  • Budzikiewicz , H. , Alpin , R. T. , Lightner , D. A. , Djerassi , C. , Mechoulam , R. and Gaoni , Y. 1965 . Mass spectroscopy and its application to structural and stereochemical problems. 68. Mass spectroscopic studies of constituents of hashish . Tetrahedron , 21 : 1881 – 1888 .
  • Brenneisen , R. and ElSohly , M. A. 1988 . Chromatographic and spectroscopic profiles of cannabis of different origins: part I . J. Foren. Sci. , 33 ( 6 ) : 1385 – 1404 .
  • Ingkaninan , K. , Hazekamp , A. , Hoek , A. C. , Balconi , S. and Verpoorte , R. 2000 . Application of centrifugal partition chromatography in a general separation and dereplication procedure for plant extracts . J. Liq. Chromatogr. Relat. Technol. , 23 ( 14 ) : 2195 – 2208 .
  • Kanter , S. L. , Musumeci , M. R. and Hollister , L. E. 1979 . Quantitative determination of delta 9‐tetrahydrocannabinol and delta 9‐tetrahydro‐cannabinolic acid in marihuana by high‐pressure liquid chromatography . J. Chromatogr. , 171 : 504
  • Hazekamp , A. , Choi , Y. H. and Verpoorte , R. 2004 . Quantitative analysis of cannabinoids from Cannabis sativa using 1H‐NMR . Chem. Pharm Bull. , 52 : 718 – 721 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.