MASS SPECTROMETRY IN PHARMACEUTICAL ANALYSIS*

REFERENCES

• Abramson F P. Mass spectrometry in pharmacology. Meth Biochem Anal 1990; 34: 289
   PubMedGoogle Scholar
• Burlingame A L, Baillie T A, Russell D H. Mass spectrometry. Anal Chem. 1992; 64: 467R
   Web of Science ®Google Scholar
• Burlingame A L, Boyd R K, Gaskell S J. Mass spectrometry. Anal Chem. 1994; 66: 634R
   Google Scholar
• Siuzdak G. The emergence of mass spectrometry in biochemical research. Proc Natl Acad Sci (USA) 1994; 91: 11290
   PubMed Web of Science ®Google Scholar
• Ashton D S, Beddell C R, Green B N, Oliver R WA. Rapid validation of molecular structures of biological samples by electrospray-mass spectrometry. FEBS Lett 1994; 342: 1
   PubMed Web of Science ®Google Scholar
• Gelpi E. Biomedical and biochemical applications of liquid chromatography-mass spectrometry. J Chromatogr A 1995; 703: 59
   PubMed Web of Science ®Google Scholar
• Brewer E, Henion J. Atmospheric pressure ionization LC/MS/MS techniques for drug disposition studies. J Pharm Sci 1998; 87: 395
   PubMed Web of Science ®Google Scholar
• Niessen W M. Advances in instrumentation in liquid chromatography-mass spectrometry and related liquid-introduction techniques. J Chromatogr A 1998; 794: 407
   PubMed Web of Science ®Google Scholar
• Fenn J B, Mann M, Meng C K, Wong S F, Whitehouse C M. Electrospray ionization—Principles and practice. Mass Spec Rev 1990; 9: 37
   Web of Science ®Google Scholar
• Hamdan M, Curcuruto O. Development of the electrospray ionisation technique. Int J Mass Spectrom Ion Processes 1991; 108: 93
   Web of Science ®Google Scholar
• Huang E C, Henion J D. Packed-capillary liquid chromatography/ion-spray tandem mass spectrometry determination of biomolecules. Anal Chem 1991; 63: 732
   Web of Science ®Google Scholar
• Bruins A P. Mass spectrometry with ion sources operating at atmospheric pressure. Mass Spec Rev 1991; 10: 53
   Web of Science ®Google Scholar
• Wachs T, Conboy J C, Garcia F, Henion J D. Liquid chromatography-mass spectrometry and related techniques via atmospheric pressure ionization. J Chromatogr Sci 1991; 29: 357
   Web of Science ®Google Scholar
• Niessen W MA, Tinke A P. Liquid chromatography-mass spectrometry. General principles and instrumentation. J Chromatogr A 1995; 703: 37
   Web of Science ®Google Scholar
• Arpino P. Combined liquid-chromatography mass spectrometry. Techniques and mechanisms of thermospray. Mass Spec Rev 1990; 9: 631
   Web of Science ®Google Scholar
• Baillie T A. Advances in the application of mass spectrometry to studies of drug metabolism, pharmacokinetics and toxicology. Int J Mass Spectrom Ion Processes 1992; 118/119: 289
   Web of Science ®Google Scholar
• Naylor S, Kajbaf M, Lamb J H, Jahanshahi M, Gorrod J W. An evaluation of tandem mass spectrometry in drug metabolism studies. Biol Mass Spectrom 1993; 22: 388
   PubMedGoogle Scholar
• Blair I A. Mass-spectrometry in drug disposition and pharmacokinetics. Pharmacokinetics of Drugs—Handbook of Experimental Pharmacology, P G Welling, L P Balant. Springer-Verlag, Berlin 1994; 41
   Google Scholar
• Lee P WN, Byerley L O, Bergner E A. Mass isotopomer analysis: Theoretical and practical considerations. Biol Mass Spectrom 1991; 20: 451
   PubMedGoogle Scholar
• Barbalas M P, Garland W A. A computer program for the deconvolution of mass spectral peak abundance data from experiments using stable isotopes. J Pharm Sci 1996; 80: 922
   Google Scholar
• Kasuya F, Igarashi K, Fukui M. Metabolism of chlorpheniramine in rat and human by use of stable isotopes. Xenobiotica 1991; 21: 97
   PubMed Web of Science ®Google Scholar
• Weidolf L, Covey T R. Studies on the metabolism of omeprazole in the rat using liquid chromatography/ionspray mass spectrometry and the isotope cluster technique with [34S]omeprazole. Rapid Commun Mass Spectrom 1992; 6: 192
   PubMed Web of Science ®Google Scholar
• Korzekwa K, Howard W N, Trager W F. The use of Brauman's least squares approach for the quantification of deuterated chlorophenols. Biomed Environ Mass Spectrom 1990; 19: 211
   PubMedGoogle Scholar
• Shinohara Y, Baba S. Stable isotope methodology in the pharmacokinetic studies of androgenic steroids in humans. Steroids 1990; 55: 170
   PubMed Web of Science ®Google Scholar
• Wolen R L. The application of stable isotopes to studies of drug bioavailability and bioequivalence. J Clin Pharmacol 1986; 26: 419
   PubMed Web of Science ®Google Scholar
• Avery M J, Mitchell D Y, Falkner F C, Fouda H G. Simultaneous determination of tenidap and its stable isotope analog in serum by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. Biol Mass Spectrom 1992; 21: 353
   PubMedGoogle Scholar
• Prakash C, Adedoyin A, Wilkinson G R, Blair I A. Enantiospecific quantification of hexobarbital and its metabolites in biological fluids by gas chromatography/electron capture negative ion chemical ionization mass spectrometry. Biol Mass Spectrom 1991; 20: 559
   PubMedGoogle Scholar
• Fischer C, Schonberger F, Muck W, Heuck K, Eichelbaum M. Simultaneous assessment of the intravenous and oral disposition of the enantiomers of racemic nimodipine by chiral stationary-phase high-performance liquid chromatography and gas chromatography/mass spectroscopy combined with a stable isotope technique. J Pharm Sci 1993; 82: 244
   PubMed Web of Science ®Google Scholar
• Adedoyin A, Prakash C, O'Shea D, Blair I A, Wilkinson G R. Stereoselective disposition of hexobarbital and its metabolites: Relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects. Pharmacogenetics 1994; 4: 27
   PubMedGoogle Scholar
• Eriksson U G, Hoffman K-J, Simonsson R, Regardh C G. Pharmacokinetics of the enantiomers of felodipine in the dog after oral and intravenous administration of a pseudoracemic mixture. Xenobiotica 1991; 21: 75
   PubMed Web of Science ®Google Scholar
• Shinohara Y, Magara H, Baba S. Stereoselective pharmacokinetics and inversion of suprofen enantiomers in humans. J Pharm Sci 1991; 80: 1075
   PubMed Web of Science ®Google Scholar
• Abramson F P. CRIMS—chemical reaction interface mass spectrometry. Adv Mass Spectrom 1994; 13: 341
   Google Scholar
• Goldthwaite C A, Jr., Hsieh F-Y, Womble S W, Nobes B J, Blair I A. Liquid chromatography chemical reaction interface mass spectrometry (LC/CRI MS) as an alternative to radioisotopes for quantitative drug metabolism studies. Anal Chem 1996; 68: 2996
   PubMed Web of Science ®Google Scholar
• Abramson F P, Teffera Y, Kusmierz J, Steenwyk R C, Pearson P G. Replacing C-14 with stable isotopes in drug metabolism studies. Drug Metab Disp 1996; 24: 697
