135
Views
33
CrossRef citations to date
0
Altmetric
Research Article

Porcine Insulin Biodegradable Polyester Microspheres: Stability and In Vitro Release Characteristics

&
Pages 1-9 | Received 05 Jun 1998, Accepted 03 May 1999, Published online: 18 Jan 2000

REFERENCES

  • Langer R. New methods of drug delivery. Science 1990; 249: 1527–1533
  • Chien Y. W. Human insulin: Basic sciences to therapeutic uses. Drug Dev. Ind. Pharm. 1996; 22(8)753–789
  • Furr B. J. A., Hutchinson F. G. A biodegradable delivery system for peptide: Preclinical experience with the gonadotropin releasing hormone agonist Zoladex®. J. Controlled Release 1992; 21: 117–128
  • Lewis D. D. M. Chasin, R. LangerControlled release of bioactive agents from lactide/glycolide polymer. Biodegradable Polymers as Drug Delivery Systems, . Marcel Dekker, New York 1990; 1–41
  • Ogawa Y., Okada H., Yamamoto M., Shinamoto T. In vivo release profiles of leuprolide acetate from microcapsules prepared with polylactic acids or copoly(lactic/glycolic) acids and in vivo degradation of these polymers. Chem. Pharm. Bull. 1988; 36: 2576–2588
  • Cohen S., Yoshioka T., Lucarelli M., Hwang L. H., Langer R. Controlled delivery systems for proteins based on poly(lactic/glycolic) microsphere. Pharm. Res. 1991; 8: 713–720
  • Alonso M. J., Cohen S., Park T. G., Gupta R. K., Siber G. R., Langer R. Determinants of release rate of tetanus vaccine from polyester microspheres. Pharm. Res. 1993; 10: 945–953
  • Lu W., Park T. G. Protein release from Poly(lactic-co-glycolic acid) microspheres: Protein stability problems. J. Pharm. Sci. Technol. 1995; 49(1)13–19
  • Johnson R. E., Lanaski L. A., Gupta V., Griffin M. J., Gaud H. T., Needham T. E., Zia H. Stability of atriopeptin III in poly(D,L-lactide-co-glycolide) microspheres. J. Controlled Release 1991; 17: 61–68
  • Cleland J. L., Mac A., Boyd B., Yang J., Duenas E. T., Yeung D., Brooks D., Hsu C., Chu H., Mukku V., Jones A. J. S. The stability of Recombinant Human Growth Hormone in Poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm. Res. 1997; 14(4)420–425
  • Soriano I., Evora C., Llabres M. Preparation and evaluation of insulin-loaded poly(DL-lactide) microspheres using an experimental design. Int. J. Pharm. 1996; 142: 135–142
  • Kwong A. K., Chou S., Sun A. M., Sefton M. V., Goosen M. F. A. In vitro and in vivo release of insulin from Poly(Lactic acid) microbeads and pellets. J Controlled Release 1986; 4: 47–62
  • Young J. F. Humidity control in the laboratory using salt solutions—a review. J. Appl. Chem. 1967; 17: 241–245
  • Sundby F. Separation and characterization of acid-induced insulin transformation products by paper electrophoresis in 7 M urea. J. Biol. Chem. 1962; 237(11)3406–3411
  • Brange J., Langkjaer L. Y. J. Wang, R. PearlmanInsulin structure and stability. Stability and Characterization of Protein and Peptide Drugs: Case Histories, . Plenum Press, New York 1993; 315–350
  • Official Monograph for Insulin Human. United States Pharmacoepia. 23rd ed., The United States Pharmacopeial Convention, Rockville, MD 1995; 809–810
  • Brange J. Chemical stability of insulin 4. Mechanisms and kinetics of chemical transformations in pharmaceutical formulation. Acta Pharm. Nord. 1992; 4(4)209–222
  • Darrington R. T., Anderson B. D. Effects of insulin concentration and self-association on the partitioning of its A-21 cyclic anhydride intermediate to Desamido insulin and covalent dimer. Pharm. Res. 1995; 12(7)1077–1084
  • Strickley R. G., Anderson B. D. Solid-state stability of human insulin II.Effect of water on reactive intermediate partitioning in lyophiles from pH 2–5 solutions: Stabilization against covalent dimer formation. J. Pharm. Sci. 1997; 86(6)645–653
  • Darrington R. T., Anderson B. D. Evidence for a common intermediate in insulin deamidation and covalent dimer formation: Effects of pH and aniline trapping in dilute acidic solutions. J. Pharm. Sci. 1995; 84: 275–282

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.