Advanced search
Publication Cover
Pharmaceutical Development and Technology Volume 8, 2003 - Issue 4
Submit an article Journal homepage
96
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Use of a Fluidized Bed Hammer Mill for Size Reduction and Classification: Effects of Process Variables and Starting Materials on the Particle Size Distribution of Milled Lactose Batches

C. C. Lee Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Republic of Singapore
,
L. W. Chan Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Republic of Singapore
&
Paul W. S. Heng Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Republic of Singapore
Pages 431-442 | Received 03 Jan 2003, Accepted 15 Mar 2003, Published online: 18 Sep 2003

References

  • Tee S. K., Marriott C., Zeng X. M., Martin G. P. The use of different sugars as fine and coarse carriers for aerosolised salbutamol sulphate. Int. J. Pharm. 2000; 208(1–2)111–123
  • Sebhatu T., Alderborn G. Relationships between the effective interparticulate contact area and the tensile strength of tablets of amorphous and crystalline lactose of varying particle size. Eur. J. Pharm. Sci. 1999; 8(4)235–242
  • Okimoto K., Ohike A., Ibuki R., Aoki O., Ohnishi N., Rajewski R. A., Stella V. J., Irie T., Uekama K. Factors affecting membrane‐controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE)(7m)‐beta‐CD as both a solubilizer and osmotic agent. J. Control. Release 1999; 60(2–3)311–319
  • Mackaplow M. B., Rosen L. A., Michaels J. N. Effect of primary particle size on granule growth and endpoint determination in high‐shear wet granulation. Powder Technol. 2000; 108(1)32–45
  • Barra J., Falson‐Rieg F., Doelker E. Influence of the organization of binary mixes on their compactibility. Pharm. Res. 1999; 16(9)1449–1455
  • Djamarani K. M., Clark I. M. Characterization of particle size based on fine and coarse fractions. Powder Technol. 1997; 93: 101–108
  • Galk J., Peukert W. Production of narrow size distribution in air classifier mills (ACM). 9th European Symposium on Comminution, AlbiFrance, Sept., 8–10. EFCE, 1998; Vol. 2: 567–576
  • Hajratwala B. R. Particle size reduction by a hammer mill I: Effect of output screen size, feed particle size, and mill speed. J. Pharm. Sci. 1982; 71(2)188–190
  • Zhang Y., Johnson K. C. Effect of drug particle size on content uniformity of low‐dose solid dosage forms. Int. J. Pharm. 1997; 154: 179–183
  • Holger W., Wolfgang M., Rainer H. M. Analysis of particle size distribution of micronized lactose by laser diffractometry. Pharm. Ind. 1996; 58(4)354–357
  • Rosin P., Rammler E. J. The laws governing the fineness of powdered coal. Inst. Fuel 1933; 7: 29–36
  • Carr R. L., Jr. Evaluating flow properties of solids. Chem. Eng. January 18, 1965; 72(2)163–168
  • Heng P. W.S., Chan L. W., Lee C. C. Ultrafine grinding using a fluidised bed opposed jet mill: effects of process parameters on the size distribution of milled particles. STP Pharma Sci. 2000; 10(1)445–451

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.