   PubMed Web of Science ®Google Scholar
• Fenselau C. Tandem mass spectrometry: The competitive edge for pharmacology. Annual Review of Pharmacology and Toxicology, A K Cho. Annual Reviews, Inc., Palo Alto, CA 1992; 555
   Google Scholar
• Hunt D F, Henderson R A, Shabonowitz J, Sakaguchi K, Michel H, Sevilir N, Cox A L, Appella E, Engelhard V H. Characterization of peptides bound to class I MHC molecule HLA-A2.1 by mass spectrometry. Science 1992; 255: 1261
   PubMed Web of Science ®Google Scholar
• Naylor S, Kajbaf M, Lamb J H, Jahanshahi M, Gorrod J W. Rapid identification of cimetropium bromide metabolites using constant neutral loss tandem mass spectrometry. Biol Mass Spectrom 1992; 21: 165
   Google Scholar
• Vrbanac J J, O'Leary I A, Baczynskyj L. Utility of the parent-neutral loss scan screening technique: Partial characterization of urinary metabolites of U-78875 in monkey urine. Biol Mass Spectrom 1992; 21: 517
   PubMedGoogle Scholar
• Baillie T A, Davis M R. Mass spectrometry in the analysis of glutathione conjugates. Biol Mass Spectrom 1993; 226: 319
   Google Scholar
• Baillie T A. The role of LC-ionspray MS/MS in studies of drug metabolism and toxicology. 42nd ASMS Conf. Mass Spectrometry and Allied Topics. 1994, 862
   Google Scholar
• Mirkes P E, Brown N A, Kajbaf M, Lamb J H, Farmer P B, Naylor S. Identification of cyclophosphamide-DNA adducts in rat embryos exposed in vitro to 4-hydroperoxycyclophosphamide. Chem Res Toxicol 1992; 5: 382
   PubMed Web of Science ®Google Scholar
• Voyksner R D, Pack T. Investigation of collisional-activation decomposition process and spectra in the transport region of an electrospray single-quadrupole mass spectrometer. Rapid Commun Mass Spectrom 1991; 5: 263
   PubMed Web of Science ®Google Scholar
• Brashear W T, Kuhnert B R, Wei R. Structural determination of the conjugated metabolites of ritodrine. Drug Metab Dispos 1990; 18: 488
   PubMed Web of Science ®Google Scholar
• Changchit A, Gal J, Zirrolli J A. Stereospecific gas chromatographic/mass spectrometric assay of the chiral labetalol metabolite 3-amino-1-phenylbutane. Biol Mass Spectrom 1991; 20: 751
   PubMedGoogle Scholar
• Komatsu S, Murata S, Aoyama H, Zenki T, Ozawa N, Tateishi M, Vrbanac J J. Micro-quantitative determination of ciprostene in plasma by gas chromatography-mass spectrometry coupled with an antibody extraction. J Chromatogr 1991; 568: 460
   PubMed Web of Science ®Google Scholar
• Leis H J, Malle E. Deuterium-labelling and quantitative measurement of ketotifen in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. Biol Mass Spectrom 1991; 20: 467
   PubMedGoogle Scholar
• Neal J M, Howald W N, Kunze K L, Lawrence R F, Trager W F. Application of negative-ion chemical ionization isotope dilution gas chromatograph-mass spectrometry to single-dose bioavailability studies of mefloquine. J Chromatogr B 1994; 661: 263
   PubMed Web of Science ®Google Scholar
• Lang C C, Stein C M, Nelson R A, He H B, Belas F J, Blair I A, Wood M, Wood A JJ. Sympathoinhibitory response to clonidine is blunted in patients with heart failure. Hypertension 1997; 30: 392
   PubMed Web of Science ®Google Scholar
• Momerency G, Van Cauwenberghe K, Highley M S, Harper P G, van Oosterom A T, De Bruijin E A. Partitioning of ifosfamide and its metabolites between red blood cells and plasma. J Pharm Sci 1996; 85: 262
   PubMed Web of Science ®Google Scholar
• Fitzgerald R L, Herold D A. Serum total testosterone: Immunoassay compared with negative chemical ionization gas chromatography-mass spectrometry. Clin Chem 1996; 42: 749
   PubMed Web of Science ®Google Scholar
• Vachharajani N N, Shyu W C, Greene D S, Barbhaiya R H. The pharmacokinetics of butorphanol and its metabolites at steady state following nasal administration in humans. Biopharm Drug Dispos 1997; 18: 191
   PubMed Web of Science ®Google Scholar
• Blair I A. Electron capture negative ion chemical ionization mass spectrometry of lipid mediators. Methods in Enzymology, R C Murphy, F A Fitzpatrick. Academic Press, San Diego, CA 1990; 13
   Google Scholar
• Webster L K, Ellis A G, Kestell P, Rewcastle G W. Metabolism and elimination of 5,6-dimethylxanthenone-4-acetic acid in the isolated perfused rat liver. Drug Metab Dispos 1995; 23: 363
   PubMed Web of Science ®Google Scholar
• Kajbaf M, Jahanshahi M, Pattichis K, Gorrod J W, Naylor S. Rapid and efficient purification of cimetropium bromide and mifentidine drug metabolite mixtures derived from microsomal incubates for analysis by mass spectrometry. J Chromatogr 1992; 575: 75
   PubMed Web of Science ®Google Scholar
• Jackson C-JC, Hubbard J W, McKay G, Cooper J K, Hawes E M, Midha K K. Identification of phase-I and phase-II metabolites of fluphenazine in rat bile. Drug Metab Dispos 1991; 19: 188
   PubMed Web of Science ®Google Scholar
• Jackson C-JC, Hubbard J W, Midha K K. Biosynthesis and characterization for glucuronide metabolites of fluphenazine: 7-hydroxyfluphenazine glucuronide and fluphenazine glucuronide. Xenobiotica 1991; 21: 383
   PubMed Web of Science ®Google Scholar
• Mays D C, Dixon K F, Balboa A, Pawluk L J, Bauer M R, Nawoot S, Gerber N. A nonprimate animal model applicable to zidovudine pharmacokinetics in humans: Inhibition of glucuronidation and renal excretion of zidovudine by probenecid in rats. J Pharm Exp Ther 1991; 259: 1261
   PubMed Web of Science ®Google Scholar
• Tanaka M, Ono K, Hakusui H, Takegoshi T, Watanabe Y, Kanao M. Identification of DP-1904 and its ester glucuronide in human urine and determination of their enantiomeric compositions by high-performance liquid chromatography with optical activity and ultraviolet detection. Drug Metab Dispos 1990; 18: 698
   PubMed Web of Science ®Google Scholar
• Luo H, Hawes E M, McKay G, Korchinski E D, Midha K K. The quaternary ammonium-linked glucuronide of doxepin: A major metabolite in depressed patients treated with doxepin. Drug Metab Dispos 1991; 19: 722
   PubMed Web of Science ®Google Scholar
• Luo H, McKay G, Midha K K. Identification of clozapine N(+)-glucuronide in the urine of patients treated with clozapine using electrospray mass spectrometry. Biol Mass Spectrom 1994; 23: 147
   PubMedGoogle Scholar
• Luo H, Hawes E M, McKay G, Korchinski E D, Midha K K. N(+)-glucuronidation of aliphatic tertiary amines in human: Antidepressant versus antipsychotic drugs. Xenobiotica 1995; 25: 291
   PubMed Web of Science ®Google Scholar
