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Pharmaceutical Development and Technology Volume 8, 2003 - Issue 4
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Research Article

Influence of the Aqueous Film Coating Process on the Properties and Stability of Tablets Containing a Moisture‐Labile Drug

Mirja Ruotsalainen Pharmaceutical Technology Division, Department of Pharmacy, University of Helsinki, P.O. Box 56, FIN‐00014, Finland
,
Jyrki Heinämäki Pharmaceutical Technology Division, Department of Pharmacy, University of Helsinki, P.O. Box 56, FIN‐00014, Finland
,
Krista Taipale Pharmaceutical Technology Division, Department of Pharmacy, University of Helsinki, P.O. Box 56, FIN‐00014, Finland
&
Jouko Yliruusi Pharmaceutical Technology Division, Department of Pharmacy, University of Helsinki, P.O. Box 56, FIN‐00014, Finland; Viikki Drug Discovery Technology Center, University of Helsinki, P.O. Box 56, FIN‐00014, Finland
Pages 443-451 | Received 24 Nov 2002, Accepted 15 Mar 2003, Published online: 18 Sep 2003

References

  • Ruotsalainen M., Heinämäki J., Rantanen J., Yliruusi J. Development of an automation system for a tablet coater. AAPS PharmSciTech 2002; 3(2)14
  • Heinämäki J., Ruotsalainen M., Lehtola V.‐M., Antikainen O., Yliruusi J. Optimization of aqueous‐based film coating of tablets performed by a side‐vented pan‐coating system. Pharm. Dev. Technol. 1997; 2(4)357–364
  • Twitchell A. M., Hogan J. E., Aulton M. E. The behaviour of film coating droplets on the impingement onto uncoated and coated tablet. STP Pharma Sci. 1995; 5(3)190–195
  • Obara S., McGinity J. W. Influence of processing variables on the properties of free films prepared from aqueous polymeric dispersions by a spray technique. Int. J. Pharm. 1995; 126: 1–10
  • Okutgen E., Jordan M., Hogan J. E., Aulton M. E. Effects of tablet core dimensional instability on the generation of internal stresses within film coats. Part III: exposure to temperatures and relative humidities which mimic the film coating process. Drug Dev. Ind. Pharm. 1991; 17(14)2005–2016
  • Poukavoos N., Peck G. E. The effect of swelling characteristics of superdisintegrants on the aqueous coating solution penetration into the tablet matrix during the film coating process. Pharm. Res. 1993; 10(9)1363–1370
  • Healy M. A., Corrigan O. I., Allan J. E.M. The effect of dissolution on the surface texture of model solid‐dosage forms as assessed by non‐contact laser profilometry. Pharm. Technol. Eur. 1995; 9: 14–22
  • Riippi M., Antikainen O., Niskanen T., Yliruusi J. The effect of compression force on surface structure, breaking strength, friability and disintegration time of erythromycin acistrate tablets. Eur. J. Pharm. Biopharm. 1998; 46: 339–345
  • Poukavoos N., Peck G. E. Effect of aqueous film coating conditions on water removal efficiency and physical properties of coated tablet cores containing superdisintegrants. Drug Dev. Ind. Pharm. 1994; 20(9)1535–1554
  • Ahlneck C., Alderborn G. Solid state stability of acetylsalicylic acid in binary mixtures with microcrystalline and microfine cellulose. Acta Pharm. Suec. 1988; 25: 41–52
  • Angberg M., Nyström C., Castensson S. Evaluation of heat‐conduction microcalorimetry in pharmaceutical stability studies. IV. The influence of microcrystalline cellulose on the hydration rate of anhydrous lactose. Int. J. Pharm. 1991; 77: 269–277
  • Dalton C. R., Hancock B. C. Processing and storage effects on water vapor sorption by some model pharmaceutical solid dosage fomulations. Int. J. Pharm. 1997; 156: 143–151
  • Faroongsang D., Peck G. E. The role of liquid water uptake by an insoluble tablet containing a disintegrant. Drug Dev. Ind. Pharm. 1994; 20(10)1777–1794
  • Felton L. A., Shah N. H., Zhang G., Infeld M. H., Malick A. W., McGinity J. W. Physical–mechanical properties of film‐coated soft gelatin capsules. Int. J. Pharm. 1996; 127: 203–211

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