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Pharmaceutical Development and Technology Volume 8, 2003 - Issue 4
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Research Article

Using Rate of Acid Neutralization to Characterize Aluminum Phosphate Adjuvant

Dongping Jiang Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana, 47907‐1336, USA
,
Clifford T. Johnston Department of Agronomy, Purdue University, West Lafayette, Indiana, 47907, USA
&
Stanley L. Hem Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana, 47907‐1336, USA
Pages 349-356 | Received 02 Jan 2003, Accepted 11 Feb 2003, Published online: 18 Sep 2003

References

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  • Shirodkar S., Hutchinson R. L., Perry D. L., White J. L., Hem S. L. Aluminum compounds used as adjuvants in vaccines. Pharm. Res. 1990; 7: 1282–1288
  • Burrell L. S., Johnston C. T., Schulze D., Klein J., White J. L., Hem S. L. Aluminium phosphate adjuvants prepared by precipitation at constant pH. Part I: composition and structure. Vaccine 2001; 19: 275–281
  • Burrell L. S., Johnston C. T., Schulze D., Klein J., White J. L., Hem S. L. Aluminium phosphate adjuvants prepared by precipitation at constant pH. Part II: physicochemical properties. Vaccine 2001; 19: 282–287
  • White J. L., Hem S. L. F. Brown, M. Corbel, E. GriffithsCharacterization of aluminium‐containing adjuvants. Physico‐Chemical Procedures for the Characterization of Vaccines, . Karger, Basel 2000; 217–228
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  • Seeber S. J., White J. L., Hem S. L. Predicting the adsorption of proteins by aluminium‐containing adjuvants. Vaccine 1991; 9: 201–203
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  • Chang M.‐F., White J. L., Nail S. L., Hem S. L. Role of the electrostatic attractive force in the adsorption of proteins by aluminum hydroxide adjuvant. PDA J. Pharm. Sci. Technol. 1997; 51: 25–29
  • Parks G. A. The isoelectric points of solid oxides, solid hydroxides, and aqueous hydroxo complex systems. Chem. Rev. 1965; 65: 177–198
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  • Righetti D. G., Caravaggio T. Isoelectric points and molecular weights of proteins. J. Chromatogr. 1976; 127: 12–28
  • Serna C. J., White J. L., Hem S. L. Nature of amorphous aluminum hydroxycarbonate. J. Pharm. Sci. 1978; 67: 1144–1147
  • Serna C. J., Lyons J. C., White J. L., Hem S. L. Stabilization of aluminum hydroxide gel by specifically adsorbed carbonate. J. Pharm. Sci. 1983; 72: 769–771
  • Burrell L. S., White J. L., Hem S. L. Stability of aluminum‐containing adjuvants during aging at room temperature. Vaccine 2000; 18: 2188–2192

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