• Kenny P TM, Orlando R. Tandem mass spectrometric analysis of peptides at the femtomole level. Anal Chem 1992; 64: 957
   PubMed Web of Science ®Google Scholar
• Huang E C, Wachs T, Conboy J J, Henion J D. Atmospheric pressure ionization mass spectrometry. Anal Chem 1990; 62: 713A
   Web of Science ®Google Scholar
• Wang-Iverson D, Arnold M E, Jemal M, Cohen A I. Determination of SQ 33,600, a phosphinic acid containing HMG CoA reductase inhibitor, in human serum by high-performance liquid chromatography combined with ionspray mass spectrometry. Biol Mass Spectrom 1992; 21: 189
   PubMedGoogle Scholar
• Rule G S, Henion J D. Determination of drugs from urine by on-line immunoaffinity chromatography-high-performance liquid chromatography-mass spectrometry. J Chromatogr 1992; 582: 103
   PubMed Web of Science ®Google Scholar
• Whitman D A, Abbott V, Fregien K, Bowers L D. Recent advances in high-performance liquid chromatography/mass spectrometry and high-performance liquid chromatography/tandem mass spectrometry: Detection of cyclosporine and metabolites in kidney and liver tissue. Ther Drug Monitor 1993; 15: 552
   PubMed Web of Science ®Google Scholar
• Swart P J, Oelen W EM, Bruins A P, Tepper P G, de Zeeuw R A. Determination of the dopamine D2 agonist N-0923 and its major metabolites in perfused rat livers by HPLC-UV-atmospheric pressure ionization mass spectrometry. J Anal Toxicol 1994; 18: 71
   PubMed Web of Science ®Google Scholar
• Qin X-Z, Ip D P, Chang K HC, Dradransky P M, Brooks M A, Sakuma T. Pharmaceutical application of LC-MS. 1—Characterization of a famotidine degradate in a package screening study by LC-APCI MS. J Pharm Biomed Anal 1994; 12: 221
   PubMed Web of Science ®Google Scholar
• Wieboldt R, Campbell D A, Henion J. Quantitative liquid chromatographic-tandem mass spectrometric determination of orlistat in plasma with a quadrupole ion trap. J Chromatogr B 1998; 708: 121
   PubMed Web of Science ®Google Scholar
• Tiller P R, Land A P, Jardine I, Murphy D M, Sozio R, Ayrton A, Schaefer W H. Application of liquid chromatography-mass spectrometry(n) analyses to the characterization of novel glyburide metabolites formed in vitro. J Chromatogr A 1998; 794: 15
   PubMed Web of Science ®Google Scholar
• Chauret N, Nicoll-Griffith D, Friesen R, Li C, Trimble L, Dube D, Fortin R, Girard Y, Yergey J. Microsomal metabolism of the 5-lipoxygenase inhibitors L-746,530 and L-739,010 to reactive intermediates that covalently bind to protein: The role of the 6,8-dioxabicyclo[3,2,1]octanyl moiety. Drug Metab Dispos 1995; 23: 1325
   PubMed Web of Science ®Google Scholar
• Nicoll-Griffith D A, Gupta N, Twa S P, Williams H, Trimble L A, Yergey J A. Verlukast (MK-0679) conjugation with glutathione by rat liver and kidney cytosols and excretion in the bile. Drug Metab Dispos 1995; 23: 1085
   PubMed Web of Science ®Google Scholar
• Wu J T, Qian M G, Li M X, Zheng K, Huang D H, Lubman D M. On-line analysis by capillary separations interfaced to an ion trap storage/reflectron time-of-flight mass spectrometer. J Chromatogr A 1998; 794: 377
   PubMed Web of Science ®Google Scholar
• Bach G A, Henion J. Quantitative capillary electrophoresis-ion-trap mass spectrometry determination of methylphenidate in human urine. J Chromatogr B 1998; 707: 275
   PubMed Web of Science ®Google Scholar
• Kebarle P, Tang L. From ions in solution to ions in gas phase: The mechanism of electrospray mass spectrometry. Anal Chem 1993; 65: 972A
   Web of Science ®Google Scholar
• Poon G K, Mistry P, Lewis S. Electrospray ionization mass spectrometry of platinum anticancer agents. Biol Mass Spectrom 1991; 20: 687
   PubMedGoogle Scholar
• Everett D W, Chando T J, Didonato G C, Singhvi S M, Pan H Y, Weinstein S H. Biotransformation of pravastatin sodium in humans. Drug Metab Dispos 1991; 19: 740
   PubMed Web of Science ®Google Scholar
• Perkins J R, Parker C E, Tomer K B. Nanoscale separations combined with electrospray ionization mass spectrometry: Sulfonamide determination. J Am Soc Mass Spectrom 1992; 3: 139
   PubMed Web of Science ®Google Scholar
• Debrauwer L, Bories G. Electrospray ionization mass spectrometry of some beta-agonists. Rapid Commun Mass Spectrom 1992; 6: 382
   Web of Science ®Google Scholar
• Lanting A BL, Bruins A P, Drenth B FH, de Jonge K, Ensing K, de Zeeuw R A, Meijer D KE. Identification with liquid chromatography-ionspray mass spectrometry of the metabolites of the enantiomers N-methyl dextrorphan and N-methyl levorphanol after rat liver perfusion. Biomed Mass Spectrom 1993; 22: 226
   Google Scholar
• Tomlinson A J, Benson L M, Johnson K L, Naylor S. Investigation of the metabolic fate of the neuroleptic drug haloperidol by capillary electrophoresis-electrospray ionization mass spectrometry. J Chromatogr Biomed Appl. 1993; 621: 239
   Google Scholar
• Subramanyam B, Pond S M, Eyles D W, Whiteford H A, Fouda H G, Castagnoli N, Jr. Identification of potentially neurotoxic pyridinium metabolite in the urine of schizophrenic patients treated with haloperidol. Biochem Biophys Res Commun 1991; 181: 573
   PubMed Web of Science ®Google Scholar
• Schneider R P, Lynch M J, Ericson J F, Fouda H G. Electrospray ionization mass spectrometry of semduramicin and other polyether ionophores. Anal Chem 1991; 63: 1789
   PubMed Web of Science ®Google Scholar
• Lee K, Vanderberghe Y, Herin M, Cavalier R, Beck D, Li A, Verbeke N, Lesne M, Roba J. Comparative metabolism of SC-42867 and SC-51089, two PGE2 antagonists, in rat and human hepatocyte cultures. Xenobiotica 1994; 24: 25
   PubMed Web of Science ®Google Scholar
• Pham-Huy C, Sadeg N, Becue T, Martin C, Mahuzier G, Warnet J-M, Hamon M, Claude J R. In vitro metabolism of cyclosporin A with rabbit renal or hepatic microsomes: Analysis of HPLC-FPIA and HPLC-MS. Arch Toxicol 1995; 69: 346
   PubMed Web of Science ®Google Scholar
• Ulgen M, Kajbaf M, Lamb J H, Jahanshahi M, Gorrod J W, Naylor S. Characterization of N-benzylcarbazole and its metabolites from microsomal mixtures by tandem mass spectrometry. Eur J Drug Metab Pharmacokinet 1994; 19: 343
   PubMed Web of Science ®Google Scholar
• Yeung B, Vouros P, Siu-Caldera M-L, Reddy G S. Characterization of the metabolic pathway of 1,25-dihydroxy-16-ene vitamin D3 in rat kidney by on-line high performance liquid chromatography-electrospray tandem mass spectrometry. Biochem Pharmacol 1995; 49: 1099
   PubMed Web of Science ®Google Scholar
• Ogunbiyi O, Kajbaf M, Lamb J H, Jahanshahi M, Gorrod J W, Naylor S. Characterization of 2-amino-1-benzylbenzimidazole and its metabolites using tandem mass spectrometry. Toxicol Lett 1995; 78: 25
   PubMed Web of Science ®Google Scholar
• Ding A, Zia-Amirhosseini P, McDonagh A F, Burlingame A L, Benet L. Reactivity of tolmetin glucuronide with human serum albumin. Identification of binding sites and mechanisms of reaction by tandem mass spectrometry. Drug Metab Dispos 1995; 23(3)369
   PubMed Web of Science ®Google Scholar
• Ding A, Ojinωa J C, McDonagh A F, Burlingame A L, Benet L Z. Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry. Proc Natl Acad Sci (USA) 1993; 90: 3797
   PubMed Web of Science ®Google Scholar
• van Tellingen O, Sonneveldt A LC, Beijnen J H, Nooijen W J, Kettenes-van den Bosch J J, Versluis C, Bult A. Plasma pharmacokinetics, tissue disposition, excretion and metabolism of vinleucinol in mice as determined by high-performance liquid chromatography. Cancer Chemother Pharmacol 1994; 33: 425
   PubMed Web of Science ®Google Scholar
• Kassahun K, Hu P, Grillo M P, Davis M R, Jin L, Baillie T A. Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes. Chemico-Biol Int 1994; 90: 253
   PubMed Web of Science ®Google Scholar
• Tang W, Abbott F S. Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates. Chem Res Toxicol 1996; 9: 517
   PubMed Web of Science ®Google Scholar
• Jin L, Davis M R, Hu P, Baillie T A. Identification of novel glutathione conjugates of disulfiram and diethyldithiocarbamate in rat bile by liquid chromatography-tandem mass spectrometry. Evidence for metabolic activation of disulfiram in vivo. Chem Res Toxicol 1994; 7: 526
   PubMed Web of Science ®Google Scholar
• Poon G K, Chui Y C, McCague R, Lonning P E, Feng R, Rowlands M G, Jarman M. Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients. Drug Metab Dispos 1993; 21: 1119
   PubMed Web of Science ®Google Scholar
• Mewes K, Blanz J, Ehninger G, Gebhardt R, Zeller K-P. Cytochrome P-450-induced cytotoxicity of mitoxantrone by formation of electrophilic intermediates. Cancer Res 1993; 53: 5135
   PubMed Web of Science ®Google Scholar
• Davis M R, Kassahun K, Jochheim C M, Brandt K M, Baillie T A. Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N′-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro. Chem Res Toxicol 1993; 6: 376
   PubMed Web of Science ®Google Scholar
• Jin L, Baillie T A, Davis M R, Kharasch E D. Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: Evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase. Biochem Biophys Res Commun 1995; 210: 498
   PubMed Web of Science ®Google Scholar
• Hofmann U, Fromm M F, Johnson S, Mikus G. Simultaneous determination of dihydrocodeine and dihydromorphine in serum by gas chromatography-tandem mass spectrometry. J Chromatogr B 1995; 663: 59
   PubMed Web of Science ®Google Scholar
• Engel G, Hofmann U, Eichelbaum M. Highly sensitive and specific gas chromatographic-tandem mass spectrometric method for the determination of trace amounts of antipyrine metabolites in biological material. J Chromatogr B 1995; 666: 111
   PubMed Web of Science ®Google Scholar
• Gilbert J D, Greber T F, Ellis J D, Barrish A, Olah T V, Fernandez-Metzler C, Yuan A S, Burke C J. The development and cross-validation of methods based on radioimmunoassay and LC/MS-MS for the quantification of the class III antiarrhythmic agent, MK-0499, in human plasma and urine. J Pharm Biomed Anal 1995; 13: 937
   PubMed Web of Science ®Google Scholar
• Martin L BI, Schreiner A F, van Breemen R B. Characterization of cisplatin adducts of oligonucleotides by fast atom bombardment mass spectrometry. Anal Biochem 1991; 193: 6
   PubMed Web of Science ®Google Scholar
• Burinsky D J, Dunphy R, Oyler A R, Shaw C J, Cotter M L. Characterization of a synthetic peptide impurity by fast-atom bombardment-tandem mass spectrometry and gas chromatography-mass spectrometry. J Pharm Sci 1992; 81: 597
   PubMed Web of Science ®Google Scholar
• Kajbaf M, Lamb J H, Naylor S, Pattichis K, Gorrod J W. Identification of metabolites derived from the H2-receptor antagonist mifentidine using tandem mass spectrometry. Anal Chim Acta 1991; 247: 151
   Web of Science ®Google Scholar
• Kurono M, Itogawa A, Yoshida K, Naruto S, Rudewicz P, Kanai M. Identification of AJ-2615 and its S-oxidized metabolites in rat plasma by use of tandem-mass spectrometry. Biol Mass Spectrom 1992; 21: 17
   PubMedGoogle Scholar
• Weber G L, Steenwyk R C, Nelson S D, Pearson P G. Identification of N-acetylcysteine conjugates of 1,2-dibromo-3-chloropropane: Evidence for cytochrome P450 and glutathione mediated bioactivation pathway. Chem Res Toxicol 1995; 8: 560
   PubMed Web of Science ®Google Scholar
• van Bakergem E, van der Hoeven R A, Niessen W M, Tjaden U R, van der Greef J, Poon G K, McCague R. On-line continuous-flow dialysis thermospray tandem mass spectrometry for quantitative screening of drugs in plasma: Rogletimide. J Chromatogr 1992; 598: 189
   PubMed Web of Science ®Google Scholar
• Menacherry S D, Justice J B, Jr. In vivo microdialysis and thermospray tandem mass spectrometry of the dopamine uptake blocker 1-(2-[bis(4-fluorophenyl)-methoxy]ethyl)-4-(3-phenylpropyl)-pipe razine (GBR-12909). Anal Chem 1990; 62: 597
   PubMed Web of Science ®Google Scholar
• Caprioli R M, Lin S-N. On-line analysis of penicillin blood levels in the live rat by combined microdialysis/fast-atom bombardment mass spectrometry. Proc Natl Acad Sci (USA) 1990; 87: 240
   PubMed Web of Science ®Google Scholar
• Matuszewski B K, Constanzer M L, Chavez-Eng C M. Matrix effect in quantitative LC/MS/MS analyses of biological fluids: A method for determination of finasteride in human plasma at picogram per milliliter concentrations. Anal Chem 1998; 70: 882
   PubMed Web of Science ®Google Scholar
• Shaefer W H, Dixon F, Jr. Effect of high-performance liquid chromatography mobile phase components on sensitivity in negative atmospheric pressure chemical ionization liquid chromatography-mass spectrometry. J Am Soc Mass Spectrom 1996; 7: 1059
   PubMed Web of Science ®Google Scholar
• Borel A G, Abbott F S. Identification of carbamoylated thiol conjugates as metabolites of the antineoplastic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, in rats and humans. Drug Metab Dispos 1993; 21: 889
   PubMed Web of Science ®Google Scholar
• Poon G K, Chui Y C, Jarman M, Rowlands M G, Kokkonen P S, Niessen W MA, van der Greef J V. Investigation of conjugated metabolites of 4-hydroxyandrost-4-ene-3,17-dione in patient urine by liquid chromatography-atmospheric pressure ionization mass spectrometry. Drug Metab Dispos 1992; 20: 941
   PubMed Web of Science ®Google Scholar
• Olah T V, Gilbert J D, Barrish A. Determination of the beta-adrenergic blocker timolol in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. J Pharm Biomed Anal 1993; 11: 157
   PubMed Web of Science ®Google Scholar
• Fouda H G, Schneider R P. Quantitative determination of the antibiotic azithromycin in human serum by high-performance liquid chromatography (HPLC)-atmospheric pressure chemical ionization mass spectrometry: Correlation with a standard HPLC-electrochemical method. Ther Drug Monitor 1995; 17: 179
   PubMed Web of Science ®Google Scholar
• Taylor L C, Johnson R L, St John-Williams L, Johnson T, Chang S Y. The use of low-energy collisionally activated dissociation negative-ion tandem mass spectrometry for the characterization of dog and human urinary metabolites of the drug BW 1370U87. Rapid Commun Mass Spectrom 1994; 8: 265
   PubMed Web of Science ®Google Scholar
• Yergey A L, Teffera Y, Esteban N V, Abramson F P. Direct determination of human urinary cortisol metabolites by HPLC/CRIMS. Steroids 1995; 60: 295
   PubMed Web of Science ®Google Scholar
• Teffera Y, Abramson F P. Application of high-performance liquid chromatography/chemical reaction interface mass spectrometry for the analysis of conjugated metabolites: A demonstration using deuterated acetaminophen. Biol Mass Spectrom 1994; 23: 776
   PubMedGoogle Scholar
• Song H, Abramson F P. Drug metabolism studies using “intrinsic” vs “extrinsic” labels: A demonstration using 15N vs 35Cl in midazolam. Drug Metab Dispos 1993; 21: 868
   PubMed Web of Science ®Google Scholar
• Song H, Abramson F P. Selective detection of chlorine-containing compounds by gas chromatography/chemical reaction interface mass spectrometry. Anal Chem 1993; 65: 447
   PubMed Web of Science ®Google Scholar
• Kusmierz J J, Abramson F P. Tracing 15N with chemical reaction interface mass spectrometry: A demonstration using 15N-labeled glutamine and asparagine substrates in cell culture. Biol Mass Spectrom 1994; 23: 756
   PubMedGoogle Scholar
• Hsieh F-Y, Jr., Goldthwaite C A, Nobes B J, Mayol R F, Klunk L J, Blair I A. Quantification of drug metabolism using a combination of chemical reaction interface mass spectrometry and NMR. Proc 42nd ASMS Conf on Mass Spectrometry and Allied Topics. 1994, 615
   Google Scholar
• Browne T R, Szabo G K, Ajami A, Wagner D. Performance of human mass balance/metabolite identification studies using stable isotope (13C15N) labeling and continuous-flow isotope-ratio mass spectrometry as an alternative to radioactive labeling methods. J Clin Pharmacol 1993; 33: 246
   PubMed Web of Science ®Google Scholar
• Johansson I M, Pavelka R, Henion J D. Determination of small drug molecules by capillary electrophoresis-atmospheric pressure ionization mass spectrometry. J Chromatogr 1991; 559: 515
   PubMed Web of Science ®Google Scholar
• Tomlinson A J, Benson J M, Johnson K L, Naylor S. Investigation of drug metabolism using capillary electrophoresis with photodiode array detection and online mass spectrometry equipped with an array detector. Electrophoresis 1994; 15: 62
   PubMed Web of Science ®Google Scholar
• Ramsey R S, Goeringer D E, McLuckey S A. Active chemical background and noise reduction in capillary electrophoresis/ion trap mass spectrometry. Anal Chem 1993; 65: 3521
   PubMed Web of Science ®Google Scholar
• Tomlinson A J, Benson L M, Gorrod J W, Naylor S. Investigation of the in vitro metabolism of the H2-antagonist mifentidine by on-line capillary electrophoresis-mass spectrometry using non-aqueous separation conditions. J Chromatogr B 1994; 657: 373
   PubMed Web of Science ®Google Scholar
• Lu W, Poon G K, Carmichael P L, Cole R B. Analysis of tamoxifen and its metabolites by on-line capillary electrophoresis-electrospray ionization mass spectrometry employing nonaqueous media containing surfactants. Anal Chem 1996; 68: 668
   PubMed Web of Science ®Google Scholar
• Lamoree M H, Reinhoud N J, Tjaden U R, Niessen W MA, van der Greef J. On-capillary isotachophoresis for loadability enhancement in capillary zone electro-phoresis/mass spectrometry of beta-agonists. Biol Mass Spectrom 1994; 23: 339
   PubMedGoogle Scholar
• Naylor S, Tomlinson A J, Benson L M, Gorrod J W. Capillary electrophoresis and capillary electrophoresis-mass spectrometry in drug and metabolite analysis. Eur J Drug Metab Pharmacokinet 1994; 19: 235
   PubMed Web of Science ®Google Scholar
• Chapman J R, Gallagher R T, Barton E C, Curtis J M, Derrick P J. Advantages of high-resolution and high-mass range magnetic-sector mass spectrometry for electrospray ionization. Org Mass Spectrom 1992; 27: 195
   Google Scholar
• Cody R B, Tamura J, Musselman B D. Electrospray ionization/magnetic sector mass spectrometry: Calibration, resolution, and accurate mass measurements. Anal Chem 1992; 64: 1561
   Web of Science ®Google Scholar
• Dobberstein P, Schroder E. Accurate mass determination of a high molecular weight protein using electrospray ionization with a magnetic sector instrument. Rapid Commun Mass Spectrom 1993; 7: 861
   Web of Science ®Google Scholar
• Hofstadler S A, Schmidt E, Guan Z, Laude D A, Jr. Concentric tube vacuum chamber for high magnetic field, high pressure ionization in a Fourier transform ion cyclotron resonance mass spectrometer. J Am Soc Mass Spectrom 1993; 4: 168
   PubMed Web of Science ®Google Scholar
• Beu S C, Senko M W, Quinn J P, McLafferty F W. Improved Fourier-transform ion-cyclotron-resonance mass spectrometry of large biomolecules. J Am Soc Mass Spectrom 1993; 4: 190
   PubMed Web of Science ®Google Scholar
• Winger B E, Hofstadler S A, Bruce J E, Udseth H R, Smith R D. High resolution mass measurements of biomolecules using a new electrospray ionization ion cyclotron resonance mass spectrometer. J Am Soc Mass Spectrom 1993; 4: 566
   PubMed Web of Science ®Google Scholar
• Little D P, Speir J P, Senko M W, O'Connor P B, McLafferty F W. Infrared multiphoton dissociation of large multiply charged ions for biomolecule sequencing. Anal Chem 1994; 66: 2809
   PubMed Web of Science ®Google Scholar
• Senko M W, Speir J P, McLafferty F W. Collisional activation of large multiply charged ions using Fourier transform mass spectrometry. Anal Chem 1994; 66: 2801
   PubMed Web of Science ®Google Scholar
• Wahl J H, Hofstadler S A, Smith R D. Direct electrospray ion current monitoring detection and its use with on-line capillary electrophoresis mass spectrometry. Anal Chem 1995; 67: 462
   Web of Science ®Google Scholar
• Coutts R T, Jamali F, Malek F, Peliowski A, Finer N N. Urinary metabolites of doxapram in premature neonates. Xenobiotica 1991; 21: 1407
   PubMed Web of Science ®Google Scholar
• Solouki T, Marto J A, White F M, Guan S, Marshall A G. Attomole biomolecule mass analysis by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance. Anal Chem 1995; 67: 4139
   PubMed Web of Science ®Google Scholar
• Henion J D, Wachs T, Mordehai A. Recent developments in electrospray mass spectrometry including implementation on an ion trap. J Pharm Biomed Anal 1993; 11: 1049
   PubMed Web of Science ®Google Scholar
• Kaiser R E, Jr., Williams J D, Lammert S A, Cooks R G. Thermospray liquid chromatography-mass spectrometry with a quadrupole ion trap mass spectrometry. J Chromatogr 1991; 562: 3
   PubMed Web of Science ®Google Scholar
• He L, Liang L, Lubman D M. Continuous-flow MALDI mass spectrometry using an ion trap/reflection time-of-flight detector. Anal Chem 1995; 67: 4127
   Web of Science ®Google Scholar
• Kleintop B L, Eades D M, Yost R A. Operation of a quadrupole ion trap for particle beam LC/MS analyses. Anal Chem 1993; 65: 1295
   Web of Science ®Google Scholar
• Bier M E, Winkler P C, Herron J R. Coupling a particle beam interface directly into a quadrupole ion trap mass spectrometer. J Am Soc Mass Spectrom 1993; 4: 38
   PubMed Web of Science ®Google Scholar
• McLuckey S A, Van Berkel G J, Glish G L, Huang E C, Henion J D. Ion spray liquid chromatography/ion tran mass spectrometry determination of biomolecules. Anal Chem 1991; 63: 375
   Web of Science ®Google Scholar
• Lin H-Y, Voyksner R D. Determination of environmental contaminants using an electrospray interface combined with an ion trap mass spectrometer. Anal Chem 1993; 65: 451
   Web of Science ®Google Scholar
• McLuckey S A, Van Berkel G J, Goeringer D E, Glish G L. Ion trap mass spectrometry. Using high-pressure ionization. Anal Chem 1994; 66: 737A
   Web of Science ®Google Scholar
• Wells G, Huston C. High-resolution selected ion monitoring in a quadrupole ion trap mass spectrometer. Anal Chem 1995; 67: 3650
   Web of Science ®Google Scholar
• Hillenkamp F, Karas M, Beavis R C, Chait B T. Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers. Anal Chem 1991; 63: 1193A
   PubMed Web of Science ®Google Scholar
• Walker K L, Chiu R W, Monnig C A, Wilkins C L. Off-line coupling of capillary electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Chem 1995; 67: 4197
   PubMed Web of Science ®Google Scholar
• Boyle J G, Whitehouse C M. Time-of-flight mass spectrometry with an electrospray ion beam. Anal Chem 1992; 64: 2084
   PubMed Web of Science ®Google Scholar
• Michael S M, Chien B M, Lubman D M. Detection of electrospray ionization using a quadrupole ion trap storage/reflection time-of-flight mass spectrometer. Anal Chem 1993; 65: 2614
   Web of Science ®Google Scholar
• Verentchikov A N, Ens W, Standing K G. Reflecting time-of-flight mass spectrometer with an electrospray ion source and orthogonal extraction. Anal Chem 1994; 66: 126
   PubMed Web of Science ®Google Scholar
• Mutlib A E, Nelson W L. Synthesis and identification of the N-glucuronides of norgallopamil and norverapamil unusual metabolites of gallopamil and verapamil. J Pharm Exp Ther 1990; 252: 593
   PubMed Web of Science ®Google Scholar
• Magdalou J, Herber R, Bidfault R, Siest G. In vitro N-glucuronidation of a novel antiepileptic drug, lamotrigine, by human liver microsomes. J Pharm Exp Ther 1992; 260: 1166
   PubMed Web of Science ®Google Scholar
• Niemeijer N R, Gerding T K, DeZeeuw R A. Glucuronidation of labetalol at the two hydroxy positions by bovine liver microsomes. Isolation, purification, and structure elucidation of the glucuronides of labetalol. Drug Metab Dispos 1991; 19: 20
   PubMed Web of Science ®Google Scholar
• Magistrelli A, Villa P, Benfenati E, Modest E J, Salmona M, Tacconi M T. Fate of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET18-OME) in malignant cells, normal cells, and isolated and perfused rat liver. Drug Metab Dispos 1995; 23: 113
   PubMed Web of Science ®Google Scholar
• Bezek S, Kukan M, Kallay Z, Trnovec T, Stefek M, Piotrovskiy L B. Disposition of ethimizol, a xanthine-related inotropic drug, in perfused rat liver and isolated hepatocytes. Drug Metab Dispos 1990; 18: 88
   PubMed Web of Science ®Google Scholar
• Jajoo H K, Blair I A, Klunk L J, Mayol R F. In vitro metabolism of the antianxiety drug buspirone as a predictor of its metabolism in vivo. Xenobiotica 1990; 20: 779
   PubMed Web of Science ®Google Scholar
• Idowu O R, Peggins J O, Brewer T G, Kelley C. Metabolism of a candidate 8-aminoquinoline antimalarial agent, WR, 238605, by rat liver microsomes. Drug Metab Dispos 1995; 23: 1
   PubMed Web of Science ®Google Scholar
• Chauret N, Li C, Ducharme Y, Trimble L A, Yergey J A, Ramachandran C, Nicoll-Griffith D A. In vitro and in vivo biotransformations of the naphthalenic lignan lactone 5-lipoxygenase inhibitor, L-702,539. Drug Metab Dispos 1995; 23: 65
   PubMed Web of Science ®Google Scholar
• Stearns R A, Chakravarty P K, Chen R, Chiu S-HL. Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Drug Metab Dispos 1995; 23: 207
   PubMed Web of Science ®Google Scholar
• Wienkers L C, Steenwyk R C, Mizsak S A, Pearson P G. In vitro metabolism of tirilazad mesylate in male and female rats. Contribution of cytochrome P4502C11 and delta4-5alpha-reductase. Drug Metab Dispos 1995; 23: 383
   PubMed Web of Science ®Google Scholar
• Christians U, Radeke H, Kownatzki R, Schiebel H M, Schottmann R, Sewing K-F. Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations. Clin Biochem 1991; 24: 271
   PubMed Web of Science ®Google Scholar
• Sanins S M, Adams W J, Kaiser D G, Halstead G W, Baillie T A. Studies on the metabolism and chiral inversion of ibuprofen in isolated rat hepatocytes. Drug Metab Dispos 1990; 18: 527
   PubMed Web of Science ®Google Scholar
• Renner U, Blanz J, Freund S, Waidelich D, Ehninger G, Zeller K-P. Biotransformation of CI-937 in primary cultures of rat hepatocytes. Formation of glutathione conjugates. Drug Metab Dispos 1995; 23: 94
   PubMed Web of Science ®Google Scholar
• Lampen A, Christians U, Guengerich F P, Watkins P B, Kolars J C, Bader A, Gonschior A-K, Dralle H, Hackbarth I, Sewing K-F. Metabolism of the immunosuppressant tacrolimus in the small intestine: Cytochrome P450, drug interactions, and interindividual variability. Drug Metab Dispos 1995; 23: 1315
   PubMed Web of Science ®Google Scholar
• Jajoo H K, Blair I A, Klunk L J, Mayol R F. Characterization of in vitro metabolites of the antipsychotic drug tiospirone by mass spectrometry. Biomed Environ Mass Spectrom 1990; 19: 281
   PubMedGoogle Scholar
• Madden S, Back D J. Metabolism of norgestimate by human gastrointestinal mucosa and liver microsomes in vitro. J Steroid Biochem Mol Biol 1991; 38: 497
   PubMed Web of Science ®Google Scholar
• Christians U, Strohmeyer S, Kownatzki R, Schiebel H-M, Bleck J, Greipel J, Kohlhaw K, Schottmann R, Sewing K-F. Investigations on the metabolic pathways of cyclosporine. I. Excretion of cyclosporine and its metabolites in human bile-isolation of 12 new cyclosporine metabolites. Xenobiotica 1991; 21: 1185
   PubMed Web of Science ®Google Scholar
• Li J, Norwood D L, Mao L-F, Schulz H. Mitochondrial metabolism of valproic acid. Biochemistry 1991; 30: 338
   Web of Science ®Google Scholar
• Bjorge S M, Baillie T A. Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations. Drug Metab Dispos 1991; 19: 823
   PubMed Web of Science ®Google Scholar
• Mao L-F, Millington D S, Schulz H. Formation of a free acid acyl adenylate during the activation of 2-propylpentanoic acid. J Biol Chem 1992; 267: 3143
   PubMed Web of Science ®Google Scholar
• Tracy J W, Catto B A, Webster L T, Jr. Formation of N-(5-nitro-2-thiazolyl)-N′-carboxymethylurea from 5-hydroxyniridazole. Role of aldehyde dehydrogenase in the oxidative metabolism of niridazole. Drug Metab Dispos 1991; 19: 508
   PubMed Web of Science ®Google Scholar
• Cretton E M, Waterhous D V, Bevan R, Sommadossi J-P. Glucuronidation of 3′-azido-3′-deoxythymidine by rat and human liver microsomes. Drug Metab Dispos 1990; 18: 369
   PubMed Web of Science ®Google Scholar
• Poon G K, Walter B, Lonning P E, Horton M N, McCague R. Identification of tamoxifen metabolites in human Hep G2 cell line, human liver homogenate, and patients on long-term therapy for breast cancer. Drug Metab Dispos 1995; 23: 377
   PubMed Web of Science ®Google Scholar
• Kharasch E D, Hill H F, Eddy A C. Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism. Anesthesiology 1991; 75: 520
   PubMed Web of Science ®Google Scholar
• Parkash M K, Caldwell J. Metabolism and excretion of [14C] furfural in the rat and mouse. Food Chem Toxicol 1994; 32: 887
   PubMed Web of Science ®Google Scholar
• Asami M, Yamamura M, Takasaki W, Tanaka Y. Quantitative determination of diol metabolites of CS-670, a new antiinflammatory agent, by capillary column gas chromatography-mass spectrometry. J Chromatogr B 1995; 665: 107
   PubMed Web of Science ®Google Scholar
• Warner E, Rajan J V, Wynshaw-Boris A, Xu J, Yin G Y, Abel K J, Weber B L, Chodosh L A. The risk of breast cancer associated with mammographic parenchymal patterns: A meta analysis of the published literature to examine the effect of methods of classification. Cancer Detect Prevent 1995; 16: 67
   Google Scholar
• Ruenitz P C, Bai X. Acidic metabolites of tamoxifen. Aspects of formation and fate in the female rat. Drug Metab Dispos 1995; 23: 993
   PubMed Web of Science ®Google Scholar
• Zhang K, Lepage F, Cuvier G, Astoin J, Rashed M S, Baillie T A. The metabolic fate of stiripentol in the rat. Studies on cytochrome P-450-mediated methylenedioxy ring cleavage and side chain isomerism. Drug Metab Dispos 1990; 18: 794
   PubMed Web of Science ®Google Scholar
• Shore L J, Fenselau C, King A R, Dickinson R G. Characterization and formation of the glutathione conjugate of clofibric acid. Drug Metab Dispos 1995; 23: 119
   PubMed Web of Science ®Google Scholar
• Coutts R T, Hussain M S, Micetich R G, Daneshtalab M. The metabolism of trimipramine in the rat. Biomed Environ Mass Spectrom 1990; 19: 793
   PubMedGoogle Scholar
• Yeh S Y. N-depyridination and N-dedimethylaminoethylation of tripelennamine and pyrilamine in the rat. Drug Metab Dispos 1990; 18: 453
   PubMed Web of Science ®Google Scholar
• Brown N D, Phillips L R, Leader H, Chiang P K. Isolation and identification of beta-hydroxyethylaprophen: A urinary metabolite of aprophen in rats. J Chromatogr 1991; 563: 466
   PubMed Web of Science ®Google Scholar
• Maurizis J C, Nicolas C, Verny M, Ollier M, Faurie M, Payard M, Veyre A. Biodistribution and metabolism in rats and mice of bucromarone. Drug Metab Dispos 1991; 19: 94
   PubMed Web of Science ®Google Scholar
• Fouda H G, Lukaszewicz J, Clark D A, Hulin B. Metabolism of a new thiazolidinedione hypoglycemic agent CP-68,722 in rat: Metabolite identification by gas chromatography mass spectrometry. Xenobiotica 1991; 21: 925
   PubMed Web of Science ®Google Scholar
• Woolf T F, Bjorge S M, Black A E, Holmes A, Chang T. Metabolism of the acyl-CoA: Cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide in rat and monkey. Drug Metab Dispos 1991; 19: 696
   PubMed Web of Science ®Google Scholar
• Grech-Belanger O, Turgeon J, Lalande M, Belanger P M. Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation. Drug Metab Dispos 1991; 19: 458
   PubMed Web of Science ®Google Scholar
• Yang J T, Adusumalli V E, Wong K K, Kucharczyk N, Sofia R D. Felbamate metabolism in the rat, rabbit, and dog. Drug Metab Dispos 1991; 19: 1126
   PubMed Web of Science ®Google Scholar
• Sanins S M, Adams W J, Kaiser D G, Halstead G W, Hosley J, Barnes H, Baillie T A. Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat. Drug Metab Dispos 1991; 19: 405
   PubMed Web of Science ®Google Scholar
• Usansky J I, Damani L A. The urinary metabolic profile of metyrapone in the rat. Identification of two novel isomeric metyrapone N-oxide metabolites. Drug Metab Dispos 1992; 20: 64
   PubMed Web of Science ®Google Scholar
• Yamada Y, Ohashi R, Sugawara Y, Otsuka M, Takaiti O. Metabolic fate of the new angiotensin-converting enzyme inhibitor imidapril in animals. Arzneim Forsch/Drug Res 1992; 42: 490
   PubMed Web of Science ®Google Scholar
• Chan R L, Hsieh S C, Haroldsen P E, Ho W, Nestor J J, Jr. Disposition of RS-26306, a potent luteinizing hormone-releasing hormone antagonist, in monkeys and rats after single intravenous and subcutaneous administration. Drug Metab Dispos 1991; 19: 858
   PubMed Web of Science ®Google Scholar
• Knadler M P, Ackermann B L, Coutant J E, Hurst G H. Metabolism of the anticoagulant peptide, MDL, 28,050, in rats. Drug Metab Dispos 1992; 20: 89
   PubMed Web of Science ®Google Scholar
• Atsumi R, Suzuki W, Hakusui H. Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion. Xenobiotica 1991; 9: 1159
   Google Scholar
• Jaworski T J, Hawes E M, Hubbard J W, McKay G, Midha K K. The metabolites of chlorpromazine N-oxide in rat bile. Xenobiotica 1991; 21: 1451
   PubMed Web of Science ®Google Scholar
• Patel D K, Woolley J L, Jr., Shockcor J P, Johnson R L, Taylor L C, Sigel C W. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos 1991; 19: 491
   PubMed Web of Science ®Google Scholar
• Ali M H, Abramson F P, Ferrerolf D D, Cohn V H. Metabolism studies of the antischistosomal drug praziquantel using tandem mass spectrometry: Distribution of parent drug and ten metabolites obtained from control and schistosome-infected mouse urine. Biomed Environ Mass Spectrom 1990; 19: 186
   PubMedGoogle Scholar
• Muck W M, Henion J D. High-performance liquid chromatography/tandem mass spectrometry: Its use for the identification of stanozolol and its major metabolites in human and equine urine. Biomed Environ Mass Spectrom 1990; 19: 37
   PubMedGoogle Scholar
• Blanz J, Mewes K, Ehninger G, Proksch B, Greger B, Waidelich D, Zeller K-P. Isolation and structure elucidation of urinary metabolites of mitoxantrone. Cancer Res 1991; 51: 3427
   PubMed Web of Science ®Google Scholar
• Jin L, Davis M R, Kharasch E D, Doss G A, Baillie T A. Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane. Chem Res Toxicol 1996; 9: 555
   PubMed Web of Science ®Google Scholar
• De Vries J X, Walter-Sack I, Voss A, Forster W, Pous P I, Stoetzer F, Spraul M, Ackermann M, Moyna G. Metabolism of benzbromarone in man: Structures of new oxidative metabolites, 6-hydroxy and 1′-oxo-benzbromarone, and the enantioselective formation, and elimination of 1′-hydroxybenzbromarone. Xenobiotica 1993; 23: 1435
   PubMed Web of Science ®Google Scholar
• Kristinsson J, Snooradottir I, Johannsson M. The metabolism of mebeverine in man: Identification of urinary metabolites by gas chromatography/mass spectrometry. Pharmacol Toxicol 1994; 74: 174
   PubMedGoogle Scholar
• Kassahun K, Farrell K, Abbott F. Identification of characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans. Drug Metab Dispos 1991; 19: 525
   PubMed Web of Science ®Google Scholar
• Sinz M W, Remmel R P. Isolation and characterization of a novel quaternary ammonium-linked glucuronide of lamotrigine. Drug Metab Dispos 1991; 19: 149
   PubMed Web of Science ®Google Scholar
• MacDonald J I, Dickinson R G, Reid R S, Edom R W, King A R, Verbeeck R K. Identification of a hydroxy metabolite of diflunisal in rat and human urine. Xenobiotica 1991; 21: 1521
   PubMed Web of Science ®Google Scholar
• Walle T, Walle U K, Kumar G N, Bhalla K N. Taxol metabolism and disposition in cancer patients. Drug Metab Dispos 1995; 23: 506
   PubMed Web of Science ®Google Scholar
• Blanz J, Mewes K, Ehninger G, Proksch B, Waidelich D, Greger B., Zeller K-P. Evidence for oxidative activation of mitoxantrone in human, pig, and rat. Drug Metab Dispos 1991; 19: 871
   PubMed Web of Science ®Google Scholar
• Treston A M, Hooper W D. Urinary metabolites of phenobarbitone, primidone, and their N-methyl and N-ethyl derivatives in humans. Xenobiotica 1992; 22: 385
   PubMed Web of Science ®Google Scholar
• Kassahun K, Farrell K, Zheng J, Abbott F. Metabolic profiling of valproic acid in patients using negative-ion chemical ionization gas chromatography-mass spectrometry. J Chromatogr 1990; 527: 327
   PubMed Web of Science ®Google Scholar
• Brown S Y, Garland W A, Fukuda E K. Isolation and characterization of an unusual glucuronide conjugate of rimantadine. Drug Metab Dispos 1990; 18: 546
   PubMed Web of Science ®Google Scholar
• Hofmann U, Eichelbaum M, Seefried S, Meese C O. Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-l-cysteine. Drug Metab Disp 1991; 19: 222
   PubMed Web of Science ®Google Scholar
• Blanz J, Renner U, Schmeer K, Ehninger G, Zeller K P. Detection and identification of human urinary metabolites of biantrazole (CI-941). Drug Metab Dispos 1993; 21: 955
   PubMed Web of Science ®Google Scholar
• Dueker S R, Jones A D, Smith G M, Clifford A J. Stable isotope methods for the study of beta-carotene-d8 metabolism in humans utilizing tandem mass spectrometry and high-performance liquid chromatography. Anal Chem 1994; 66: 4177
   PubMed Web of Science ®Google Scholar
• Poon G K, Raynaud F I, Mistry P, Odell D E, Kelland L R, Harrap K R, Barnard C FJ, Murrer B A. Metabolic studies of an orally active platinum anticancer drug by liquid chromatography-electrospray ionization-mass spectrometry. J Chromatogr A 1995; 712: 61
   PubMed Web of Science ®Google Scholar
• Mutlib A E, Strupczewski J T, Chesson S M. Application of hyphenated LC/NMR and LC/MS techniques in rapid identification of in vitro and in vivo metabolites of iloperidone. Drug Metab Dispos 1995; 23: 951
   PubMed Web of Science ®Google Scholar
• Rozman E, Galceran M T, Anglada L, Albet C. Investigation of the metabolism of ebrotidine in human urine by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. Drug Metab Dispos 1995; 23: 976
   PubMed Web of Science ®Google Scholar
• Shirley M A, Guan X, Kaiser D G, Halstead G W, Baillie T A. Taurine conjugation of ibuprofen in humans and in rat liver in vitro. Relationship to metabolic chiral inversion. J Pharmacol Exp Ther 1994; 269: 1166
   PubMed Web of Science ®Google Scholar
• Chait B T, Kent S BH. Weighing naked proteins: Practical, high-accuracy mass measurement of peptides and proteins. Science 1992; 257: 1885
   PubMed Web of Science ®Google Scholar
• Siegel M M, Hollander I J, Hamann P R, James J P, Hinman L, Smith B J, Farnsworth A PH, Phipps A, King D J, Karas M, Ingendoh A, Hillenkamp F. Matrix-assisted UV-laser desorption/ionization mass spectrometric analysis of monoclonal antibodies for the determination of carbohydrate, conjugated chelator, and conjugated drug content. Anal Chem 1991; 63: 2470
   PubMed Web of Science ®Google Scholar
• Griffey R H, Greig M J, Gaus H J, Liu K, Monteith D, Winniman M, Cummins L L. Characterization of oligonucleotide metabolism in vivo via liquid chromatography/electrospray tandem mass spectrometry with a quadrupole ion trap mass spectrometer. J Mass Spectrom 1997; 32: 305
   PubMed Web of Science ®Google Scholar
• Shockcor J P, Unger S E, Wilson I D, Foxall P J, Nicholson J K, Lindon J C. Combined HPLC, NMR, spectroscopy, and ion-trap mass spectrometry with application to the detection and characterization of xenobiotic and endogenous metabolites in human urine. Anal Chem 1996; 68: 4431
   PubMed Web of Science ®Google Scholar
• Wang H, Hackett M. Ionization within a cylindrical capacitor: Electrospray without an externally applied high voltage. Anal Chem 1998; 70: 205
   Web of Science ®Google Scholar